Endoscopic Enucleation versus Open Prostatectomy for Treating Large Benign Prostatic Hyperplasia: A Meta-Analysis of Randomized Controlled Trials
Identifieur interne : 000970 ( Ncbi/Merge ); précédent : 000969; suivant : 000971Endoscopic Enucleation versus Open Prostatectomy for Treating Large Benign Prostatic Hyperplasia: A Meta-Analysis of Randomized Controlled Trials
Auteurs : Maoyin Li [République populaire de Chine] ; Jianguang Qiu [République populaire de Chine] ; Qi Hou [République populaire de Chine] ; Dejuan Wang [République populaire de Chine] ; Wentao Huang [République populaire de Chine] ; Cheng Hu [République populaire de Chine] ; Ke Li [République populaire de Chine] ; Xin Gao [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
To evaluate the overall efficacy and safety of endoscopic enucleation of the prostate (EP) vs open prostatectomy (OP) for large benign prostatic hyperplasia (BPH).
We conducted an electronic search of PubMed/Medline, EMBASE, The Cochrane Library, and Web of Science to detect all relevant randomized controlled trials (RCTs) comparing EP with OP. A meta-analysis was performed using Review Manager 5.3.
Seven RCTs (735 patients) were included. At the 3-, 6- and 12-month follow-up, there were no significant differences in the International Prostate Symptom Score (IPSS), maximum flow rate (Qmax), quality of life (QoL) score and post-void residual urine volume (PVR) between EP and OP. The International Index of Erectile Function (IIEF-5) was higher with EP (weighted mean difference [WMD]: 1.00, 95% confidence interval [CI]: 0.21 to 1.78, p=0.01) at the 12-month follow-up. The catheterization time (WMD: 3.80 d, 95%CI: -5.11 to -2.48, P<0.00001) and hospital stay (WMD: 4.93 d, 95%CI: -5.96 to -3.89, P<0.00001) were shorter with EP. The duration of operation was longer for EP compared with OP (WMD: 16.21 min, 95%CI: 3.72 to 28.70, P=0.01). The resected tissue weight (WMD: -9.63 g, 95%CI: -14.46 to -4.81, P<0.0001) and decrease in hemoglobin (WMD: -1.14 g/dL, 95%CI: -1.81 to -0.47, P=0.0008) were less with EP. EP was associated with fewer blood transfusions (risk ratio: 0.22, 95%CI: 0.10 to 0.47, P=0.0001). There were no significant differences between EP and OP when comparing other complications.
Although only a limited number of RCTs with relatively limited follow-up are available, EP is shown to have a similar postoperative profile and comparable safety to OP. By contrast, EP may have a more desirable perioperative profile. EP appears to be an effective and safe minimally invasive option for treating large prostates that requires only brief convalescence.
Url:
DOI: 10.1371/journal.pone.0121265
PubMed: 25826453
PubMed Central: 4380430
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id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Hou, Qi" sort="Hou, Qi" uniqKey="Hou Q" first="Qi" last="Hou">Qi Hou</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Urology, Central Hospital of Longgang District, Shenzhen, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Central Hospital of Longgang District, Shenzhen</wicri:regionArea><placeName><settlement type="city">Shenzhen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Dejuan" sort="Wang, Dejuan" uniqKey="Wang D" first="Dejuan" last="Wang">Dejuan Wang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Huang, Wentao" sort="Huang, Wentao" uniqKey="Huang W" first="Wentao" last="Huang">Wentao Huang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country 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type="main">Endoscopic Enucleation versus Open Prostatectomy for Treating Large Benign Prostatic Hyperplasia: A Meta-Analysis of Randomized Controlled Trials</title><author><name sortKey="Li, Maoyin" sort="Li, Maoyin" uniqKey="Li M" first="Maoyin" last="Li">Maoyin Li</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Qiu, Jianguang" sort="Qiu, Jianguang" uniqKey="Qiu J" first="Jianguang" last="Qiu">Jianguang Qiu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Hou, Qi" sort="Hou, Qi" uniqKey="Hou Q" first="Qi" last="Hou">Qi Hou</name><affiliation wicri:level="3"><nlm:aff id="aff002"><addr-line>Department of Urology, Central Hospital of Longgang District, Shenzhen, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Central Hospital of Longgang District, Shenzhen</wicri:regionArea><placeName><settlement type="city">Shenzhen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Dejuan" sort="Wang, Dejuan" uniqKey="Wang D" first="Dejuan" last="Wang">Dejuan Wang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Huang, Wentao" sort="Huang, Wentao" uniqKey="Huang W" first="Wentao" last="Huang">Wentao Huang</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Hu, Cheng" sort="Hu, Cheng" uniqKey="Hu C" first="Cheng" last="Hu">Cheng Hu</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Li, Ke" sort="Li, Ke" uniqKey="Li K" first="Ke" last="Li">Ke Li</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Gao, Xin" sort="Gao, Xin" uniqKey="Gao X" first="Xin" last="Gao">Xin Gao</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Objectives</title><p>To evaluate the overall efficacy and safety of endoscopic enucleation of the prostate (EP) vs open prostatectomy (OP) for large benign prostatic hyperplasia (BPH).</p></sec><sec id="sec002"><title>Methods</title><p>We conducted an electronic search of PubMed/Medline, EMBASE, The Cochrane Library, and Web of Science to detect all relevant randomized controlled trials (RCTs) comparing EP with OP. A meta-analysis was performed using Review Manager 5.3.</p></sec><sec id="sec003"><title>Results</title><p>Seven RCTs (735 patients) were included. At the 3-, 6- and 12-month follow-up, there were no significant differences in the International Prostate Symptom Score (IPSS), maximum flow rate (Qmax), quality of life (QoL) score and post-void residual urine volume (PVR) between EP and OP. The International Index of Erectile Function (IIEF-5) was higher with EP (weighted mean difference [WMD]: 1.00, 95% confidence interval [CI]: 0.21 to 1.78, p=0.01) at the 12-month follow-up. The catheterization time (WMD: 3.80 d, 95%CI: -5.11 to -2.48, P<0.00001) and hospital stay (WMD: 4.93 d, 95%CI: -5.96 to -3.89, P<0.00001) were shorter with EP. The duration of operation was longer for EP compared with OP (WMD: 16.21 min, 95%CI: 3.72 to 28.70, P=0.01). The resected tissue weight (WMD: -9.63 g, 95%CI: -14.46 to -4.81, P<0.0001) and decrease in hemoglobin (WMD: -1.14 g/dL, 95%CI: -1.81 to -0.47, P=0.0008) were less with EP. EP was associated with fewer blood transfusions (risk ratio: 0.22, 95%CI: 0.10 to 0.47, P=0.0001). There were no significant differences between EP and OP when comparing other complications.</p></sec><sec id="sec004"><title>Conclusions</title><p>Although only a limited number of RCTs with relatively limited follow-up are available, EP is shown to have a similar postoperative profile and comparable safety to OP. By contrast, EP may have a more desirable perioperative profile. EP appears to be an effective and safe minimally invasive option for treating large prostates that requires only brief convalescence.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mcconnell, Jd" uniqKey="Mcconnell J">JD McConnell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Girman, Cj" uniqKey="Girman C">CJ Girman</name></author><author><name sortKey="Jacobsen, Sj" uniqKey="Jacobsen S">SJ Jacobsen</name></author><author><name sortKey="Tsukamoto, T" uniqKey="Tsukamoto T">T Tsukamoto</name></author><author><name sortKey="Richard, F" uniqKey="Richard F">F Richard</name></author><author><name sortKey="Garraway, Wm" uniqKey="Garraway W">WM Garraway</name></author><author><name sortKey="Sagnier, Pp" uniqKey="Sagnier P">PP Sagnier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Welch, G" uniqKey="Welch G">G Welch</name></author><author><name sortKey="Weinger, K" uniqKey="Weinger K">K Weinger</name></author><author><name sortKey="Barry, Mj" uniqKey="Barry M">MJ Barry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gu, Fl" uniqKey="Gu F">FL Gu</name></author><author><name sortKey="Xia, Tl" uniqKey="Xia T">TL Xia</name></author><author><name sortKey="Kong, Xt" uniqKey="Kong X">XT Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oelke, M" uniqKey="Oelke M">M Oelke</name></author><author><name sortKey="Bachmann, A" uniqKey="Bachmann A">A Bachmann</name></author><author><name sortKey="Descazeaud, A" uniqKey="Descazeaud A">A Descazeaud</name></author><author><name sortKey="Emberton, M" uniqKey="Emberton M">M Emberton</name></author><author><name sortKey="Gravas, S" uniqKey="Gravas S">S Gravas</name></author><author><name sortKey="Michel, Mc" uniqKey="Michel M">MC Michel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naspro, R" uniqKey="Naspro R">R Naspro</name></author><author><name sortKey="Suardi, N" uniqKey="Suardi N">N Suardi</name></author><author><name sortKey="Salonia, A" uniqKey="Salonia A">A Salonia</name></author><author><name sortKey="Scattoni, V" uniqKey="Scattoni V">V Scattoni</name></author><author><name sortKey="Guazzoni, G" uniqKey="Guazzoni G">G Guazzoni</name></author><author><name sortKey="Colombo, R" uniqKey="Colombo R">R Colombo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuntz, Rm" uniqKey="Kuntz R">RM Kuntz</name></author><author><name sortKey="Lehrich, K" uniqKey="Lehrich K">K Lehrich</name></author><author><name sortKey="Ahyai, Sa" uniqKey="Ahyai S">SA Ahyai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suer, E" uniqKey="Suer E">E Suer</name></author><author><name sortKey="Gokce, I" uniqKey="Gokce I">I Gokce</name></author><author><name sortKey="Yaman, O" uniqKey="Yaman O">O Yaman</name></author><author><name sortKey="Anafarta, K" uniqKey="Anafarta K">K Anafarta</name></author><author><name sortKey="Gogus, O" uniqKey="Gogus O">O Gogus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serretta, V" uniqKey="Serretta V">V Serretta</name></author><author><name sortKey="Morgia, G" uniqKey="Morgia G">G Morgia</name></author><author><name sortKey="Fondacaro, L" uniqKey="Fondacaro L">L Fondacaro</name></author><author><name sortKey="Curto, G" uniqKey="Curto G">G Curto</name></author><author><name sortKey="Lo Bianco, A" uniqKey="Lo Bianco A">A Lo bianco</name></author><author><name sortKey="Pirritano, D" uniqKey="Pirritano D">D Pirritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahyai, Sa" uniqKey="Ahyai S">SA Ahyai</name></author><author><name sortKey="Gilling, P" uniqKey="Gilling P">P Gilling</name></author><author><name sortKey="Kaplan, Sa" uniqKey="Kaplan S">SA Kaplan</name></author><author><name sortKey="Kuntz, Rm" uniqKey="Kuntz R">RM Kuntz</name></author><author><name sortKey="Madersbacher, S" uniqKey="Madersbacher S">S Madersbacher</name></author><author><name sortKey="Montorsi, F" uniqKey="Montorsi F">F Montorsi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilling, Pj" uniqKey="Gilling P">PJ Gilling</name></author><author><name sortKey="Cass, Cb" uniqKey="Cass C">CB Cass</name></author><author><name sortKey="Cresswell, Md" uniqKey="Cresswell M">MD Cresswell</name></author><author><name sortKey="Fraundorfer, Mr" uniqKey="Fraundorfer M">MR Fraundorfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Ah" uniqKey="Tan A">AH Tan</name></author><author><name sortKey="Gilling, Pj" uniqKey="Gilling P">PJ Gilling</name></author><author><name sortKey="Kennett, Km" uniqKey="Kennett K">KM Kennett</name></author><author><name sortKey="Frampton, C" uniqKey="Frampton C">C Frampton</name></author><author><name sortKey="Westenberg, Am" uniqKey="Westenberg A">AM Westenberg</name></author><author><name sortKey="Fraundorfer, Mr" uniqKey="Fraundorfer M">MR Fraundorfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carmignani, L" uniqKey="Carmignani L">L Carmignani</name></author><author><name sortKey="Picozzi, S" uniqKey="Picozzi S">S Picozzi</name></author><author><name sortKey="Casellato, S" uniqKey="Casellato S">S Casellato</name></author><author><name sortKey="Bozzini, G" uniqKey="Bozzini G">G Bozzini</name></author><author><name sortKey="Maruccia, S" uniqKey="Maruccia S">S Maruccia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, A" uniqKey="Xu A">A Xu</name></author><author><name sortKey="Zou, Y" uniqKey="Zou Y">Y Zou</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Zheng, S" uniqKey="Zheng S">S Zheng</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zheng, Sb" uniqKey="Zheng S">SB Zheng</name></author><author><name sortKey="Liu, Cx" uniqKey="Liu C">CX Liu</name></author><author><name sortKey="Xu, Yw" uniqKey="Xu Y">YW Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilling, Pj" uniqKey="Gilling P">PJ Gilling</name></author><author><name sortKey="Kennett, Km" uniqKey="Kennett K">KM Kennett</name></author><author><name sortKey="Fraundorfer, Mr" uniqKey="Fraundorfer M">MR Fraundorfer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jadad, Ar" uniqKey="Jadad A">AR Jadad</name></author><author><name sortKey="Moore, Ra" uniqKey="Moore R">RA Moore</name></author><author><name sortKey="Carroll, D" uniqKey="Carroll D">D Carroll</name></author><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author><author><name sortKey="Reynolds, Dj" uniqKey="Reynolds D">DJ Reynolds</name></author><author><name sortKey="Gavaghan, Dj" uniqKey="Gavaghan D">DJ Gavaghan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kjaergard, Ll" uniqKey="Kjaergard L">LL Kjaergard</name></author><author><name sortKey="Villumsen, J" uniqKey="Villumsen J">J Villumsen</name></author><author><name sortKey="Gluud, C" uniqKey="Gluud C">C Gluud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dersimonian, R" uniqKey="Dersimonian R">R DerSimonian</name></author><author><name sortKey="Laird, N" uniqKey="Laird N">N Laird</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mantel, N" uniqKey="Mantel N">N Mantel</name></author><author><name sortKey="Haenszel, W" uniqKey="Haenszel W">W Haenszel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Du, Cj" uniqKey="Du C">CJ Du</name></author><author><name sortKey="Xu, G" uniqKey="Xu G">G Xu</name></author><author><name sortKey="Chen, Jm" uniqKey="Chen J">JM Chen</name></author><author><name sortKey="Jing, X" uniqKey="Jing X">X Jing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Jm" uniqKey="Rao J">JM Rao</name></author><author><name sortKey="Yang, Jr" uniqKey="Yang J">JR Yang</name></author><author><name sortKey="Ren, Yx" uniqKey="Ren Y">YX Ren</name></author><author><name sortKey="He, J" uniqKey="He J">J He</name></author><author><name sortKey="Ding, P" uniqKey="Ding P">P Ding</name></author><author><name sortKey="Yang, Jh" uniqKey="Yang J">JH Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ou, Rb" uniqKey="Ou R">RB Ou</name></author><author><name sortKey="Deng, Xr" uniqKey="Deng X">XR Deng</name></author><author><name sortKey="Yang, Wj" uniqKey="Yang W">WJ Yang</name></author><author><name sortKey="Wei, Xh" uniqKey="Wei X">XH Wei</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Xie, Kj" uniqKey="Xie K">KJ Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Zhu, L" uniqKey="Zhu L">L Zhu</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name></author><author><name sortKey="Zheng, Z" uniqKey="Zheng Z">Z Zheng</name></author><author><name sortKey="Ge, R" uniqKey="Ge R">R Ge</name></author><author><name sortKey="Wu, M" uniqKey="Wu M">M Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Geavlete, B" uniqKey="Geavlete B">B Geavlete</name></author><author><name sortKey="Stanescu, F" uniqKey="Stanescu F">F Stanescu</name></author><author><name sortKey="Iacoboaie, C" uniqKey="Iacoboaie C">C Iacoboaie</name></author><author><name sortKey="Geavlete, P" uniqKey="Geavlete P">P Geavlete</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author><author><name sortKey="Pham, B" uniqKey="Pham B">B Pham</name></author><author><name sortKey="Jones, A" uniqKey="Jones A">A Jones</name></author><author><name sortKey="Cook, Dj" uniqKey="Cook D">DJ Cook</name></author><author><name sortKey="Jadad, Ar" uniqKey="Jadad A">AR Jadad</name></author><author><name sortKey="Moher, M" uniqKey="Moher M">M Moher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freyer, Pj" uniqKey="Freyer P">PJ Freyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varkarakis, I" uniqKey="Varkarakis I">I Varkarakis</name></author><author><name sortKey="Kyriakakis, Z" uniqKey="Kyriakakis Z">Z Kyriakakis</name></author><author><name sortKey="Delis, A" uniqKey="Delis A">A Delis</name></author><author><name sortKey="Protogerou, V" uniqKey="Protogerou V">V Protogerou</name></author><author><name sortKey="Deliveliotis, C" uniqKey="Deliveliotis C">C Deliveliotis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruskewitz, R" uniqKey="Bruskewitz R">R Bruskewitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lukacs, B" uniqKey="Lukacs B">B Lukacs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahlstrand, C" uniqKey="Ahlstrand C">C Ahlstrand</name></author><author><name sortKey="Carlsson, P" uniqKey="Carlsson P">P Carlsson</name></author><author><name sortKey="Jonsson, B" uniqKey="Jonsson B">B Jonsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mozes, B" uniqKey="Mozes B">B Mozes</name></author><author><name sortKey="Cohen, Yc" uniqKey="Cohen Y">YC Cohen</name></author><author><name sortKey="Olmer, L" uniqKey="Olmer L">L Olmer</name></author><author><name sortKey="Shabtai, E" uniqKey="Shabtai E">E Shabtai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Zheng, S" uniqKey="Zheng S">S Zheng</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Xu, K" uniqKey="Xu K">K Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuntz, Rm" uniqKey="Kuntz R">RM Kuntz</name></author><author><name sortKey="Lehrich, K" uniqKey="Lehrich K">K Lehrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kuntz, Rm" uniqKey="Kuntz R">RM Kuntz</name></author><author><name sortKey="Lehrich, K" uniqKey="Lehrich K">K Lehrich</name></author><author><name sortKey="Ahyai, S" uniqKey="Ahyai S">S Ahyai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Hakim, A" uniqKey="El Hakim A">A El-Hakim</name></author><author><name sortKey="Elhilali, Mm" uniqKey="Elhilali M">MM Elhilali</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25826453</article-id><article-id pub-id-type="pmc">4380430</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0121265</article-id><article-id pub-id-type="publisher-id">PONE-D-14-46418</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Endoscopic Enucleation versus Open Prostatectomy for Treating Large Benign Prostatic Hyperplasia: A Meta-Analysis of Randomized Controlled Trials</article-title><alt-title alt-title-type="running-head">Endoscopic Enucleation vs OP for Large BPH:A Meta Analysis</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Li</surname><given-names>Maoyin</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Qiu</surname><given-names>Jianguang</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hou</surname><given-names>Qi</given-names></name><xref ref-type="aff" rid="aff002"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Dejuan</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Wentao</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hu</surname><given-names>Cheng</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Ke</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="aff001"><sup>1</sup></xref><xref rid="cor001" ref-type="corresp">*</xref></contrib></contrib-group><aff id="aff001"><label>1</label><addr-line>Department of Urology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China</addr-line></aff><aff id="aff002"><label>2</label><addr-line>Department of Urology, Central Hospital of Longgang District, Shenzhen, China</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Schwentner</surname><given-names>Christian</given-names></name><role>Academic Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>Eberhard Karls University, GERMANY</addr-line></aff><author-notes><fn fn-type="conflict" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con" id="contrib001"><p>Conceived and designed the experiments: ML JQ XG. Performed the experiments: ML JQ QH DW WH CH. Analyzed the data: ML DW WH KL. Contributed reagents/materials/analysis tools: DW WH CH. Wrote the paper: ML JQ QH.</p></fn><corresp id="cor001">* E-mail: <email>gaoxin44@vip.163.com</email></corresp></author-notes><pub-date pub-type="epub"><day>31</day><month>3</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>10</volume><issue>3</issue><elocation-id>e0121265</elocation-id><history><date date-type="received"><day>9</day><month>11</month><year>2014</year></date><date date-type="accepted"><day>29</day><month>1</month><year>2015</year></date></history><permissions><copyright-year>2015</copyright-year><copyright-holder>Li et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="pone.0121265.pdf"></self-uri><abstract><sec id="sec001"><title>Objectives</title><p>To evaluate the overall efficacy and safety of endoscopic enucleation of the prostate (EP) vs open prostatectomy (OP) for large benign prostatic hyperplasia (BPH).</p></sec><sec id="sec002"><title>Methods</title><p>We conducted an electronic search of PubMed/Medline, EMBASE, The Cochrane Library, and Web of Science to detect all relevant randomized controlled trials (RCTs) comparing EP with OP. A meta-analysis was performed using Review Manager 5.3.</p></sec><sec id="sec003"><title>Results</title><p>Seven RCTs (735 patients) were included. At the 3-, 6- and 12-month follow-up, there were no significant differences in the International Prostate Symptom Score (IPSS), maximum flow rate (Qmax), quality of life (QoL) score and post-void residual urine volume (PVR) between EP and OP. The International Index of Erectile Function (IIEF-5) was higher with EP (weighted mean difference [WMD]: 1.00, 95% confidence interval [CI]: 0.21 to 1.78, p=0.01) at the 12-month follow-up. The catheterization time (WMD: 3.80 d, 95%CI: -5.11 to -2.48, P<0.00001) and hospital stay (WMD: 4.93 d, 95%CI: -5.96 to -3.89, P<0.00001) were shorter with EP. The duration of operation was longer for EP compared with OP (WMD: 16.21 min, 95%CI: 3.72 to 28.70, P=0.01). The resected tissue weight (WMD: -9.63 g, 95%CI: -14.46 to -4.81, P<0.0001) and decrease in hemoglobin (WMD: -1.14 g/dL, 95%CI: -1.81 to -0.47, P=0.0008) were less with EP. EP was associated with fewer blood transfusions (risk ratio: 0.22, 95%CI: 0.10 to 0.47, P=0.0001). There were no significant differences between EP and OP when comparing other complications.</p></sec><sec id="sec004"><title>Conclusions</title><p>Although only a limited number of RCTs with relatively limited follow-up are available, EP is shown to have a similar postoperative profile and comparable safety to OP. By contrast, EP may have a more desirable perioperative profile. EP appears to be an effective and safe minimally invasive option for treating large prostates that requires only brief convalescence.</p></sec></abstract><funding-group><funding-statement>The authors have no support or funding to report.</funding-statement></funding-group><counts><fig-count count="1"></fig-count><table-count count="5"></table-count><page-count count="14"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li><li>Shenzhen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Li, Maoyin" sort="Li, Maoyin" uniqKey="Li M" first="Maoyin" last="Li">Maoyin Li</name></region><name sortKey="Gao, Xin" sort="Gao, Xin" uniqKey="Gao X" first="Xin" last="Gao">Xin Gao</name><name sortKey="Hou, Qi" sort="Hou, Qi" uniqKey="Hou Q" first="Qi" last="Hou">Qi Hou</name><name sortKey="Hu, Cheng" sort="Hu, Cheng" uniqKey="Hu C" first="Cheng" last="Hu">Cheng Hu</name><name sortKey="Huang, Wentao" sort="Huang, Wentao" uniqKey="Huang W" first="Wentao" last="Huang">Wentao Huang</name><name sortKey="Li, Ke" sort="Li, Ke" uniqKey="Li K" first="Ke" last="Li">Ke Li</name><name sortKey="Qiu, Jianguang" sort="Qiu, Jianguang" uniqKey="Qiu J" first="Jianguang" last="Qiu">Jianguang Qiu</name><name sortKey="Wang, Dejuan" sort="Wang, Dejuan" uniqKey="Wang D" first="Dejuan" last="Wang">Dejuan Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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