TmDOTA-: a sensitive probe for MR thermometry in vivo.
Identifieur interne : 000015 ( Ncbi/Checkpoint ); précédent : 000014; suivant : 000016TmDOTA-: a sensitive probe for MR thermometry in vivo.
Auteurs : C S Zuo [États-Unis] ; A. Mahmood ; A D SherrySource :
- Journal of magnetic resonance (San Diego, Calif. : 1997) [ 1090-7807 ] ; 2001.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Calcium, Chelating Agents, Heterocyclic Compounds, 1-Ring.
- Animals, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Models, Anatomic, Protons, Rats, Temperature.
Abstract
The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.
DOI: 10.1006/jmre.2001.2356
PubMed: 11444943
Affiliations:
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Mahmood</name></author><author><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name></author></analytic><series><title level="j">Journal of magnetic resonance (San Diego, Calif. : 1997)</title><idno type="ISSN">1090-7807</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calcium (chemistry)</term><term>Chelating Agents (chemistry)</term><term>Heterocyclic Compounds, 1-Ring (chemistry)</term><term>Hydrogen-Ion Concentration</term><term>Magnetic Resonance Spectroscopy</term><term>Models, Anatomic</term><term>Protons</term><term>Rats</term><term>Temperature</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Calcium ()</term><term>Chélateurs ()</term><term>Composés hétéromonocycliques ()</term><term>Concentration en ions d'hydrogène</term><term>Modèles anatomiques</term><term>Protons</term><term>Rats</term><term>Spectroscopie par résonance magnétique</term><term>Température</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium</term><term>Chelating Agents</term><term>Heterocyclic Compounds, 1-Ring</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Hydrogen-Ion Concentration</term><term>Magnetic Resonance Spectroscopy</term><term>Models, Anatomic</term><term>Protons</term><term>Rats</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Calcium</term><term>Chélateurs</term><term>Composés hétéromonocycliques</term><term>Concentration en ions d'hydrogène</term><term>Modèles anatomiques</term><term>Protons</term><term>Rats</term><term>Spectroscopie par résonance magnétique</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Mahmood, A" sort="Mahmood, A" uniqKey="Mahmood A" first="A" last="Mahmood">A. Mahmood</name><name sortKey="Sherry, A D" sort="Sherry, A D" uniqKey="Sherry A" first="A D" last="Sherry">A D Sherry</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Zuo, C S" sort="Zuo, C S" uniqKey="Zuo C" first="C S" last="Zuo">C S Zuo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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