Chelating Agents and the Regulation of Metal Ions
Identifieur interne : 000075 ( Pmc/Corpus ); précédent : 000074; suivant : 000076Chelating Agents and the Regulation of Metal Ions
Auteurs : Robert A. BulmanSource :
- Metal-Based Drugs [ 0793-0291 ] ; 1994.
Abstract
Up to about the early 1980s it was perhaps still possible to summarize in a review of a moderate length the development of the medicinal applications of chelation chemistry and the exploitation of such chemistry in regulating the metal ion concentrations in the body. However, in the last few years there has a great surge in the development of chelation chemistry and its usage in medicine and related areas of life sciences research. It is no longer the case that such a review primarily concentrates upon the use of chelating agents in removing toxic metals from the body but it must now cover the use of chelating agents in the imaging procedures nuclear medicine and magnetic resonance imaging (MRI), the use of chelating agents in unravelling the biochemistry of reactive oxidative species (ROS) and the control and measurement of intracellular calcium ions. It is in the recent applications that there have been the greatest developments over the last ten years.
Url:
DOI: 10.1155/MBD.1994.87
PubMed: 18476223
PubMed Central: 2364881
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chelating Agents and the Regulation of Metal Ions</title><author><name sortKey="Bulman, Robert A" sort="Bulman, Robert A" uniqKey="Bulman R" first="Robert A." last="Bulman">Robert A. Bulman</name><affiliation><nlm:aff id="aff1"><addr-line>61 Oxford Crescent, Didcot</addr-line><addr-line>Oxfordshire</addr-line><addr-line>OX11 7AL</addr-line><country>United Kingdom</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18476223</idno><idno type="pmc">2364881</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2364881</idno><idno type="RBID">PMC:2364881</idno><idno type="doi">10.1155/MBD.1994.87</idno><date when="1994">1994</date><idno type="wicri:Area/Pmc/Corpus">000075</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000075</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Chelating Agents and the Regulation of Metal Ions</title><author><name sortKey="Bulman, Robert A" sort="Bulman, Robert A" uniqKey="Bulman R" first="Robert A." last="Bulman">Robert A. Bulman</name><affiliation><nlm:aff id="aff1"><addr-line>61 Oxford Crescent, Didcot</addr-line><addr-line>Oxfordshire</addr-line><addr-line>OX11 7AL</addr-line><country>United Kingdom</country></nlm:aff></affiliation></author></analytic><series><title level="j">Metal-Based Drugs</title><idno type="ISSN">0793-0291</idno><imprint><date when="1994">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Up to about the early 1980s it was perhaps still possible to summarize in a review of a moderate
length the development of the medicinal applications of chelation chemistry and the exploitation of
such chemistry in regulating the metal ion concentrations in the body. However, in the last few years
there has a great surge in the development of chelation chemistry and its usage in medicine and
related areas of life sciences research. It is no longer the case that such a review primarily
concentrates upon the use of chelating agents in removing toxic metals from the body but it must
now cover the use of chelating agents in the imaging procedures nuclear medicine and magnetic
resonance imaging (MRI), the use of chelating agents in unravelling the biochemistry of reactive
oxidative species (ROS) and the control and measurement of intracellular calcium ions. It is in the
recent applications that there have been the greatest developments over the last ten years.</p></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Met Based Drugs</journal-id><journal-title>Metal-Based Drugs</journal-title><issn pub-type="ppub">0793-0291</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18476223</article-id><article-id pub-id-type="pmc">2364881</article-id><article-id pub-id-type="pii">S079302919400011X</article-id><article-id pub-id-type="doi">10.1155/MBD.1994.87</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Chelating Agents and the Regulation of Metal Ions</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bulman</surname><given-names>Robert A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>61 Oxford Crescent, Didcot</addr-line><addr-line>Oxfordshire</addr-line><addr-line>OX11 7AL</addr-line><country>United Kingdom</country></aff><pub-date pub-type="ppub"><year>1994</year></pub-date><volume>1</volume><issue>2-3</issue><fpage>87</fpage><lpage>106</lpage><history><date date-type="received"><day>2</day><month>9</month><year>1993</year></date></history><permissions><copyright-statement>Copyright © 1994 Hindawi Publishing Corporation.</copyright-statement><copyright-year>1994</copyright-year><copyright-holder>Hindawi Publishing Corporation</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/"><p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p></license></permissions><abstract><p>Up to about the early 1980s it was perhaps still possible to summarize in a review of a moderate
length the development of the medicinal applications of chelation chemistry and the exploitation of
such chemistry in regulating the metal ion concentrations in the body. However, in the last few years
there has a great surge in the development of chelation chemistry and its usage in medicine and
related areas of life sciences research. It is no longer the case that such a review primarily
concentrates upon the use of chelating agents in removing toxic metals from the body but it must
now cover the use of chelating agents in the imaging procedures nuclear medicine and magnetic
resonance imaging (MRI), the use of chelating agents in unravelling the biochemistry of reactive
oxidative species (ROS) and the control and measurement of intracellular calcium ions. It is in the
recent applications that there have been the greatest developments over the last ten years.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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