Cerebral cortex modulation of pain
Identifieur interne : 000266 ( Ncbi/Merge ); précédent : 000265; suivant : 000267Cerebral cortex modulation of pain
Auteurs : Yu-Feng Xie [République populaire de Chine, États-Unis] ; Fu-Quan Huo [République populaire de Chine] ; Jing-Shi Tang [République populaire de Chine]Source :
- Acta Pharmacologica Sinica [ 1671-4083 ] ; 2008.
Abstract
Pain is a complex experience encompassing sensory-discriminative, affective-motivational and cognitiv e-emotional components mediated by different mechanisms. Contrary to the traditional view that the cerebral cortex is not involved in pain perception, an extensive cortical network associated with pain processing has been revealed using multiple methods over the past decades. This network consistently includes, at least, the anterior cingulate cortex, the agranular insular cortex, the primary (SI) and secondary somatosensory (SII) cortices, the ventrolateral orbital cortex and the motor cortex. These cortical structures constitute the medial and lateral pain systems, the nucleus submedius-ventrolateral orbital cortex-periaqueductal gray system and motor cortex system, respectively. Multiple neurotransmitters, including opioid, glutamate, GABA and dopamine, are involved in the modulation of pain by these cortical structures. In addition, glial cells may also be involved in cortical modulation of pain and serve as one target for pain management research. This review discusses recent studies of pain modulation by these cerebral cortical structures in animals and human.
Url:
DOI: 10.1038/aps.2008.14
PubMed: 19079295
PubMed Central: 4006538
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<front><div type="abstract" xml:lang="en"><p>Pain is a complex experience encompassing sensory-discriminative, affective-motivational and cognitiv e-emotional components mediated by different mechanisms. Contrary to the traditional view that the cerebral cortex is not involved in pain perception, an extensive cortical network associated with pain processing has been revealed using multiple methods over the past decades. This network consistently includes, at least, the anterior cingulate cortex, the agranular insular cortex, the primary (SI) and secondary somatosensory (SII) cortices, the ventrolateral orbital cortex and the motor cortex. These cortical structures constitute the medial and lateral pain systems, the nucleus submedius-ventrolateral orbital cortex-periaqueductal gray system and motor cortex system, respectively. Multiple neurotransmitters, including opioid, glutamate, GABA and dopamine, are involved in the modulation of pain by these cortical structures. In addition, glial cells may also be involved in cortical modulation of pain and serve as one target for pain management research. This review discusses recent studies of pain modulation by these cerebral cortical structures in animals and human.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Acta Pharmacol Sin</journal-id>
<journal-id journal-id-type="iso-abbrev">Acta Pharmacol. Sin</journal-id>
<journal-title-group><journal-title>Acta Pharmacologica Sinica</journal-title>
</journal-title-group>
<issn pub-type="ppub">1671-4083</issn>
<issn pub-type="epub">1745-7254</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19079295</article-id>
<article-id pub-id-type="pmc">4006538</article-id>
<article-id pub-id-type="pii">aps200814</article-id>
<article-id pub-id-type="doi">10.1038/aps.2008.14</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cerebral cortex modulation of pain</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Xie</surname>
<given-names>Yu-feng</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Huo</surname>
<given-names>Fu-quan</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tang</surname>
<given-names>Jing-shi</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<aff id="aff1"><label>1</label>
<institution>Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiao-tong University</institution>
, Xi'an 710061,<country>China</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Department of Pharmacology, Health Science Centre, University of Tennessee</institution>
,<country>USA</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
E-mail: <email>yufeng71@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>01</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>12</month>
<year>2008</year>
</pub-date>
<volume>30</volume>
<issue>1</issue>
<fpage>31</fpage>
<lpage>41</lpage>
<history><date date-type="received"><day>17</day>
<month>08</month>
<year>2008</year>
</date>
<date date-type="accepted"><day>29</day>
<month>10</month>
<year>2008</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2009 CPS and SIMM</copyright-statement>
<copyright-year>2009</copyright-year>
<copyright-holder>CPS and SIMM</copyright-holder>
</permissions>
<abstract><p>Pain is a complex experience encompassing sensory-discriminative, affective-motivational and cognitiv e-emotional components mediated by different mechanisms. Contrary to the traditional view that the cerebral cortex is not involved in pain perception, an extensive cortical network associated with pain processing has been revealed using multiple methods over the past decades. This network consistently includes, at least, the anterior cingulate cortex, the agranular insular cortex, the primary (SI) and secondary somatosensory (SII) cortices, the ventrolateral orbital cortex and the motor cortex. These cortical structures constitute the medial and lateral pain systems, the nucleus submedius-ventrolateral orbital cortex-periaqueductal gray system and motor cortex system, respectively. Multiple neurotransmitters, including opioid, glutamate, GABA and dopamine, are involved in the modulation of pain by these cortical structures. In addition, glial cells may also be involved in cortical modulation of pain and serve as one target for pain management research. This review discusses recent studies of pain modulation by these cerebral cortical structures in animals and human.</p>
</abstract>
<kwd-group><kwd>anterior cingulate cortex</kwd>
<kwd>agranular insular cortex</kwd>
<kwd>ventrolateral orbital cortex</kwd>
<kwd>periaqueductal gray</kwd>
<kwd>primary and secondary</kwd>
<kwd>somatosensory cortices</kwd>
<kwd>motor cortex</kwd>
<kwd>nociception</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="fig1"><label>Figure 1</label>
<caption><p>A schematic diagram showing the cortical structures involved in pain modulation.</p>
</caption>
<graphic xlink:href="aps200814f1"></graphic>
</fig>
<fig id="fig2"><label>Figure 2</label>
<caption><p>A schematic diagram showing the Sm-VLO-PAG pathway and interactions between neurotransmitters in nociception modulation in the rat. +, excitation; −, inhibition; ENK, enkephalinergic terminal.</p>
</caption>
<graphic xlink:href="aps200814f2"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Xie, Yu Feng" sort="Xie, Yu Feng" uniqKey="Xie Y" first="Yu-Feng" last="Xie">Yu-Feng Xie</name>
</noRegion>
<name sortKey="Huo, Fu Quan" sort="Huo, Fu Quan" uniqKey="Huo F" first="Fu-Quan" last="Huo">Fu-Quan Huo</name>
<name sortKey="Tang, Jing Shi" sort="Tang, Jing Shi" uniqKey="Tang J" first="Jing-Shi" last="Tang">Jing-Shi Tang</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Xie, Yu Feng" sort="Xie, Yu Feng" uniqKey="Xie Y" first="Yu-Feng" last="Xie">Yu-Feng Xie</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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