Pharmacology and toxicology of lutetium chloride
Identifieur interne : 002446 ( Istex/Corpus ); précédent : 002445; suivant : 002447Pharmacology and toxicology of lutetium chloride
Auteurs : Thomas J. Haley ; N. Komesu ; M. Efros ; L. Koste ; H. C. UphamSource :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1964-10.
English descriptors
- KwdEn :
- Abraded skin, Acetylcholine, Chloride, Complete healing, Dosage range, Epinephrine, Glucuronide, Guinea pigs, Haley, Histopathological, Histopathological examination, Intradermal, Intradermal injection, Irritation index, Lutetium, Lutetium chloride, Maximum irritation index, Nodule, Nodule formation, Nuclear medicine, Oxazepam, Rabbit ileum, Rare earths, Skin irritation, Slope value, Small intestine, Standard errors, Unchanged drug, Urine.
- Teeft :
- Abraded skin, Acetylcholine, Chloride, Complete healing, Dosage range, Epinephrine, Glucuronide, Guinea pigs, Haley, Histopathological, Histopathological examination, Intradermal, Intradermal injection, Irritation index, Lutetium, Lutetium chloride, Maximum irritation index, Nodule, Nodule formation, Nuclear medicine, Oxazepam, Rabbit ileum, Rare earths, Skin irritation, Slope value, Small intestine, Standard errors, Unchanged drug, Urine.
Abstract
The pharmacological and toxicological properties of lutetium chloride have been investigated. The intraperitoneal and oral LD50′s were 315 and 7.1 mg./Kg., respectively. Studies of chronic toxicity showed no effect on growth and the hemogram or any internal organ changes at autopsy. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Nodules were formed at the site of intradermal injection. Pharmacological studies showed the chemical to be a depressant on all systems studied. Death resulted from cardiovascular collapse coupled with respiratory paralysis. Such effects could not be counteracted by atropinization or epinephrine injection.
Url:
DOI: 10.1002/jps.2600531011
Links to Exploration step
ISTEX:A361DC59B05E569B8F49670126B369FB3A2A6169Le document en format XML
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Studies of chronic toxicity showed no effect on growth and the hemogram or any internal organ changes at autopsy. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Nodules were formed at the site of intradermal injection. Pharmacological studies showed the chemical to be a depressant on all systems studied. Death resulted from cardiovascular collapse coupled with respiratory paralysis. 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type="first">Thomas J.</forename><surname>Haley</surname></persName><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles<address><country key="US"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">N.</forename><surname>Komesu</surname></persName><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles<address><country key="US"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">M.</forename><surname>Efros</surname></persName><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles<address><country key="US"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">L.</forename><surname>Koste</surname></persName><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles<address><country key="US"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">H. C.</forename><surname>Upham</surname></persName><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles<address><country key="US"></country></address></affiliation></author><idno type="istex">A361DC59B05E569B8F49670126B369FB3A2A6169</idno><idno type="ark">ark:/67375/WNG-K03HRD84-F</idno><idno type="DOI">10.1002/jps.2600531011</idno><idno type="unit">JPS2600531011</idno><idno type="toTypesetVersion">file:JPS.JPS2600531011.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Pharmaceutical Sciences</title><title level="j" type="alt">JOURNAL OF PHARMACEUTICAL SCIENCES</title><idno type="pISSN">0022-3549</idno><idno type="eISSN">1520-6017</idno><idno type="book-DOI">10.1002/(ISSN)1520-6017</idno><idno type="book-part-DOI">10.1002/jps.v53:10</idno><idno type="product">JPS</idno><imprint><biblScope unit="vol">53</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1186">1186</biblScope><biblScope unit="page" to="1188">1188</biblScope><biblScope unit="page-count">3</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Washington</pubPlace><date type="published" when="1964-10"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>The pharmacological and toxicological properties of lutetium chloride have been investigated. 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C.</givenNames><familyName>Upham</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles</unparsedAffiliation></affiliation></affiliationGroup><fundingInfo><fundingAgency>U. S. Atomic Energy Commission, Washington, D. C.</fundingAgency><fundingNumber>AT(04‐1)‐GEN‐12</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The pharmacological and toxicological properties of lutetium chloride have been investigated. The intraperitoneal and oral LD<sub>50</sub>′s were 315 and 7.1 mg./Kg., respectively. Studies of chronic toxicity showed no effect on growth and the hemogram or any internal organ changes at autopsy. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Nodules were formed at the site of intradermal injection. Pharmacological studies showed the chemical to be a depressant on all systems studied. Death resulted from cardiovascular collapse coupled with respiratory paralysis. Such effects could not be counteracted by atropinization or epinephrine injection.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Presented to the Scientific Section, A.Ph.A., New York City meeting, August 1964.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Pharmacology and toxicology of lutetium chloride</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pharmacology and Toxicology of Lutetium Chloride</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Pharmacology and toxicology of lutetium chloride</title></titleInfo><name type="personal"><namePart type="given">Thomas J.</namePart><namePart type="family">Haley</namePart><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Komesu</namePart><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Efros</namePart><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Koste</namePart><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. C.</namePart><namePart type="family">Upham</namePart><affiliation>Laboratory of Nuclear Medicine and Radiation Biology, Department of Biophysics and Nuclear Medicine, School of Medicine, University of California at Los Angeles, Los Angeles</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Washington</placeTerm></place><dateIssued encoding="w3cdtf">1964-10</dateIssued><dateCaptured encoding="w3cdtf">1964-03-13</dateCaptured><dateValid encoding="w3cdtf">1964-04-27</dateValid><copyrightDate encoding="w3cdtf">1964</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">1</extent><extent unit="references">23</extent></physicalDescription><abstract lang="en">The pharmacological and toxicological properties of lutetium chloride have been investigated. The intraperitoneal and oral LD50′s were 315 and 7.1 mg./Kg., respectively. Studies of chronic toxicity showed no effect on growth and the hemogram or any internal organ changes at autopsy. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Nodules were formed at the site of intradermal injection. Pharmacological studies showed the chemical to be a depressant on all systems studied. Death resulted from cardiovascular collapse coupled with respiratory paralysis. Such effects could not be counteracted by atropinization or epinephrine injection.</abstract><note type="content">*Presented to the Scientific Section, A.Ph.A., New York City meeting, August 1964.</note><note type="funding">U. S. Atomic Energy Commission, Washington, D. C. - No. AT(04‐1)‐GEN‐12; </note><relatedItem type="host"><titleInfo><title>Journal of Pharmaceutical Sciences</title></titleInfo><titleInfo type="abbreviated"><title>J. Pharm. Sci.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0022-3549</identifier><identifier type="eISSN">1520-6017</identifier><identifier type="DOI">10.1002/(ISSN)1520-6017</identifier><identifier type="PublisherID">JPS</identifier><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>53</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1186</start><end>1188</end><total>3</total></extent></part></relatedItem><identifier type="istex">A361DC59B05E569B8F49670126B369FB3A2A6169</identifier><identifier type="ark">ark:/67375/WNG-K03HRD84-F</identifier><identifier type="DOI">10.1002/jps.2600531011</identifier><identifier type="ArticleID">JPS2600531011</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1964 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/A361DC59B05E569B8F49670126B369FB3A2A6169/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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