Near infrared activation of an anticancer Pt(IV) complex by Tm-doped upconversion nanoparticles.
Identifieur interne : 000121 ( Main/Merge ); précédent : 000120; suivant : 000122Near infrared activation of an anticancer Pt(IV) complex by Tm-doped upconversion nanoparticles.
Auteurs : Emmanuel Ruggiero [Espagne] ; Javier Hernández-Gil ; Juan C. Mareque-Rivas ; Luca SalassaSource :
- Chemical communications (Cambridge, England) [ 1364-548X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Antineoplastic Agents, Organoplatinum Compounds, Prodrugs, Thulium.
- chemistry : Nanoparticles.
- Infrared Rays, Photolysis.
Abstract
The Pt(IV) complex cis,cis,trans-[Pt(NH3)2(Cl)2(O2CCH2CH2CO2H)2] is photoactivated by near infrared light (980 nm) using NaYF4:Yb(3+)/Tm(3+)@NaYF4 core-shell upconversion nanoparticles. Coupling of this cisplatin precursor with the biocompatible PEGylated phospholipid DSPE-PEG(2000)-NH2 affords a valuable approach to decorate the surface of the nanoparticles, providing novel photoactivatable nanomaterials capable of releasing Pt(II) species upon NIR light excitation.
DOI: 10.1039/c4cc07960d
PubMed: 25536114
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pubmed:25536114Le document en format XML
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<author><name sortKey="Mareque Rivas, Juan C" sort="Mareque Rivas, Juan C" uniqKey="Mareque Rivas J" first="Juan C" last="Mareque-Rivas">Juan C. Mareque-Rivas</name>
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<author><name sortKey="Mareque Rivas, Juan C" sort="Mareque Rivas, Juan C" uniqKey="Mareque Rivas J" first="Juan C" last="Mareque-Rivas">Juan C. Mareque-Rivas</name>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques ()</term>
<term>Composés organiques du platine ()</term>
<term>Nanoparticules ()</term>
<term>Photolyse</term>
<term>Promédicaments ()</term>
<term>Rayons infrarouges</term>
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<term>Organoplatinum Compounds</term>
<term>Prodrugs</term>
<term>Thulium</term>
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<term>Composés organiques du platine</term>
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<front><div type="abstract" xml:lang="en">The Pt(IV) complex cis,cis,trans-[Pt(NH3)2(Cl)2(O2CCH2CH2CO2H)2] is photoactivated by near infrared light (980 nm) using NaYF4:Yb(3+)/Tm(3+)@NaYF4 core-shell upconversion nanoparticles. Coupling of this cisplatin precursor with the biocompatible PEGylated phospholipid DSPE-PEG(2000)-NH2 affords a valuable approach to decorate the surface of the nanoparticles, providing novel photoactivatable nanomaterials capable of releasing Pt(II) species upon NIR light excitation.</div>
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