Placebo effects in laser-evoked pain potentials
Identifieur interne : 001686 ( Main/Exploration ); précédent : 001685; suivant : 001687Placebo effects in laser-evoked pain potentials
Auteurs : Tor D. Wager [États-Unis] ; Dagfinn Matre [Norvège] ; Kenneth L. Casey [États-Unis]Source :
- Brain, behavior, and immunity [ 0889-1591 ] ; 2006.
Abstract
Placebo treatment may affect multiple components of pain, including inhibition of nociceptive input, automatic or deliberative appraisal of pain, or cognitive judgments involved in pain reporting. If placebo analgesia is due in part to an attenuation of early nociceptive processing, then pain-evoked event-related potentials (ERPs) should be reduced with placebo. In this study, we tested for placebo effects in P2 laser-evoked potentials at midline scalp electrodes. We found that placebo treatment produced significant decreases in P2 amplitude, and that P2 placebo responses were large enough to reflect a meaningful difference in nociceptive processing. However, we also found evidence that the very robust placebo-induced decreases in reported pain are not solely explained by early reductions in P2. N2 amplitude was affected by neither placebo nor reduction of laser intensity. These results suggest that placebo treatment affects early nociceptive processing, but that another component of placebo effects in reported pain occurs later, either in evaluation of pain or cognitive judgments about pain reports.
Url:
DOI: 10.1016/j.bbi.2006.01.007
PubMed: 16571371
PubMed Central: 3735137
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000332
- to stream Pmc, to step Curation: 000332
- to stream Pmc, to step Checkpoint: 000361
- to stream Ncbi, to step Merge: 000146
- to stream Ncbi, to step Curation: 000146
- to stream Ncbi, to step Checkpoint: 000146
- to stream Main, to step Merge: 001737
- to stream Main, to step Curation: 001686
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Placebo effects in laser-evoked pain potentials</title><author><name sortKey="Wager, Tor D" sort="Wager, Tor D" uniqKey="Wager T" first="Tor D." last="Wager">Tor D. Wager</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Psychology, Columbia University, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Columbia University, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Matre, Dagfinn" sort="Matre, Dagfinn" uniqKey="Matre D" first="Dagfinn" last="Matre">Dagfinn Matre</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Physiology, National Institute of Occupational Health, 0033 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Physiology, National Institute of Occupational Health, 0033 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Casey, Kenneth L" sort="Casey, Kenneth L" uniqKey="Casey K" first="Kenneth L." last="Casey">Kenneth L. Casey</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16571371</idno><idno type="pmc">3735137</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735137</idno><idno type="RBID">PMC:3735137</idno><idno type="doi">10.1016/j.bbi.2006.01.007</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000332</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000332</idno><idno type="wicri:Area/Pmc/Curation">000332</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000332</idno><idno type="wicri:Area/Pmc/Checkpoint">000361</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000361</idno><idno type="wicri:Area/Ncbi/Merge">000146</idno><idno type="wicri:Area/Ncbi/Curation">000146</idno><idno type="wicri:Area/Ncbi/Checkpoint">000146</idno><idno type="wicri:doubleKey">0889-1591:2006:Wager T:placebo:effects:in</idno><idno type="wicri:Area/Main/Merge">001737</idno><idno type="wicri:Area/Main/Curation">001686</idno><idno type="wicri:Area/Main/Exploration">001686</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Placebo effects in laser-evoked pain potentials</title><author><name sortKey="Wager, Tor D" sort="Wager, Tor D" uniqKey="Wager T" first="Tor D." last="Wager">Tor D. Wager</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Psychology, Columbia University, New York, NY 10027, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Columbia University, New York, NY 10027</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Matre, Dagfinn" sort="Matre, Dagfinn" uniqKey="Matre D" first="Dagfinn" last="Matre">Dagfinn Matre</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Physiology, National Institute of Occupational Health, 0033 Oslo, Norway</nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Physiology, National Institute of Occupational Health, 0033 Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Casey, Kenneth L" sort="Casey, Kenneth L" uniqKey="Casey K" first="Kenneth L." last="Casey">Kenneth L. Casey</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><series><title level="j">Brain, behavior, and immunity</title><idno type="ISSN">0889-1591</idno><idno type="eISSN">1090-2139</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Placebo treatment may affect multiple components of pain, including inhibition of nociceptive input, automatic or deliberative appraisal of pain, or cognitive judgments involved in pain reporting. If placebo analgesia is due in part to an attenuation of early nociceptive processing, then pain-evoked event-related potentials (ERPs) should be reduced with placebo. In this study, we tested for placebo effects in P2 laser-evoked potentials at midline scalp electrodes. We found that placebo treatment produced significant decreases in P2 amplitude, and that P2 placebo responses were large enough to reflect a meaningful difference in nociceptive processing. However, we also found evidence that the very robust placebo-induced decreases in reported pain are not solely explained by early reductions in P2. N2 amplitude was affected by neither placebo nor reduction of laser intensity. These results suggest that placebo treatment affects early nociceptive processing, but that another component of placebo effects in reported pain occurs later, either in evaluation of pain or cognitive judgments about pain reports.</p></div></front></TEI><affiliations><list><country><li>Norvège</li><li>États-Unis</li></country><region><li>Michigan</li><li>État de New York</li><li>Østlandet</li></region><settlement><li>New York</li><li>Oslo</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Wager, Tor D" sort="Wager, Tor D" uniqKey="Wager T" first="Tor D." last="Wager">Tor D. Wager</name></region><name sortKey="Casey, Kenneth L" sort="Casey, Kenneth L" uniqKey="Casey K" first="Kenneth L." last="Casey">Kenneth L. Casey</name></country><country name="Norvège"><region name="Østlandet"><name sortKey="Matre, Dagfinn" sort="Matre, Dagfinn" uniqKey="Matre D" first="Dagfinn" last="Matre">Dagfinn Matre</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001686 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001686 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3735137
|texte= Placebo effects in laser-evoked pain potentials
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:16571371" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ThuliumV1
| This area was generated with Dilib version V0.6.21. |  |