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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain temperature and pH measured by <sup>1</sup>H chemical shift imaging of a thulium agent</title><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Trubel, Hubert K" sort="Trubel, Hubert K" uniqKey="Trubel H" first="Hubert K." last="Trubel">Hubert K. Trubel</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">University of Witten/Herdecke, Germany</nlm:aff></affiliation></author><author><name sortKey="Rycyna, Robert E" sort="Rycyna, Robert E" uniqKey="Rycyna R" first="Robert E." last="Rycyna">Robert E. Rycyna</name><affiliation><nlm:aff id="A6">Bruker BioSpin MRI, Billerica, MA 01821, USA</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Biomedical Engineering Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19130468</idno><idno type="pmc">2735415</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735415</idno><idno type="RBID">PMC:2735415</idno><idno type="doi">10.1002/nbm.1312</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000110</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000110</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Brain temperature and pH measured by <sup>1</sup>H chemical shift imaging of a thulium agent</title><author><name sortKey="Coman, Daniel" sort="Coman, Daniel" uniqKey="Coman D" first="Daniel" last="Coman">Daniel Coman</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author><author><name sortKey="Trubel, Hubert K" sort="Trubel, Hubert K" uniqKey="Trubel H" first="Hubert K." last="Trubel">Hubert K. Trubel</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A5">University of Witten/Herdecke, Germany</nlm:aff></affiliation></author><author><name sortKey="Rycyna, Robert E" sort="Rycyna, Robert E" uniqKey="Rycyna R" first="Robert E." last="Rycyna">Robert E. Rycyna</name><affiliation><nlm:aff id="A6">Bruker BioSpin MRI, Billerica, MA 01821, USA</nlm:aff></affiliation></author><author><name sortKey="Hyder, Fahmeed" sort="Hyder, Fahmeed" uniqKey="Hyder F" first="Fahmeed" last="Hyder">Fahmeed Hyder</name><affiliation><nlm:aff id="A1">Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation><affiliation><nlm:aff id="A4">Biomedical Engineering Yale University, New Haven, CT 06520, USA</nlm:aff></affiliation></author></analytic><series><title level="j">NMR in biomedicine</title><idno type="ISSN">0952-3480</idno><idno type="eISSN">1099-1492</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P3">Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly due to lack of precise and non-invasive methods. At 11.7T, we demonstrate that a thulium-based macrocyclic complex infused through the blood stream can be used to obtain temperature and pH maps of rat brain <italic>in vivo</italic> by <sup>1</sup>H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi-parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium-based method compared well with other methods for temperature (<sup>1</sup>H magnetic resonance spectroscopy (MRS) of N-acetyl aspartate and water; copper-constantan thermocouple wire) and pH (<sup>31</sup>P MRS of inorganic phosphate and phosphocreatine) assessment, as established by <italic>in vitro</italic> and <italic>in vivo</italic> studies. <italic>In vitro</italic> studies in phantoms with two compartments of differing pH values observed under different ambient temperature conditions generated precise temperature and pH distribution maps. <italic>In vivo</italic> studies in α-chloralose anesthetized and renal-ligated rats revealed temperature (33–34 °C) and pH (7.3–7.4) distributions in the cerebral cortex which are in agreement with observations by other methods. These results demonstrate that the thulium sensor can be used to measure temperature and pH distributions in rat brain <italic>in vivo</italic> simultaneously and accurately with <sup>1</sup>H CSI.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8915233</journal-id><journal-id journal-id-type="pubmed-jr-id">1782</journal-id><journal-id journal-id-type="nlm-ta">NMR Biomed</journal-id><journal-title>NMR in biomedicine</journal-title><issn pub-type="ppub">0952-3480</issn><issn pub-type="epub">1099-1492</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19130468</article-id><article-id pub-id-type="pmc">2735415</article-id><article-id pub-id-type="doi">10.1002/nbm.1312</article-id><article-id pub-id-type="manuscript">NIHMS134178</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Brain temperature and pH measured by <sup>1</sup>H chemical shift imaging of a thulium agent</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coman</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="A1">‖</xref><xref ref-type="aff" rid="A2">§</xref><xref ref-type="aff" rid="A3">*</xref></contrib><contrib contrib-type="author"><name><surname>Trubel</surname><given-names>Hubert K.</given-names></name><xref ref-type="aff" rid="A1">‖</xref><xref ref-type="aff" rid="A3">*</xref><xref ref-type="aff" rid="A5">†</xref><xref ref-type="author-notes" rid="FN1">+</xref></contrib><contrib contrib-type="author"><name><surname>Rycyna</surname><given-names>Robert E.</given-names></name><xref ref-type="aff" rid="A6">#</xref><xref ref-type="author-notes" rid="FN2">⊥</xref></contrib><contrib contrib-type="author"><name><surname>Hyder</surname><given-names>Fahmeed</given-names></name><xref ref-type="aff" rid="A1">‖</xref><xref ref-type="aff" rid="A2">§</xref><xref ref-type="aff" rid="A3">*</xref><xref ref-type="aff" rid="A4">‡</xref></contrib></contrib-group><aff id="A1"><label>‖</label>Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT 06520, USA</aff><aff id="A2"><label>§</label>Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT 06520, USA</aff><aff id="A3"><label>*</label>Department of Diagnostic Radiology, Yale University, New Haven, CT 06520, USA</aff><aff id="A4"><label>‡</label>Biomedical Engineering Yale University, New Haven, CT 06520, USA</aff><aff id="A5"><label>†</label>University of Witten/Herdecke, Germany</aff><aff id="A6"><label>#</label>Bruker BioSpin MRI, Billerica, MA 01821, USA</aff><author-notes><corresp id="cor1">Address correspondence and reprint requests to: Fahmeed Hyder / Daniel Coman, N135 TAC (MRRC), 300 Cedar Street, Yale University, New Haven, CT 06510, USA, Tel: +1-203-785-6205, Fax: +1-203-785-6643, <email>fahmeed.hyder@yale.edu</email>/<email>daniel.coman@yale.edu</email></corresp><fn id="FN1"><label>+</label><p id="P1">currently at Bayer HealthCare AG, Wuppertal, Germany</p></fn><fn id="FN2"><label>⊥</label><p id="P2">currently at Philips Healthcare, Highland Heights, OH 44143-213, USA</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>7</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>31</day><month>8</month><year>2009</year></pub-date><volume>22</volume><issue>2</issue><fpage>229</fpage><lpage>239</lpage><abstract><p id="P3">Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly due to lack of precise and non-invasive methods. At 11.7T, we demonstrate that a thulium-based macrocyclic complex infused through the blood stream can be used to obtain temperature and pH maps of rat brain <italic>in vivo</italic> by <sup>1</sup>H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi-parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium-based method compared well with other methods for temperature (<sup>1</sup>H magnetic resonance spectroscopy (MRS) of N-acetyl aspartate and water; copper-constantan thermocouple wire) and pH (<sup>31</sup>P MRS of inorganic phosphate and phosphocreatine) assessment, as established by <italic>in vitro</italic> and <italic>in vivo</italic> studies. <italic>In vitro</italic> studies in phantoms with two compartments of differing pH values observed under different ambient temperature conditions generated precise temperature and pH distribution maps. <italic>In vivo</italic> studies in α-chloralose anesthetized and renal-ligated rats revealed temperature (33–34 °C) and pH (7.3–7.4) distributions in the cerebral cortex which are in agreement with observations by other methods. These results demonstrate that the thulium sensor can be used to measure temperature and pH distributions in rat brain <italic>in vivo</italic> simultaneously and accurately with <sup>1</sup>H CSI.</p></abstract><kwd-group><kwd>biosensor</kwd><kwd>blood flow</kwd><kwd>energetics</kwd><kwd>metabolism</kwd><kwd>paramagnetic</kwd><kwd>tumor</kwd></kwd-group><contract-num rid="MH1">R01 MH067528-05</contract-num><contract-num rid="DC1">R01 DC003710-09</contract-num><contract-num rid="NS1">P30 NS052519-02</contract-num><contract-sponsor id="MH1">National Institute of Mental Health : NIMH</contract-sponsor><contract-sponsor id="DC1">National Institute on Deafness and Other Communication Disorders : NIDCD</contract-sponsor><contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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