Transient and selective suppression of neural activity with infrared light
Identifieur interne : 000732 ( Ncbi/Curation ); précédent : 000731; suivant : 000733Transient and selective suppression of neural activity with infrared light
Auteurs : Austin R. Duke [États-Unis] ; Michael W. Jenkins [États-Unis] ; Hui Lu [États-Unis] ; Jeffrey M. Mcmanus [États-Unis] ; Hillel J. Chiel [États-Unis] ; E. Duco Jansen [États-Unis]Source :
- Scientific Reports [ 2045-2322 ] ; 2013.
Abstract
Analysis and control of neural circuitry requires the ability to selectively activate or inhibit neurons. Previous work showed that infrared laser light selectively excited neural activity in endogenous unmyelinated and myelinated axons. However, inhibition of neuronal firing with infrared light was only observed in limited cases, is not well understood and was not precisely controlled. Using an experimentally tractable unmyelinated preparation for detailed investigation and a myelinated preparation for validation, we report that it is possible to selectively and transiently inhibit electrically-initiated axonal activation, as well as to both block or enhance the propagation of action potentials of specific motor neurons. Thus, in addition to previously shown excitation, we demonstrate an optical method of suppressing components of the nervous system with functional spatiotemporal precision. We believe this technique is well-suited for non-invasive investigations of diverse excitable tissues and may ultimately be applied for treating neurological disorders.
Url:
DOI: 10.1038/srep02600
PubMed: 24009039
PubMed Central: 3764437
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Duke</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Vanderbilt University</institution>, Nashville, TN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jenkins, Michael W" sort="Jenkins, Michael W" uniqKey="Jenkins M" first="Michael W." last="Jenkins">Michael W. 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Mcmanus</name><affiliation wicri:level="1"><nlm:aff id="a3"><institution>Department of Biology, Case Western Reserve University</institution>, Cleveland, OH,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chiel, Hillel J" sort="Chiel, Hillel J" uniqKey="Chiel H" first="Hillel J." last="Chiel">Hillel J. 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Duco Jansen</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Department of Biomedical Engineering, Vanderbilt University</institution>, Nashville, TN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="a5"><institution>Department of Neurological Surgery, Vanderbilt University</institution>, Nashville, TN,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Analysis and control of neural circuitry requires the ability to selectively activate or inhibit neurons. Previous work showed that infrared laser light selectively excited neural activity in endogenous unmyelinated and myelinated axons. However, inhibition of neuronal firing with infrared light was only observed in limited cases, is not well understood and was not precisely controlled. Using an experimentally tractable unmyelinated preparation for detailed investigation and a myelinated preparation for validation, we report that it is possible to selectively and transiently inhibit electrically-initiated axonal activation, as well as to both block or enhance the propagation of action potentials of specific motor neurons. Thus, in addition to previously shown excitation, we demonstrate an optical method of suppressing components of the nervous system with functional spatiotemporal precision. We believe this technique is well-suited for non-invasive investigations of diverse excitable tissues and may ultimately be applied for treating neurological disorders.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Martens, H C" uniqKey="Martens H">H. C. Martens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slavin, K V" uniqKey="Slavin K">K. V. Slavin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peckham, P H" uniqKey="Peckham P">P. H. Peckham</name></author><author><name sortKey="Knutson, J S" uniqKey="Knutson J">J. S. Knutson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Konrad, P" uniqKey="Konrad P">P. Konrad</name></author><author><name sortKey="Shanks, T" uniqKey="Shanks T">T. Shanks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grill, W M" uniqKey="Grill W">W. M. 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Rajguru</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fried, N M" uniqKey="Fried N">N. M. Fried</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Llewellyn, M E" uniqKey="Llewellyn M">M. E. Llewellyn</name></author><author><name sortKey="Thompson, K R" uniqKey="Thompson K">K. R. Thompson</name></author><author><name sortKey="Deisseroth, K" uniqKey="Deisseroth K">K. Deisseroth</name></author><author><name sortKey="Delp, S L" uniqKey="Delp S">S. L. Delp</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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