ThuliumV1, Ncbi, Curation, bibRecord, 000B44

The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.

Identifieur interne : 000B44 ( Ncbi/Curation ); précédent : 000B43; suivant : 000B45

The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.

Auteurs : K. Schom Cker ; W G Franke ; E. Henke ; W D Fromm ; G. Maka ; G J Beyer

Source :

European journal of nuclear medicine [ 0340-6997 ] ; 1986.

RBID : pubmed:3456891

Descripteurs français

KwdFr :
- Acide citrique, Animaux, Cinétique, Citrates (métabolisme), Composés du fer II (métabolisme), Fer (pharmacologie), Gallium (pharmacologie), Lignées consanguines de souris, Radio-isotopes, Radio-isotopes du fer, Radio-isotopes du gallium, Répartition dans les tissus, Souris, Thulium (métabolisme), Thulium (pharmacologie), Tumeurs expérimentales de la mamelle (métabolisme).
MESH :
- métabolisme : Citrates, Composés du fer II, Thulium, Tumeurs expérimentales de la mamelle.
- pharmacologie : Fer, Gallium, Thulium.
- Acide citrique, Animaux, Cinétique, Lignées consanguines de souris, Radio-isotopes, Radio-isotopes du fer, Radio-isotopes du gallium, Répartition dans les tissus, Souris.

English descriptors

KwdEn :
- Animals, Citrates (metabolism), Citric Acid, Ferrous Compounds (metabolism), Gallium (pharmacology), Gallium Radioisotopes, Iron (pharmacology), Iron Radioisotopes, Kinetics, Mammary Neoplasms, Experimental (metabolism), Mice, Mice, Inbred Strains, Radioisotopes, Thulium (metabolism), Thulium (pharmacology), Tissue Distribution.
MESH :
- chemical , metabolism : Citrates, Ferrous Compounds, Thulium.
- chemical , pharmacology : Gallium, Iron, Thulium.
- metabolism : Mammary Neoplasms, Experimental.
- Animals, Citric Acid, Gallium Radioisotopes, Iron Radioisotopes, Kinetics, Mice, Mice, Inbred Strains, Radioisotopes, Tissue Distribution.

Abstract

The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio.

PubMed: 3456891

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pubmed:3456891

Le document en format XML

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<author><name sortKey="Schom Cker, K" sort="Schom Cker, K" uniqKey="Schom Cker K" first="K" last="Schom Cker">K. Schom Cker</name>
</author>
<author><name sortKey="Franke, W G" sort="Franke, W G" uniqKey="Franke W" first="W G" last="Franke">W G Franke</name>
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<author><name sortKey="Henke, E" sort="Henke, E" uniqKey="Henke E" first="E" last="Henke">E. Henke</name>
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<author><name sortKey="Fromm, W D" sort="Fromm, W D" uniqKey="Fromm W" first="W D" last="Fromm">W D Fromm</name>
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<author><name sortKey="Maka, G" sort="Maka, G" uniqKey="Maka G" first="G" last="Maka">G. Maka</name>
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<author><name sortKey="Beyer, G J" sort="Beyer, G J" uniqKey="Beyer G" first="G J" last="Beyer">G J Beyer</name>
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<author><name sortKey="Franke, W G" sort="Franke, W G" uniqKey="Franke W" first="W G" last="Franke">W G Franke</name>
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<author><name sortKey="Henke, E" sort="Henke, E" uniqKey="Henke E" first="E" last="Henke">E. Henke</name>
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<author><name sortKey="Fromm, W D" sort="Fromm, W D" uniqKey="Fromm W" first="W D" last="Fromm">W D Fromm</name>
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<author><name sortKey="Maka, G" sort="Maka, G" uniqKey="Maka G" first="G" last="Maka">G. Maka</name>
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<series><title level="j">European journal of nuclear medicine</title>
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<imprint><date when="1986" type="published">1986</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Citrates (metabolism)</term>
<term>Citric Acid</term>
<term>Ferrous Compounds (metabolism)</term>
<term>Gallium (pharmacology)</term>
<term>Gallium Radioisotopes</term>
<term>Iron (pharmacology)</term>
<term>Iron Radioisotopes</term>
<term>Kinetics</term>
<term>Mammary Neoplasms, Experimental (metabolism)</term>
<term>Mice</term>
<term>Mice, Inbred Strains</term>
<term>Radioisotopes</term>
<term>Thulium (metabolism)</term>
<term>Thulium (pharmacology)</term>
<term>Tissue Distribution</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Acide citrique</term>
<term>Animaux</term>
<term>Cinétique</term>
<term>Citrates (métabolisme)</term>
<term>Composés du fer II (métabolisme)</term>
<term>Fer (pharmacologie)</term>
<term>Gallium (pharmacologie)</term>
<term>Lignées consanguines de souris</term>
<term>Radio-isotopes</term>
<term>Radio-isotopes du fer</term>
<term>Radio-isotopes du gallium</term>
<term>Répartition dans les tissus</term>
<term>Souris</term>
<term>Thulium (métabolisme)</term>
<term>Thulium (pharmacologie)</term>
<term>Tumeurs expérimentales de la mamelle (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Citrates</term>
<term>Ferrous Compounds</term>
<term>Thulium</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Gallium</term>
<term>Iron</term>
<term>Thulium</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mammary Neoplasms, Experimental</term>
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<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Citrates</term>
<term>Composés du fer II</term>
<term>Thulium</term>
<term>Tumeurs expérimentales de la mamelle</term>
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<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Fer</term>
<term>Gallium</term>
<term>Thulium</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Citric Acid</term>
<term>Gallium Radioisotopes</term>
<term>Iron Radioisotopes</term>
<term>Kinetics</term>
<term>Mice</term>
<term>Mice, Inbred Strains</term>
<term>Radioisotopes</term>
<term>Tissue Distribution</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Acide citrique</term>
<term>Animaux</term>
<term>Cinétique</term>
<term>Lignées consanguines de souris</term>
<term>Radio-isotopes</term>
<term>Radio-isotopes du fer</term>
<term>Radio-isotopes du gallium</term>
<term>Répartition dans les tissus</term>
<term>Souris</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en">The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio.</div>
</front>
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The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.

The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki