Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices.
Identifieur interne : 000050 ( Ncbi/Curation ); précédent : 000049; suivant : 000051Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices.
Auteurs : U. Bingel [Allemagne] ; M. Quante ; R. Knab ; B. Bromm ; C. Weiller ; C. BüchelSource :
- NeuroImage [ 1053-8119 ] ; 2003.
Descripteurs français
- KwdFr :
- Adulte, Cartographie cérébrale, Cortex cérébral (physiologie), Cortex somatosensoriel (physiologie), Dominance cérébrale (physiologie), Femelle, Humains, Imagerie par résonance magnétique, Main (innervation), Mâle, Neuroanalyseurs (physiologie), Nocicepteurs (physiologie), Réseau nerveux (physiologie), Seuil nociceptif (physiologie), Thalamus (physiologie).
- MESH :
- physiologie : Cortex cérébral, Cortex somatosensoriel, Dominance cérébrale, Neuroanalyseurs, Nocicepteurs, Réseau nerveux, Seuil nociceptif, Thalamus.
- innervation : Adulte, Cartographie cérébrale, Femelle, Humains, Imagerie par résonance magnétique, Main, Mâle.
English descriptors
- KwdEn :
- Adult, Brain Mapping, Cerebral Cortex (physiology), Dominance, Cerebral (physiology), Female, Hand (innervation), Humans, Magnetic Resonance Imaging, Male, Nerve Net (physiology), Neural Analyzers (physiology), Nociceptors (physiology), Pain Threshold (physiology), Somatosensory Cortex (physiology), Thalamus (physiology).
- MESH :
- innervation : Hand.
- physiology : Cerebral Cortex, Dominance, Cerebral, Nerve Net, Neural Analyzers, Nociceptors, Pain Threshold, Somatosensory Cortex, Thalamus.
- Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male.
Abstract
Pain is processed in multiple brain areas, indicating the complexity of pain perception. The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. We used single-trial functional magnetic resonance imaging (fMRI) to assess hemodynamic responses to right and left painful stimulation. Thulium-YAG-(yttrium-aluminium-granate)-laser-evoked pain stimuli, without concomitant tactile component, were applied to either hand in a randomized order. A contralateral bias of the BOLD response was investigated to determine areas involved in the coding of the side of stimulation, which we observed in primary (SI) and secondary (SII) somatosensory cortex, insula, and the thalamus. This suggests that these structures provide spatial information of selective nociceptive stimuli. More importantly, this contralateral bias of activation allowed functionally segregated activations within the SII complex, the insula, and the thalamus. Only distinct subregions of the SII complex, the posterior insula and the lateral thalamus, but not the remaining SII complex, the anterior insula and the medial thalamus, showed a contralaterally biased representation of painful stimuli. This result supports the hypothesis that sensory-discriminative attributes of painful stimuli, such as those related to body side, are topospecifically represented within the forebrain projections of the nociceptive system and highlights the concept of functional segregation and specialization within these structures.
PubMed: 12667851
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000702
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000702
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000702
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000050
Links to Exploration step
pubmed:12667851Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices.</title><author><name sortKey="Bingel, U" sort="Bingel, U" uniqKey="Bingel U" first="U" last="Bingel">U. Bingel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Hamburg University Medical School, Hamburg, Germany. bingel@uke.uni-hamburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Hamburg University Medical School, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Quante, M" sort="Quante, M" uniqKey="Quante M" first="M" last="Quante">M. Quante</name></author><author><name sortKey="Knab, R" sort="Knab, R" uniqKey="Knab R" first="R" last="Knab">R. Knab</name></author><author><name sortKey="Bromm, B" sort="Bromm, B" uniqKey="Bromm B" first="B" last="Bromm">B. Bromm</name></author><author><name sortKey="Weiller, C" sort="Weiller, C" uniqKey="Weiller C" first="C" last="Weiller">C. Weiller</name></author><author><name sortKey="Buchel, C" sort="Buchel, C" uniqKey="Buchel C" first="C" last="Büchel">C. Büchel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12667851</idno><idno type="pmid">12667851</idno><idno type="wicri:Area/PubMed/Corpus">000702</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000702</idno><idno type="wicri:Area/PubMed/Curation">000702</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000702</idno><idno type="wicri:Area/PubMed/Checkpoint">000702</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000702</idno><idno type="wicri:Area/Ncbi/Merge">000050</idno><idno type="wicri:Area/Ncbi/Curation">000050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices.</title><author><name sortKey="Bingel, U" sort="Bingel, U" uniqKey="Bingel U" first="U" last="Bingel">U. Bingel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Hamburg University Medical School, Hamburg, Germany. bingel@uke.uni-hamburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Hamburg University Medical School, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Quante, M" sort="Quante, M" uniqKey="Quante M" first="M" last="Quante">M. Quante</name></author><author><name sortKey="Knab, R" sort="Knab, R" uniqKey="Knab R" first="R" last="Knab">R. Knab</name></author><author><name sortKey="Bromm, B" sort="Bromm, B" uniqKey="Bromm B" first="B" last="Bromm">B. Bromm</name></author><author><name sortKey="Weiller, C" sort="Weiller, C" uniqKey="Weiller C" first="C" last="Weiller">C. Weiller</name></author><author><name sortKey="Buchel, C" sort="Buchel, C" uniqKey="Buchel C" first="C" last="Büchel">C. Büchel</name></author></analytic><series><title level="j">NeuroImage</title><idno type="ISSN">1053-8119</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Cerebral Cortex (physiology)</term><term>Dominance, Cerebral (physiology)</term><term>Female</term><term>Hand (innervation)</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Nerve Net (physiology)</term><term>Neural Analyzers (physiology)</term><term>Nociceptors (physiology)</term><term>Pain Threshold (physiology)</term><term>Somatosensory Cortex (physiology)</term><term>Thalamus (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Cartographie cérébrale</term><term>Cortex cérébral (physiologie)</term><term>Cortex somatosensoriel (physiologie)</term><term>Dominance cérébrale (physiologie)</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Main (innervation)</term><term>Mâle</term><term>Neuroanalyseurs (physiologie)</term><term>Nocicepteurs (physiologie)</term><term>Réseau nerveux (physiologie)</term><term>Seuil nociceptif (physiologie)</term><term>Thalamus (physiologie)</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Hand</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cortex cérébral</term><term>Cortex somatosensoriel</term><term>Dominance cérébrale</term><term>Neuroanalyseurs</term><term>Nocicepteurs</term><term>Réseau nerveux</term><term>Seuil nociceptif</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebral Cortex</term><term>Dominance, Cerebral</term><term>Nerve Net</term><term>Neural Analyzers</term><term>Nociceptors</term><term>Pain Threshold</term><term>Somatosensory Cortex</term><term>Thalamus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="fr"><term>Adulte</term><term>Cartographie cérébrale</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Main</term><term>Mâle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pain is processed in multiple brain areas, indicating the complexity of pain perception. The ability to locate pain plays a pivotal role in immediate defense and withdrawal behavior. However, how the brain localizes nociceptive information without additional information from somatotopically organized mechano-receptive pathways is not well understood. We used single-trial functional magnetic resonance imaging (fMRI) to assess hemodynamic responses to right and left painful stimulation. Thulium-YAG-(yttrium-aluminium-granate)-laser-evoked pain stimuli, without concomitant tactile component, were applied to either hand in a randomized order. A contralateral bias of the BOLD response was investigated to determine areas involved in the coding of the side of stimulation, which we observed in primary (SI) and secondary (SII) somatosensory cortex, insula, and the thalamus. This suggests that these structures provide spatial information of selective nociceptive stimuli. More importantly, this contralateral bias of activation allowed functionally segregated activations within the SII complex, the insula, and the thalamus. Only distinct subregions of the SII complex, the posterior insula and the lateral thalamus, but not the remaining SII complex, the anterior insula and the medial thalamus, showed a contralaterally biased representation of painful stimuli. This result supports the hypothesis that sensory-discriminative attributes of painful stimuli, such as those related to body side, are topospecifically represented within the forebrain projections of the nociceptive system and highlights the concept of functional segregation and specialization within these structures.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000050 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000050 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:12667851
|texte= Single trial fMRI reveals significant contralateral bias in responses to laser pain within thalamus and somatosensory cortices.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:12667851" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ThuliumV1
| This area was generated with Dilib version V0.6.21. |  |