Undecaprenyl Pyrophosphate Involvement in Susceptibility of Bacillus subtilis to Rare Earth Elements
Identifieur interne : 000689 ( Main/Merge ); précédent : 000688; suivant : 000690Undecaprenyl Pyrophosphate Involvement in Susceptibility of Bacillus subtilis to Rare Earth Elements
Auteurs : Takashi Inaoka [Japon] ; Kozo Ochi [Japon]Source :
- Journal of Bacteriology [ 0021-9193 ] ; 2012.
Abstract
The rare earth element scandium has weak antibacterial potency. We identified a mutation responsible for a scandium-resistant phenotype in
Url:
DOI: 10.1128/JB.01147-12
PubMed: 22904278
PubMed Central: 3458658
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Undecaprenyl Pyrophosphate Involvement in Susceptibility of <named-content content-type="genus-species">Bacillus subtilis</named-content> to Rare Earth Elements</title><author><name sortKey="Inaoka, Takashi" sort="Inaoka, Takashi" uniqKey="Inaoka T" first="Takashi" last="Inaoka">Takashi Inaoka</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Food Research Institute-National Agriculture Research Organization, Tsukuba, Ibaraki, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>National Food Research Institute-National Agriculture Research Organization, Tsukuba, Ibaraki</wicri:regionArea><wicri:noRegion>Ibaraki</wicri:noRegion></affiliation></author><author><name sortKey="Ochi, Kozo" sort="Ochi, Kozo" uniqKey="Ochi K" first="Kozo" last="Ochi">Kozo Ochi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Science, Hiroshima Institute of Technology, Saeki-ku, Hiroshima, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Life Science, Hiroshima Institute of Technology, Saeki-ku, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22904278</idno><idno type="pmc">3458658</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458658</idno><idno type="RBID">PMC:3458658</idno><idno type="doi">10.1128/JB.01147-12</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000275</idno><idno type="wicri:Area/Pmc/Curation">000275</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000275</idno><idno type="wicri:Area/Pmc/Checkpoint">000208</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000208</idno><idno type="wicri:Area/Ncbi/Merge">000599</idno><idno type="wicri:Area/Ncbi/Curation">000599</idno><idno type="wicri:Area/Ncbi/Checkpoint">000599</idno><idno type="wicri:doubleKey">0021-9193:2012:Inaoka T:undecaprenyl:pyrophosphate:involvement</idno><idno type="wicri:Area/Main/Merge">000689</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Undecaprenyl Pyrophosphate Involvement in Susceptibility of <named-content content-type="genus-species">Bacillus subtilis</named-content> to Rare Earth Elements</title><author><name sortKey="Inaoka, Takashi" sort="Inaoka, Takashi" uniqKey="Inaoka T" first="Takashi" last="Inaoka">Takashi Inaoka</name><affiliation wicri:level="1"><nlm:aff id="aff1">National Food Research Institute-National Agriculture Research Organization, Tsukuba, Ibaraki, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>National Food Research Institute-National Agriculture Research Organization, Tsukuba, Ibaraki</wicri:regionArea><wicri:noRegion>Ibaraki</wicri:noRegion></affiliation></author><author><name sortKey="Ochi, Kozo" sort="Ochi, Kozo" uniqKey="Ochi K" first="Kozo" last="Ochi">Kozo Ochi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Life Science, Hiroshima Institute of Technology, Saeki-ku, Hiroshima, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Life Science, Hiroshima Institute of Technology, Saeki-ku, Hiroshima</wicri:regionArea><wicri:noRegion>Hiroshima</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Bacteriology</title><idno type="ISSN">0021-9193</idno><idno type="eISSN">1098-5530</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The rare earth element scandium has weak antibacterial potency. We identified a mutation responsible for a scandium-resistant phenotype in <named-content content-type="genus-species">Bacillus subtilis</named-content>. This mutation was found within the <italic>uppS</italic> gene, which encodes undecaprenyl pyrophosphate synthase, and designated <italic>uppS86</italic> (for the Thr-to-Ile amino acid substitution at residue 86 of undecaprenyl pyrophosphate synthase). The <italic>uppS86</italic> mutation also gave rise to increased resistance to bacitracin, which prevents cell wall synthesis by inhibiting the dephosphorylation of undecaprenyl pyrophosphate, in addition to enhanced amylase production. Conversely, overexpression of the wild-type <italic>uppS</italic> gene resulted in increased susceptibilities to both scandium and bacitracin. Moreover, the mutant lacking undecaprenyl pyrophosphate phosphatase (BcrC) showed increased susceptibility to all rare earth elements tested. These results suggest that the accumulation of undecaprenyl pyrophosphate renders cells more susceptible to rare earth elements. The availability of undecaprenyl pyrophosphate may be an important determinant for susceptibility to rare earth elements, such as scandium.</p></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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