In vivo studies of cellular energy state, pH, and sodium in rat liver after thermal injury.
Identifieur interne : 000C22 ( Ncbi/Curation ); précédent : 000C21; suivant : 000C23In vivo studies of cellular energy state, pH, and sodium in rat liver after thermal injury.
Auteurs : Z F Xia [États-Unis] ; J W Horton ; P Y Zhao ; N. Bansal ; E E Babcock ; A D Sherry ; C R MalloySource :
- Journal of applied physiology (Bethesda, Md. : 1985) [ 8750-7587 ] ; 1994.
Descripteurs français
- KwdFr :
- Animaux, Brûlures (anatomopathologie), Brûlures (métabolisme), Composés organiques du phosphore, Composés organométalliques, Concentration en ions d'hydrogène, Eau corporelle (métabolisme), Foie (anatomopathologie), Foie (métabolisme), Foie (traumatismes), Isotopes du phosphore, Isotopes du sodium, Magnésium (métabolisme), Mâle, Métabolisme énergétique (physiologie), Potentiels de membrane (physiologie), Pression sanguine (), Rat Sprague-Dawley, Rats, Sodium (métabolisme), Sodium (sang), Spectroscopie par résonance magnétique, Thulium.
- MESH :
- anatomopathologie : Brûlures, Foie.
- métabolisme : Brûlures, Eau corporelle, Foie, Magnésium, Sodium.
- physiologie : Métabolisme énergétique, Potentiels de membrane.
- sang : Sodium.
- traumatismes : Foie.
- Animaux, Composés organiques du phosphore, Composés organométalliques, Concentration en ions d'hydrogène, Isotopes du phosphore, Isotopes du sodium, Mâle, Pression sanguine, Rat Sprague-Dawley, Rats, Spectroscopie par résonance magnétique, Thulium.
English descriptors
- KwdEn :
- Animals, Blood Pressure (drug effects), Body Water (metabolism), Burns (metabolism), Burns (pathology), Energy Metabolism (physiology), Hydrogen-Ion Concentration, Liver (injuries), Liver (metabolism), Liver (pathology), Magnesium (metabolism), Magnetic Resonance Spectroscopy, Male, Membrane Potentials (physiology), Organometallic Compounds, Organophosphorus Compounds, Phosphorus Isotopes, Rats, Rats, Sprague-Dawley, Sodium (blood), Sodium (metabolism), Sodium Isotopes, Thulium.
- MESH :
- chemical , blood : Sodium.
- chemical , metabolism : Magnesium, Sodium.
- drug effects : Blood Pressure.
- injuries : Liver.
- metabolism : Body Water, Burns, Liver.
- pathology : Burns, Liver.
- physiology : Energy Metabolism, Membrane Potentials.
- Animals, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Male, Organometallic Compounds, Organophosphorus Compounds, Phosphorus Isotopes, Rats, Rats, Sprague-Dawley, Sodium Isotopes, Thulium.
Abstract
In vivo 31P- and 23Na-magnetic resonance spectroscopy was used to measure phosphorus metabolites, intracellular pH, cytosolic free Mg2+, and intracellular Na+ in the liver of rats 24 h after 40% total body surface area full-thickness burn injury. Studies were performed during infusion of thulium (III) 1,4,7,10-tetraazacyclododecane N,N',N",N"'-tetra(methylenephosphonate), which served as the Na+ shift agent. Compared with the sham-burn group, there was a significant increase in hepatic intracellular Na+ along with a decrease in intracellular pH and free Mg2+. The ratio of intra- to extra-cellular Na+ increased, indicating a decreased Na+ gradient that may determine the hepatic transmembrane potential difference. Hepatic beta-ATP/P(i) also significantly decreased, which suggests that either ATP utilization is significantly accelerated or ATP synthesis is inhibited after the thermal injury. Of the cations measured (Na+, Mg2+, H+), the change in intracellular Na+ was most dramatic. This study demonstrates that major burn injury may cause profound changes in hepatic bioenergetics and ionic metabolism 24 h after injury and that intracellular Na+ may be a sensitive indicator of hepatic dysfunction 24 h after injury. Because these animals tolerated the shift reagent, thulium (III) 1,4,7,10-tetraazacyclododecane N,N',N",N"'-tetra(methylenephosphonate), nuclear magnetic resonance spectroscopy may prove valuable in monitoring intracellular cations in the liver after major injury.
PubMed: 8045826
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000772
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000772
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000772
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000C22
Links to Exploration step
pubmed:8045826Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In vivo studies of cellular energy state, pH, and sodium in rat liver after thermal injury.</title><author><name sortKey="Xia, Z F" sort="Xia, Z F" uniqKey="Xia Z" first="Z F" last="Xia">Z F Xia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Dallas, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Surgery, Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Horton, J W" sort="Horton, J W" uniqKey="Horton J" first="J W" last="Horton">J W Horton</name></author><author><name sortKey="Zhao, P Y" sort="Zhao, P Y" uniqKey="Zhao P" first="P Y" last="Zhao">P Y Zhao</name></author><author><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N" last="Bansal">N. Bansal</name></author><author><name sortKey="Babcock, E E" sort="Babcock, E E" uniqKey="Babcock E" first="E E" last="Babcock">E E Babcock</name></author><author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name></author><author><name sortKey="Malloy, C R" sort="Malloy, C R" uniqKey="Malloy C" first="C R" last="Malloy">C R Malloy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:8045826</idno><idno type="pmid">8045826</idno><idno type="wicri:Area/PubMed/Corpus">000772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000772</idno><idno type="wicri:Area/PubMed/Curation">000772</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000772</idno><idno type="wicri:Area/PubMed/Checkpoint">000772</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000772</idno><idno type="wicri:Area/Ncbi/Merge">000C22</idno><idno type="wicri:Area/Ncbi/Curation">000C22</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vivo studies of cellular energy state, pH, and sodium in rat liver after thermal injury.</title><author><name sortKey="Xia, Z F" sort="Xia, Z F" uniqKey="Xia Z" first="Z F" last="Xia">Z F Xia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Dallas, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Surgery, Mary Nell and Ralph B. Rogers Magnetic Resonance Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Horton, J W" sort="Horton, J W" uniqKey="Horton J" first="J W" last="Horton">J W Horton</name></author><author><name sortKey="Zhao, P Y" sort="Zhao, P Y" uniqKey="Zhao P" first="P Y" last="Zhao">P Y Zhao</name></author><author><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N" last="Bansal">N. Bansal</name></author><author><name sortKey="Babcock, E E" sort="Babcock, E E" uniqKey="Babcock E" first="E E" last="Babcock">E E Babcock</name></author><author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name></author><author><name sortKey="Malloy, C R" sort="Malloy, C R" uniqKey="Malloy C" first="C R" last="Malloy">C R Malloy</name></author></analytic><series><title level="j">Journal of applied physiology (Bethesda, Md. : 1985)</title><idno type="ISSN">8750-7587</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Blood Pressure (drug effects)</term><term>Body Water (metabolism)</term><term>Burns (metabolism)</term><term>Burns (pathology)</term><term>Energy Metabolism (physiology)</term><term>Hydrogen-Ion Concentration</term><term>Liver (injuries)</term><term>Liver (metabolism)</term><term>Liver (pathology)</term><term>Magnesium (metabolism)</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Membrane Potentials (physiology)</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Phosphorus Isotopes</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Sodium (blood)</term><term>Sodium (metabolism)</term><term>Sodium Isotopes</term><term>Thulium</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Brûlures (anatomopathologie)</term><term>Brûlures (métabolisme)</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Concentration en ions d'hydrogène</term><term>Eau corporelle (métabolisme)</term><term>Foie (anatomopathologie)</term><term>Foie (métabolisme)</term><term>Foie (traumatismes)</term><term>Isotopes du phosphore</term><term>Isotopes du sodium</term><term>Magnésium (métabolisme)</term><term>Mâle</term><term>Métabolisme énergétique (physiologie)</term><term>Potentiels de membrane (physiologie)</term><term>Pression sanguine ()</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Sodium (métabolisme)</term><term>Sodium (sang)</term><term>Spectroscopie par résonance magnétique</term><term>Thulium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Sodium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Magnesium</term><term>Sodium</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Brûlures</term><term>Foie</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term></keywords><keywords scheme="MESH" qualifier="injuries" xml:lang="en"><term>Liver</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Body Water</term><term>Burns</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Brûlures</term><term>Eau corporelle</term><term>Foie</term><term>Magnésium</term><term>Sodium</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Burns</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Métabolisme énergétique</term><term>Potentiels de membrane</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Energy Metabolism</term><term>Membrane Potentials</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Sodium</term></keywords><keywords scheme="MESH" qualifier="traumatismes" xml:lang="fr"><term>Foie</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Hydrogen-Ion Concentration</term><term>Magnetic Resonance Spectroscopy</term><term>Male</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Phosphorus Isotopes</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Sodium Isotopes</term><term>Thulium</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Concentration en ions d'hydrogène</term><term>Isotopes du phosphore</term><term>Isotopes du sodium</term><term>Mâle</term><term>Pression sanguine</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Spectroscopie par résonance magnétique</term><term>Thulium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In vivo 31P- and 23Na-magnetic resonance spectroscopy was used to measure phosphorus metabolites, intracellular pH, cytosolic free Mg2+, and intracellular Na+ in the liver of rats 24 h after 40% total body surface area full-thickness burn injury. Studies were performed during infusion of thulium (III) 1,4,7,10-tetraazacyclododecane N,N',N",N"'-tetra(methylenephosphonate), which served as the Na+ shift agent. Compared with the sham-burn group, there was a significant increase in hepatic intracellular Na+ along with a decrease in intracellular pH and free Mg2+. The ratio of intra- to extra-cellular Na+ increased, indicating a decreased Na+ gradient that may determine the hepatic transmembrane potential difference. Hepatic beta-ATP/P(i) also significantly decreased, which suggests that either ATP utilization is significantly accelerated or ATP synthesis is inhibited after the thermal injury. Of the cations measured (Na+, Mg2+, H+), the change in intracellular Na+ was most dramatic. This study demonstrates that major burn injury may cause profound changes in hepatic bioenergetics and ionic metabolism 24 h after injury and that intracellular Na+ may be a sensitive indicator of hepatic dysfunction 24 h after injury. Because these animals tolerated the shift reagent, thulium (III) 1,4,7,10-tetraazacyclododecane N,N',N",N"'-tetra(methylenephosphonate), nuclear magnetic resonance spectroscopy may prove valuable in monitoring intracellular cations in the liver after major injury.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C22 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000C22 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:8045826
|texte= In vivo studies of cellular energy state, pH, and sodium in rat liver after thermal injury.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:8045826" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ThuliumV1
| This area was generated with Dilib version V0.6.21. |  |