TmDOTP(5-) as a (23)Na shift reagent for the subcutaneously implanted 9L gliosarcoma in rats.
Identifieur interne : 002057 ( Main/Merge ); précédent : 002056; suivant : 002058TmDOTP(5-) as a (23)Na shift reagent for the subcutaneously implanted 9L gliosarcoma in rats.
Auteurs : P M Winter [États-Unis] ; N. BansalSource :
- Magnetic resonance in medicine [ 0740-3194 ] ; 2001.
Descripteurs français
- KwdFr :
- Animaux, Cellules cancéreuses en culture (physiologie), Composés organiques du phosphore, Composés organométalliques, Espace extracellulaire (métabolisme), Gliosarcome (physiopathologie), Lignée cellulaire, Liquide intracellulaire (métabolisme), Rats, Rats de lignée F344, Sodium (métabolisme), Spectroscopie par résonance magnétique (), Transplantation tumorale.
- MESH :
- métabolisme : Espace extracellulaire, Liquide intracellulaire, Sodium.
- physiologie : Cellules cancéreuses en culture.
- physiopathologie : Gliosarcome.
- Animaux, Composés organiques du phosphore, Composés organométalliques, Lignée cellulaire, Rats, Rats de lignée F344, Spectroscopie par résonance magnétique, Transplantation tumorale.
English descriptors
- KwdEn :
- Animals, Cell Line, Extracellular Space (metabolism), Gliosarcoma (physiopathology), Intracellular Fluid (metabolism), Magnetic Resonance Spectroscopy (methods), Neoplasm Transplantation, Organometallic Compounds, Organophosphorus Compounds, Rats, Rats, Inbred F344, Sodium (metabolism), Tumor Cells, Cultured (physiology).
- MESH :
- chemical , metabolism : Sodium.
- chemical : Organometallic Compounds, Organophosphorus Compounds.
- metabolism : Extracellular Space, Intracellular Fluid.
- methods : Magnetic Resonance Spectroscopy.
- physiology : Tumor Cells, Cultured.
- physiopathology : Gliosarcoma.
- Animals, Cell Line, Neoplasm Transplantation, Rats, Rats, Inbred F344.
Abstract
The use of TmDOTP(5-) as an in vivo (23)Na NMR shift reagent (SR) for subcutaneously implanted 9L gliosarcoma was evaluated. TmDOTP(5-) produced a single sharp extracellular peak after about 50-60 min of infusion, and did not cause any changes in the (31)P resonance areas or chemical shifts, suggesting that the SR is homogeneously distributed in the extracellular space and does not alter tumor bioenergetic status. TmDOTP(5-) and CoEDTA(-) as extracellular space markers gave identical results for relative extracellular space (0.25 +/- 0.03 and 0.25 +/- 0.04, respectively) and intracellular Na(+) concentration (19.3 +/- 4.0 mM and 18.6 +/- 3.9 mM, respectively), indicating that the biodistribution of the SR is the same as the well-accepted extracellular space marker. The in vivo T(1) and T(2) relaxation times of intra- and extracellular Na(+) were also measured. Our results indicate that TmDOTP(5-) promises to be an effective shift reagent and extracellular space marker in the 9L gliosarcoma and perhaps other tumors. Magn Reson Med 45:436-442, 2001.
PubMed: 11241701
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Bansal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11241701</idno><idno type="pmid">11241701</idno><idno type="wicri:Area/PubMed/Corpus">000732</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000732</idno><idno type="wicri:Area/PubMed/Curation">000732</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000732</idno><idno type="wicri:Area/PubMed/Checkpoint">000732</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000732</idno><idno type="wicri:Area/Ncbi/Merge">000010</idno><idno type="wicri:Area/Ncbi/Curation">000010</idno><idno type="wicri:Area/Ncbi/Checkpoint">000010</idno><idno type="wicri:doubleKey">0740-3194:2001:Winter P:tmdotp:as:a</idno><idno type="wicri:Area/Main/Merge">002057</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">TmDOTP(5-) as a (23)Na shift reagent for the subcutaneously implanted 9L gliosarcoma in rats.</title><author><name sortKey="Winter, P M" sort="Winter, P M" uniqKey="Winter P" first="P M" last="Winter">P M Winter</name><affiliation wicri:level="2"><nlm:affiliation>Joint Program in Biomedical Engineering, University of Texas, Arlington, Texas, and University of Texas, Southwestern Medical Center, Dallas, Texas.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Joint Program in Biomedical Engineering, University of Texas, Arlington, Texas, and University of Texas, Southwestern Medical Center, Dallas</wicri:cityArea></affiliation></author><author><name sortKey="Bansal, N" sort="Bansal, N" uniqKey="Bansal N" first="N" last="Bansal">N. Bansal</name></author></analytic><series><title level="j">Magnetic resonance in medicine</title><idno type="ISSN">0740-3194</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Extracellular Space (metabolism)</term><term>Gliosarcoma (physiopathology)</term><term>Intracellular Fluid (metabolism)</term><term>Magnetic Resonance Spectroscopy (methods)</term><term>Neoplasm Transplantation</term><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term><term>Rats</term><term>Rats, Inbred F344</term><term>Sodium (metabolism)</term><term>Tumor Cells, Cultured (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules cancéreuses en culture (physiologie)</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Espace extracellulaire (métabolisme)</term><term>Gliosarcome (physiopathologie)</term><term>Lignée cellulaire</term><term>Liquide intracellulaire (métabolisme)</term><term>Rats</term><term>Rats de lignée F344</term><term>Sodium (métabolisme)</term><term>Spectroscopie par résonance magnétique ()</term><term>Transplantation tumorale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Sodium</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Organometallic Compounds</term><term>Organophosphorus Compounds</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Extracellular Space</term><term>Intracellular Fluid</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espace extracellulaire</term><term>Liquide intracellulaire</term><term>Sodium</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules cancéreuses en culture</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Tumor Cells, Cultured</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Gliosarcome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Gliosarcoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Neoplasm Transplantation</term><term>Rats</term><term>Rats, Inbred F344</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Composés organiques du phosphore</term><term>Composés organométalliques</term><term>Lignée cellulaire</term><term>Rats</term><term>Rats de lignée F344</term><term>Spectroscopie par résonance magnétique</term><term>Transplantation tumorale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The use of TmDOTP(5-) as an in vivo (23)Na NMR shift reagent (SR) for subcutaneously implanted 9L gliosarcoma was evaluated. TmDOTP(5-) produced a single sharp extracellular peak after about 50-60 min of infusion, and did not cause any changes in the (31)P resonance areas or chemical shifts, suggesting that the SR is homogeneously distributed in the extracellular space and does not alter tumor bioenergetic status. TmDOTP(5-) and CoEDTA(-) as extracellular space markers gave identical results for relative extracellular space (0.25 +/- 0.03 and 0.25 +/- 0.04, respectively) and intracellular Na(+) concentration (19.3 +/- 4.0 mM and 18.6 +/- 3.9 mM, respectively), indicating that the biodistribution of the SR is the same as the well-accepted extracellular space marker. The in vivo T(1) and T(2) relaxation times of intra- and extracellular Na(+) were also measured. Our results indicate that TmDOTP(5-) promises to be an effective shift reagent and extracellular space marker in the 9L gliosarcoma and perhaps other tumors. Magn Reson Med 45:436-442, 2001.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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