Magnetically Aligned Phospholipid Bilayers with Positive Ordering: A New Model Membrane System
Identifieur interne : 002779 ( Main/Exploration ); précédent : 002778; suivant : 002780Magnetically Aligned Phospholipid Bilayers with Positive Ordering: A New Model Membrane System
Auteurs : R. Scott Prosser [États-Unis] ; Jimmy S. Hwang [États-Unis] ; Regitze R. Vold [États-Unis]Source :
- Biophysical Journal [ 0006-3495 ] ; 1998.
Descripteurs français
- KwdFr :
- Wicri :
English descriptors
- KwdEn :
- Acta, Alkyl chains, Anisotropy, Bicellar, Bicellar samples, Bicelle, Bicelles, Bilayer, Bilayered, Bilayers, Biochemistry, Biochim, Biophys, Biophysical, Bleaney, Chem, Chemical shifts, Conformational changes, Deuterium, Deuterium spectra, Deuteron, Dhpc, Dimyristoylphosphatidylcholine (chemistry), Discotic, Discotic nematic, Dmpc, Dmpc spectra, Headgroup, Ideal bicelle, Ion, Isotropic, Isotropic phase, Isotropic resonance, Lafleur, Lanthanide, Lanthanide ions, Lecithin, Lipid, Lipid Bilayers (chemistry), Magnetic alignment, Magnetic anisotropy, Magnetic field, Magnetic fields, Magnetic properties, Magnetic resonance, Magnetic susceptibility, Magnetics, Mcgarvey, Membrane, Membrane proteins, Mesogenic unit, Metals, Rare Earth, Methylene, Methylene groups, Micelles, Model membranes, Models, Biological, Models, Molecular, Molecular Conformation, Molecular axis, Negative order, Nematic, Nuclear Magnetic Resonance, Biomolecular, Order parameter, Order parameters, Orientational, Orientational order, Other words, Paramagnetic ions, Paramagnetic shifts, Parameter, Peptide, Phospholipid, Phospholipid Ethers (chemistry), Phospholipid bicelles, Phospholipid bilayers, Phospholipid membranes, Prestegard, Principal axis, Prosser, Quadrupolar, Quadrupolar splitting, Quadrupolar splittings, Realignment, Room temperature, Sample preparation, Sander, Schwonek, Seelig, Small amount, Smectic, Smectic phase, Spectrum, Splitting, Splittings, Structural studies, Susceptibility, Temperature dependence, Thermodynamics, Thulium, Trivalent, Trivalent ions, Trivalent lanthanide ions, Vold, Wide range.
- MESH :
- chemical , chemistry : Dimyristoylphosphatidylcholine, Lipid Bilayers, Phospholipid Ethers.
- Teeft :
- Acta, Alkyl chains, Anisotropy, Bicellar, Bicellar samples, Bicelle, Bicelles, Bilayer, Bilayered, Bilayers, Biochemistry, Biochim, Biophys, Biophysical, Bleaney, Chem, Chemical shifts, Conformational changes, Deuterium, Deuterium spectra, Deuteron, Dhpc, Discotic, Discotic nematic, Dmpc, Dmpc spectra, Headgroup, Ideal bicelle, Ion, Isotropic, Isotropic phase, Isotropic resonance, Lafleur, Lanthanide, Lanthanide ions, Lecithin, Lipid, Magnetic alignment, Magnetic anisotropy, Magnetic field, Magnetic fields, Magnetic properties, Magnetic resonance, Magnetic susceptibility, Magnetics, Mcgarvey, Membrane, Membrane proteins, Mesogenic unit, Metals, Rare Earth, Methylene, Methylene groups, Micelles, Model membranes, Models, Biological, Models, Molecular, Molecular Conformation, Molecular axis, Negative order, Nematic, Nuclear Magnetic Resonance, Biomolecular, Order parameter, Order parameters, Orientational, Orientational order, Other words, Paramagnetic ions, Paramagnetic shifts, Parameter, Peptide, Phospholipid, Phospholipid bicelles, Phospholipid bilayers, Phospholipid membranes, Prestegard, Principal axis, Prosser, Quadrupolar, Quadrupolar splitting, Quadrupolar splittings, Realignment, Room temperature, Sample preparation, Sander, Schwonek, Seelig, Small amount, Smectic, Smectic phase, Spectrum, Splitting, Splittings, Structural studies, Susceptibility, Temperature dependence, Thermodynamics, Thulium, Trivalent, Trivalent ions, Trivalent lanthanide ions, Vold, Wide range.
Abstract
Abstract: A stable smectic phospholipid bilayer phase aligned with the director parallel to the magnetic field can be generated by the addition of certain trivalent paramagnetic lanthanide ions to a bicellar solution of dimyristoylphosphatidylcholine (DMPC) and dihexanoylphosphatidylcholine (DHPC) in water. Suitable lanthanide ions are those with positive anisotropy of their magnetic susceptibility, namely Eu3+, Er3+, Tm3+, and Yb3+. For samples doped with Tm3+, this phase extends over a wide range of Tm3+ concentrations (6–40mM) and temperatures (35–90°C) and appears to undergo a transition from a fluid nematic discotic to a fluid, but highly ordered, smectic phase at a temperature that depends on the thulium concentration. As a membrane mimetic, these new, positively ordered phospholipid phases have high potential for structural studies using a variety of techniques such as magnetic resonance (EMR and NMR), small-angle x-ray and neutron diffraction, as well as optical and infrared spectroscopy.
Url:
- https://api.istex.fr/document/E23026121987B88C68DD0FA466BF719888E54859/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299583
DOI: 10.1016/S0006-3495(98)77949-4
Affiliations:
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Le document en format XML
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<author><name sortKey="Hwang, Jimmy S" sort="Hwang, Jimmy S" uniqKey="Hwang J" first="Jimmy S." last="Hwang">Jimmy S. Hwang</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acta</term>
<term>Alkyl chains</term>
<term>Anisotropy</term>
<term>Bicellar</term>
<term>Bicellar samples</term>
<term>Bicelle</term>
<term>Bicelles</term>
<term>Bilayer</term>
<term>Bilayered</term>
<term>Bilayers</term>
<term>Biochemistry</term>
<term>Biochim</term>
<term>Biophys</term>
<term>Biophysical</term>
<term>Bleaney</term>
<term>Chem</term>
<term>Chemical shifts</term>
<term>Conformational changes</term>
<term>Deuterium</term>
<term>Deuterium spectra</term>
<term>Deuteron</term>
<term>Dhpc</term>
<term>Dimyristoylphosphatidylcholine (chemistry)</term>
<term>Discotic</term>
<term>Discotic nematic</term>
<term>Dmpc</term>
<term>Dmpc spectra</term>
<term>Headgroup</term>
<term>Ideal bicelle</term>
<term>Ion</term>
<term>Isotropic</term>
<term>Isotropic phase</term>
<term>Isotropic resonance</term>
<term>Lafleur</term>
<term>Lanthanide</term>
<term>Lanthanide ions</term>
<term>Lecithin</term>
<term>Lipid</term>
<term>Lipid Bilayers (chemistry)</term>
<term>Magnetic alignment</term>
<term>Magnetic anisotropy</term>
<term>Magnetic field</term>
<term>Magnetic fields</term>
<term>Magnetic properties</term>
<term>Magnetic resonance</term>
<term>Magnetic susceptibility</term>
<term>Magnetics</term>
<term>Mcgarvey</term>
<term>Membrane</term>
<term>Membrane proteins</term>
<term>Mesogenic unit</term>
<term>Metals, Rare Earth</term>
<term>Methylene</term>
<term>Methylene groups</term>
<term>Micelles</term>
<term>Model membranes</term>
<term>Models, Biological</term>
<term>Models, Molecular</term>
<term>Molecular Conformation</term>
<term>Molecular axis</term>
<term>Negative order</term>
<term>Nematic</term>
<term>Nuclear Magnetic Resonance, Biomolecular</term>
<term>Order parameter</term>
<term>Order parameters</term>
<term>Orientational</term>
<term>Orientational order</term>
<term>Other words</term>
<term>Paramagnetic ions</term>
<term>Paramagnetic shifts</term>
<term>Parameter</term>
<term>Peptide</term>
<term>Phospholipid</term>
<term>Phospholipid Ethers (chemistry)</term>
<term>Phospholipid bicelles</term>
<term>Phospholipid bilayers</term>
<term>Phospholipid membranes</term>
<term>Prestegard</term>
<term>Principal axis</term>
<term>Prosser</term>
<term>Quadrupolar</term>
<term>Quadrupolar splitting</term>
<term>Quadrupolar splittings</term>
<term>Realignment</term>
<term>Room temperature</term>
<term>Sample preparation</term>
<term>Sander</term>
<term>Schwonek</term>
<term>Seelig</term>
<term>Small amount</term>
<term>Smectic</term>
<term>Smectic phase</term>
<term>Spectrum</term>
<term>Splitting</term>
<term>Splittings</term>
<term>Structural studies</term>
<term>Susceptibility</term>
<term>Temperature dependence</term>
<term>Thermodynamics</term>
<term>Thulium</term>
<term>Trivalent</term>
<term>Trivalent ions</term>
<term>Trivalent lanthanide ions</term>
<term>Vold</term>
<term>Wide range</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Conformation moléculaire</term>
<term>Dimyristoylphosphatidylcholine ()</term>
<term>Double couche lipidique ()</term>
<term>Magnétisme</term>
<term>Micelles</term>
<term>Modèles biologiques</term>
<term>Modèles moléculaires</term>
<term>Résonance magnétique nucléaire biomoléculaire</term>
<term>Terres rares</term>
<term>Thermodynamique</term>
<term>Éther-phospholipides ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Dimyristoylphosphatidylcholine</term>
<term>Lipid Bilayers</term>
<term>Phospholipid Ethers</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Acta</term>
<term>Alkyl chains</term>
<term>Anisotropy</term>
<term>Bicellar</term>
<term>Bicellar samples</term>
<term>Bicelle</term>
<term>Bicelles</term>
<term>Bilayer</term>
<term>Bilayered</term>
<term>Bilayers</term>
<term>Biochemistry</term>
<term>Biochim</term>
<term>Biophys</term>
<term>Biophysical</term>
<term>Bleaney</term>
<term>Chem</term>
<term>Chemical shifts</term>
<term>Conformational changes</term>
<term>Deuterium</term>
<term>Deuterium spectra</term>
<term>Deuteron</term>
<term>Dhpc</term>
<term>Discotic</term>
<term>Discotic nematic</term>
<term>Dmpc</term>
<term>Dmpc spectra</term>
<term>Headgroup</term>
<term>Ideal bicelle</term>
<term>Ion</term>
<term>Isotropic</term>
<term>Isotropic phase</term>
<term>Isotropic resonance</term>
<term>Lafleur</term>
<term>Lanthanide</term>
<term>Lanthanide ions</term>
<term>Lecithin</term>
<term>Lipid</term>
<term>Magnetic alignment</term>
<term>Magnetic anisotropy</term>
<term>Magnetic field</term>
<term>Magnetic fields</term>
<term>Magnetic properties</term>
<term>Magnetic resonance</term>
<term>Magnetic susceptibility</term>
<term>Magnetics</term>
<term>Mcgarvey</term>
<term>Membrane</term>
<term>Membrane proteins</term>
<term>Mesogenic unit</term>
<term>Metals, Rare Earth</term>
<term>Methylene</term>
<term>Methylene groups</term>
<term>Micelles</term>
<term>Model membranes</term>
<term>Models, Biological</term>
<term>Models, Molecular</term>
<term>Molecular Conformation</term>
<term>Molecular axis</term>
<term>Negative order</term>
<term>Nematic</term>
<term>Nuclear Magnetic Resonance, Biomolecular</term>
<term>Order parameter</term>
<term>Order parameters</term>
<term>Orientational</term>
<term>Orientational order</term>
<term>Other words</term>
<term>Paramagnetic ions</term>
<term>Paramagnetic shifts</term>
<term>Parameter</term>
<term>Peptide</term>
<term>Phospholipid</term>
<term>Phospholipid bicelles</term>
<term>Phospholipid bilayers</term>
<term>Phospholipid membranes</term>
<term>Prestegard</term>
<term>Principal axis</term>
<term>Prosser</term>
<term>Quadrupolar</term>
<term>Quadrupolar splitting</term>
<term>Quadrupolar splittings</term>
<term>Realignment</term>
<term>Room temperature</term>
<term>Sample preparation</term>
<term>Sander</term>
<term>Schwonek</term>
<term>Seelig</term>
<term>Small amount</term>
<term>Smectic</term>
<term>Smectic phase</term>
<term>Spectrum</term>
<term>Splitting</term>
<term>Splittings</term>
<term>Structural studies</term>
<term>Susceptibility</term>
<term>Temperature dependence</term>
<term>Thermodynamics</term>
<term>Thulium</term>
<term>Trivalent</term>
<term>Trivalent ions</term>
<term>Trivalent lanthanide ions</term>
<term>Vold</term>
<term>Wide range</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Biochimie</term>
<term>Conformation moléculaire</term>
<term>Dimyristoylphosphatidylcholine</term>
<term>Double couche lipidique</term>
<term>Magnétisme</term>
<term>Micelles</term>
<term>Modèles biologiques</term>
<term>Modèles moléculaires</term>
<term>Résonance magnétique nucléaire biomoléculaire</term>
<term>Terres rares</term>
<term>Thermodynamique</term>
<term>Éther-phospholipides</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Abstract: A stable smectic phospholipid bilayer phase aligned with the director parallel to the magnetic field can be generated by the addition of certain trivalent paramagnetic lanthanide ions to a bicellar solution of dimyristoylphosphatidylcholine (DMPC) and dihexanoylphosphatidylcholine (DHPC) in water. Suitable lanthanide ions are those with positive anisotropy of their magnetic susceptibility, namely Eu3+, Er3+, Tm3+, and Yb3+. For samples doped with Tm3+, this phase extends over a wide range of Tm3+ concentrations (6–40mM) and temperatures (35–90°C) and appears to undergo a transition from a fluid nematic discotic to a fluid, but highly ordered, smectic phase at a temperature that depends on the thulium concentration. As a membrane mimetic, these new, positively ordered phospholipid phases have high potential for structural studies using a variety of techniques such as magnetic resonance (EMR and NMR), small-angle x-ray and neutron diffraction, as well as optical and infrared spectroscopy.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<region><li>Californie</li>
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<tree><country name="États-Unis"><region name="Californie"><name sortKey="Prosser, R Scott" sort="Prosser, R Scott" uniqKey="Prosser R" first="R. Scott" last="Prosser">R. Scott Prosser</name>
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<name sortKey="Hwang, Jimmy S" sort="Hwang, Jimmy S" uniqKey="Hwang J" first="Jimmy S." last="Hwang">Jimmy S. Hwang</name>
<name sortKey="Vold, Regitze R" sort="Vold, Regitze R" uniqKey="Vold R" first="Regitze R." last="Vold">Regitze R. Vold</name>
<name sortKey="Vold, Regitze R" sort="Vold, Regitze R" uniqKey="Vold R" first="Regitze R." last="Vold">Regitze R. Vold</name>
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