Modified natural nanoparticles as contrast agents for medical imaging
Identifieur interne : 000F32 ( Main/Exploration ); précédent : 000F31; suivant : 000F33Modified natural nanoparticles as contrast agents for medical imaging
Auteurs : David P. Cormode [États-Unis] ; Peter A. Jarzyna [États-Unis] ; Willem J. M. Mulder [États-Unis] ; Zahi A. Fayad [États-Unis]Source :
- Advanced drug delivery reviews [ 0169-409X ] ; 2009.
Abstract
The development of novel and effective contrast agents is one of the drivers of the ongoing improvement in medical imaging. Many of the new agents reported are nanoparticle-based. There are a variety of natural nanoparticles known, e.g. lipoproteins, viruses or ferritin. Natural nanoparticles have advantages as delivery platforms such as biodegradability. In addition, our understanding of natural nanoparticles is quite advanced, allowing their adaptation as contrast agents. They can be labeled with small molecules or ions such as Gd3+ to act as contrast agents for magnetic resonance imaging, 18F to act as positron emission tomography contrast agents or fluorophores to act as contrast agents for fluorescence techniques. Additionally, inorganic nanoparticles such as iron oxide, gold nanoparticles or quantum dots can be incorporated to add further contrast functionality. Furthermore, these natural nanoparticle contrast agents can be rerouted from their natural targets via the attachment of targeting molecules. In this review, we discuss the various modified natural nanoparticles that have been exploited as contrast agents.
Url:
DOI: 10.1016/j.addr.2009.11.005
PubMed: 19900496
PubMed Central: 2827667
Affiliations:
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Cormode</name><affiliation wicri:level="2"><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York</wicri:cityArea></affiliation></author><author><name sortKey="Jarzyna, Peter A" sort="Jarzyna, Peter A" uniqKey="Jarzyna P" first="Peter A." last="Jarzyna">Peter A. Jarzyna</name><affiliation wicri:level="2"><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York</wicri:cityArea></affiliation></author><author><name sortKey="Mulder, Willem J M" sort="Mulder, Willem J M" uniqKey="Mulder W" first="Willem J. M." last="Mulder">Willem J. M. Mulder</name><affiliation wicri:level="2"><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York</wicri:cityArea></affiliation></author><author><name sortKey="Fayad, Zahi A" sort="Fayad, Zahi A" uniqKey="Fayad Z" first="Zahi A." last="Fayad">Zahi A. Fayad</name><affiliation wicri:level="2"><nlm:aff id="A1"> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York, NY 10029</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea> Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1234, New York</wicri:cityArea></affiliation></author></analytic><series><title level="j">Advanced drug delivery reviews</title><idno type="ISSN">0169-409X</idno><idno type="eISSN">1872-8294</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The development of novel and effective contrast agents is one of the drivers of the ongoing improvement in medical imaging. Many of the new agents reported are nanoparticle-based. There are a variety of natural nanoparticles known, e.g. lipoproteins, viruses or ferritin. Natural nanoparticles have advantages as delivery platforms such as biodegradability. In addition, our understanding of natural nanoparticles is quite advanced, allowing their adaptation as contrast agents. They can be labeled with small molecules or ions such as Gd<sup>3+</sup> to act as contrast agents for magnetic resonance imaging, <sup>18</sup>F to act as positron emission tomography contrast agents or fluorophores to act as contrast agents for fluorescence techniques. Additionally, inorganic nanoparticles such as iron oxide, gold nanoparticles or quantum dots can be incorporated to add further contrast functionality. Furthermore, these natural nanoparticle contrast agents can be rerouted from their natural targets via the attachment of targeting molecules. In this review, we discuss the various modified natural nanoparticles that have been exploited as contrast agents.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Cormode, David P" sort="Cormode, David P" uniqKey="Cormode D" first="David P." last="Cormode">David P. 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