Production, quality control, and bio-distribution studies of 159Gd-EDTMP as a palliative agent for bone pain
Identifieur interne : 000110 ( Main/Exploration ); précédent : 000109; suivant : 000111Production, quality control, and bio-distribution studies of 159Gd-EDTMP as a palliative agent for bone pain
Auteurs : Simindokht Shirvani Arani [Iran] ; Somaye Ghasemi [Iran] ; Ali Bahrami Samani [Iran] ; Mojtaba Shamsaei Zafarghandi [Iran]Source :
- Electronic Physician [ 2008-5842 ] ; 2015.
Abstract
Particle-emitting, bone-seeking radiopharmaceuticals have attracted the attention of the nuclear medicine community over the last three decades for the treatment of the pain of osteoblastic metastases. The objectives of this research were to produce quality-controlled 159Gd-EDTMP in order to provide a new therapeutic radiopharmaceutical for use in clinical applications.
The investigation was an experimental study in which 159Gd (T1/2=18.479 h, Eβ (max)=970.60 keV, Eγ=363.55 (11.4%) keV] was produced by thermal neutron bombardment of natural Gd2O3 at the Tehran Research Reactor (TRR) for a period of 7 d at a flux of 3–4×1013 neutrons/cm2.s. It was then quality-controlled and used to radio-label the in-house prepared ethylene diamine tetra acetic acid (EDTM).
Complexation parameters were optimized to achieve maximum yields (>99%). The radiochemical purity of 159Gd-EDTMP was checked by radio thin layer chromatography RTLC. It was found to retain its stability at room temperature (>95%). Bio-distribution studies of the complexes conducted in wild rats showed significant bone uptake with rapid clearance from blood.
The properties of the 159Gd-EDTMP that was produced suggest then use of a new, efficient, palliative therapeutic agent for metastatic bone pain instead of some other current radiopharmaceuticals.
Url:
DOI: 10.14661/2015.977-984
PubMed: 26052408
PubMed Central: 4455298
Affiliations:
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Student, Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, P. O. Box 15875-4413, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>M.Sc. Student, Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, P. O. Box 15875-4413, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Samani, Ali Bahrami" sort="Samani, Ali Bahrami" uniqKey="Samani A" first="Ali Bahrami" last="Samani">Ali Bahrami Samani</name><affiliation wicri:level="1"><nlm:aff id="af3-977-984">Assistant Professor, Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, P. O. Box: 14155-1339, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, P. O. 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Student, Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, P. O. Box 15875-4413, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>M.Sc. Student, Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, P. O. Box 15875-4413, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author><author><name sortKey="Samani, Ali Bahrami" sort="Samani, Ali Bahrami" uniqKey="Samani A" first="Ali Bahrami" last="Samani">Ali Bahrami Samani</name><affiliation wicri:level="1"><nlm:aff id="af3-977-984">Assistant Professor, Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, P. O. Box: 14155-1339, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor, Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, P. O. Box: 14155-1339</wicri:regionArea><wicri:noRegion>P. O. Box: 14155-1339</wicri:noRegion></affiliation></author><author><name sortKey="Zafarghandi, Mojtaba Shamsaei" sort="Zafarghandi, Mojtaba Shamsaei" uniqKey="Zafarghandi M" first="Mojtaba Shamsaei" last="Zafarghandi">Mojtaba Shamsaei Zafarghandi</name><affiliation wicri:level="1"><nlm:aff id="af4-977-984">Associate Professor Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, P. O. Box 15875-4413, Tehran, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Associate Professor Faculty of Nuclear Engineering and Physics, Amirkabir University of Technology, P. O. Box 15875-4413, Tehran</wicri:regionArea><wicri:noRegion>Tehran</wicri:noRegion></affiliation></author></analytic><series><title level="j">Electronic Physician</title><idno type="eISSN">2008-5842</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction:</title><p>Particle-emitting, bone-seeking radiopharmaceuticals have attracted the attention of the nuclear medicine community over the last three decades for the treatment of the pain of osteoblastic metastases. The objectives of this research were to produce quality-controlled <sup>159</sup>Gd-EDTMP in order to provide a new therapeutic radiopharmaceutical for use in clinical applications.</p></sec><sec><title>Methods:</title><p>The investigation was an experimental study in which <sup>159</sup>Gd (T1/2=18.479 h, Eβ (max)=970.60 keV, Eγ=363.55 (11.4%) keV] was produced by thermal neutron bombardment of natural Gd<sub>2</sub>O<sub>3</sub> at the Tehran Research Reactor (TRR) for a period of 7 d at a flux of 3–4×10<sup>13</sup> neutrons/cm<sup>2</sup>.s. It was then quality-controlled and used to radio-label the in-house prepared ethylene diamine tetra acetic acid (EDTM).</p></sec><sec><title>Results:</title><p>Complexation parameters were optimized to achieve maximum yields (>99%). The radiochemical purity of <sup>159</sup>Gd-EDTMP was checked by radio thin layer chromatography RTLC. It was found to retain its stability at room temperature (>95%). Bio-distribution studies of the complexes conducted in wild rats showed significant bone uptake with rapid clearance from blood.</p></sec><sec><title>Conclusion:</title><p>The properties of the <sup>159</sup>Gd-EDTMP that was produced suggest then use of a new, efficient, palliative therapeutic agent for metastatic bone pain instead of some other current radiopharmaceuticals.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Coleman, Re" uniqKey="Coleman R">RE Coleman</name></author><author><name sortKey="Rubens, Rd" uniqKey="Rubens R">RD Rubens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mundy, Gr" uniqKey="Mundy G">GR Mundy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aldo, N" uniqKey="Aldo N">N Aldo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmes, A" uniqKey="Holmes A">A 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Ramaldes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beyer, Gj" uniqKey="Beyer G">GJ Beyer</name></author><author><name sortKey="Offord, R" uniqKey="Offord R">R Offord</name></author><author><name sortKey="Kunzi, G" uniqKey="Kunzi G">G Künzi</name></author><author><name sortKey="Aleksandrova, Y" uniqKey="Aleksandrova Y">Y Aleksandrova</name></author><author><name sortKey="Ravn, U" uniqKey="Ravn U">U Ravn</name></author><author><name sortKey="Jahn, S" uniqKey="Jahn S">S Jahn</name></author><author><name sortKey="Barker, J" uniqKey="Barker J">J Barker</name></author><author><name sortKey="Tengblad, O" uniqKey="Tengblad O">O Tengblad</name></author><author><name sortKey="Lindroos, M" uniqKey="Lindroos M">M Lindroos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moedritzer, K" uniqKey="Moedritzer K">K Moedritzer</name></author><author><name sortKey="Irani, Rr" uniqKey="Irani R">RR Irani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shirvani Arani, S" uniqKey="Shirvani Arani S">S Shirvani-Arani</name></author><author><name sortKey="Bahrami Samani, A" uniqKey="Bahrami Samani A">A Bahrami-Samani</name></author><author><name sortKey="Meftahi, M" uniqKey="Meftahi M">M Meftahi</name></author><author><name sortKey="Jalilian, Ar" uniqKey="Jalilian A">AR Jalilian</name></author><author><name sortKey="Ghannadi Maragheh, M" uniqKey="Ghannadi Maragheh M">M Ghannadi-Maragheh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Arani, Simindokht Shirvani" sort="Arani, Simindokht Shirvani" uniqKey="Arani S" first="Simindokht Shirvani" last="Arani">Simindokht Shirvani Arani</name></noRegion><name sortKey="Ghasemi, Somaye" sort="Ghasemi, Somaye" uniqKey="Ghasemi S" first="Somaye" last="Ghasemi">Somaye Ghasemi</name><name sortKey="Samani, Ali Bahrami" sort="Samani, Ali Bahrami" uniqKey="Samani A" first="Ali Bahrami" last="Samani">Ali Bahrami Samani</name><name sortKey="Zafarghandi, Mojtaba Shamsaei" sort="Zafarghandi, Mojtaba Shamsaei" uniqKey="Zafarghandi M" first="Mojtaba Shamsaei" last="Zafarghandi">Mojtaba Shamsaei Zafarghandi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26052408" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ThuliumV1
| This area was generated with Dilib version V0.6.21. |  |