On-resonance low B1 pulses for imaging of the effects of PARACEST agents.
Identifieur interne : 001856 ( Main/Curation ); précédent : 001855; suivant : 001857On-resonance low B1 pulses for imaging of the effects of PARACEST agents.
Auteurs : Elena Vinogradov [États-Unis] ; Shanrong Zhang ; Angelo Lubag ; James A. Balschi ; A Dean Sherry ; Robert E. LenkinskiSource :
- Journal of magnetic resonance (San Diego, Calif. : 1997) [ 1090-7807 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Contrast Media, Lanthanoid Series Elements, Organometallic Compounds.
- methods : Magnetic Resonance Imaging.
Abstract
Application of the exchange-sensitive, low-power RF pulses positioned on the bulk water resonance for imaging of the effects of PARACEST agents is proposed as an alternative to the standard CW off-resonance irradiation. Specifically, we applied a low-power WALTZ-16 RF train, with the 90 degrees pulse unit replaced by a pulse of the fixed length (WALTZ-16*). Using this sequence, the bulk water signal was found to be sensitive to exchange lifetimes with PARACEST complex bound protons, the transverse relaxation time of bulk water, and longitudinal relaxation time of bound protons. In this report, the concept of using WALTZ-16* to "activate" a PARACEST effect is introduced and some of the salient features of this technique with respect to experimental conditions and performance levels are discussed. Computational predictions are verified and explored by comparison with experimental spectroscopic and imaging data. It is shown that WALTZ-16* can be used to detect PARACEST agents with an RF intensity as low as 200 Hz for concentrations as low as a few tens of microM for lanthanide chelates having appropriate water-exchange rates (Tm,Dy).
DOI: 10.1016/j.jmr.2005.05.016
PubMed: 15979362
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000659
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000659
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000659
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000125
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000125
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000125
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001911
Links to Exploration step
pubmed:15979362Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">On-resonance low B1 pulses for imaging of the effects of PARACEST agents.</title>
<author><name sortKey="Vinogradov, Elena" sort="Vinogradov, Elena" uniqKey="Vinogradov E" first="Elena" last="Vinogradov">Elena Vinogradov</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. evinogra@bidmc.harvard.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Shanrong" sort="Zhang, Shanrong" uniqKey="Zhang S" first="Shanrong" last="Zhang">Shanrong Zhang</name>
</author>
<author><name sortKey="Lubag, Angelo" sort="Lubag, Angelo" uniqKey="Lubag A" first="Angelo" last="Lubag">Angelo Lubag</name>
</author>
<author><name sortKey="Balschi, James A" sort="Balschi, James A" uniqKey="Balschi J" first="James A" last="Balschi">James A. Balschi</name>
</author>
<author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A Dean" last="Sherry">A Dean Sherry</name>
</author>
<author><name sortKey="Lenkinski, Robert E" sort="Lenkinski, Robert E" uniqKey="Lenkinski R" first="Robert E" last="Lenkinski">Robert E. Lenkinski</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="doi">10.1016/j.jmr.2005.05.016</idno>
<idno type="RBID">pubmed:15979362</idno>
<idno type="pmid">15979362</idno>
<idno type="wicri:Area/PubMed/Corpus">000659</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000659</idno>
<idno type="wicri:Area/PubMed/Curation">000659</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000659</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000659</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000659</idno>
<idno type="wicri:Area/Ncbi/Merge">000125</idno>
<idno type="wicri:Area/Ncbi/Curation">000125</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000125</idno>
<idno type="wicri:doubleKey">1090-7807:2005:Vinogradov E:on:resonance:low</idno>
<idno type="wicri:Area/Main/Merge">001911</idno>
<idno type="wicri:Area/Main/Curation">001856</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">On-resonance low B1 pulses for imaging of the effects of PARACEST agents.</title>
<author><name sortKey="Vinogradov, Elena" sort="Vinogradov, Elena" uniqKey="Vinogradov E" first="Elena" last="Vinogradov">Elena Vinogradov</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. evinogra@bidmc.harvard.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Shanrong" sort="Zhang, Shanrong" uniqKey="Zhang S" first="Shanrong" last="Zhang">Shanrong Zhang</name>
</author>
<author><name sortKey="Lubag, Angelo" sort="Lubag, Angelo" uniqKey="Lubag A" first="Angelo" last="Lubag">Angelo Lubag</name>
</author>
<author><name sortKey="Balschi, James A" sort="Balschi, James A" uniqKey="Balschi J" first="James A" last="Balschi">James A. Balschi</name>
</author>
<author><name sortKey="Sherry, A Dean" sort="Sherry, A Dean" uniqKey="Sherry A" first="A Dean" last="Sherry">A Dean Sherry</name>
</author>
<author><name sortKey="Lenkinski, Robert E" sort="Lenkinski, Robert E" uniqKey="Lenkinski R" first="Robert E" last="Lenkinski">Robert E. Lenkinski</name>
</author>
</analytic>
<series><title level="j">Journal of magnetic resonance (San Diego, Calif. : 1997)</title>
<idno type="ISSN">1090-7807</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Contrast Media (chemistry)</term>
<term>Lanthanoid Series Elements (chemistry)</term>
<term>Magnetic Resonance Imaging (methods)</term>
<term>Organometallic Compounds (chemistry)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Composés organométalliques ()</term>
<term>Imagerie par résonance magnétique ()</term>
<term>Lanthanides ()</term>
<term>Produits de contraste ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Contrast Media</term>
<term>Lanthanoid Series Elements</term>
<term>Organometallic Compounds</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Composés organométalliques</term>
<term>Imagerie par résonance magnétique</term>
<term>Lanthanides</term>
<term>Produits de contraste</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Application of the exchange-sensitive, low-power RF pulses positioned on the bulk water resonance for imaging of the effects of PARACEST agents is proposed as an alternative to the standard CW off-resonance irradiation. Specifically, we applied a low-power WALTZ-16 RF train, with the 90 degrees pulse unit replaced by a pulse of the fixed length (WALTZ-16*). Using this sequence, the bulk water signal was found to be sensitive to exchange lifetimes with PARACEST complex bound protons, the transverse relaxation time of bulk water, and longitudinal relaxation time of bound protons. In this report, the concept of using WALTZ-16* to "activate" a PARACEST effect is introduced and some of the salient features of this technique with respect to experimental conditions and performance levels are discussed. Computational predictions are verified and explored by comparison with experimental spectroscopic and imaging data. It is shown that WALTZ-16* can be used to detect PARACEST agents with an RF intensity as low as 200 Hz for concentrations as low as a few tens of microM for lanthanide chelates having appropriate water-exchange rates (Tm,Dy).</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001856 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001856 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Terre |area= ThuliumV1 |flux= Main |étape= Curation |type= RBID |clé= pubmed:15979362 |texte= On-resonance low B1 pulses for imaging of the effects of PARACEST agents. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:15979362" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ThuliumV1
This area was generated with Dilib version V0.6.21. |