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A Method to Convert MRI Images of Temperature Change Into Images of Absolute Temperature in Solid Tumors

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A Method to Convert MRI Images of Temperature Change Into Images of Absolute Temperature in Solid Tumors

Auteurs : Ryan M. Davis [États-Unis] ; Benjamin L. Viglianti [États-Unis] ; Pavel Yarmolenko [États-Unis] ; Ji-Young Park [États-Unis] ; Paul Stauffer [États-Unis] ; David Needham [États-Unis] ; Mark W. Dewhirst [États-Unis]

Source :

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group [ 0265-6736 ] ; 2013.

RBID : PMC:3779909

Abstract

Purpose

During hyperthermia (HT), the therapeutic response of tumors varies substantially within the target temperature range (39–43°C). Current thermometry methods are either invasive or measure only temperature change, which limits the ability to study tissue responses to HT. This study combines manganese-containing low-temperature sensitive liposomes (Mn-LTSL) with proton resonance frequency shift (PRFS) thermometry to measure absolute temperature in tumors with high spatial and temporal resolution using MRI.

Methods

Liposomes were loaded with 300mM MnSO₄. The phase transition temperature (T_m) of Mn-LTSL samples was measured by differential scanning calorimetry (DSC). The release of manganese from Mn-LTSL in saline was characterized with inductively-coupled plasma atomic emission spectroscopy. A 2T GE small animal scanner was used to acquire dynamic T₁-weighted images and temperature change images of Mn-LTSL in saline phantoms and fibrosarcoma-bearing Fisher 344 rats receiving hyperthermia after Mn-LTSL injection.

Results

The T_m of Mn-LTSL in rat blood was 42.9 ± 0.2 °C (DSC). For Mn-LTSL samples (0.06mM – 0.5mM Mn²⁺ in saline) heated monotonically from 30°C to 50°C, a peak in the rate of MRI signal enhancement occurred at 43.1 ± 0.3 °C. The same peak in signal enhancement rate was observed during heating of fibrosarcoma tumors (N=3) after injection of Mn-LTSL, and the peak was used to convert temperature change images into absolute temperature. Accuracies of calibrated temperature measurements were in the range 0.9 – 1.8°C.

Conclusion

The release of Mn2⁺ from Mn-LTSL affects the rate of MR signal enhancement which enables conversion of MRI-based temperature change images to absolute temperature.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779909

DOI: 10.3109/02656736.2013.790091
PubMed: 23957326
PubMed Central: 3779909

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PMC:3779909

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<series><title level="j">International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group</title>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P1">During hyperthermia (HT), the therapeutic response of tumors varies substantially within the target temperature range (39–43°C). Current thermometry methods are either invasive or measure only temperature change, which limits the ability to study tissue responses to HT. This study combines manganese-containing low-temperature sensitive liposomes (Mn-LTSL) with proton resonance frequency shift (PRFS) thermometry to measure absolute temperature in tumors with high spatial and temporal resolution using MRI.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Liposomes were loaded with 300mM MnSO<sub>4</sub>
. The phase transition temperature (T<sub>m</sub>
) of Mn-LTSL samples was measured by differential scanning calorimetry (DSC). The release of manganese from Mn-LTSL in saline was characterized with inductively-coupled plasma atomic emission spectroscopy. A 2T GE small animal scanner was used to acquire dynamic T<sub>1</sub>
-weighted images and temperature change images of Mn-LTSL in saline phantoms and fibrosarcoma-bearing Fisher 344 rats receiving hyperthermia after Mn-LTSL injection.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">The T<sub>m</sub>
 of Mn-LTSL in rat blood was 42.9 ± 0.2 °C (DSC). For Mn-LTSL samples (0.06mM – 0.5mM Mn<sup>2+</sup>
 in saline) heated monotonically from 30°C to 50°C, a peak in the <italic>rate</italic>
 of MRI signal enhancement occurred at 43.1 ± 0.3 °C. The same peak in signal enhancement rate was observed during heating of fibrosarcoma tumors (N=3) after injection of Mn-LTSL, and the peak was used to convert temperature change images into absolute temperature. Accuracies of calibrated temperature measurements were in the range 0.9 – 1.8°C.</p>
</sec>
<sec id="S4"><title>Conclusion</title>
<p id="P4">The release of Mn2<sup>+</sup>
 from Mn-LTSL affects the rate of MR signal enhancement which enables conversion of MRI-based temperature change images to absolute temperature.</p>
</sec>
</div>
</front>
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A Method to Convert MRI Images of Temperature Change Into Images of Absolute Temperature in Solid Tumors

A Method to Convert MRI Images of Temperature Change Into Images of Absolute Temperature in Solid Tumors

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