Biotic ligand model does not predict the bioavailability of rare Earth elements in the presence of organic ligands.
Identifieur interne : 000180 ( Main/Merge ); précédent : 000179; suivant : 000181Biotic ligand model does not predict the bioavailability of rare Earth elements in the presence of organic ligands.
Auteurs : Chun-Mei Zhao [Canada] ; Kevin J. WilkinsonSource :
- Environmental science & technology [ 1520-5851 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Acide citrique, Chlamydomonas reinhardtii, Radio-isotopes du carbone.
- pharmacocinétique : Terres rares.
- Biodisponibilité, Cinétique, Eau douce, Ligands, Modèles théoriques, Métaux.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Metals.
- chemical , metabolism : Carbon Radioisotopes, Citric Acid.
- metabolism : Chlamydomonas reinhardtii.
- chemical , pharmacokinetics : Metals, Rare Earth.
- Biological Availability, Fresh Water, Kinetics, Ligands, Models, Theoretical.
Abstract
Due to their distinct physicochemical properties, rare earth elements (REEs) are critical to high-tech and clean-energy industries; however, their bioavailability is still largely unexplored. In this paper, the bioavailability of several REEs has been carefully examined for the freshwater alga, Chlamydomonas reinhardtii. In the presence of organic ligands (L), the biouptake of REEs was much higher than that predicted by the biotic ligand model (BLM). Enhancement of the biouptake flux was observed for six ligands (metal = thulium) and six REEs (ligand = citric acid), indicating that this could be a common feature for these metals. In order to explore the mechanism for the enhanced uptake, Tm internalization was carefully evaluated. The Tm internalization flux (Jint) followed first-order (Michaelis-Menten) kinetics with a calculated maximum internalization flux (Jmax) of (1.1 ± 0.08) × 10(-14) mol · cm(-2) · s(-1) and an affinity constant for the reaction of the metal with the transport sites (KTm-R) of 10(7.1) M(-1). In the presence of citric acid, malic acid, or NTA, the Jint for Tm was more than 1 order of magnitude higher than that predicted by the BLM when algae were exposed to a constant 10(-9) M Tm(3+). The bioavailability of the metal complexes could not be explained by a piggyback internalization (through an anion channel) or the contribution of labile complexes. The enhanced biouptake was attributed to the formation of a ternary Tm complex {L-Tm-R} at the metal transport site. In the natural environment where organic ligands are ubiquitous, classic models are unlikely to predict the bioavailability of REEs to aquatic organisms.
DOI: 10.1021/es505443s
PubMed: 25611881
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Biotic ligand model does not predict the bioavailability of rare Earth elements in the presence of organic ligands.</title><author><name sortKey="Zhao, Chun Mei" sort="Zhao, Chun Mei" uniqKey="Zhao C" first="Chun-Mei" last="Zhao">Chun-Mei Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Biophysical Environmental Chemistry Group, Department of Chemistry, University of Montreal , C.P. 6128 Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Biophysical Environmental Chemistry Group, Department of Chemistry, University of Montreal , C.P. 6128 Succursale Centre-Ville, Montreal, Quebec H3C 3J7</wicri:regionArea><wicri:noRegion>Quebec H3C 3J7</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, Kevin J" sort="Wilkinson, Kevin J" uniqKey="Wilkinson K" first="Kevin J" last="Wilkinson">Kevin J. Wilkinson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="doi">10.1021/es505443s</idno><idno type="RBID">pubmed:25611881</idno><idno type="pmid">25611881</idno><idno type="wicri:Area/PubMed/Corpus">000111</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000111</idno><idno type="wicri:Area/PubMed/Curation">000111</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000111</idno><idno type="wicri:Area/PubMed/Checkpoint">000111</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000111</idno><idno type="wicri:Area/Ncbi/Merge">000945</idno><idno type="wicri:Area/Ncbi/Curation">000945</idno><idno type="wicri:Area/Ncbi/Checkpoint">000945</idno><idno type="wicri:Area/Main/Merge">000180</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Biotic ligand model does not predict the bioavailability of rare Earth elements in the presence of organic ligands.</title><author><name sortKey="Zhao, Chun Mei" sort="Zhao, Chun Mei" uniqKey="Zhao C" first="Chun-Mei" last="Zhao">Chun-Mei Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Biophysical Environmental Chemistry Group, Department of Chemistry, University of Montreal , C.P. 6128 Succursale Centre-Ville, Montreal, Quebec H3C 3J7, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Biophysical Environmental Chemistry Group, Department of Chemistry, University of Montreal , C.P. 6128 Succursale Centre-Ville, Montreal, Quebec H3C 3J7</wicri:regionArea><wicri:noRegion>Quebec H3C 3J7</wicri:noRegion></affiliation></author><author><name sortKey="Wilkinson, Kevin J" sort="Wilkinson, Kevin J" uniqKey="Wilkinson K" first="Kevin J" last="Wilkinson">Kevin J. Wilkinson</name></author></analytic><series><title level="j">Environmental science & technology</title><idno type="eISSN">1520-5851</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological Availability</term><term>Carbon Radioisotopes (metabolism)</term><term>Chlamydomonas reinhardtii (metabolism)</term><term>Citric Acid (metabolism)</term><term>Fresh Water</term><term>Kinetics</term><term>Ligands</term><term>Metals (chemistry)</term><term>Metals, Rare Earth (pharmacokinetics)</term><term>Models, Theoretical</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide citrique (métabolisme)</term><term>Biodisponibilité</term><term>Chlamydomonas reinhardtii (métabolisme)</term><term>Cinétique</term><term>Eau douce</term><term>Ligands</term><term>Modèles théoriques</term><term>Métaux ()</term><term>Radio-isotopes du carbone (métabolisme)</term><term>Terres rares (pharmacocinétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Metals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carbon Radioisotopes</term><term>Citric Acid</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chlamydomonas reinhardtii</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acide citrique</term><term>Chlamydomonas reinhardtii</term><term>Radio-isotopes du carbone</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Terres rares</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Metals, Rare Earth</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biological Availability</term><term>Fresh Water</term><term>Kinetics</term><term>Ligands</term><term>Models, Theoretical</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biodisponibilité</term><term>Cinétique</term><term>Eau douce</term><term>Ligands</term><term>Modèles théoriques</term><term>Métaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Due to their distinct physicochemical properties, rare earth elements (REEs) are critical to high-tech and clean-energy industries; however, their bioavailability is still largely unexplored. In this paper, the bioavailability of several REEs has been carefully examined for the freshwater alga, Chlamydomonas reinhardtii. In the presence of organic ligands (L), the biouptake of REEs was much higher than that predicted by the biotic ligand model (BLM). Enhancement of the biouptake flux was observed for six ligands (metal = thulium) and six REEs (ligand = citric acid), indicating that this could be a common feature for these metals. In order to explore the mechanism for the enhanced uptake, Tm internalization was carefully evaluated. The Tm internalization flux (Jint) followed first-order (Michaelis-Menten) kinetics with a calculated maximum internalization flux (Jmax) of (1.1 ± 0.08) × 10(-14) mol · cm(-2) · s(-1) and an affinity constant for the reaction of the metal with the transport sites (KTm-R) of 10(7.1) M(-1). In the presence of citric acid, malic acid, or NTA, the Jint for Tm was more than 1 order of magnitude higher than that predicted by the BLM when algae were exposed to a constant 10(-9) M Tm(3+). The bioavailability of the metal complexes could not be explained by a piggyback internalization (through an anion channel) or the contribution of labile complexes. The enhanced biouptake was attributed to the formation of a ternary Tm complex {L-Tm-R} at the metal transport site. In the natural environment where organic ligands are ubiquitous, classic models are unlikely to predict the bioavailability of REEs to aquatic organisms.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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