Analysis of early morbidity and functional outcome of thulium: yttrium-aluminum-garnet laser enucleation for benign prostate enlargement: patient age and prostate size determine adverse surgical outcome.
Identifieur interne : 000934 ( Ncbi/Merge ); précédent : 000933; suivant : 000935Analysis of early morbidity and functional outcome of thulium: yttrium-aluminum-garnet laser enucleation for benign prostate enlargement: patient age and prostate size determine adverse surgical outcome.
Auteurs : Steffen Rausch [Allemagne] ; Thomas Heider [Allemagne] ; Jens Bedke [Allemagne] ; Stephan Kruck [Allemagne] ; Christian Schwentner [Allemagne] ; Karsten Fischer [Allemagne] ; Arnulf Stenzl [Allemagne] ; Tilman K Lble [Allemagne]Source :
- Urology [ 1527-9995 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Aluminium (effets indésirables), Aluminium (usage thérapeutique), Complications postopératoires (épidémiologie), Complications postopératoires (étiologie), Facteurs de l'âge, Facteurs de risque, Facteurs temps, Humains, Hyperplasie de la prostate (), Hyperplasie de la prostate (anatomopathologie), Mâle, Prostate (anatomopathologie), Prostatectomie (), Prostatectomie (effets indésirables), Récupération fonctionnelle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Taille d'organe, Thulium (effets indésirables), Thulium (usage thérapeutique), Yttrium (effets indésirables), Yttrium (usage thérapeutique), Études prospectives.
- MESH :
- anatomopathologie : Hyperplasie de la prostate, Prostate.
- effets indésirables : Aluminium, Prostatectomie, Thulium, Yttrium.
- usage thérapeutique : Aluminium, Thulium, Yttrium.
- épidémiologie : Complications postopératoires.
- étiologie : Complications postopératoires.
- Adulte d'âge moyen, Facteurs de l'âge, Facteurs de risque, Facteurs temps, Humains, Hyperplasie de la prostate, Mâle, Prostatectomie, Récupération fonctionnelle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Taille d'organe, Études prospectives.
English descriptors
- KwdEn :
- Age Factors, Aged, Aged, 80 and over, Aluminum (adverse effects), Aluminum (therapeutic use), Humans, Male, Middle Aged, Organ Size, Postoperative Complications (epidemiology), Postoperative Complications (etiology), Prospective Studies, Prostate (pathology), Prostatectomy (adverse effects), Prostatectomy (methods), Prostatic Hyperplasia (pathology), Prostatic Hyperplasia (surgery), Recovery of Function, Risk Factors, Thulium (adverse effects), Thulium (therapeutic use), Time Factors, Treatment Outcome, Yttrium (adverse effects), Yttrium (therapeutic use).
- MESH :
- chemical , adverse effects : Aluminum, Thulium, Yttrium.
- chemical , therapeutic use : Aluminum, Thulium, Yttrium.
- adverse effects : Prostatectomy.
- epidemiology : Postoperative Complications.
- etiology : Postoperative Complications.
- methods : Prostatectomy.
- pathology : Prostate, Prostatic Hyperplasia.
- surgery : Prostatic Hyperplasia.
- Age Factors, Aged, Aged, 80 and over, Humans, Male, Middle Aged, Organ Size, Prospective Studies, Recovery of Function, Risk Factors, Time Factors, Treatment Outcome.
Abstract
To evaluate complications and functional outcome and to identify patient-associated risk factors, we analyzed consecutive patients undergoing thulium:yttrium-aluminum-garnet laser enucleation of the prostate (ThuLEP) in our department.
DOI: 10.1016/j.urology.2014.10.002
PubMed: 25530383
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Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="K Lble, Tilman" sort="K Lble, Tilman" uniqKey="K Lble T" first="Tilman" last="K Lble">Tilman K Lble</name><affiliation wicri:level="1"><nlm:affiliation>Department of Urology, Klinikum Fulda, Fulda, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Urology, Klinikum Fulda, Fulda</wicri:regionArea><wicri:noRegion>Fulda</wicri:noRegion><wicri:noRegion>Fulda</wicri:noRegion><wicri:noRegion>Fulda</wicri:noRegion></affiliation></author></analytic><series><title level="j">Urology</title><idno type="eISSN">1527-9995</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Aluminum (adverse effects)</term><term>Aluminum (therapeutic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Organ Size</term><term>Postoperative Complications (epidemiology)</term><term>Postoperative Complications (etiology)</term><term>Prospective Studies</term><term>Prostate (pathology)</term><term>Prostatectomy (adverse effects)</term><term>Prostatectomy (methods)</term><term>Prostatic Hyperplasia (pathology)</term><term>Prostatic Hyperplasia (surgery)</term><term>Recovery of Function</term><term>Risk Factors</term><term>Thulium (adverse effects)</term><term>Thulium (therapeutic use)</term><term>Time Factors</term><term>Treatment Outcome</term><term>Yttrium (adverse effects)</term><term>Yttrium (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Aluminium (effets indésirables)</term><term>Aluminium (usage thérapeutique)</term><term>Complications postopératoires (épidémiologie)</term><term>Complications postopératoires (étiologie)</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Humains</term><term>Hyperplasie de la prostate ()</term><term>Hyperplasie de la prostate (anatomopathologie)</term><term>Mâle</term><term>Prostate (anatomopathologie)</term><term>Prostatectomie ()</term><term>Prostatectomie (effets indésirables)</term><term>Récupération fonctionnelle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taille d'organe</term><term>Thulium (effets indésirables)</term><term>Thulium (usage thérapeutique)</term><term>Yttrium (effets indésirables)</term><term>Yttrium (usage thérapeutique)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Aluminum</term><term>Thulium</term><term>Yttrium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Aluminum</term><term>Thulium</term><term>Yttrium</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Prostatectomy</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hyperplasie de la prostate</term><term>Prostate</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Aluminium</term><term>Prostatectomie</term><term>Thulium</term><term>Yttrium</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Prostatectomy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Prostate</term><term>Prostatic Hyperplasia</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Prostatic Hyperplasia</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Aluminium</term><term>Thulium</term><term>Yttrium</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Complications postopératoires</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Complications postopératoires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Organ Size</term><term>Prospective Studies</term><term>Recovery of Function</term><term>Risk Factors</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de l'âge</term><term>Facteurs de risque</term><term>Facteurs temps</term><term>Humains</term><term>Hyperplasie de la prostate</term><term>Mâle</term><term>Prostatectomie</term><term>Récupération fonctionnelle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Taille d'organe</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate complications and functional outcome and to identify patient-associated risk factors, we analyzed consecutive patients undergoing thulium:yttrium-aluminum-garnet laser enucleation of the prostate (ThuLEP) in our department.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25530383</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>22</Day></DateCreated><DateCompleted><Year>2015</Year><Month>02</Month><Day>23</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1527-9995</ISSN><JournalIssue CitedMedium="Internet"><Volume>85</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Urology</Title><ISOAbbreviation>Urology</ISOAbbreviation></Journal><ArticleTitle>Analysis of early morbidity and functional outcome of thulium: yttrium-aluminum-garnet laser enucleation for benign prostate enlargement: patient age and prostate size determine adverse surgical outcome.</ArticleTitle><Pagination><MedlinePgn>182-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.urology.2014.10.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0090-4295(14)01097-8</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate complications and functional outcome and to identify patient-associated risk factors, we analyzed consecutive patients undergoing thulium:yttrium-aluminum-garnet laser enucleation of the prostate (ThuLEP) in our department.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A total of 234 patients were prospectively analyzed. Preoperative data, postoperative complications, and outcome at 6, 12, and 24 months were recorded. Individual risk factors for complications and treatment failure were assessed by univariate and multivariate analyses.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean age at surgery was 72.88 ± 7.83 years. Mean preoperative prostate size was 84.8 ± 34.9 mL. Thirty-day complication rate was 19.7%. Functional treatment failure occurred in 9.0% of all patients. Decline of mean International Prostate Symptom Score was -75%, quality of life index -76%, and postvoid residual -86% at 24 months. Maximum urine flow at 24 months was improved at +231%. In univariate analysis, age >80 years and prostate size <50 mL were significant predictors of complications, which was confirmed by multivariate analysis (P = .0277 and .0409, respectively). Age >80 years, prostate size <80 mL or <50 mL, and American Society of Anesthesiologists classification were significant predictors of functional treatment failure in univariate analysis. Prostate size <80 mL or <50 mL was significantly associated with treatment failure (P < .001) in multivariate analysis.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">ThuLEP is a safe and efficient surgical procedure, even in a patient cohort with high prostate volumes, age, and comorbidities. However, high patient age and small prostate size were significant determinants of adverse outcomes after surgery. To address the question of optimal therapy selection for patients with prostates smaller than 80 mL, further prospective randomized evaluation of ThuLEP and alternative surgical interventions is needed.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rausch</LastName><ForeName>Steffen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Urology, Klinikum Fulda, Fulda, Germany; Department of Urology, Eberhard Karls University Tübingen, Tübingen, Germany. Electronic address: steffen.rausch@med.uni-tuebingen.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heider</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Urology, Klinikum Fulda, Fulda, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bedke</LastName><ForeName>Jens</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Urology, Eberhard Karls University Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kruck</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Urology, Eberhard Karls University Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwentner</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Urology, Eberhard Karls University Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Karsten</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Urology, Klinikum Fulda, Fulda, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stenzl</LastName><ForeName>Arnulf</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Urology, Eberhard Karls University Tübingen, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kälble</LastName><ForeName>Tilman</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Urology, Klinikum Fulda, Fulda, Germany.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Urology</MedlineTA><NlmUniqueID>0366151</NlmUniqueID><ISSNLinking>0090-4295</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C503779">yttrium-aluminum-garnet</NameOfSubstance></Chemical><Chemical><RegistryNumber>58784XQC3Y</RegistryNumber><NameOfSubstance UI="D015019">Yttrium</NameOfSubstance></Chemical><Chemical><RegistryNumber>8RKC5ATI4P</RegistryNumber><NameOfSubstance UI="D013932">Thulium</NameOfSubstance></Chemical><Chemical><RegistryNumber>CPD4NFA903</RegistryNumber><NameOfSubstance UI="D000535">Aluminum</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000367">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000535">Aluminum</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009929">Organ Size</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011183">Postoperative Complications</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011467">Prostate</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011468">Prostatectomy</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011470">Prostatic Hyperplasia</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020127">Recovery of Function</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013932">Thulium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015019">Yttrium</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>8</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2014</Year><Month>9</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0090-4295(14)01097-8</ArticleId><ArticleId IdType="doi">10.1016/j.urology.2014.10.002</ArticleId><ArticleId IdType="pubmed">25530383</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Rausch, Steffen" sort="Rausch, Steffen" uniqKey="Rausch S" first="Steffen" last="Rausch">Steffen Rausch</name></region><name sortKey="Bedke, Jens" sort="Bedke, Jens" uniqKey="Bedke J" first="Jens" last="Bedke">Jens Bedke</name><name sortKey="Fischer, Karsten" sort="Fischer, Karsten" uniqKey="Fischer K" first="Karsten" last="Fischer">Karsten Fischer</name><name sortKey="Heider, Thomas" sort="Heider, Thomas" uniqKey="Heider T" first="Thomas" last="Heider">Thomas Heider</name><name sortKey="K Lble, Tilman" sort="K Lble, Tilman" uniqKey="K Lble T" first="Tilman" last="K Lble">Tilman K Lble</name><name sortKey="Kruck, Stephan" sort="Kruck, Stephan" uniqKey="Kruck S" first="Stephan" last="Kruck">Stephan Kruck</name><name sortKey="Schwentner, Christian" sort="Schwentner, Christian" uniqKey="Schwentner C" first="Christian" last="Schwentner">Christian Schwentner</name><name sortKey="Stenzl, Arnulf" sort="Stenzl, Arnulf" uniqKey="Stenzl A" first="Arnulf" last="Stenzl">Arnulf Stenzl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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