In vivo sodium chemical shift imaging.
Identifieur interne : 003882 ( Main/Merge ); précédent : 003881; suivant : 003883In vivo sodium chemical shift imaging.
Auteurs : S J Kohler [États-Unis] ; N H Kolodny ; A C Celi ; T A Burr ; D. Weinberg ; D J D'Amico ; E S GragoudasSource :
- Magnetic resonance in medicine [ 0740-3194 ] ; 1992.
Descripteurs français
- KwdFr :
- Acide édétique (analogues et dérivés), Animaux, Calcium (), Chambre antérieure du bulbe oculaire (métabolisme), Chélateurs, Composés organiques du phosphore, Composés organométalliques, Concentration en ions d'hydrogène, Corps vitré (métabolisme), Diffusion, Dysprosium, Lapins, Maquettes de structure, Sodium (), Sodium (pharmacocinétique), Spectroscopie de résonance de spin électronique, Spectroscopie par résonance magnétique.
- MESH :
- analogues et dérivés : Acide édétique.
- métabolisme : Chambre antérieure du bulbe oculaire, Corps vitré.
- pharmacocinétique : Sodium.
- Animaux, Calcium, Chélateurs, Composés organiques du phosphore, Composés organométalliques, Concentration en ions d'hydrogène, Diffusion, Dysprosium, Lapins, Maquettes de structure, Sodium, Spectroscopie de résonance de spin électronique, Spectroscopie par résonance magnétique.
English descriptors
- KwdEn :
- Animals, Anterior Chamber (metabolism), Calcium (chemistry), Chelating Agents, Diffusion, Dysprosium, Edetic Acid (analogs & derivatives), Electron Spin Resonance Spectroscopy, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Models, Structural, Organometallic Compounds, Organophosphorus Compounds, Rabbits, Sodium (chemistry), Sodium (pharmacokinetics), Vitreous Body (metabolism).
- MESH :
- chemical , analogs & derivatives : Edetic Acid.
- chemical , chemistry : Calcium, Sodium.
- metabolism : Anterior Chamber, Vitreous Body.
- chemical , pharmacokinetics : Sodium.
- Animals, Chelating Agents, Diffusion, Dysprosium, Electron Spin Resonance Spectroscopy, Hydrogen-Ion Concentration, Magnetic Resonance Spectroscopy, Models, Structural, Organometallic Compounds, Organophosphorus Compounds, Rabbits.
Abstract
The shift reagents thulium(III) 1,4,7,10-tetraazacyclododecane N,N',N",N"'tetramethylenephosphonate (TmDOTP5-), and dysprosium(III)triethylenetetramine-hexaacetate (DyTTHA3-) are compared in this work for their uses in sodium chemical shift imaging (NaCSI). In a series of experiments using phantoms we evaluated the relative contributions of bulk magnetic susceptibility (BMS) effects and hyperfine shifts to the induced 23Na chemical shift for these two shift reagents. The ratios of BMS effects to hyperfine shifts suggest that TmDOTP5- should be a more effective shift reagent than DyTTHA3- for 23Na NMR spectroscopy as well as NaCSI. The dependence on pH and free Ca2+ concentration of the 23Na NMR frequency shift induced by TmDOTP5- was evaluated. It was found that TmDOTP5- produces good spectral resolution under physiologic conditions. Examples presented from in vivo NaCSI experiments using TmDOTP5- to study diffusion in the posterior chamber of the rabbit eye and to monitor the rate of clearance of aqueous fluid from the anterior chamber demonstrate the effectiveness of this new shift reagent and of the NaCSI technique for in vivo studies.
PubMed: 1310341
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pubmed:1310341Le document en format XML
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Weinberg</name></author><author><name sortKey="D Amico, D J" sort="D Amico, D J" uniqKey="D Amico D" first="D J" last="D'Amico">D J D'Amico</name></author><author><name sortKey="Gragoudas, E S" sort="Gragoudas, E S" uniqKey="Gragoudas E" first="E S" last="Gragoudas">E S Gragoudas</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1310341</idno><idno type="pmid">1310341</idno><idno type="wicri:Area/PubMed/Corpus">000803</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000803</idno><idno type="wicri:Area/PubMed/Curation">000803</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000803</idno><idno type="wicri:Area/PubMed/Checkpoint">000803</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000803</idno><idno type="wicri:Area/Ncbi/Merge">000065</idno><idno type="wicri:Area/Ncbi/Curation">000065</idno><idno type="wicri:Area/Ncbi/Checkpoint">000065</idno><idno type="wicri:doubleKey">0740-3194:1992:Kohler S:in:vivo:sodium</idno><idno type="wicri:Area/Main/Merge">003882</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vivo sodium chemical shift imaging.</title><author><name sortKey="Kohler, S J" sort="Kohler, S J" uniqKey="Kohler S" first="S J" last="Kohler">S J Kohler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Medicine, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kolodny, N H" sort="Kolodny, N H" uniqKey="Kolodny N" first="N H" last="Kolodny">N H Kolodny</name></author><author><name sortKey="Celi, A C" sort="Celi, A C" uniqKey="Celi A" first="A C" last="Celi">A C Celi</name></author><author><name sortKey="Burr, T A" sort="Burr, T A" uniqKey="Burr T" first="T A" last="Burr">T A Burr</name></author><author><name sortKey="Weinberg, D" sort="Weinberg, D" uniqKey="Weinberg D" first="D" last="Weinberg">D. Weinberg</name></author><author><name sortKey="D Amico, D J" sort="D Amico, D J" uniqKey="D Amico D" first="D J" last="D'Amico">D J D'Amico</name></author><author><name sortKey="Gragoudas, E S" sort="Gragoudas, E S" uniqKey="Gragoudas E" first="E S" last="Gragoudas">E S Gragoudas</name></author></analytic><series><title level="j">Magnetic resonance in medicine</title><idno type="ISSN">0740-3194</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anterior Chamber (metabolism)</term><term>Calcium (chemistry)</term><term>Chelating Agents</term><term>Diffusion</term><term>Dysprosium</term><term>Edetic Acid (analogs & derivatives)</term><term>Electron Spin Resonance Spectroscopy</term><term>Hydrogen-Ion Concentration</term><term>Magnetic Resonance Spectroscopy</term><term>Models, Structural</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Rabbits</term><term>Sodium (chemistry)</term><term>Sodium (pharmacokinetics)</term><term>Vitreous Body (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide édétique (analogues et dérivés)</term><term>Animaux</term><term>Calcium ()</term><term>Chambre antérieure du bulbe oculaire (métabolisme)</term><term>Chélateurs</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Concentration en ions d'hydrogène</term><term>Corps vitré (métabolisme)</term><term>Diffusion</term><term>Dysprosium</term><term>Lapins</term><term>Maquettes de structure</term><term>Sodium ()</term><term>Sodium (pharmacocinétique)</term><term>Spectroscopie de résonance de spin électronique</term><term>Spectroscopie par résonance magnétique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Edetic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Calcium</term><term>Sodium</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Acide édétique</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Anterior Chamber</term><term>Vitreous Body</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chambre antérieure du bulbe oculaire</term><term>Corps vitré</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Sodium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Sodium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chelating Agents</term><term>Diffusion</term><term>Dysprosium</term><term>Electron Spin Resonance Spectroscopy</term><term>Hydrogen-Ion Concentration</term><term>Magnetic Resonance Spectroscopy</term><term>Models, Structural</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Rabbits</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Calcium</term><term>Chélateurs</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Concentration en ions d'hydrogène</term><term>Diffusion</term><term>Dysprosium</term><term>Lapins</term><term>Maquettes de structure</term><term>Sodium</term><term>Spectroscopie de résonance de spin électronique</term><term>Spectroscopie par résonance magnétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The shift reagents thulium(III) 1,4,7,10-tetraazacyclododecane N,N',N",N"'tetramethylenephosphonate (TmDOTP5-), and dysprosium(III)triethylenetetramine-hexaacetate (DyTTHA3-) are compared in this work for their uses in sodium chemical shift imaging (NaCSI). In a series of experiments using phantoms we evaluated the relative contributions of bulk magnetic susceptibility (BMS) effects and hyperfine shifts to the induced 23Na chemical shift for these two shift reagents. The ratios of BMS effects to hyperfine shifts suggest that TmDOTP5- should be a more effective shift reagent than DyTTHA3- for 23Na NMR spectroscopy as well as NaCSI. The dependence on pH and free Ca2+ concentration of the 23Na NMR frequency shift induced by TmDOTP5- was evaluated. It was found that TmDOTP5- produces good spectral resolution under physiologic conditions. Examples presented from in vivo NaCSI experiments using TmDOTP5- to study diffusion in the posterior chamber of the rabbit eye and to monitor the rate of clearance of aqueous fluid from the anterior chamber demonstrate the effectiveness of this new shift reagent and of the NaCSI technique for in vivo studies.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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