A mechanism of protection against intoxication with various metals
Identifieur interne : 000841 ( Istex/Corpus ); précédent : 000840; suivant : 000842A mechanism of protection against intoxication with various metals
Auteurs : H. Selye ; A. Somogyi ; I. MécsSource :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1968.
English descriptors
- KwdEn :
- Abbott laboratories, Aluminum dextran, Calcergens, Calcification, Calciphylactic, Calciphylactic challengers, Challenger, Chloride4, Chromium dextran, Dextran, Dose level, Ferric dextran, First experiment, Fisons pharmaceuticals, Inorganic salts, Intravenous injection, Light ether anesthesia, Malpighian corpuscles, Metal intoxication, Metallic chelates, Phosphate metabolism, Potent calciphylactic challengers, Potential protectors, Prophylactic effect, Rare earth metals, Selye, Splenic, Splenic calcification, Subcutaneous injection, Topical calcification, Toxic agents, Toxic doses, Unpretreated.
- Teeft :
- Abbott laboratories, Aluminum dextran, Calcergens, Calcification, Calciphylactic, Calciphylactic challengers, Challenger, Chloride4, Chromium dextran, Dextran, Dose level, Ferric dextran, First experiment, Fisons pharmaceuticals, Inorganic salts, Intravenous injection, Light ether anesthesia, Malpighian corpuscles, Metal intoxication, Metallic chelates, Phosphate metabolism, Potent calciphylactic challengers, Potential protectors, Prophylactic effect, Rare earth metals, Selye, Splenic, Splenic calcification, Subcutaneous injection, Topical calcification, Toxic agents, Toxic doses, Unpretreated.
Abstract
Abstract: Calcergens are compounds that cause topical calcification upon subcutaneous injection in unpretreated rats, whereas calciphylactic challengers do so only after systemic pretreatment with a conditioning factor (e.g., vitamin D compounds, parathyroid hormone). Both the mortality and the splenic calcification, commonly elicited by the intravenous injection of various calcergens (rare earth metal chlorides), are prevented, or at least greatly diminished, by pretreatment with calciphylactic challengers (ferric dextran, chromium dextran and, to a lesser extent, aluminum dextran). This prophylactic effect is due to the challenging metal moiety of the chelates, since dextran alone does not protect. These findings are reminiscent of earlier observations that had shown that the topical calcifying effect of calcergens is likewise inhibited by the admixture of calciphylactic challengers. It is possible that the antagonism depends upon changes in calcium or phosphorus metabolism since the eliciting agents are limited to metals having specific calcinotic effects.
Url:
DOI: 10.1016/0041-008X(68)90130-0
Links to Exploration step
ISTEX:260B3610DC9612B04DE6C6EF38F3A6F7852084EELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>A mechanism of protection against intoxication with various metals</title><author><name sortKey="Selye, H" sort="Selye, H" uniqKey="Selye H" first="H." last="Selye">H. Selye</name><affiliation><mods:affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Somogyi, A" sort="Somogyi, A" uniqKey="Somogyi A" first="A." last="Somogyi">A. Somogyi</name><affiliation><mods:affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Mecs, I" sort="Mecs, I" uniqKey="Mecs I" first="I." last="Mécs">I. Mécs</name><affiliation><mods:affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:260B3610DC9612B04DE6C6EF38F3A6F7852084EE</idno><date when="1968" year="1968">1968</date><idno type="doi">10.1016/0041-008X(68)90130-0</idno><idno type="url">https://api.istex.fr/document/260B3610DC9612B04DE6C6EF38F3A6F7852084EE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000841</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000841</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A mechanism of protection against intoxication with various metals</title><author><name sortKey="Selye, H" sort="Selye, H" uniqKey="Selye H" first="H." last="Selye">H. Selye</name><affiliation><mods:affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Somogyi, A" sort="Somogyi, A" uniqKey="Somogyi A" first="A." last="Somogyi">A. Somogyi</name><affiliation><mods:affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</mods:affiliation></affiliation></author><author><name sortKey="Mecs, I" sort="Mecs, I" uniqKey="Mecs I" first="I." last="Mécs">I. Mécs</name><affiliation><mods:affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="ISSN">0041-008X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1968">1968</date><biblScope unit="volume">13</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="30">30</biblScope><biblScope unit="page" to="36">36</biblScope></imprint><idno type="ISSN">0041-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbott laboratories</term><term>Aluminum dextran</term><term>Calcergens</term><term>Calcification</term><term>Calciphylactic</term><term>Calciphylactic challengers</term><term>Challenger</term><term>Chloride4</term><term>Chromium dextran</term><term>Dextran</term><term>Dose level</term><term>Ferric dextran</term><term>First experiment</term><term>Fisons pharmaceuticals</term><term>Inorganic salts</term><term>Intravenous injection</term><term>Light ether anesthesia</term><term>Malpighian corpuscles</term><term>Metal intoxication</term><term>Metallic chelates</term><term>Phosphate metabolism</term><term>Potent calciphylactic challengers</term><term>Potential protectors</term><term>Prophylactic effect</term><term>Rare earth metals</term><term>Selye</term><term>Splenic</term><term>Splenic calcification</term><term>Subcutaneous injection</term><term>Topical calcification</term><term>Toxic agents</term><term>Toxic doses</term><term>Unpretreated</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abbott laboratories</term><term>Aluminum dextran</term><term>Calcergens</term><term>Calcification</term><term>Calciphylactic</term><term>Calciphylactic challengers</term><term>Challenger</term><term>Chloride4</term><term>Chromium dextran</term><term>Dextran</term><term>Dose level</term><term>Ferric dextran</term><term>First experiment</term><term>Fisons pharmaceuticals</term><term>Inorganic salts</term><term>Intravenous injection</term><term>Light ether anesthesia</term><term>Malpighian corpuscles</term><term>Metal intoxication</term><term>Metallic chelates</term><term>Phosphate metabolism</term><term>Potent calciphylactic challengers</term><term>Potential protectors</term><term>Prophylactic effect</term><term>Rare earth metals</term><term>Selye</term><term>Splenic</term><term>Splenic calcification</term><term>Subcutaneous injection</term><term>Topical calcification</term><term>Toxic agents</term><term>Toxic doses</term><term>Unpretreated</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Calcergens are compounds that cause topical calcification upon subcutaneous injection in unpretreated rats, whereas calciphylactic challengers do so only after systemic pretreatment with a conditioning factor (e.g., vitamin D compounds, parathyroid hormone). Both the mortality and the splenic calcification, commonly elicited by the intravenous injection of various calcergens (rare earth metal chlorides), are prevented, or at least greatly diminished, by pretreatment with calciphylactic challengers (ferric dextran, chromium dextran and, to a lesser extent, aluminum dextran). This prophylactic effect is due to the challenging metal moiety of the chelates, since dextran alone does not protect. These findings are reminiscent of earlier observations that had shown that the topical calcifying effect of calcergens is likewise inhibited by the admixture of calciphylactic challengers. It is possible that the antagonism depends upon changes in calcium or phosphorus metabolism since the eliciting agents are limited to metals having specific calcinotic effects.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>calcergens</json:string><json:string>dextran</json:string><json:string>calciphylactic</json:string><json:string>selye</json:string><json:string>chloride4</json:string><json:string>splenic</json:string><json:string>calciphylactic challengers</json:string><json:string>calcification</json:string><json:string>challenger</json:string><json:string>unpretreated</json:string><json:string>splenic calcification</json:string><json:string>aluminum dextran</json:string><json:string>toxic doses</json:string><json:string>toxic agents</json:string><json:string>topical calcification</json:string><json:string>ferric dextran</json:string><json:string>intravenous injection</json:string><json:string>first experiment</json:string><json:string>dose level</json:string><json:string>metallic chelates</json:string><json:string>phosphate metabolism</json:string><json:string>potential protectors</json:string><json:string>chromium dextran</json:string><json:string>subcutaneous injection</json:string><json:string>light ether anesthesia</json:string><json:string>abbott laboratories</json:string><json:string>fisons pharmaceuticals</json:string><json:string>metal intoxication</json:string><json:string>prophylactic effect</json:string><json:string>potent calciphylactic challengers</json:string><json:string>inorganic salts</json:string><json:string>malpighian corpuscles</json:string><json:string>rare earth metals</json:string></teeft></keywords><author><json:item><name>H. Selye</name><affiliations><json:string>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</json:string></affiliations></json:item><json:item><name>A. Somogyi</name><affiliations><json:string>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</json:string></affiliations></json:item><json:item><name>I. Mécs</name><affiliations><json:string>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Calcergens are compounds that cause topical calcification upon subcutaneous injection in unpretreated rats, whereas calciphylactic challengers do so only after systemic pretreatment with a conditioning factor (e.g., vitamin D compounds, parathyroid hormone). Both the mortality and the splenic calcification, commonly elicited by the intravenous injection of various calcergens (rare earth metal chlorides), are prevented, or at least greatly diminished, by pretreatment with calciphylactic challengers (ferric dextran, chromium dextran and, to a lesser extent, aluminum dextran). This prophylactic effect is due to the challenging metal moiety of the chelates, since dextran alone does not protect. These findings are reminiscent of earlier observations that had shown that the topical calcifying effect of calcergens is likewise inhibited by the admixture of calciphylactic challengers. It is possible that the antagonism depends upon changes in calcium or phosphorus metabolism since the eliciting agents are limited to metals having specific calcinotic effects.</abstract><qualityIndicators><score>3.931</score><pdfVersion>1.3</pdfVersion><pdfPageSize>507 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1065</abstractCharCount><pdfWordCount>2179</pdfWordCount><pdfCharCount>15239</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>146</abstractWordCount></qualityIndicators><title>A mechanism of protection against intoxication with various metals</title><pii><json:string>0041-008X(68)90130-0</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Toxicology and Applied Pharmacology</title><language><json:string>unknown</json:string></language><publicationDate>1968</publicationDate><issn><json:string>0041-008X</json:string></issn><pii><json:string>S0041-008X(00)X0268-2</json:string></pii><volume>13</volume><issue>1</issue><pages><first>30</first><last>36</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>science</json:string><json:string>toxicology</json:string><json:string>pharmacology & pharmacy</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>biomedical research</json:string><json:string>toxicology</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string><json:string>sante publique. hygiene-medecine du travail</json:string></inist></categories><publicationDate>1968</publicationDate><copyrightDate>1968</copyrightDate><doi><json:string>10.1016/0041-008X(68)90130-0</json:string></doi><id>260B3610DC9612B04DE6C6EF38F3A6F7852084EE</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/260B3610DC9612B04DE6C6EF38F3A6F7852084EE/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/260B3610DC9612B04DE6C6EF38F3A6F7852084EE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/260B3610DC9612B04DE6C6EF38F3A6F7852084EE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">A mechanism of protection against intoxication with various metals</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1968</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">A mechanism of protection against intoxication with various metals</title><author xml:id="author-0000"><persName><forename type="first">H.</forename><surname>Selye</surname></persName><affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</affiliation></author><author xml:id="author-0001"><persName><forename type="first">A.</forename><surname>Somogyi</surname></persName><affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</affiliation></author><author xml:id="author-0002"><persName><forename type="first">I.</forename><surname>Mécs</surname></persName><affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</affiliation></author><idno type="istex">260B3610DC9612B04DE6C6EF38F3A6F7852084EE</idno><idno type="DOI">10.1016/0041-008X(68)90130-0</idno><idno type="PII">0041-008X(68)90130-0</idno></analytic><monogr><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="pISSN">0041-008X</idno><idno type="PII">S0041-008X(00)X0268-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1968"></date><biblScope unit="volume">13</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="30">30</biblScope><biblScope unit="page" to="36">36</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1968</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Calcergens are compounds that cause topical calcification upon subcutaneous injection in unpretreated rats, whereas calciphylactic challengers do so only after systemic pretreatment with a conditioning factor (e.g., vitamin D compounds, parathyroid hormone). Both the mortality and the splenic calcification, commonly elicited by the intravenous injection of various calcergens (rare earth metal chlorides), are prevented, or at least greatly diminished, by pretreatment with calciphylactic challengers (ferric dextran, chromium dextran and, to a lesser extent, aluminum dextran). This prophylactic effect is due to the challenging metal moiety of the chelates, since dextran alone does not protect. These findings are reminiscent of earlier observations that had shown that the topical calcifying effect of calcergens is likewise inhibited by the admixture of calciphylactic challengers. It is possible that the antagonism depends upon changes in calcium or phosphorus metabolism since the eliciting agents are limited to metals having specific calcinotic effects.</p></abstract></profileDesc><revisionDesc><change when="1968">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/260B3610DC9612B04DE6C6EF38F3A6F7852084EE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>YTAAP</jid><aid>68901300</aid><ce:pii>0041-008X(68)90130-0</ce:pii><ce:doi>10.1016/0041-008X(68)90130-0</ce:doi><ce:copyright type="unknown" year="1968"></ce:copyright></item-info><head><ce:title>A mechanism of protection against intoxication with various metals</ce:title><ce:author-group><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Selye</ce:surname></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Somogyi</ce:surname></ce:author><ce:author><ce:given-name>I.</ce:given-name><ce:surname>Mécs</ce:surname></ce:author><ce:affiliation><ce:textfn>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="15" month="1" year="1968"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Calcergens are compounds that cause topical calcification upon subcutaneous injection in unpretreated rats, whereas calciphylactic challengers do so only after systemic pretreatment with a conditioning factor (e.g., vitamin D compounds, parathyroid hormone). Both the mortality and the splenic calcification, commonly elicited by the intravenous injection of various calcergens (rare earth metal chlorides), are prevented, or at least greatly diminished, by pretreatment with calciphylactic challengers (ferric dextran, chromium dextran and, to a lesser extent, aluminum dextran). This prophylactic effect is due to the challenging metal moiety of the chelates, since dextran alone does not protect.</ce:simple-para><ce:simple-para>These findings are reminiscent of earlier observations that had shown that the topical calcifying effect of calcergens is likewise inhibited by the admixture of calciphylactic challengers. It is possible that the antagonism depends upon changes in calcium or phosphorus metabolism since the eliciting agents are limited to metals having specific calcinotic effects.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>A mechanism of protection against intoxication with various metals</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>A mechanism of protection against intoxication with various metals</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Selye</namePart><affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Somogyi</namePart><affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Mécs</namePart><affiliation>Institut de Médecine et de Chirurgie expérimentales Université de Montréal, Montreal, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1968</dateIssued><copyrightDate encoding="w3cdtf">1968</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Calcergens are compounds that cause topical calcification upon subcutaneous injection in unpretreated rats, whereas calciphylactic challengers do so only after systemic pretreatment with a conditioning factor (e.g., vitamin D compounds, parathyroid hormone). Both the mortality and the splenic calcification, commonly elicited by the intravenous injection of various calcergens (rare earth metal chlorides), are prevented, or at least greatly diminished, by pretreatment with calciphylactic challengers (ferric dextran, chromium dextran and, to a lesser extent, aluminum dextran). This prophylactic effect is due to the challenging metal moiety of the chelates, since dextran alone does not protect. These findings are reminiscent of earlier observations that had shown that the topical calcifying effect of calcergens is likewise inhibited by the admixture of calciphylactic challengers. It is possible that the antagonism depends upon changes in calcium or phosphorus metabolism since the eliciting agents are limited to metals having specific calcinotic effects.</abstract><relatedItem type="host"><titleInfo><title>Toxicology and Applied Pharmacology</title></titleInfo><titleInfo type="abbreviated"><title>YTAAP</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">196807</dateIssued></originInfo><identifier type="ISSN">0041-008X</identifier><identifier type="PII">S0041-008X(00)X0268-2</identifier><part><date>196807</date><detail type="volume"><number>13</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>131</end></extent><extent unit="pages"><start>30</start><end>36</end></extent></part></relatedItem><identifier type="istex">260B3610DC9612B04DE6C6EF38F3A6F7852084EE</identifier><identifier type="ark">ark:/67375/6H6-19JG2X88-0</identifier><identifier type="DOI">10.1016/0041-008X(68)90130-0</identifier><identifier type="PII">0041-008X(68)90130-0</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/260B3610DC9612B04DE6C6EF38F3A6F7852084EE/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/ThuliumV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000841 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000841 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= ThuliumV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:260B3610DC9612B04DE6C6EF38F3A6F7852084EE
|texte= A mechanism of protection against intoxication with various metals
}}
| This area was generated with Dilib version V0.6.21. |  |