Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent.
Identifieur interne : 000626 ( Ncbi/Merge ); précédent : 000625; suivant : 000627Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent.
Auteurs : Nevin Mcvicar [Canada] ; Alex X. Li ; Mojmír Such ; Robert H E. Hudson ; Ravi S. Menon ; Robert BarthaSource :
- Magnetic resonance in medicine [ 1522-2594 ] ; 2013.
Descripteurs français
- KwdFr :
- Acétamides (), Algorithmes, Animaux, Composés hétéromonocycliques (), Concentration en ions d'hydrogène, Imagerie par résonance magnétique (), Membre pelvien (), Membre pelvien (physiologie), Produits de contraste (), Reproductibilité des résultats, Sensibilité et spécificité, Souris, Souris de lignée C57BL, Thermographie ().
- MESH :
- physiologie : Membre pelvien.
- Acétamides, Algorithmes, Animaux, Composés hétéromonocycliques, Concentration en ions d'hydrogène, Imagerie par résonance magnétique, Membre pelvien, Produits de contraste, Reproductibilité des résultats, Sensibilité et spécificité, Souris, Souris de lignée C57BL, Thermographie.
English descriptors
- KwdEn :
- Acetamides (chemistry), Algorithms, Animals, Contrast Media (chemistry), Heterocyclic Compounds, 1-Ring (chemistry), Hindlimb (chemistry), Hindlimb (physiology), Hydrogen-Ion Concentration, Magnetic Resonance Imaging (methods), Mice, Mice, Inbred C57BL, Reproducibility of Results, Sensitivity and Specificity, Thermography (methods).
- MESH :
- chemical , chemistry : Acetamides, Contrast Media, Heterocyclic Compounds, 1-Ring.
- chemistry : Hindlimb.
- methods : Magnetic Resonance Imaging, Thermography.
- physiology : Hindlimb.
- Algorithms, Animals, Hydrogen-Ion Concentration, Mice, Mice, Inbred C57BL, Reproducibility of Results, Sensitivity and Specificity.
Abstract
Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and following stroke. Therefore, in vivo tissue temperature and pH may become valuable biomarkers for disease detection and the monitoring of disease progression or treatment response in conditions with altered metabolic demand. In this study, pH is measured using the amide protons of a thulium (Tm(3+)) complex with a DOTAM-Glycine-Lysine (ligand: Tm(3+)-DOTAM-Gly-Lys). The pH was uniquely determined from the linewidth of the asymmetry curve of the chemical exchange saturation transfer spectrum, independent of contrast agent concentration, or temperature for a given saturation pulse. pH maps with an inter-pixel standard deviation of less than 0.1 pH units were obtained in 10 mM Tm(3+)-DOTAM-Gly-Lys solutions with pH ranging from 6.0 to 8.0 pH units at 37°C. Temperature maps were simultaneously obtained using the chemical shift of the chemical exchange saturation transfer peak. Temperature and pH maps are demonstrated in the mouse leg (N = 3), where the mean and standard deviation for pH was 7.2 ± 0.2 pH unit and temperature was 37.4 ± 0.5°C.
DOI: 10.1002/mrm.24539
PubMed: 23165779
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pubmed:23165779Le document en format XML
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Li</name></author><author><name sortKey="Such, Mojmir" sort="Such, Mojmir" uniqKey="Such M" first="Mojmír" last="Such">Mojmír Such</name></author><author><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H E" last="Hudson">Robert H E. Hudson</name></author><author><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S" last="Menon">Ravi S. Menon</name></author><author><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23165779</idno><idno type="pmid">23165779</idno><idno type="doi">10.1002/mrm.24539</idno><idno type="wicri:Area/PubMed/Corpus">000326</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000326</idno><idno type="wicri:Area/PubMed/Curation">000326</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000326</idno><idno type="wicri:Area/PubMed/Checkpoint">000326</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000326</idno><idno type="wicri:Area/Ncbi/Merge">000626</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent.</title><author><name sortKey="Mcvicar, Nevin" sort="Mcvicar, Nevin" uniqKey="Mcvicar N" first="Nevin" last="Mcvicar">Nevin Mcvicar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Western Ontario, London, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X" last="Li">Alex X. Li</name></author><author><name sortKey="Such, Mojmir" sort="Such, Mojmir" uniqKey="Such M" first="Mojmír" last="Such">Mojmír Such</name></author><author><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H E" last="Hudson">Robert H E. Hudson</name></author><author><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S" last="Menon">Ravi S. Menon</name></author><author><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name></author></analytic><series><title level="j">Magnetic resonance in medicine</title><idno type="eISSN">1522-2594</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetamides (chemistry)</term><term>Algorithms</term><term>Animals</term><term>Contrast Media (chemistry)</term><term>Heterocyclic Compounds, 1-Ring (chemistry)</term><term>Hindlimb (chemistry)</term><term>Hindlimb (physiology)</term><term>Hydrogen-Ion Concentration</term><term>Magnetic Resonance Imaging (methods)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Thermography (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acétamides ()</term><term>Algorithmes</term><term>Animaux</term><term>Composés hétéromonocycliques ()</term><term>Concentration en ions d'hydrogène</term><term>Imagerie par résonance magnétique ()</term><term>Membre pelvien ()</term><term>Membre pelvien (physiologie)</term><term>Produits de contraste ()</term><term>Reproductibilité des résultats</term><term>Sensibilité et spécificité</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Thermographie ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Acetamides</term><term>Contrast Media</term><term>Heterocyclic Compounds, 1-Ring</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hindlimb</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Thermography</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Membre pelvien</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hindlimb</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Animals</term><term>Hydrogen-Ion Concentration</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acétamides</term><term>Algorithmes</term><term>Animaux</term><term>Composés hétéromonocycliques</term><term>Concentration en ions d'hydrogène</term><term>Imagerie par résonance magnétique</term><term>Membre pelvien</term><term>Produits de contraste</term><term>Reproductibilité des résultats</term><term>Sensibilité et spécificité</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Thermographie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and following stroke. Therefore, in vivo tissue temperature and pH may become valuable biomarkers for disease detection and the monitoring of disease progression or treatment response in conditions with altered metabolic demand. In this study, pH is measured using the amide protons of a thulium (Tm(3+)) complex with a DOTAM-Glycine-Lysine (ligand: Tm(3+)-DOTAM-Gly-Lys). The pH was uniquely determined from the linewidth of the asymmetry curve of the chemical exchange saturation transfer spectrum, independent of contrast agent concentration, or temperature for a given saturation pulse. pH maps with an inter-pixel standard deviation of less than 0.1 pH units were obtained in 10 mM Tm(3+)-DOTAM-Gly-Lys solutions with pH ranging from 6.0 to 8.0 pH units at 37°C. Temperature maps were simultaneously obtained using the chemical shift of the chemical exchange saturation transfer peak. Temperature and pH maps are demonstrated in the mouse leg (N = 3), where the mean and standard deviation for pH was 7.2 ± 0.2 pH unit and temperature was 37.4 ± 0.5°C.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23165779</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>18</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>18</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-2594</ISSN><JournalIssue CitedMedium="Internet"><Volume>70</Volume><Issue>4</Issue><PubDate><Year>2013</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Magnetic resonance in medicine</Title><ISOAbbreviation>Magn Reson Med</ISOAbbreviation></Journal><ArticleTitle>Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent.</ArticleTitle><Pagination><MedlinePgn>1016-25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mrm.24539</ELocationID><Abstract><AbstractText>Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and following stroke. Therefore, in vivo tissue temperature and pH may become valuable biomarkers for disease detection and the monitoring of disease progression or treatment response in conditions with altered metabolic demand. In this study, pH is measured using the amide protons of a thulium (Tm(3+)) complex with a DOTAM-Glycine-Lysine (ligand: Tm(3+)-DOTAM-Gly-Lys). The pH was uniquely determined from the linewidth of the asymmetry curve of the chemical exchange saturation transfer spectrum, independent of contrast agent concentration, or temperature for a given saturation pulse. pH maps with an inter-pixel standard deviation of less than 0.1 pH units were obtained in 10 mM Tm(3+)-DOTAM-Gly-Lys solutions with pH ranging from 6.0 to 8.0 pH units at 37°C. Temperature maps were simultaneously obtained using the chemical shift of the chemical exchange saturation transfer peak. Temperature and pH maps are demonstrated in the mouse leg (N = 3), where the mean and standard deviation for pH was 7.2 ± 0.2 pH unit and temperature was 37.4 ± 0.5°C.</AbstractText><CopyrightInformation>Copyright © 2012 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McVicar</LastName><ForeName>Nevin</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Alex X</ForeName><Initials>AX</Initials></Author><Author ValidYN="Y"><LastName>Suchý</LastName><ForeName>Mojmír</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hudson</LastName><ForeName>Robert H E</ForeName><Initials>RH</Initials></Author><Author ValidYN="Y"><LastName>Menon</LastName><ForeName>Ravi S</ForeName><Initials>RS</Initials></Author><Author ValidYN="Y"><LastName>Bartha</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>11</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Magn Reson Med</MedlineTA><NlmUniqueID>8505245</NlmUniqueID><ISSNLinking>0740-3194</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C522450">1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000081">Acetamides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003287">Contrast Media</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006573">Heterocyclic Compounds, 1-Ring</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000081">Acetamides</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000465">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003287">Contrast Media</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006573">Heterocyclic Compounds, 1-Ring</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006614">Hindlimb</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000737">chemistry</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D006863">Hydrogen-Ion Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008279">Magnetic Resonance Imaging</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051379">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008810">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015203">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012680">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013817">Thermography</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000379">methods</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">CEST</Keyword><Keyword MajorTopicYN="N">MRI</Keyword><Keyword MajorTopicYN="N">PARACEST</Keyword><Keyword MajorTopicYN="N">contrast agent</Keyword><Keyword MajorTopicYN="N">in vivo</Keyword><Keyword MajorTopicYN="N">pH</Keyword><Keyword MajorTopicYN="N">temperature</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>6</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>10</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2012</Year><Month>10</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2012</Year><Month>11</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>11</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23165779</ArticleId><ArticleId IdType="doi">10.1002/mrm.24539</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bartha, Robert" sort="Bartha, Robert" uniqKey="Bartha R" first="Robert" last="Bartha">Robert Bartha</name><name sortKey="Hudson, Robert H E" sort="Hudson, Robert H E" uniqKey="Hudson R" first="Robert H E" last="Hudson">Robert H E. Hudson</name><name sortKey="Li, Alex X" sort="Li, Alex X" uniqKey="Li A" first="Alex X" last="Li">Alex X. Li</name><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S" last="Menon">Ravi S. Menon</name><name sortKey="Such, Mojmir" sort="Such, Mojmir" uniqKey="Such M" first="Mojmír" last="Such">Mojmír Such</name></noCountry><country name="Canada"><noRegion><name sortKey="Mcvicar, Nevin" sort="Mcvicar, Nevin" uniqKey="Mcvicar N" first="Nevin" last="Mcvicar">Nevin Mcvicar</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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