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Boosting 19F MRI—SNR efficient detection of paramagnetic contrast agents using ultrafast sequences

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Boosting 19F MRI—SNR efficient detection of paramagnetic contrast agents using ultrafast sequences

Auteurs : Florian Schmid [Allemagne] ; Carsten Höltke [Allemagne] ; David Parker [Royaume-Uni] ; Cornelius Faber [Allemagne]

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RBID : ISTEX:862645D9FC73109CBD77C9F7C6DE6F30DB9ADC1C

English descriptors

Abstract

19F MRI offers high specificity but usually low sensitivity. Here, paramagnetic relaxation enhancement is assessed as a method to improve SNR efficiency in 19F MRI. Compounds with short relaxation times are used that combine fluorine and a paramagnetic ion within the same molecule. Different molecular designs provide T1 values in the range of 1.4–15 ms and T2*/T1 ratios from 0.3 to 1. Gradient echo, as well as ultrafast radial MR sequences, is optimized to achieve highest SNR efficiency. Compared to nonparamagnetic compounds, ultrafast sequences can yield a gain of up to a factor 27 in sensitivity, whereas the gain with gradient echo is only factor 11. Comparison among the paramagnetic compounds shows that T2*/T1 close to unity is a prerequisite for highest SNR efficiency gain and that best results are obtained for compounds with T1 in the range of 1–5 ms. Magn Reson Med 69:1056–1062, 2013. © 2012 Wiley Periodicals, Inc.

Url:
DOI: 10.1002/mrm.24341

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ISTEX:862645D9FC73109CBD77C9F7C6DE6F30DB9ADC1C

Le document en format XML

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<div type="abstract">19F MRI offers high specificity but usually low sensitivity. Here, paramagnetic relaxation enhancement is assessed as a method to improve SNR efficiency in 19F MRI. Compounds with short relaxation times are used that combine fluorine and a paramagnetic ion within the same molecule. Different molecular designs provide T1 values in the range of 1.4–15 ms and T2*/T1 ratios from 0.3 to 1. Gradient echo, as well as ultrafast radial MR sequences, is optimized to achieve highest SNR efficiency. Compared to nonparamagnetic compounds, ultrafast sequences can yield a gain of up to a factor 27 in sensitivity, whereas the gain with gradient echo is only factor 11. Comparison among the paramagnetic compounds shows that T2*/T1 close to unity is a prerequisite for highest SNR efficiency gain and that best results are obtained for compounds with T1 in the range of 1–5 ms. Magn Reson Med 69:1056–1062, 2013. © 2012 Wiley Periodicals, Inc.</div>
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