Boosting 19F MRI—SNR efficient detection of paramagnetic contrast agents using ultrafast sequences
Identifieur interne : 001D84 ( Istex/Curation ); précédent : 001D83; suivant : 001D85Boosting 19F MRI—SNR efficient detection of paramagnetic contrast agents using ultrafast sequences
Auteurs : Florian Schmid [Allemagne] ; Carsten Höltke [Allemagne] ; David Parker [Royaume-Uni] ; Cornelius Faber [Allemagne]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 2013-04.
English descriptors
- KwdEn :
- Acquisition matrix, Acquisition time, Acquisition window, Best results, Chemical structures, Clinical radiology, Compound, Contrast agent, Contrast agents, Conventional sequence, Correlation coefficient, Data acquisition, Detection limit, Different concentrations, Echo images, Echo position, Echo time, Ernst angle, Excitation, Excitation pulse, Flip angle, Free induction decay, Gradient echo, Gradient trajectory, Grant number, Grant sponsor, Great importance, High signal, Higher ratio, Image distortions, Imaging, Lanthanide, Lanthanide ions, Little time, Magn reson, Magnetic resonance, Mass spectrometry, Molecular design, Molecular imaging, Molecular structure, Nonparamagnetic, Nonparamagnetic compounds, Nonparamagnetic references, Other hand, Paramagnetic compounds, Paramagnetic lanthanide complexes, Paramagnetic relaxation enhancement, Perfluorocarbon nanoparticles, Radial acquisition, Relaxation, Relaxation rates, Relaxation time, Relaxation times, Same molecule, Short relaxation times, Signal decay, Standard deviation, Ultrafast, Ultrafast sequences, Ultrashort echo time imaging, Whole sample, Wiley periodicals.
- Teeft :
- Acquisition matrix, Acquisition time, Acquisition window, Best results, Chemical structures, Clinical radiology, Compound, Contrast agent, Contrast agents, Conventional sequence, Correlation coefficient, Data acquisition, Detection limit, Different concentrations, Echo images, Echo position, Echo time, Ernst angle, Excitation, Excitation pulse, Flip angle, Free induction decay, Gradient echo, Gradient trajectory, Grant number, Grant sponsor, Great importance, High signal, Higher ratio, Image distortions, Imaging, Lanthanide, Lanthanide ions, Little time, Magn reson, Magnetic resonance, Mass spectrometry, Molecular design, Molecular imaging, Molecular structure, Nonparamagnetic, Nonparamagnetic compounds, Nonparamagnetic references, Other hand, Paramagnetic compounds, Paramagnetic lanthanide complexes, Paramagnetic relaxation enhancement, Perfluorocarbon nanoparticles, Radial acquisition, Relaxation, Relaxation rates, Relaxation time, Relaxation times, Same molecule, Short relaxation times, Signal decay, Standard deviation, Ultrafast, Ultrafast sequences, Ultrashort echo time imaging, Whole sample, Wiley periodicals.
Abstract
19F MRI offers high specificity but usually low sensitivity. Here, paramagnetic relaxation enhancement is assessed as a method to improve SNR efficiency in 19F MRI. Compounds with short relaxation times are used that combine fluorine and a paramagnetic ion within the same molecule. Different molecular designs provide T1 values in the range of 1.4–15 ms and T2*/T1 ratios from 0.3 to 1. Gradient echo, as well as ultrafast radial MR sequences, is optimized to achieve highest SNR efficiency. Compared to nonparamagnetic compounds, ultrafast sequences can yield a gain of up to a factor 27 in sensitivity, whereas the gain with gradient echo is only factor 11. Comparison among the paramagnetic compounds shows that T2*/T1 close to unity is a prerequisite for highest SNR efficiency gain and that best results are obtained for compounds with T1 in the range of 1–5 ms. Magn Reson Med 69:1056–1062, 2013. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/mrm.24341
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<front><div type="abstract">19F MRI offers high specificity but usually low sensitivity. Here, paramagnetic relaxation enhancement is assessed as a method to improve SNR efficiency in 19F MRI. Compounds with short relaxation times are used that combine fluorine and a paramagnetic ion within the same molecule. Different molecular designs provide T1 values in the range of 1.4–15 ms and T2*/T1 ratios from 0.3 to 1. Gradient echo, as well as ultrafast radial MR sequences, is optimized to achieve highest SNR efficiency. Compared to nonparamagnetic compounds, ultrafast sequences can yield a gain of up to a factor 27 in sensitivity, whereas the gain with gradient echo is only factor 11. Comparison among the paramagnetic compounds shows that T2*/T1 close to unity is a prerequisite for highest SNR efficiency gain and that best results are obtained for compounds with T1 in the range of 1–5 ms. Magn Reson Med 69:1056–1062, 2013. © 2012 Wiley Periodicals, Inc.</div>
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