23Na chemical shift imaging and Gd enhancement of myocardial edema
Identifieur interne : 000768 ( Main/Merge ); précédent : 000767; suivant : 00076923Na chemical shift imaging and Gd enhancement of myocardial edema
Auteurs : Eissa N. E. Aguor [Pays-Bas] ; Cees W. A. Van De Kolk [Pays-Bas] ; Fatih Arslan [Pays-Bas] ; Marcel G. J. Nederhoff [Pays-Bas] ; Pieter A. F. M. Doevendans [Pays-Bas] ; Gerard Pasterkamp [Pays-Bas] ; Gustav J. Strijkers [Pays-Bas] ; Cees J. A. Van Echteld [Pays-Bas, Suisse]Source :
- The International Journal of Cardiovascular Imaging [ 1569-5794 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Composés organiques du phosphore, Composés organométalliques, Diagnostic différentiel, Facteurs temps, Imagerie par résonance magnétique, Infarctus du myocarde (anatomopathologie), Isotopes du sodium, Myocarde (anatomopathologie), Myocarde (métabolisme), Mâle, Oedème cardiaque (anatomopathologie), Oedème cardiaque (diagnostic), Oedème cardiaque (métabolisme), Perfusion, Produits de contraste, Rat Wistar, Rats, Spectroscopie par résonance magnétique, Techniques in vitro, Valeur prédictive des tests.
- MESH :
- anatomopathologie : Infarctus du myocarde, Myocarde, Oedème cardiaque.
- diagnostic : Oedème cardiaque.
- métabolisme : Myocarde, Oedème cardiaque.
- Animaux, Composés organiques du phosphore, Composés organométalliques, Diagnostic différentiel, Facteurs temps, Imagerie par résonance magnétique, Isotopes du sodium, Mâle, Perfusion, Produits de contraste, Rat Wistar, Rats, Spectroscopie par résonance magnétique, Techniques in vitro, Valeur prédictive des tests.
English descriptors
- KwdEn :
- Animals, Contrast Media, Diagnosis, Differential, Edema, Cardiac (diagnosis), Edema, Cardiac (metabolism), Edema, Cardiac (pathology), In Vitro Techniques, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Myocardial Infarction (pathology), Myocardium (metabolism), Myocardium (pathology), Organometallic Compounds, Organophosphorus Compounds, Perfusion, Predictive Value of Tests, Rats, Rats, Wistar, Sodium Isotopes, Time Factors.
- MESH :
- chemical : Contrast Media, Organometallic Compounds, Organophosphorus Compounds, Sodium Isotopes.
- diagnosis : Edema, Cardiac.
- metabolism : Edema, Cardiac, Myocardium.
- pathology : Edema, Cardiac, Myocardial Infarction, Myocardium.
- Animals, Diagnosis, Differential, In Vitro Techniques, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Male, Perfusion, Predictive Value of Tests, Rats, Rats, Wistar, Time Factors.
Abstract
Myocardial edema can arise in several disease states. MRI contrast agent can accumulate in edematous tissue, which complicates differential diagnosis with contrast-enhanced (CE)-MRI and might lead to overestimation of infarct size. Sodium Chemical Shift Imaging (23Na-CSI) may provide an alternative for edema imaging. We have developed a non-infarct, isolated rat heart model with two levels of edema, which was studied with 23Na-CSI and CE-MRI. In edematous, but viable tissue the extracellular sodium (Nae+) signal is hypothesized to increase, but not the intracellular sodium (Nai+) signal. Isolated hearts were perfused at 60 (n = 6) and 140 mmHg (n = 5). Dimethyl methylphosphonate (DMMP) and phenylphosphonate (PPA) were used to follow edema formation by 31P-MR Spectroscopy. In separate groups, Thulium(III)1,4,7,10 tetraazacyclododecane-
Url:
DOI: 10.1007/s10554-012-0093-6
PubMed: 22790331
PubMed Central: 3560947
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PMC:3560947Le document en format XML
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Na chemical shift imaging and Gd enhancement of myocardial edema</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><sup>23</sup>
Na chemical shift imaging and Gd enhancement of myocardial edema</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Contrast Media</term>
<term>Diagnosis, Differential</term>
<term>Edema, Cardiac (diagnosis)</term>
<term>Edema, Cardiac (metabolism)</term>
<term>Edema, Cardiac (pathology)</term>
<term>In Vitro Techniques</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Male</term>
<term>Myocardial Infarction (pathology)</term>
<term>Myocardium (metabolism)</term>
<term>Myocardium (pathology)</term>
<term>Organometallic Compounds</term>
<term>Organophosphorus Compounds</term>
<term>Perfusion</term>
<term>Predictive Value of Tests</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Sodium Isotopes</term>
<term>Time Factors</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Composés organiques du phosphore</term>
<term>Composés organométalliques</term>
<term>Diagnostic différentiel</term>
<term>Facteurs temps</term>
<term>Imagerie par résonance magnétique</term>
<term>Infarctus du myocarde (anatomopathologie)</term>
<term>Isotopes du sodium</term>
<term>Myocarde (anatomopathologie)</term>
<term>Myocarde (métabolisme)</term>
<term>Mâle</term>
<term>Oedème cardiaque (anatomopathologie)</term>
<term>Oedème cardiaque (diagnostic)</term>
<term>Oedème cardiaque (métabolisme)</term>
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<term>Produits de contraste</term>
<term>Rat Wistar</term>
<term>Rats</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Techniques in vitro</term>
<term>Valeur prédictive des tests</term>
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<term>Organophosphorus Compounds</term>
<term>Sodium Isotopes</term>
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<term>Oedème cardiaque</term>
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<term>Myocardium</term>
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<term>Oedème cardiaque</term>
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<term>Myocardium</term>
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<term>Diagnosis, Differential</term>
<term>In Vitro Techniques</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic Resonance Spectroscopy</term>
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<term>Perfusion</term>
<term>Predictive Value of Tests</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Time Factors</term>
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<term>Composés organiques du phosphore</term>
<term>Composés organométalliques</term>
<term>Diagnostic différentiel</term>
<term>Facteurs temps</term>
<term>Imagerie par résonance magnétique</term>
<term>Isotopes du sodium</term>
<term>Mâle</term>
<term>Perfusion</term>
<term>Produits de contraste</term>
<term>Rat Wistar</term>
<term>Rats</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Techniques in vitro</term>
<term>Valeur prédictive des tests</term>
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<front><div type="abstract" xml:lang="en"><p>Myocardial edema can arise in several disease states. MRI contrast agent can accumulate in edematous tissue, which complicates differential diagnosis with contrast-enhanced (CE)-MRI and might lead to overestimation of infarct size. Sodium Chemical Shift Imaging (<sup>23</sup>
Na-CSI) may provide an alternative for edema imaging. We have developed a non-infarct, isolated rat heart model with two levels of edema, which was studied with <sup>23</sup>
Na-CSI and CE-MRI. In edematous, but viable tissue the extracellular sodium (Na<sub arrange="stack">e</sub>
<sup arrange="stack">+</sup>
) signal is hypothesized to increase, but not the intracellular sodium (Na<sub arrange="stack">i</sub>
<sup arrange="stack">+</sup>
) signal. Isolated hearts were perfused at 60 (n = 6) and 140 mmHg (n = 5). Dimethyl methylphosphonate (DMMP) and phenylphosphonate (PPA) were used to follow edema formation by <sup>31</sup>
P-MR Spectroscopy. In separate groups, Thulium(III)1,4,7,10 tetraazacyclododecane-<italic>N</italic>
,<italic>N</italic>
′,<italic>N</italic>
″,<italic>N</italic>
′′′-tetra(methylenephosphonate) (TmDOTP<sup>5−</sup>
) and Gadovist were used for <sup>23</sup>
Na-CSI (n = 8) and CE-MRI (n = 6), respectively. PPA normalized signal intensity (SI) was higher at 140 versus 60 mmHg, with a ratio of 1.27 ± 0.12 (<italic>p</italic>
< 0.05). The (DMMP-PPA)/dry weight ratio, as a marker of intracellular volume, remained unchanged. The mid-heart cross sectional area (CSA) of the left ventricle (LV) was significantly increased at 140 mmHg. In addition, at 140 mmHg, the LV Na<sub arrange="stack">e</sub>
<sup arrange="stack">+</sup>
SI increased with a 140 mmHg/60 mmHg ratio of 1.24 ± 0.18 (<italic>p</italic>
< 0.05). Na<sub arrange="stack">i</sub>
<sup arrange="stack">+</sup>
SI remained essentially unchanged. With CE-MRI, a subendocardially enhanced CSA was identified, increasing from 0.20 ± 0.02 cm<sup>2</sup>
at 60 mmHg to 0.31 ± 0.02 cm<sup>2</sup>
at 140 mmHg (<italic>p</italic>
< 0.05). Edema shows up in both CE-MRI and Na<sub arrange="stack">e</sub>
<sup arrange="stack">+</sup>
. High perfusion pressure causes more edema subendocardially than subepicardially. <sup>23</sup>
Na-CSI is an attractive alternative for imaging of edema and is a promising tool to discriminate between edema, acute and chronic MI.</p>
</div>
</front>
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<author><name sortKey="Wise, D" uniqKey="Wise D">D Wise</name>
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<author><name sortKey="Burkhoff, D" uniqKey="Burkhoff D">D Burkhoff</name>
</author>
<author><name sortKey="Cannon, Pj" uniqKey="Cannon P">PJ Cannon</name>
</author>
<author><name sortKey="Katz, J" uniqKey="Katz J">J Katz</name>
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<biblStruct><analytic><author><name sortKey="De Jong, S" uniqKey="De Jong S">S de Jong</name>
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<author><name sortKey="Zwanenburg, Jj" uniqKey="Zwanenburg J">JJ Zwanenburg</name>
</author>
<author><name sortKey="Visser, F" uniqKey="Visser F">F Visser</name>
</author>
<author><name sortKey="Van Der Nagel, R" uniqKey="Van Der Nagel R">R van der Nagel</name>
</author>
<author><name sortKey="Van Rijen, Hv" uniqKey="Van Rijen H">HV van Rijen</name>
</author>
<author><name sortKey="Vos, Ma" uniqKey="Vos M">MA Vos</name>
</author>
<author><name sortKey="De Bakker, Jm" uniqKey="De Bakker J">JM de Bakker</name>
</author>
<author><name sortKey="Luijten, Pr" uniqKey="Luijten P">PR Luijten</name>
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