Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent
Identifieur interne : 000940 ( Istex/Corpus ); précédent : 000939; suivant : 000941Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent
Auteurs : Daniel Coman ; Hubert K. Trubel ; Robert E. Rycyna ; Fahmeed HyderSource :
- NMR in Biomedicine [ 0952-3480 ] ; 2009-02.
English descriptors
- KwdEn :
- Acquisition time, Appl physiol, Biomed, Biosensor imaging, Birds method, Blood volume, Body temperature, Brain temperature, Bruker, Bruker horizontalbore spectrometer, Bruker spectrometer, Chemical exchange saturation transfer, Chemical shift, Chemical shift determination, Chemical shift imaging, Chemical shift measurement, Chemical shifts, Circumventricular organs, Coman, Copyright, Different ambient temperature conditions, Different conditions, Dummy scans, Error analysis, Excellent agreement, Exogenous, Exogenous agent, Extracellular, Extracellular space, Fenestrated vessels, Good agreement, Hyder, Imaging, Infusion, Inner compartments, Inorganic phosphate, Intracellular, Intracellular proteins, John wiley sons, Lanthanide, Local region, Magn, Magn reson, Magn reson imaging, Magnetic resonance spectroscopy, National institutes, Noise amplitude, Other methods, Other resonances, Oxford optronix, Paracest agents, Paramagnetic lanthanide complexes, Phantom, Phantom experiments, Physiol, Physiological parameters, Previous results, Proton, Proton chemical shifts, Proton resonances, Random noise, Recent study, Redundant deviation, Relaxation times, Renal ligation, Reson, Results show, Sagittal sinus, Shift reagent, Similar conditions, Simultaneous temperature, Smallest error, Spectral overlap, Standard deviation, Standard deviations, Surface coil, Temperature dependence, Temperature determination, Temperature dynamics, Temperature mapping, Temperature measurements, Temperature sensitivity, Temperature values, Thermocouple wire, Thermocouple wires, Thulium, Thulium sensor, Tmdotp5, Total acquisition time, Trubel, Vital parameters, Vivo, Vivo conditions, Vivo ratio, Vivo results, Vivo studies, Vivo temperature, Vivo tmdotp5, Voxel, Voxel size, Water proton resonance frequency, Water protons, Water resonance, Water signal, Water suppression, Yale university.
- Teeft :
- Acquisition time, Appl physiol, Biomed, Biosensor imaging, Birds method, Blood volume, Body temperature, Brain temperature, Bruker, Bruker horizontalbore spectrometer, Bruker spectrometer, Chemical exchange saturation transfer, Chemical shift, Chemical shift determination, Chemical shift imaging, Chemical shift measurement, Chemical shifts, Circumventricular organs, Coman, Copyright, Different ambient temperature conditions, Different conditions, Dummy scans, Error analysis, Excellent agreement, Exogenous, Exogenous agent, Extracellular, Extracellular space, Fenestrated vessels, Good agreement, Hyder, Imaging, Infusion, Inner compartments, Inorganic phosphate, Intracellular, Intracellular proteins, John wiley sons, Lanthanide, Local region, Magn, Magn reson, Magn reson imaging, Magnetic resonance spectroscopy, National institutes, Noise amplitude, Other methods, Other resonances, Oxford optronix, Paracest agents, Paramagnetic lanthanide complexes, Phantom, Phantom experiments, Physiol, Physiological parameters, Previous results, Proton, Proton chemical shifts, Proton resonances, Random noise, Recent study, Redundant deviation, Relaxation times, Renal ligation, Reson, Results show, Sagittal sinus, Shift reagent, Similar conditions, Simultaneous temperature, Smallest error, Spectral overlap, Standard deviation, Standard deviations, Surface coil, Temperature dependence, Temperature determination, Temperature dynamics, Temperature mapping, Temperature measurements, Temperature sensitivity, Temperature values, Thermocouple wire, Thermocouple wires, Thulium, Thulium sensor, Tmdotp5, Total acquisition time, Trubel, Vital parameters, Vivo, Vivo conditions, Vivo ratio, Vivo results, Vivo studies, Vivo temperature, Vivo tmdotp5, Voxel, Voxel size, Water proton resonance frequency, Water protons, Water resonance, Water signal, Water suppression, Yale university.
Abstract
Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly because of lack of precise and non‐invasive methods. At 11.7 T, we demonstrate that a thulium‐based macrocyclic complex infused through the bloodstream can be used to obtain temperature and pH maps of rat brain in vivo by 1H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi‐parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium‐based method compared well with other methods for temperature (1H MRS of N‐acetylaspartate and water; copper–constantan thermocouple wire) and pH (31P MRS of inorganic phosphate and phosphocreatine) assessment, as established by in vitro and in vivo studies. In vitro studies in phantoms with two compartments of different pH value observed under different ambient temperature conditions generated precise temperature and pH distribution maps. In vivo studies in α‐chloralose‐anesthetized and renal‐ligated rats revealed temperature (33–34°C) and pH (7.3–7.4) distributions in the cerebral cortex that are in agreement with observations by other methods. These results show that the thulium sensor can be used to measure temperature and pH distributions in rat brain in vivo simultaneously and accurately with using biosensor imaging of redundant. Copyright © 2008 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/nbm.1312
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly because of lack of precise and non‐invasive methods. At 11.7 T, we demonstrate that a thulium‐based macrocyclic complex infused through the bloodstream can be used to obtain temperature and pH maps of rat brain in vivo by 1H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi‐parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium‐based method compared well with other methods for temperature (1H MRS of N‐acetylaspartate and water; copper–constantan thermocouple wire) and pH (31P MRS of inorganic phosphate and phosphocreatine) assessment, as established by in vitro and in vivo studies. In vitro studies in phantoms with two compartments of different pH value observed under different ambient temperature conditions generated precise temperature and pH distribution maps. In vivo studies in α‐chloralose‐anesthetized and renal‐ligated rats revealed temperature (33–34°C) and pH (7.3–7.4) distributions in the cerebral cortex that are in agreement with observations by other methods. These results show that the thulium sensor can be used to measure temperature and pH distributions in rat brain in vivo simultaneously and accurately with using biosensor imaging of redundant. Copyright © 2008 John Wiley & Sons, Ltd.</div>
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<p>Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly because of lack of precise and non‐invasive methods. At 11.7 T, we demonstrate that a thulium‐based macrocyclic complex infused through the bloodstream can be used to obtain temperature and pH maps of rat brain <hi rend="italic">in vivo</hi>
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<p>Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly because of lack of precise and non‐invasive methods. At 11.7 T, we demonstrate that a thulium‐based macrocyclic complex infused through the bloodstream can be used to obtain temperature and pH maps of rat brain <i>in vivo</i>
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H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi‐parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium‐based method compared well with other methods for temperature (<sup>1</sup>
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<noteGroup><note xml:id="fn1"><p>Bayer HealthCare AG, Wuppertal, Germany.</p>
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<mods version="3.6"><titleInfo lang="en"><title>Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent</title>
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<titleInfo type="abbreviated" lang="en"><title>BRAIN TEMPERATURE AND PH ASSESSED BY NMR</title>
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<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Brain temperature and pH measured by 1H chemical shift imaging of a thulium agent</title>
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<name type="personal"><namePart type="given">Daniel</namePart>
<namePart type="family">Coman</namePart>
<affiliation>Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</affiliation>
<affiliation>Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</affiliation>
<affiliation>Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</affiliation>
<affiliation>E-mail: daniel.coman@yale.edu</affiliation>
<affiliation>Correspondence address: N143 TAC, 300 Cedar Street, Magnetic Resonance Research Center, Yale University, New Haven CT 06510, USA.</affiliation>
<role><roleTerm type="text">author</roleTerm>
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<name type="personal"><namePart type="given">Hubert K.</namePart>
<namePart type="family">Trubel</namePart>
<affiliation>Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</affiliation>
<affiliation>Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</affiliation>
<affiliation>University of Witten/Herdecke, Germany</affiliation>
<description>Bayer HealthCare AG, Wuppertal, Germany.</description>
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<name type="personal"><namePart type="given">Robert E.</namePart>
<namePart type="family">Rycyna</namePart>
<affiliation>Bruker BioSpin MRI, Billerica, MA, USA</affiliation>
<description>Philips Healthcare, Highland Heights, OH, USA.</description>
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<name type="personal"><namePart type="given">Fahmeed</namePart>
<namePart type="family">Hyder</namePart>
<affiliation>Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA</affiliation>
<affiliation>Core Center for Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, USA</affiliation>
<affiliation>Department of Diagnostic Radiology, Yale University, New Haven, CT, USA</affiliation>
<affiliation>Biomedical Engineering, Yale University, New Haven, CT, USA</affiliation>
<affiliation>E-mail: fahmeed.hyder@yale.edu</affiliation>
<affiliation>Correspondence address: N143 TAC, 300 Cedar Street, Magnetic Resonance Research Center, Yale University, New Haven CT 06510, USA.</affiliation>
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<place><placeTerm type="text">Chichester, UK</placeTerm>
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<dateIssued encoding="w3cdtf">2009-02</dateIssued>
<dateCaptured encoding="w3cdtf">2008-04-03</dateCaptured>
<dateValid encoding="w3cdtf">2008-06-19</dateValid>
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<abstract lang="en">Temperature and pH are two of the most important physiological parameters and are believed to be tightly regulated because they are intricately related to energy metabolism in living organisms. Temperature and/or pH data in mammalian brain are scarce, however, mainly because of lack of precise and non‐invasive methods. At 11.7 T, we demonstrate that a thulium‐based macrocyclic complex infused through the bloodstream can be used to obtain temperature and pH maps of rat brain in vivo by 1H chemical shift imaging (CSI) of the sensor itself in conjunction with a multi‐parametric model that depends on several proton resonances of the sensor. Accuracies of temperature and pH determination with the thulium sensor – which has a predominantly extracellular presence – depend on stable signals during the course of the CSI experiment as well as redundancy for temperature and pH sensitivities contained within the observed signals. The thulium‐based method compared well with other methods for temperature (1H MRS of N‐acetylaspartate and water; copper–constantan thermocouple wire) and pH (31P MRS of inorganic phosphate and phosphocreatine) assessment, as established by in vitro and in vivo studies. In vitro studies in phantoms with two compartments of different pH value observed under different ambient temperature conditions generated precise temperature and pH distribution maps. In vivo studies in α‐chloralose‐anesthetized and renal‐ligated rats revealed temperature (33–34°C) and pH (7.3–7.4) distributions in the cerebral cortex that are in agreement with observations by other methods. These results show that the thulium sensor can be used to measure temperature and pH distributions in rat brain in vivo simultaneously and accurately with using biosensor imaging of redundant. Copyright © 2008 John Wiley & Sons, Ltd.</abstract>
<abstract type="graphical" lang="en">In the present work we demonstrate that a thulium‐based macrocyclic complex, TmDOTP5−, infused through the bloodstream can be used to obtain temperature and pH maps of rat brain in vivo by 1H chemical shift imaging in conjunction with a multi‐parametric model that depends on three proton resonances of the sensor. In vivo studies in α‐chloralose‐anesthetized and renal‐ligated rats revealed temperature (33–34°C) and pH (7.3–7.4) distributions in the cerebral cortex which are in agreement with observations by other methods.</abstract>
<subject lang="en"><genre>keywords</genre>
<topic>biosensor</topic>
<topic>blood flow</topic>
<topic>lanthanide ion</topic>
<topic>PARACEST</topic>
<topic>paramagnetic</topic>
<topic>tumor</topic>
<topic>thulium</topic>
<topic>pH</topic>
<topic>temperature</topic>
<topic>brain</topic>
</subject>
<relatedItem type="host"><titleInfo><title>NMR in Biomedicine</title>
<subTitle>An International Journal Devoted to the Development and Application of Magnetic Resonance In vivo</subTitle>
</titleInfo>
<titleInfo type="abbreviated"><title>NMR Biomed.</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<subject><genre>article-category</genre>
<topic>Research Article</topic>
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<identifier type="ISSN">0952-3480</identifier>
<identifier type="eISSN">1099-1492</identifier>
<identifier type="DOI">10.1002/(ISSN)1099-1492</identifier>
<identifier type="PublisherID">NBM</identifier>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>22</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>2</number>
</detail>
<extent unit="pages"><start>229</start>
<end>239</end>
<total>11</total>
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<identifier type="istex">2ACF5C37153A539FFA9164F726C043FFDD9D58FE</identifier>
<identifier type="ark">ark:/67375/WNG-C20DJV64-H</identifier>
<identifier type="DOI">10.1002/nbm.1312</identifier>
<identifier type="ArticleID">NBM1312</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2008 John Wiley & Sons, Ltd.</accessCondition>
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