Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides
Identifieur interne : 000758 ( Ncbi/Merge ); précédent : 000757; suivant : 000759Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides
Auteurs : Nabila Belhaj ; Frédéric Desor ; Céline Gleizes ; Frédéric M. Denis ; Elmira Arab-Tehrany ; Rachid Soulimani ; Michel LinderSource :
- Marine Drugs [ 1660-3397 ] ; 2013.
Abstract
A phospholipopeptidic complex obtained by the enzymatic hydrolysis of salmon heads in green conditions; exert anxiolytic-like effects in a time and dose-dependent manner, with no affection of locomotor activity. This study focused on the physico-chemical properties of the lipidic and peptidic fractions from this natural product. The characterization of mineral composition, amino acid and fatty acids was carried out. Stability of nanoemulsions allowed us to realize a behavioral study conducted with four different tests on 80 mice. This work highlighted the dose dependent effects of the natural complex and its various fractions over a period of 14 days compared to a conventional anxiolytic. The intracellular redox status of neural cells was evaluated in order to determine the free radicals scavenging potential of these products in the central nervous system (CNS), after mice sacrifice. The complex peptidic fraction showed a strong scavenging property and similar results were found for the complex as well as its lipidic fraction. For the first time, the results of this study showed the anxiolytic-like and neuroprotective properties of a phospholipopeptidic complex extracted from salmon head. The applications on anxiety disorders might be relevant, depending on the doses, the fraction used and the chronicity of the supplementation.
Url:
DOI: 10.3390/md11114294
PubMed: 24177675
PubMed Central: 3853729
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides</title><author><name sortKey="Belhaj, Nabila" sort="Belhaj, Nabila" uniqKey="Belhaj N" first="Nabila" last="Belhaj">Nabila Belhaj</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author><author><name sortKey="Desor, Frederic" sort="Desor, Frederic" uniqKey="Desor F" first="Frédéric" last="Desor">Frédéric Desor</name><affiliation><nlm:aff id="af2-marinedrugs-11-04294">Food Neurotoxicology, Micropollutants and Food Contaminants (MRCA), University of Lorraine, Research Unit on Animal and Functionality of Animal Products (URAFPA), Institut National de la Recherche Agronomique (INRA), BP 4102, Metz 57040, France; E-Mails:<email>frederic.desor@univ-lorraine.fr</email> (F.D.);<email>rachid.soulimani@univ-lorraine.fr</email> (R.S.)</nlm:aff></affiliation></author><author><name sortKey="Gleizes, Celine" sort="Gleizes, Celine" uniqKey="Gleizes C" first="Céline" last="Gleizes">Céline Gleizes</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author><author><name sortKey="Denis, Frederic M" sort="Denis, Frederic M" uniqKey="Denis F" first="Frédéric M." last="Denis">Frédéric M. Denis</name><affiliation><nlm:aff id="af3-marinedrugs-11-04294">Le Stum Laboratory, Larmor Plage 56260, France; E-Mail:<email>infomed@labo-lestum.com</email></nlm:aff></affiliation></author><author><name sortKey="Arab Tehrany, Elmira" sort="Arab Tehrany, Elmira" uniqKey="Arab Tehrany E" first="Elmira" last="Arab-Tehrany">Elmira Arab-Tehrany</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author><author><name sortKey="Soulimani, Rachid" sort="Soulimani, Rachid" uniqKey="Soulimani R" first="Rachid" last="Soulimani">Rachid Soulimani</name><affiliation><nlm:aff id="af2-marinedrugs-11-04294">Food Neurotoxicology, Micropollutants and Food Contaminants (MRCA), University of Lorraine, Research Unit on Animal and Functionality of Animal Products (URAFPA), Institut National de la Recherche Agronomique (INRA), BP 4102, Metz 57040, France; E-Mails:<email>frederic.desor@univ-lorraine.fr</email> (F.D.);<email>rachid.soulimani@univ-lorraine.fr</email> (R.S.)</nlm:aff></affiliation></author><author><name sortKey="Linder, Michel" sort="Linder, Michel" uniqKey="Linder M" first="Michel" last="Linder">Michel Linder</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24177675</idno><idno type="pmc">3853729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3853729</idno><idno type="RBID">PMC:3853729</idno><idno type="doi">10.3390/md11114294</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000381</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000381</idno><idno type="wicri:Area/Pmc/Curation">000381</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000381</idno><idno type="wicri:Area/Pmc/Checkpoint">000204</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000204</idno><idno type="wicri:Area/Ncbi/Merge">000758</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides</title><author><name sortKey="Belhaj, Nabila" sort="Belhaj, Nabila" uniqKey="Belhaj N" first="Nabila" last="Belhaj">Nabila Belhaj</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author><author><name sortKey="Desor, Frederic" sort="Desor, Frederic" uniqKey="Desor F" first="Frédéric" last="Desor">Frédéric Desor</name><affiliation><nlm:aff id="af2-marinedrugs-11-04294">Food Neurotoxicology, Micropollutants and Food Contaminants (MRCA), University of Lorraine, Research Unit on Animal and Functionality of Animal Products (URAFPA), Institut National de la Recherche Agronomique (INRA), BP 4102, Metz 57040, France; E-Mails:<email>frederic.desor@univ-lorraine.fr</email> (F.D.);<email>rachid.soulimani@univ-lorraine.fr</email> (R.S.)</nlm:aff></affiliation></author><author><name sortKey="Gleizes, Celine" sort="Gleizes, Celine" uniqKey="Gleizes C" first="Céline" last="Gleizes">Céline Gleizes</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author><author><name sortKey="Denis, Frederic M" sort="Denis, Frederic M" uniqKey="Denis F" first="Frédéric M." last="Denis">Frédéric M. Denis</name><affiliation><nlm:aff id="af3-marinedrugs-11-04294">Le Stum Laboratory, Larmor Plage 56260, France; E-Mail:<email>infomed@labo-lestum.com</email></nlm:aff></affiliation></author><author><name sortKey="Arab Tehrany, Elmira" sort="Arab Tehrany, Elmira" uniqKey="Arab Tehrany E" first="Elmira" last="Arab-Tehrany">Elmira Arab-Tehrany</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author><author><name sortKey="Soulimani, Rachid" sort="Soulimani, Rachid" uniqKey="Soulimani R" first="Rachid" last="Soulimani">Rachid Soulimani</name><affiliation><nlm:aff id="af2-marinedrugs-11-04294">Food Neurotoxicology, Micropollutants and Food Contaminants (MRCA), University of Lorraine, Research Unit on Animal and Functionality of Animal Products (URAFPA), Institut National de la Recherche Agronomique (INRA), BP 4102, Metz 57040, France; E-Mails:<email>frederic.desor@univ-lorraine.fr</email> (F.D.);<email>rachid.soulimani@univ-lorraine.fr</email> (R.S.)</nlm:aff></affiliation></author><author><name sortKey="Linder, Michel" sort="Linder, Michel" uniqKey="Linder M" first="Michel" last="Linder">Michel Linder</name><affiliation><nlm:aff id="af1-marinedrugs-11-04294">Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</nlm:aff></affiliation></author></analytic><series><title level="j">Marine Drugs</title><idno type="eISSN">1660-3397</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A phospholipopeptidic complex obtained by the enzymatic hydrolysis of salmon heads in green conditions; exert anxiolytic-like effects in a time and dose-dependent manner, with no affection of locomotor activity. This study focused on the physico-chemical properties of the lipidic and peptidic fractions from this natural product. The characterization of mineral composition, amino acid and fatty acids was carried out. Stability of nanoemulsions allowed us to realize a behavioral study conducted with four different tests on 80 mice. This work highlighted the dose dependent effects of the natural complex and its various fractions over a period of 14 days compared to a conventional anxiolytic. The intracellular redox status of neural cells was evaluated in order to determine the free radicals scavenging potential of these products in the central nervous system (CNS), after mice sacrifice. The complex peptidic fraction showed a strong scavenging property and similar results were found for the complex as well as its lipidic fraction. For the first time, the results of this study showed the anxiolytic-like and neuroprotective properties of a phospholipopeptidic complex extracted from salmon head. The applications on anxiety disorders might be relevant, depending on the doses, the fraction used and the chronicity of the supplementation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ohman, A" uniqKey="Ohman A">A. Öhman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graziani, P" uniqKey="Graziani P">P. Graziani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Emilien, G" uniqKey="Emilien G">G. Emilien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinberger, D R" uniqKey="Weinberger D">D.R. Weinberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gross, C" uniqKey="Gross C">C. Gross</name></author><author><name sortKey="Hen, R" uniqKey="Hen R">R. Hen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kessler, R C" uniqKey="Kessler R">R.C. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Mar Drugs</journal-id><journal-id journal-id-type="iso-abbrev">Mar Drugs</journal-id><journal-id journal-id-type="publisher-id">marinedrugs</journal-id><journal-title-group><journal-title>Marine Drugs</journal-title></journal-title-group><issn pub-type="epub">1660-3397</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24177675</article-id><article-id pub-id-type="pmc">3853729</article-id><article-id pub-id-type="doi">10.3390/md11114294</article-id><article-id pub-id-type="publisher-id">marinedrugs-11-04294</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Anxiolytic-Like Effect of a Salmon Phospholipopeptidic Complex Composed of Polyunsaturated Fatty Acids and Bioactive Peptides</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Belhaj</surname><given-names>Nabila</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-11-04294">1</xref></contrib><contrib contrib-type="author"><name><surname>Desor</surname><given-names>Frédéric</given-names></name><xref ref-type="aff" rid="af2-marinedrugs-11-04294">2</xref></contrib><contrib contrib-type="author"><name><surname>Gleizes</surname><given-names>Céline</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-11-04294">1</xref></contrib><contrib contrib-type="author"><name><surname>Denis</surname><given-names>Frédéric M.</given-names></name><xref ref-type="aff" rid="af3-marinedrugs-11-04294">3</xref></contrib><contrib contrib-type="author"><name><surname>Arab-Tehrany</surname><given-names>Elmira</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-11-04294">1</xref></contrib><contrib contrib-type="author"><name><surname>Soulimani</surname><given-names>Rachid</given-names></name><xref ref-type="aff" rid="af2-marinedrugs-11-04294">2</xref></contrib><contrib contrib-type="author"><name><surname>Linder</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="af1-marinedrugs-11-04294">1</xref><xref rid="c1-marinedrugs-11-04294" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-marinedrugs-11-04294"><label>1</label>Laboratory of Biomolecular Engineering, University of Lorraine, École Nationale Supérieure d’Agronomie et des Industries Alimentaires (ENSAIA), National School on Agronomy and Food Industry 2, Avenue de la Forêt de Haye TSA 40602 54518, Vandoeuvre Cedex, France; E-Mails:<email>belhaj.nabila@hotmail.fr</email> (N.B.);<email>gleizes.celine@gmail.com</email> (C.G.);<email>elmira.arab-tehrany@univ-lorraine.fr</email> (E.A.-T.)</aff><aff id="af2-marinedrugs-11-04294"><label>2</label>Food Neurotoxicology, Micropollutants and Food Contaminants (MRCA), University of Lorraine, Research Unit on Animal and Functionality of Animal Products (URAFPA), Institut National de la Recherche Agronomique (INRA), BP 4102, Metz 57040, France; E-Mails:<email>frederic.desor@univ-lorraine.fr</email> (F.D.);<email>rachid.soulimani@univ-lorraine.fr</email> (R.S.)</aff><aff id="af3-marinedrugs-11-04294"><label>3</label>Le Stum Laboratory, Larmor Plage 56260, France; E-Mail:<email>infomed@labo-lestum.com</email></aff><author-notes><corresp id="c1-marinedrugs-11-04294"><label>*</label> Author to whom correspondence should be addressed; E-Mail: <email>michel.linder@univ-lorraine.fr</email>; Tel.: +33-383595879; Fax: +33-383595772.</corresp></author-notes><pub-date pub-type="epub"><day>30</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="collection"><month>11</month><year>2013</year></pub-date><volume>11</volume><issue>11</issue><fpage>4294</fpage><lpage>4317</lpage><history><date date-type="received"><day>17</day><month>7</month><year>2013</year></date><date date-type="rev-recd"><day>20</day><month>8</month><year>2013</year></date><date date-type="accepted"><day>22</day><month>8</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/3.0/"><license-p>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>).</license-p></license></permissions><abstract><p>A phospholipopeptidic complex obtained by the enzymatic hydrolysis of salmon heads in green conditions; exert anxiolytic-like effects in a time and dose-dependent manner, with no affection of locomotor activity. This study focused on the physico-chemical properties of the lipidic and peptidic fractions from this natural product. The characterization of mineral composition, amino acid and fatty acids was carried out. Stability of nanoemulsions allowed us to realize a behavioral study conducted with four different tests on 80 mice. This work highlighted the dose dependent effects of the natural complex and its various fractions over a period of 14 days compared to a conventional anxiolytic. The intracellular redox status of neural cells was evaluated in order to determine the free radicals scavenging potential of these products in the central nervous system (CNS), after mice sacrifice. The complex peptidic fraction showed a strong scavenging property and similar results were found for the complex as well as its lipidic fraction. For the first time, the results of this study showed the anxiolytic-like and neuroprotective properties of a phospholipopeptidic complex extracted from salmon head. The applications on anxiety disorders might be relevant, depending on the doses, the fraction used and the chronicity of the supplementation.</p></abstract><kwd-group><kwd>nanoemulsion</kwd><kwd>anti-anxiety activity</kwd><kwd>PUFA</kwd><kwd>reactive oxygen species</kwd><kwd>neuroprotective effect</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Arab Tehrany, Elmira" sort="Arab Tehrany, Elmira" uniqKey="Arab Tehrany E" first="Elmira" last="Arab-Tehrany">Elmira Arab-Tehrany</name><name sortKey="Belhaj, Nabila" sort="Belhaj, Nabila" uniqKey="Belhaj N" first="Nabila" last="Belhaj">Nabila Belhaj</name><name sortKey="Denis, Frederic M" sort="Denis, Frederic M" uniqKey="Denis F" first="Frédéric M." last="Denis">Frédéric M. Denis</name><name sortKey="Desor, Frederic" sort="Desor, Frederic" uniqKey="Desor F" first="Frédéric" last="Desor">Frédéric Desor</name><name sortKey="Gleizes, Celine" sort="Gleizes, Celine" uniqKey="Gleizes C" first="Céline" last="Gleizes">Céline Gleizes</name><name sortKey="Linder, Michel" sort="Linder, Michel" uniqKey="Linder M" first="Michel" last="Linder">Michel Linder</name><name sortKey="Soulimani, Rachid" sort="Soulimani, Rachid" uniqKey="Soulimani R" first="Rachid" last="Soulimani">Rachid Soulimani</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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