Simultaneous in vivo pH and temperature mapping using a PARACEST‐MRI contrast agent
Identifieur interne : 000124 ( Istex/Curation ); précédent : 000123; suivant : 000125Simultaneous in vivo pH and temperature mapping using a PARACEST‐MRI contrast agent
Auteurs : Nevin Mcvicar [Canada] ; Alex X. Li [Canada] ; Mojmír Such [Canada] ; Robert H. E. Hudson [Canada] ; Ravi S. Menon [Canada] ; Robert Bartha [Canada]Source :
- Magnetic Resonance in Medicine [ 0740-3194 ] ; 2013-10.
Descripteurs français
- Wicri :
- topic : Taux de change.
English descriptors
- KwdEn :
- Agent concentration, Aime, Amide, Amide proton chemical shift, Amide protons, Angew chem, Aqueous solution, Aqueous solutions, Asymmetry curve, Bloch equations, Bulk water, Bulk water protons, Cest, Cest effect, Cest peak, Cest spectra, Cest spectrum, Chem, Chemical exchange saturation transfer, Chemical shift, Continuous wave presaturation pulse, Contrast agent, Contrast agents, Data matrix, Delli castelli, Endogenous, Exchange rate, Exponential function, Extracellular, Full width, Imaging, Linewidth, Linewidth measurements, Linewidths, Magn, Magn reson, Magn reson imaging, Magnetization, Metabolic demand, Mtrasym, Mtrasym curve, Mtrasym curves, Mtrasym linewidth, Noise ratio, Novel method, Paracest, Paracest agent, Paracest agents, Phantom, Pixel, Postinjection, Preinjection, Presaturation, Presaturation pulse, Proton, Ratiometric methods, Relaxation rates, Relaxation time, Reson, Resonance frequency, Saturation, Saturation power, Saturation pulse, Standard deviation, Temperature mapping, Temperature maps, Temperature measurement, Terreno, Vivo, Vivo extracellular, Western ontario, Zijl.
- Teeft :
- Agent concentration, Aime, Amide, Amide proton chemical shift, Amide protons, Angew chem, Aqueous solution, Aqueous solutions, Asymmetry curve, Bloch equations, Bulk water, Bulk water protons, Cest, Cest effect, Cest peak, Cest spectra, Cest spectrum, Chem, Chemical exchange saturation transfer, Chemical shift, Continuous wave presaturation pulse, Contrast agent, Contrast agents, Data matrix, Delli castelli, Endogenous, Exchange rate, Exponential function, Extracellular, Full width, Imaging, Linewidth, Linewidth measurements, Linewidths, Magn, Magn reson, Magn reson imaging, Magnetization, Metabolic demand, Mtrasym, Mtrasym curve, Mtrasym curves, Mtrasym linewidth, Noise ratio, Novel method, Paracest, Paracest agent, Paracest agents, Phantom, Pixel, Postinjection, Preinjection, Presaturation, Presaturation pulse, Proton, Ratiometric methods, Relaxation rates, Relaxation time, Reson, Resonance frequency, Saturation, Saturation power, Saturation pulse, Standard deviation, Temperature mapping, Temperature maps, Temperature measurement, Terreno, Vivo, Vivo extracellular, Western ontario, Zijl.
Abstract
Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and following stroke. Therefore, in vivo tissue temperature and pH may become valuable biomarkers for disease detection and the monitoring of disease progression or treatment response in conditions with altered metabolic demand. In this study, pH is measured using the amide protons of a thulium (Tm3+) complex with a DOTAM‐Glycine‐Lysine (ligand: Tm3+‐DOTAM‐Gly‐Lys). The pH was uniquely determined from the linewidth of the asymmetry curve of the chemical exchange saturation transfer spectrum, independent of contrast agent concentration, or temperature for a given saturation pulse. pH maps with an inter‐pixel standard deviation of less than 0.1 pH units were obtained in 10 mM Tm3+‐DOTAM‐Gly‐Lys solutions with pH ranging from 6.0 to 8.0 pH units at 37°C. Temperature maps were simultaneously obtained using the chemical shift of the chemical exchange saturation transfer peak. Temperature and pH maps are demonstrated in the mouse leg (N = 3), where the mean and standard deviation for pH was 7.2 ± 0.2 pH unit and temperature was 37.4 ± 0.5°C. Magn Reson Med, 70:1016–1025, 2013. © 2012 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/mrm.24539
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E." last="Hudson">Robert H. E. Hudson</name><affiliation wicri:level="1"><mods:affiliation>Department of Chemistry, University of Western Ontario, Ontario, London, Canada</mods:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Chemistry, University of Western Ontario, Ontario, London</wicri:regionArea></affiliation></author><author><name sortKey="Menon, Ravi S" sort="Menon, Ravi S" uniqKey="Menon R" first="Ravi S." last="Menon">Ravi S. 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level="j" type="main">Magnetic Resonance in Medicine</title><title level="j" type="alt">MAGNETIC RESONANCE IN MEDICINE</title><idno type="ISSN">0740-3194</idno><idno type="eISSN">1522-2594</idno><imprint><biblScope unit="vol">70</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="1016">1016</biblScope><biblScope unit="page" to="1025">1025</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2013-10">2013-10</date></imprint><idno type="ISSN">0740-3194</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0740-3194</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agent concentration</term><term>Aime</term><term>Amide</term><term>Amide proton chemical shift</term><term>Amide protons</term><term>Angew chem</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Asymmetry curve</term><term>Bloch equations</term><term>Bulk water</term><term>Bulk water protons</term><term>Cest</term><term>Cest effect</term><term>Cest peak</term><term>Cest spectra</term><term>Cest spectrum</term><term>Chem</term><term>Chemical exchange saturation transfer</term><term>Chemical shift</term><term>Continuous wave presaturation pulse</term><term>Contrast agent</term><term>Contrast agents</term><term>Data matrix</term><term>Delli castelli</term><term>Endogenous</term><term>Exchange rate</term><term>Exponential function</term><term>Extracellular</term><term>Full width</term><term>Imaging</term><term>Linewidth</term><term>Linewidth measurements</term><term>Linewidths</term><term>Magn</term><term>Magn reson</term><term>Magn reson imaging</term><term>Magnetization</term><term>Metabolic demand</term><term>Mtrasym</term><term>Mtrasym curve</term><term>Mtrasym curves</term><term>Mtrasym linewidth</term><term>Noise ratio</term><term>Novel method</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Phantom</term><term>Pixel</term><term>Postinjection</term><term>Preinjection</term><term>Presaturation</term><term>Presaturation pulse</term><term>Proton</term><term>Ratiometric methods</term><term>Relaxation rates</term><term>Relaxation time</term><term>Reson</term><term>Resonance frequency</term><term>Saturation</term><term>Saturation power</term><term>Saturation pulse</term><term>Standard deviation</term><term>Temperature mapping</term><term>Temperature maps</term><term>Temperature measurement</term><term>Terreno</term><term>Vivo</term><term>Vivo extracellular</term><term>Western ontario</term><term>Zijl</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Agent concentration</term><term>Aime</term><term>Amide</term><term>Amide proton chemical shift</term><term>Amide protons</term><term>Angew chem</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Asymmetry curve</term><term>Bloch equations</term><term>Bulk water</term><term>Bulk water protons</term><term>Cest</term><term>Cest effect</term><term>Cest peak</term><term>Cest spectra</term><term>Cest spectrum</term><term>Chem</term><term>Chemical exchange saturation transfer</term><term>Chemical shift</term><term>Continuous wave presaturation pulse</term><term>Contrast agent</term><term>Contrast agents</term><term>Data matrix</term><term>Delli castelli</term><term>Endogenous</term><term>Exchange rate</term><term>Exponential function</term><term>Extracellular</term><term>Full width</term><term>Imaging</term><term>Linewidth</term><term>Linewidth measurements</term><term>Linewidths</term><term>Magn</term><term>Magn reson</term><term>Magn reson imaging</term><term>Magnetization</term><term>Metabolic demand</term><term>Mtrasym</term><term>Mtrasym curve</term><term>Mtrasym curves</term><term>Mtrasym linewidth</term><term>Noise ratio</term><term>Novel method</term><term>Paracest</term><term>Paracest agent</term><term>Paracest agents</term><term>Phantom</term><term>Pixel</term><term>Postinjection</term><term>Preinjection</term><term>Presaturation</term><term>Presaturation pulse</term><term>Proton</term><term>Ratiometric methods</term><term>Relaxation rates</term><term>Relaxation time</term><term>Reson</term><term>Resonance frequency</term><term>Saturation</term><term>Saturation power</term><term>Saturation pulse</term><term>Standard deviation</term><term>Temperature mapping</term><term>Temperature maps</term><term>Temperature measurement</term><term>Terreno</term><term>Vivo</term><term>Vivo extracellular</term><term>Western ontario</term><term>Zijl</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Taux de change</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Altered tissue temperature and/or pH is a common feature in pathological conditions, where metabolic demand exceeds oxygen supply such as in tumors and following stroke. Therefore, in vivo tissue temperature and pH may become valuable biomarkers for disease detection and the monitoring of disease progression or treatment response in conditions with altered metabolic demand. In this study, pH is measured using the amide protons of a thulium (Tm3+) complex with a DOTAM‐Glycine‐Lysine (ligand: Tm3+‐DOTAM‐Gly‐Lys). The pH was uniquely determined from the linewidth of the asymmetry curve of the chemical exchange saturation transfer spectrum, independent of contrast agent concentration, or temperature for a given saturation pulse. pH maps with an inter‐pixel standard deviation of less than 0.1 pH units were obtained in 10 mM Tm3+‐DOTAM‐Gly‐Lys solutions with pH ranging from 6.0 to 8.0 pH units at 37°C. Temperature maps were simultaneously obtained using the chemical shift of the chemical exchange saturation transfer peak. Temperature and pH maps are demonstrated in the mouse leg (N = 3), where the mean and standard deviation for pH was 7.2 ± 0.2 pH unit and temperature was 37.4 ± 0.5°C. Magn Reson Med, 70:1016–1025, 2013. © 2012 Wiley Periodicals, Inc.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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