Continuous-wave infrared optical nerve stimulation for potential diagnostic applications.
Identifieur interne : 006141 ( Main/Exploration ); précédent : 006140; suivant : 006142Continuous-wave infrared optical nerve stimulation for potential diagnostic applications.
Auteurs : Serhat Tozburun [États-Unis] ; Christopher M. Cilip ; Gwen A. Lagoda ; Arthur L. Burnett ; Nathaniel M. FriedSource :
- Journal of biomedical optics [ 1560-2281 ]
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- innervation : Cavernous Sinus.
- surgery : Prostatic Neoplasms.
- Animals, Electric Stimulation, Humans, Infrared Rays, Lasers, Male, Models, Animal, Optical Devices, Optical Phenomena, Rats, Rats, Sprague-Dawley.
Abstract
Optical nerve stimulation using infrared laser radiation has recently been developed as a potential alternative to electrical nerve stimulation. However, recent studies have focused primarily on pulsed delivery of the laser radiation and at relatively low pulse rates. The objective of this study is to demonstrate faster optical stimulation of the prostate cavernous nerves using continuous-wave (cw) infrared laser radiation for potential diagnostic applications. A thulium fiber laser (λ=1870 nm) is used for noncontact optical stimulation of the rat prostate cavernous nerves in vivo. Optical nerve stimulation, as measured by an intracavernous pressure (ICP) response in the penis, is achieved with the laser operating in either cw mode, or with a 5-ms pulse duration at 10, 20, 30, 40, 50, and 100 Hz. Successful optical stimulation is observed to be primarily dependent on a threshold nerve temperature (42 to 45 °C), rather than an incident fluence, as previously reported. cw optical nerve stimulation provides a significantly faster ICP response time using a lower power (and also less expensive) laser than pulsed stimulation. cw optical nerve stimulation may therefore represent an alternative mode of stimulation for intraoperative diagnostic applications where a rapid response is critical, such as identification of the cavernous nerves during prostate cancer surgery.
DOI: 10.1117/1.3500656
PubMed: 21054094
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Continuous-wave infrared optical nerve stimulation for potential diagnostic applications.</title><author><name sortKey="Tozburun, Serhat" sort="Tozburun, Serhat" uniqKey="Tozburun S" first="Serhat" last="Tozburun">Serhat Tozburun</name><affiliation wicri:level="1"><nlm:affiliation>University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223-0001, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223-0001</wicri:regionArea><wicri:noRegion>North Carolina 28223-0001</wicri:noRegion></affiliation></author><author><name sortKey="Cilip, Christopher M" sort="Cilip, Christopher M" uniqKey="Cilip C" first="Christopher M" last="Cilip">Christopher M. Cilip</name></author><author><name sortKey="Lagoda, Gwen A" sort="Lagoda, Gwen A" uniqKey="Lagoda G" first="Gwen A" last="Lagoda">Gwen A. Lagoda</name></author><author><name sortKey="Burnett, Arthur L" sort="Burnett, Arthur L" uniqKey="Burnett A" first="Arthur L" last="Burnett">Arthur L. Burnett</name></author><author><name sortKey="Fried, Nathaniel M" sort="Fried, Nathaniel M" uniqKey="Fried N" first="Nathaniel M" last="Fried">Nathaniel M. Fried</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2010 Sep-Oct</MedlineDate></PubDate></date><idno type="doi">10.1117/1.3500656</idno><idno type="RBID">pubmed:21054094</idno><idno type="pmid">21054094</idno><idno type="wicri:Area/PubMed/Corpus">000469</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000469</idno><idno type="wicri:Area/PubMed/Curation">000469</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000469</idno><idno type="wicri:Area/PubMed/Checkpoint">000469</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000469</idno><idno type="wicri:Area/Ncbi/Merge">000418</idno><idno type="wicri:Area/Ncbi/Curation">000418</idno><idno type="wicri:Area/Ncbi/Checkpoint">000418</idno><idno type="wicri:Area/Main/Merge">006595</idno><idno type="wicri:Area/Main/Curation">006141</idno><idno type="wicri:Area/Main/Exploration">006141</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Continuous-wave infrared optical nerve stimulation for potential diagnostic applications.</title><author><name sortKey="Tozburun, Serhat" sort="Tozburun, Serhat" uniqKey="Tozburun S" first="Serhat" last="Tozburun">Serhat Tozburun</name><affiliation wicri:level="1"><nlm:affiliation>University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223-0001, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of North Carolina at Charlotte, Department of Physics and Optical Science, Charlotte, North Carolina 28223-0001</wicri:regionArea><wicri:noRegion>North Carolina 28223-0001</wicri:noRegion></affiliation></author><author><name sortKey="Cilip, Christopher M" sort="Cilip, Christopher M" uniqKey="Cilip C" first="Christopher M" last="Cilip">Christopher M. Cilip</name></author><author><name sortKey="Lagoda, Gwen A" sort="Lagoda, Gwen A" uniqKey="Lagoda G" first="Gwen A" last="Lagoda">Gwen A. Lagoda</name></author><author><name sortKey="Burnett, Arthur L" sort="Burnett, Arthur L" uniqKey="Burnett A" first="Arthur L" last="Burnett">Arthur L. Burnett</name></author><author><name sortKey="Fried, Nathaniel M" sort="Fried, Nathaniel M" uniqKey="Fried N" first="Nathaniel M" last="Fried">Nathaniel M. Fried</name></author></analytic><series><title level="j">Journal of biomedical optics</title><idno type="eISSN">1560-2281</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cavernous Sinus (innervation)</term><term>Electric Stimulation</term><term>Humans</term><term>Infrared Rays</term><term>Lasers</term><term>Male</term><term>Models, Animal</term><term>Optical Devices</term><term>Optical Phenomena</term><term>Prostatic Neoplasms (surgery)</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Dispositifs optiques</term><term>Humains</term><term>Lasers</term><term>Modèles animaux</term><term>Mâle</term><term>Phénomènes optiques</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Rayons infrarouges</term><term>Sinus caverneux (innervation)</term><term>Stimulation électrique</term><term>Tumeurs de la prostate ()</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Cavernous Sinus</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Electric Stimulation</term><term>Humans</term><term>Infrared Rays</term><term>Lasers</term><term>Male</term><term>Models, Animal</term><term>Optical Devices</term><term>Optical Phenomena</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="fr"><term>Animaux</term><term>Dispositifs optiques</term><term>Humains</term><term>Lasers</term><term>Modèles animaux</term><term>Mâle</term><term>Phénomènes optiques</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Rayons infrarouges</term><term>Sinus caverneux</term><term>Stimulation électrique</term><term>Tumeurs de la prostate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Optical nerve stimulation using infrared laser radiation has recently been developed as a potential alternative to electrical nerve stimulation. However, recent studies have focused primarily on pulsed delivery of the laser radiation and at relatively low pulse rates. The objective of this study is to demonstrate faster optical stimulation of the prostate cavernous nerves using continuous-wave (cw) infrared laser radiation for potential diagnostic applications. A thulium fiber laser (λ=1870 nm) is used for noncontact optical stimulation of the rat prostate cavernous nerves in vivo. Optical nerve stimulation, as measured by an intracavernous pressure (ICP) response in the penis, is achieved with the laser operating in either cw mode, or with a 5-ms pulse duration at 10, 20, 30, 40, 50, and 100 Hz. Successful optical stimulation is observed to be primarily dependent on a threshold nerve temperature (42 to 45 °C), rather than an incident fluence, as previously reported. cw optical nerve stimulation provides a significantly faster ICP response time using a lower power (and also less expensive) laser than pulsed stimulation. cw optical nerve stimulation may therefore represent an alternative mode of stimulation for intraoperative diagnostic applications where a rapid response is critical, such as identification of the cavernous nerves during prostate cancer surgery.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Burnett, Arthur L" sort="Burnett, Arthur L" uniqKey="Burnett A" first="Arthur L" last="Burnett">Arthur L. Burnett</name><name sortKey="Cilip, Christopher M" sort="Cilip, Christopher M" uniqKey="Cilip C" first="Christopher M" last="Cilip">Christopher M. Cilip</name><name sortKey="Fried, Nathaniel M" sort="Fried, Nathaniel M" uniqKey="Fried N" first="Nathaniel M" last="Fried">Nathaniel M. Fried</name><name sortKey="Lagoda, Gwen A" sort="Lagoda, Gwen A" uniqKey="Lagoda G" first="Gwen A" last="Lagoda">Gwen A. Lagoda</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Tozburun, Serhat" sort="Tozburun, Serhat" uniqKey="Tozburun S" first="Serhat" last="Tozburun">Serhat Tozburun</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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