Pharmacology and toxicology of lutetium chloride
Identifieur interne : 002446 ( Istex/Corpus ); précédent : 002445; suivant : 002447Pharmacology and toxicology of lutetium chloride
Auteurs : Thomas J. Haley ; N. Komesu ; M. Efros ; L. Koste ; H. C. UphamSource :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1964-10.
English descriptors
- KwdEn :
- Abraded skin, Acetylcholine, Chloride, Complete healing, Dosage range, Epinephrine, Glucuronide, Guinea pigs, Haley, Histopathological, Histopathological examination, Intradermal, Intradermal injection, Irritation index, Lutetium, Lutetium chloride, Maximum irritation index, Nodule, Nodule formation, Nuclear medicine, Oxazepam, Rabbit ileum, Rare earths, Skin irritation, Slope value, Small intestine, Standard errors, Unchanged drug, Urine.
- Teeft :
- Abraded skin, Acetylcholine, Chloride, Complete healing, Dosage range, Epinephrine, Glucuronide, Guinea pigs, Haley, Histopathological, Histopathological examination, Intradermal, Intradermal injection, Irritation index, Lutetium, Lutetium chloride, Maximum irritation index, Nodule, Nodule formation, Nuclear medicine, Oxazepam, Rabbit ileum, Rare earths, Skin irritation, Slope value, Small intestine, Standard errors, Unchanged drug, Urine.
Abstract
The pharmacological and toxicological properties of lutetium chloride have been investigated. The intraperitoneal and oral LD50′s were 315 and 7.1 mg./Kg., respectively. Studies of chronic toxicity showed no effect on growth and the hemogram or any internal organ changes at autopsy. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Nodules were formed at the site of intradermal injection. Pharmacological studies showed the chemical to be a depressant on all systems studied. Death resulted from cardiovascular collapse coupled with respiratory paralysis. Such effects could not be counteracted by atropinization or epinephrine injection.
Url:
DOI: 10.1002/jps.2600531011
Links to Exploration step
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<p>The pharmacological and toxicological properties of lutetium chloride have been investigated. The intraperitoneal and oral LD<sub>50</sub>
′s were 315 and 7.1 mg./Kg., respectively. Studies of chronic toxicity showed no effect on growth and the hemogram or any internal organ changes at autopsy. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Nodules were formed at the site of intradermal injection. Pharmacological studies showed the chemical to be a depressant on all systems studied. Death resulted from cardiovascular collapse coupled with respiratory paralysis. Such effects could not be counteracted by atropinization or epinephrine injection.</p>
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<abstract lang="en">The pharmacological and toxicological properties of lutetium chloride have been investigated. The intraperitoneal and oral LD50′s were 315 and 7.1 mg./Kg., respectively. Studies of chronic toxicity showed no effect on growth and the hemogram or any internal organ changes at autopsy. Transient ocular irritation was observed, and the chemical produced extensive scar formation when applied to abraded skin. Nodules were formed at the site of intradermal injection. Pharmacological studies showed the chemical to be a depressant on all systems studied. Death resulted from cardiovascular collapse coupled with respiratory paralysis. Such effects could not be counteracted by atropinization or epinephrine injection.</abstract>
<note type="content">*Presented to the Scientific Section, A.Ph.A., New York City meeting, August 1964.</note>
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