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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sexual outcome of patients undergoing thulium laser enucleation of the prostate for benign prostatic hyperplasia</title><author><name sortKey="Carmignani, Luca" sort="Carmignani, Luca" uniqKey="Carmignani L" first="Luca" last="Carmignani">Luca Carmignani</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Bozzini, Giorgio" sort="Bozzini, Giorgio" uniqKey="Bozzini G" first="Giorgio" last="Bozzini">Giorgio Bozzini</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Macchi, Alberto" sort="Macchi, Alberto" uniqKey="Macchi A" first="Alberto" last="Macchi">Alberto Macchi</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Maruccia, Serena" sort="Maruccia, Serena" uniqKey="Maruccia S" first="Serena" last="Maruccia">Serena Maruccia</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Picozzi, Stefano" sort="Picozzi, Stefano" uniqKey="Picozzi S" first="Stefano" last="Picozzi">Stefano Picozzi</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Casellato, Stefano" sort="Casellato, Stefano" uniqKey="Casellato S" first="Stefano" last="Casellato">Stefano Casellato</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25652616</idno><idno type="pmc">4577594</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577594</idno><idno type="RBID">PMC:4577594</idno><idno type="doi">10.4103/1008-682X.139255</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000028</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000028</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sexual outcome of patients undergoing thulium laser enucleation of the prostate for benign prostatic hyperplasia</title><author><name sortKey="Carmignani, Luca" sort="Carmignani, Luca" uniqKey="Carmignani L" first="Luca" last="Carmignani">Luca Carmignani</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Bozzini, Giorgio" sort="Bozzini, Giorgio" uniqKey="Bozzini G" first="Giorgio" last="Bozzini">Giorgio Bozzini</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Macchi, Alberto" sort="Macchi, Alberto" uniqKey="Macchi A" first="Alberto" last="Macchi">Alberto Macchi</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Maruccia, Serena" sort="Maruccia, Serena" uniqKey="Maruccia S" first="Serena" last="Maruccia">Serena Maruccia</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Picozzi, Stefano" sort="Picozzi, Stefano" uniqKey="Picozzi S" first="Stefano" last="Picozzi">Stefano Picozzi</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author><author><name sortKey="Casellato, Stefano" sort="Casellato, Stefano" uniqKey="Casellato S" first="Stefano" last="Casellato">Stefano Casellato</name><affiliation><nlm:aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</nlm:aff></affiliation></author></analytic><series><title level="j">Asian Journal of Andrology</title><idno type="ISSN">1008-682X</idno><idno type="eISSN">1745-7262</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Treatment of patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) may affect the quality of sexual function and ejaculation. The effect of new surgical procedures, which are currently available to treat BPH, on erection and ejaculation, has been poorly studied. This study aimed to assess the effect of thulium laser enucleation of the prostate (ThuLEP) on sexual function and retrograde ejaculation in patients with LUTS secondary to BPH. We performed a prospective study in 110 consecutive patients who had undergone ThuLEP to analyze changes in sexual function and urinary symptoms. To evaluate changes in erection and ejaculation, and the effect of urinary symptoms on the quality of life (QoL), five validated questionnaires were used: the ICIQ-MLUTSsex, MSHQ-EjD, International Index of Erectile Function 5, International Prognostic Scoring System (IPSS) questionnaire, and QoL index of the intraclass correlation coefficients. Patients also underwent IPSS and flowmetry to assess the outcome of flow. Patients were evaluated before surgery and 3–6 months after ThuLEP, whereas those with previous abdominal surgery were excluded. The patients’ mean age was 67.83 years. Postoperative urinary symptoms improved after surgery. No significant differences in erectile function before and after surgery were observed. As compared with other techniques described in the literature, the percentage of patients with conserved ejaculation increased by 52.7% after ThuLEP. ThuLEP positively affects urinary symptoms and their effect on the QoL of patients as assessed by questionnaire scores. While endoscopic management of BPH (e.g. transurethral resection of the prostate) causes retrograde ejaculation in most patients, those who undergo ThuLEP have conserved ejaculation and erectile function.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Serretta, V" uniqKey="Serretta V">V Serretta</name></author><author><name sortKey="Morgia, G" uniqKey="Morgia G">G Morgia</name></author><author><name sortKey="Fondacaro, L" uniqKey="Fondacaro L">L Fondacaro</name></author><author><name sortKey="Curto, G" uniqKey="Curto G">G Curto</name></author><author><name sortKey="Lo Bianco, A" uniqKey="Lo Bianco A">A Lo bianco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mearini, E" uniqKey="Mearini E">E Mearini</name></author><author><name sortKey="Marzi, M" uniqKey="Marzi M">M Marzi</name></author><author><name sortKey="Mearini, L" uniqKey="Mearini L">L Mearini</name></author><author><name 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Asian J Androl</journal-id><journal-id journal-id-type="iso-abbrev">Asian J. Androl</journal-id><journal-id journal-id-type="publisher-id">AJA</journal-id><journal-title-group><journal-title>Asian Journal of Andrology</journal-title></journal-title-group><issn pub-type="ppub">1008-682X</issn><issn pub-type="epub">1745-7262</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25652616</article-id><article-id pub-id-type="pmc">4577594</article-id><article-id pub-id-type="publisher-id">AJA-17-802</article-id><article-id pub-id-type="doi">10.4103/1008-682X.139255</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Sexual outcome of patients undergoing thulium laser enucleation of the prostate for benign prostatic hyperplasia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Carmignani</surname><given-names>Luca</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Bozzini</surname><given-names>Giorgio</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Macchi</surname><given-names>Alberto</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Maruccia</surname><given-names>Serena</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Picozzi</surname><given-names>Stefano</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Casellato</surname><given-names>Stefano</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1">Academic Department of Urology, IRCCS Policlinico San Donato, University of Milan, Milan, Italy.</aff><author-notes><corresp id="cor1">Correspondence: Dr. L Carmignani (<email xlink:href="luca.carmignani@unimi.it">luca.carmignani@unimi.it</email>)
</corresp></author-notes><pub-date pub-type="ppub"><season>Sep-Oct</season><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>1</month><year>2015</year></pub-date><volume>17</volume><issue>5</issue><fpage>802</fpage><lpage>806</lpage><history><date date-type="received"><day>30</day><month>1</month><year>2014</year></date><date date-type="rev-recd"><day>23</day><month>3</month><year>2014</year></date><date date-type="accepted"><day>18</day><month>7</month><year>2014</year></date></history><permissions><copyright-statement>Copyright: © Asian Journal of Andrology</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms</license-p></license></permissions><abstract><p>Treatment of patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) may affect the quality of sexual function and ejaculation. The effect of new surgical procedures, which are currently available to treat BPH, on erection and ejaculation, has been poorly studied. This study aimed to assess the effect of thulium laser enucleation of the prostate (ThuLEP) on sexual function and retrograde ejaculation in patients with LUTS secondary to BPH. We performed a prospective study in 110 consecutive patients who had undergone ThuLEP to analyze changes in sexual function and urinary symptoms. To evaluate changes in erection and ejaculation, and the effect of urinary symptoms on the quality of life (QoL), five validated questionnaires were used: the ICIQ-MLUTSsex, MSHQ-EjD, International Index of Erectile Function 5, International Prognostic Scoring System (IPSS) questionnaire, and QoL index of the intraclass correlation coefficients. Patients also underwent IPSS and flowmetry to assess the outcome of flow. Patients were evaluated before surgery and 3–6 months after ThuLEP, whereas those with previous abdominal surgery were excluded. The patients’ mean age was 67.83 years. Postoperative urinary symptoms improved after surgery. No significant differences in erectile function before and after surgery were observed. As compared with other techniques described in the literature, the percentage of patients with conserved ejaculation increased by 52.7% after ThuLEP. ThuLEP positively affects urinary symptoms and their effect on the QoL of patients as assessed by questionnaire scores. While endoscopic management of BPH (e.g. transurethral resection of the prostate) causes retrograde ejaculation in most patients, those who undergo ThuLEP have conserved ejaculation and erectile function.</p></abstract><kwd-group><kwd>antegrade ejaculation</kwd><kwd>benign prostatic hyperplasia</kwd><kwd>sexual function</kwd><kwd>thulium laser enucleation of the prostate</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="sec1-1"><title>INTRODUCTION</title><p>Benign prostatic hyperplasia (BPH) is a common medical condition. Transurethral resection of the prostate is currently considered the surgical gold standard worldwide to treat BPH, as well as open prostatectomy (Millin <italic>vs</italic> the transvesical approach) for an enlarged prostate. Nevertheless these procedures often expose older patients to increased perioperative morbidity.<xref rid="ref1" ref-type="bibr">1</xref><xref rid="ref2" ref-type="bibr">2</xref></p><p>Indications for surgical treatment of BPH are explained in the EAU Guidelines and are strictly related to lower urinary tract symptoms (LUTS).<xref rid="ref3" ref-type="bibr">3</xref> Holmium laser enucleation of the prostate (HoLEP), which is a further option, is also performed as an accepted alternative to transurethral resection of the prostate and open procedures.<xref rid="ref4" ref-type="bibr">4</xref> The effects of the latest surgical procedures for treating BPH have been poorly studied, and their effect on the quality of sexual function, mainly associated with ejaculation, is unknown. Previous studies have reported a consistent decrease in the International Index of Erectile Function 5 (IIEF-5) score, which measures orgasmic function, without any difference among analyzed procedures.<xref rid="ref5" ref-type="bibr">5</xref></p><p>Thulium laser enucleation of the prostate (ThuLEP) is a new procedure for treating BPH.<xref rid="ref6" ref-type="bibr">6</xref> The 2010 nm-wavelength thulium laser conducts through saline and enables incision and coagulation of prostatic tissue. Similar to HoLEP, ThuLEP has been implemented with development of the soft tissue morcellator to allow complete enucleation.<xref rid="ref7" ref-type="bibr">7</xref></p><p>To the best of our knowledge, sexual function in men who have undergone ThuLEP has not been evaluated in a prospective study relying on validated instruments. Therefore, in the current study, we assessed the effect of ThuLEP on sexual function of some patients with LUTS secondary to BPH and retrograde ejaculation.</p></sec><sec sec-type="methods" id="sec1-2"><title>PATIENTS AND METHODS</title><sec id="sec2-1"><title></title><sec id="sec3-1"><title>Patients’ selection</title><p>We performed a prospective study on changes in sexual function. The study was approved by our Local Ethical Committee. A total of 180 consecutive patients, who had symptomatic BPH and had a surgical indication according to EAU Guidelines,<xref rid="ref3" ref-type="bibr">3</xref> were enrolled in this study from January 2012 to January 2013. Patients who were older than 80 years old who had previous open or endoscopic management of BPH and abdominal surgery, were not included in the study to avoid any bias related to postsurgical overactive bladder syndrome.</p></sec><sec id="sec3-2"><title>Treatment and follow-up</title><p>According to the exclusion criteria mentioned below, 110 patients were recruited and each of them was treated with ThuLEP with the Cyber TM 150 device (Quanta System, Solbiate Olona, Varese, Italy). All of the surgical procedures were performed by three surgeons (LC, SC, and GB) who were fully trained in ThuLEP. This surgical technique has already been previously described.<xref rid="ref6" ref-type="bibr">6</xref> A maximum power of 110 W was set for each case. The Piranha Morcellator device (Richard Wolf, Knittlingen, Germany) was used at the end of the enucleation step. Postoperative Foley catheter irrigation was performed and removed the day after surgery. Patients were assessed by a prostate physical examination, total serum prostate specific antigen levels, digital rectal examination, urine culture, transrectal ultrasound (TRUS) (to evaluate prostatic volume), the International Prognostic Scoring System (IPSS), and uroflowmetry. Some of them also underwent a urodynamic study to assess whether detrusor hypocontractility could explain altered flow. Patients with a prostate specific antigen level higher than 4 ng ml<sup>−1</sup> underwent TRUS biopsy to exclude cases of prostatic carcinoma.</p></sec><sec id="sec3-3"><title>Questionnaires and statistical analysis employed</title><p>To assess changes in erection and ejaculation, and the effect of urinary symptoms on the quality of life (QoL), five validated questionnaires were used: the ICIQ-MLUTSsex, MSHQ-EjD,<xref rid="ref8" ref-type="bibr">8</xref> IIEF-5, IPSS questionnaire, and QoL Index of the intraclass correlation coefficients. Patients were evaluated preoperatively and at 3 and 6 months after ThuLEP. Flowmetry was performed during the follow-up period to assess changes in flow. Patients were asked not to ride a bicycle or motorbike during the 1<sup>st</sup> month after surgery to decrease the risk of hematuria and clot retention.</p><p>The collected data were analyzed by an online regression (Student's <italic>t</italic>-test, Chi-square test, and logistic regression analysis) tool at <ext-link ext-link-type="uri" xlink:href="www.xuru.org">www.xuru.org</ext-link> using linear least squares fittings. For all statistical comparisons, significance was considered at <italic>P</italic> < 0.05.</p></sec></sec></sec><sec sec-type="results" id="sec1-3"><title>RESULTS</title><p><bold><xref ref-type="table" rid="T1">Table 1</xref></bold> shows the patients’ characteristics. The patients’ mean age was 67.83 years (standard deviation [s.d.]: 7.74; range: 52.28–85.13 years). The mean prostate volume was 75.46 ml (s.d.: 43.75; range: 21.77–235.12 ml). Sixty-nine (62.7%) patients had been previously treated with alpha blockers, while six of them (8.7%) received a combination of finasteride and alpha blockers. Not all of the patients (16/110, 14.5%) reported a stable heterosexual relationship of at least 6 months duration. Thirty-one (28.2%) patients had undergone TRUS biopsy before ThuLEP.</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Patients characteristics</p></caption><graphic xlink:href="AJA-17-802-g001"></graphic></table-wrap><p><bold><xref ref-type="table" rid="T2">Table 2</xref></bold> shows the changes in scores of the questionnaires used. <bold><xref ref-type="table" rid="T3">Table 3</xref></bold> shows flowmetry results. A significant and sustained improvement in the scores of questionnaires for evaluating urinary symptoms was observed. There was no significant difference in patients’ erectile function before and after surgery. Analysis of the postoperative MSHQ-EjD showed 58 (52.7%) patients with consistent ejaculation function (EF) after ThuLEP. This rate was 78.4% (58/74) when we excluded patients with previous ED, no possibility of having sexual intercourse, and those with previous ejaculatory dysfunction not related to alpha blockers. Seven of the 58 patients (12.1%) reported painful ejaculation. Analysis of the postoperative ICIQ-MLUTSsex questionnaire showed no significant change in erectile function after ThuLEP. A similar result was obtained for the IIEF-5 Questionnaire (<bold><xref ref-type="table" rid="T4">Table 4</xref></bold>). Interestingly, patients who maintained their antegrade ejaculation were found to be more sexually satisfied than the other patients.</p><table-wrap id="T2" position="float"><label>Table 2</label><caption><p>Changes in scores on the questionnaires employed</p></caption><graphic xlink:href="AJA-17-802-g002"></graphic></table-wrap><table-wrap id="T3" position="float"><label>Table 3</label><caption><p>Flowmetry improvement</p></caption><graphic xlink:href="AJA-17-802-g003"></graphic></table-wrap><table-wrap id="T4" position="float"><label>Table 4</label><caption><p>Postoperative outcomes on erection and ejaculation (MSHQ-EjD and ICIQ-MLUTSsex)</p></caption><graphic xlink:href="AJA-17-802-g004"></graphic></table-wrap><p>A total of 51.7% (30/58) of patients expertise blood in seminal liquid after the surgical procedure. All of these patients who had undergone TRUS biopsy, also experienced it. Eight (7.3%, 8/110) patients were re-admitted because of clot retention. Adverse events, as well as operative and postoperative findings are shown in <bold><xref ref-type="table" rid="T5">Table 5</xref></bold>. Two patients had to be re-operated during hospitalization because of gross hematuria after accidental catheter removal. No ureteral strictures were observed during follow-up.</p><table-wrap id="T5" position="float"><label>Table 5</label><caption><p>Operative and postoperative findings and adverse events</p></caption><graphic xlink:href="AJA-17-802-g005"></graphic></table-wrap></sec><sec sec-type="discussion" id="sec1-4"><title>DISCUSSION</title><p>Benign prostatic hyperplasia is a common condition in middle-aged and older men. Many surgical treatments have been offered as alternative to current BPH gold standards.<xref rid="ref3" ref-type="bibr">3</xref> Most of these treatments are not as durable or effective as TURP and open prostatectomies for BPH, and these surgical techniques still have a consistent rate of morbidity. Even in skilled hands, bleeding and TUR syndrome remain the most dangerous complications for patients undergoing TURP.<xref rid="ref9" ref-type="bibr">9</xref><xref rid="ref10" ref-type="bibr">10</xref> Bleeding, length of hospitalization, and postoperative detrusor contractions, besides common complications following any open surgical approach, are quite frequent in any open prostatectomy performed for large BPH.<xref rid="ref1" ref-type="bibr">1</xref><xref rid="ref2" ref-type="bibr">2</xref></p><p>Laser-based techniques for BPH have increased in recent years. Their characteristics determine their versatility in BPH and endoscopic treatments for stones. HoLEP is equivalent to TURP and open prostatectomies with respect to clinical outcomes and QoL. However, HoLEP is superior with regard to perioperative morbidity with reduced bladder irrigation, catheter time and hospital stay, even though an equivalent volume of prostatic tissue is resected or enucleated.<xref rid="ref11" ref-type="bibr">11</xref></p><p>Thulium laser enucleation of the prostate is currently used to treat BPH.<xref rid="ref6" ref-type="bibr">6</xref><xref rid="ref12" ref-type="bibr">12</xref><xref rid="ref13" ref-type="bibr">13</xref> Gross <italic>et al.</italic><xref rid="ref14" ref-type="bibr">14</xref> showed that, similar to HoLEP, thullium vapo-enucleation of the prostate (ThuVEP), which has a different surgical technique, has an equivalent clinical outcome on LUTS compared with gold standard techniques. ThuVEP also minimizes the transfusion rate, the length of hospitalization, and postoperative complications.</p><p>Some evidence supports the theory that BPH combined with sexual and ejaculatory dysfunction are simply coexisting, and this is mainly related to metabolic and hormonal changes, usually affecting men.<xref rid="ref5" ref-type="bibr">5</xref> The multinational survey of the aging male, a large-scale, multinational survey on approximately 14,000 men aged 50–80 years, reported that although 90% of men had LUTS, 83% of them still had sexual activity.<xref rid="ref15" ref-type="bibr">15</xref> This survey also highlighted that erectile and EF play an important role in the QoL, even in aged men with symptomatic BPH.</p><p>Some studies have provided controversial evidence regarding postoperative erectile dysfunction (ED) after TURP and open prostatectomies for BPH.<xref rid="ref16" ref-type="bibr">16</xref><xref rid="ref17" ref-type="bibr">17</xref> Wasson <italic>et al.</italic><xref rid="ref18" ref-type="bibr">18</xref> investigated ED after TURP in an untreated group and did not find any increase in the rate of ED in the TURP group. Induced neuropraxia by different forms of energy has been indicated as a possible reason of a transient postoperative ED. Conversely, evidence has indicated a strict correlation between surgical management of BPH and retrograde ejaculation. To the best of our knowledge, our study is the first to focus on sexual and EF after ThuLEP.</p><p>Briganti <italic>et al.</italic><xref rid="ref19" ref-type="bibr">19</xref> achieved an equivalent outcome with regard to ED and EF between TURP and HoLEP. This suggests that these two surgical approaches are similarly associated with a high risk of postoperative ejaculatory dysfunction, mainly owing to retrograde ejaculation. Our series, using different questionnaires preoperatively and postoperatively, showed an overall conservation rate of antegrade ejaculation of 52.7%. If only those patients with possibilities of sexual intercourse were included, this rate was 78.3%. However, the rate of ED after ThuLEP was only 2.7% (<bold><xref ref-type="table" rid="T4">Table 4</xref></bold>). <bold><xref ref-type="table" rid="T6">Table 6</xref></bold> shows the outcomes of male sexual function in different laser prostate surgical techniques; the final results can be easily compared with those of the current study.<xref rid="ref11" ref-type="bibr">11</xref><xref rid="ref20" ref-type="bibr">20</xref><xref rid="ref21" ref-type="bibr">21</xref><xref rid="ref22" ref-type="bibr">22</xref><xref rid="ref23" ref-type="bibr">23</xref><xref rid="ref24" ref-type="bibr">24</xref><xref rid="ref25" ref-type="bibr">25</xref><xref rid="ref26" ref-type="bibr">26</xref><xref rid="ref27" ref-type="bibr">27</xref><xref rid="ref28" ref-type="bibr">28</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref29" ref-type="bibr">29</xref><xref rid="ref30" ref-type="bibr">30</xref><xref rid="ref31" ref-type="bibr">31</xref><xref rid="ref32" ref-type="bibr">32</xref><xref rid="ref33" ref-type="bibr">33</xref></p><table-wrap id="T6" position="float"><label>Table 6</label><caption><p>Outcome of male sexual function in different laser prostate surgical techniques</p></caption><graphic xlink:href="AJA-17-802-g006"></graphic></table-wrap><p>Several previous studies, mainly on alpha blockers, have shown how antegrade ejaculation can positively affect sexual satisfaction. There were also no significant differences in EF among three different groups with regard to prostatic volume (<40 ml, ≥40 ml and <100 ml, >100 ml). It is not the prostatic volume that may affect or not antegrade ejaculation after ThuLEP (<bold><xref ref-type="table" rid="T7">Table 7</xref></bold>). The reason for such a good result could be related to the surgical technique of laser enucleation of the prostate.<xref rid="ref6" ref-type="bibr">6</xref> A less deep incision typical of a thulium laser device (0.1–0.2 mm) can also determine the absence of transient ED because it does not involve neurovascular bundles of the capsule in the so-called neuropraxia phenomenon.<xref rid="ref34" ref-type="bibr">34</xref> On the same hand similar aspects have been underlined by a recent study by Xia.<xref rid="ref35" ref-type="bibr">35</xref> Further, from an anatomical and prospective view, further studies are required to better understand how EF can be better preserved. Also a comparison to TURP in a prospective study would have possibly shown the good results of ThuLEP regarding EF.</p><table-wrap id="T7" position="float"><label>Table 7</label><caption><p>Sexual outcome compared to preoperative prostatic volume</p></caption><graphic xlink:href="AJA-17-802-g007"></graphic></table-wrap><p>In our study, the good results on the postoperative IPSS and flowmetry showed that ThuLEP allowed radical prostatic adenoma enucleation. Preserved antegrade ejaculation was not correlated to partial enucleation of prostatic adenoma, as normally occurs during alpha blocker therapy when retrograde ejaculation appears and disappears once therapy is stopped.</p><p>A reduced learning curve is another important advantage of the proposed new surgical technique.<xref rid="ref6" ref-type="bibr">6</xref> This can be achieved with the help of a PC-based dry simulator and 15–20 tutorated cases. The dry simulator is made by Quanta System.</p><p>In the current study, clot retention was the main complication owing to anticoagulants taken by patients because of cardiovascular issues. Blood in seminal fluid is a surgical-related side effect, mainly found in patients with a previous TRUS biopsy.</p></sec><sec sec-type="conclusions" id="sec1-5"><title>CONCLUSIONS</title><p>Thulium laser enucleation of the prostate is an efficient technique, which is performed with a safe energy source. ThuLEP represents a simple new shift in the endoscopic management of BPH and can be used to treat prostates of any size. This technique improves the scores of questionnaires that are used to assess urinary symptoms and their effect on the QoL in patients. Antegrade ejaculation is mainly conserved in patients who undergo ThuLEP, with good effects on erectile function. Further, from a mainly anatomical and prospective view, further studies are required to better understand how EF can be better preserved with ThuLEP.</p></sec><sec id="sec1-6"><title>AUTHOR CONTRIBUTION</title><p>LC and GB have made the study design and the critical review. GB and SP has been involved in data interpretation, performed the statistical analysis and drafting the manuscript. AM and SM has been involved in data collections. SC was involved in drafting the manuscript with regards to layout. 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