Encoding the frequency dependence in MRI contrast media: the emerging class of CEST agents
Identifieur interne : 002F16 ( Istex/Curation ); précédent : 002F15; suivant : 002F17Encoding the frequency dependence in MRI contrast media: the emerging class of CEST agents
Auteurs : Enzo Terreno [Italie] ; Daniela Delli Castelli [Italie] ; Silvio Aime [Italie]Source :
- Contrast Media & Molecular Imaging [ 1555-4309 ] ; 2010-03.
Descripteurs français
- Wicri :
- topic : Droit d'auteur, Taux de change, Glucose, Polymère.
English descriptors
- KwdEn :
- Adduct, Aime, Amide, Amide protons, Angew, Angew chem, Balaban, Bulk water, Bulk water protons, Bulk water signal, Castelli, Cest, Cest agent, Cest agents, Cest contrast, Cest effect, Cest experiment, Cest peak, Cest probe, Cest properties, Chem, Chemical exchange saturation transfer, Chemical shift, Contrast agent, Contrast agents, Contrast media, Copyright, Delli, Delli castelli, Diamagnetic, Engl, Enhancement, Exchange rate, Glucose, Imaging, Intraliposomal, Intraliposomal water protons, Ioff, John wiley sons, Kcest, Lipocest, Lipocest agents, Liposome, Magn, Magn reson, Magnetization, Mobile protons, Molecular imaging, Nanoparticles, Osmotically, Pagel, Paracest, Paracest agent, Paracest agents, Paramagnetic liposomes, Polymer, Promising class, Proton, Rcest, Reagent, Reson, Saturation, Saturation scheme, Saturation transfer, Shift reagent, Spillover, Terreno, Visualization, Water protons, Woessner, Zhang, Zhou, Zijl.
- Teeft :
- Adduct, Aime, Amide, Amide protons, Angew, Angew chem, Balaban, Bulk water, Bulk water protons, Bulk water signal, Castelli, Cest, Cest agent, Cest agents, Cest contrast, Cest effect, Cest experiment, Cest peak, Cest probe, Cest properties, Chem, Chemical exchange saturation transfer, Chemical shift, Contrast agent, Contrast agents, Contrast media, Copyright, Delli, Delli castelli, Diamagnetic, Engl, Enhancement, Exchange rate, Glucose, Imaging, Intraliposomal, Intraliposomal water protons, Ioff, John wiley sons, Kcest, Lipocest, Lipocest agents, Liposome, Magn, Magn reson, Magnetization, Mobile protons, Molecular imaging, Nanoparticles, Osmotically, Pagel, Paracest, Paracest agent, Paracest agents, Paramagnetic liposomes, Polymer, Promising class, Proton, Rcest, Reagent, Reson, Saturation, Saturation scheme, Saturation transfer, Shift reagent, Spillover, Terreno, Visualization, Water protons, Woessner, Zhang, Zhou, Zijl.
Abstract
CEST agents represent a very promising class of MRI contrast media as they encode a frequency dependence that is not like the classical relaxation‐based agents. This peculiar property enables novel applications such as the detection of more than one agent in the same MR image as well as the set‐up of ratiometric methods for the quantitative assessment of physico‐chemical and biological parameters that characterize the micro‐environment in which they are distributed. This survey is aimed at providing the reader with the basic properties and the potential of these compounds. Fundamental aspects, such as the theoretical basis of the saturation transfer via chemical exchange, the generation of the CEST contrast, the classification and sensitivity of CEST agents, and some representative examples displaying their potential in the field of MR‐molecular imaging, are presented and discussed in detail. Copyright © 2010 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/cmmi.369
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water protons</term><term>Ioff</term><term>John wiley sons</term><term>Kcest</term><term>Lipocest</term><term>Lipocest agents</term><term>Liposome</term><term>Magn</term><term>Magn reson</term><term>Magnetization</term><term>Mobile protons</term><term>Molecular imaging</term><term>Nanoparticles</term><term>Osmotically</term><term>Pagel</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paramagnetic liposomes</term><term>Polymer</term><term>Promising class</term><term>Proton</term><term>Rcest</term><term>Reagent</term><term>Reson</term><term>Saturation</term><term>Saturation scheme</term><term>Saturation transfer</term><term>Shift reagent</term><term>Spillover</term><term>Terreno</term><term>Visualization</term><term>Water protons</term><term>Woessner</term><term>Zhang</term><term>Zhou</term><term>Zijl</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adduct</term><term>Aime</term><term>Amide</term><term>Amide protons</term><term>Angew</term><term>Angew chem</term><term>Balaban</term><term>Bulk water</term><term>Bulk water protons</term><term>Bulk water signal</term><term>Castelli</term><term>Cest</term><term>Cest agent</term><term>Cest agents</term><term>Cest contrast</term><term>Cest effect</term><term>Cest experiment</term><term>Cest peak</term><term>Cest probe</term><term>Cest properties</term><term>Chem</term><term>Chemical exchange saturation transfer</term><term>Chemical shift</term><term>Contrast agent</term><term>Contrast agents</term><term>Contrast media</term><term>Copyright</term><term>Delli</term><term>Delli castelli</term><term>Diamagnetic</term><term>Engl</term><term>Enhancement</term><term>Exchange rate</term><term>Glucose</term><term>Imaging</term><term>Intraliposomal</term><term>Intraliposomal water protons</term><term>Ioff</term><term>John wiley sons</term><term>Kcest</term><term>Lipocest</term><term>Lipocest agents</term><term>Liposome</term><term>Magn</term><term>Magn reson</term><term>Magnetization</term><term>Mobile protons</term><term>Molecular imaging</term><term>Nanoparticles</term><term>Osmotically</term><term>Pagel</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Paramagnetic liposomes</term><term>Polymer</term><term>Promising class</term><term>Proton</term><term>Rcest</term><term>Reagent</term><term>Reson</term><term>Saturation</term><term>Saturation scheme</term><term>Saturation transfer</term><term>Shift reagent</term><term>Spillover</term><term>Terreno</term><term>Visualization</term><term>Water protons</term><term>Woessner</term><term>Zhang</term><term>Zhou</term><term>Zijl</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Droit d'auteur</term><term>Taux de change</term><term>Glucose</term><term>Polymère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CEST agents represent a very promising class of MRI contrast media as they encode a frequency dependence that is not like the classical relaxation‐based agents. This peculiar property enables novel applications such as the detection of more than one agent in the same MR image as well as the set‐up of ratiometric methods for the quantitative assessment of physico‐chemical and biological parameters that characterize the micro‐environment in which they are distributed. This survey is aimed at providing the reader with the basic properties and the potential of these compounds. Fundamental aspects, such as the theoretical basis of the saturation transfer via chemical exchange, the generation of the CEST contrast, the classification and sensitivity of CEST agents, and some representative examples displaying their potential in the field of MR‐molecular imaging, are presented and discussed in detail. Copyright © 2010 John Wiley & Sons, Ltd.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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