Colloidal silver as an antimicrobial agent: fact or fiction?
Identifieur interne : 000C40 ( Main/Corpus ); précédent : 000C39; suivant : 000C41Colloidal silver as an antimicrobial agent: fact or fiction?
Auteurs : P. Van Hasselt ; B A Gashe ; J. AhmadSource :
- Journal of wound care [ 0969-0700 ] ; 2004.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Anti-Infective Agents, Colloids, Silver Compounds.
- drug effects : Aspergillus niger, Pseudomonas aeruginosa, Staphylococcus aureus.
- Treatment Outcome.
Abstract
OBJECTIVE
Colloidal silver preparations are marketed on the internet as omnipotent antimicrobial agents, but scientific support for these claims is lacking. This study reports the results of in vitro tests of colloidal silver's antimicrobial activity against several pathogenic or non-pathogenic microorganisms.
METHOD
Three samples of colloidal silver were tested: one available commercially on the internet (silver concentration of 22 ppm) and two samples (concentrations of 403 and 413 ppm) which were prepared in our laboratory using standard chemical methods.
RESULTS
In an agar-well diffusion assay none of the three colloidal silver solutions had any effect on the growth of the test organisms. All tested bacterial strains were sensitive to ciprofloxacin. Colloidal silver 22 ppm showed no bactericidal activity in phenol coefficient tests.
CONCLUSION
As the tested colloidal silver solutions did not show any antimicrobial effect in vitro on the microorganisms, claims of colloidal silver's antimicrobial potency are misleading and there is no place for it as an antiseptic.
DOI: 10.12968/jowc.2004.13.4.26606
PubMed: 15114827
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pubmed:15114827Le document en format XML
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Ahmad</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15114827</idno><idno type="pmid">15114827</idno><idno type="doi">10.12968/jowc.2004.13.4.26606</idno><idno type="wicri:Area/Main/Corpus">000C40</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000C40</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Colloidal silver as an antimicrobial agent: fact or fiction?</title><author><name sortKey="Van Hasselt, P" sort="Van Hasselt, P" uniqKey="Van Hasselt P" first="P" last="Van Hasselt">P. Van Hasselt</name><affiliation><nlm:affiliation>Ear Clinic, Bamalete Lutheran Hospital, Ramotswa, Botswana. pvhasselt@planet.nl</nlm:affiliation></affiliation></author><author><name sortKey="Gashe, B A" sort="Gashe, B A" uniqKey="Gashe B" first="B A" last="Gashe">B A Gashe</name></author><author><name sortKey="Ahmad, J" sort="Ahmad, J" uniqKey="Ahmad J" first="J" last="Ahmad">J. Ahmad</name></author></analytic><series><title level="j">Journal of wound care</title><idno type="ISSN">0969-0700</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Infective Agents (pharmacology)</term><term>Aspergillus niger (drug effects)</term><term>Colloids (pharmacology)</term><term>Pseudomonas aeruginosa (drug effects)</term><term>Silver Compounds (pharmacology)</term><term>Staphylococcus aureus (drug effects)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Infective Agents</term><term>Colloids</term><term>Silver Compounds</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Aspergillus niger</term><term>Pseudomonas aeruginosa</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>Colloidal silver preparations are marketed on the internet as omnipotent antimicrobial agents, but scientific support for these claims is lacking. This study reports the results of in vitro tests of colloidal silver's antimicrobial activity against several pathogenic or non-pathogenic microorganisms.</p></div><div type="abstract" xml:lang="en"><p><b>METHOD</b></p><p>Three samples of colloidal silver were tested: one available commercially on the internet (silver concentration of 22 ppm) and two samples (concentrations of 403 and 413 ppm) which were prepared in our laboratory using standard chemical methods.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In an agar-well diffusion assay none of the three colloidal silver solutions had any effect on the growth of the test organisms. All tested bacterial strains were sensitive to ciprofloxacin. Colloidal silver 22 ppm showed no bactericidal activity in phenol coefficient tests.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>As the tested colloidal silver solutions did not show any antimicrobial effect in vitro on the microorganisms, claims of colloidal silver's antimicrobial potency are misleading and there is no place for it as an antiseptic.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15114827</PMID><DateCompleted><Year>2004</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0969-0700</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>4</Issue><PubDate><Year>2004</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Journal of wound care</Title><ISOAbbreviation>J Wound Care</ISOAbbreviation></Journal><ArticleTitle>Colloidal silver as an antimicrobial agent: fact or fiction?</ArticleTitle><Pagination><MedlinePgn>154-5</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Colloidal silver preparations are marketed on the internet as omnipotent antimicrobial agents, but scientific support for these claims is lacking. 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Colloidal silver 22 ppm showed no bactericidal activity in phenol coefficient tests.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">As the tested colloidal silver solutions did not show any antimicrobial effect in vitro on the microorganisms, claims of colloidal silver's antimicrobial potency are misleading and there is no place for it as an antiseptic.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>van Hasselt</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Ear Clinic, Bamalete Lutheran Hospital, Ramotswa, Botswana. pvhasselt@planet.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gashe</LastName><ForeName>B A</ForeName><Initials>BA</Initials></Author><Author ValidYN="Y"><LastName>Ahmad</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Wound Care</MedlineTA><NlmUniqueID>9417080</NlmUniqueID><ISSNLinking>0969-0700</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D003102">Colloids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018030">Silver Compounds</NameOfSubstance></Chemical></ChemicalList><CitationSubset>N</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001234" MajorTopicYN="N">Aspergillus niger</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003102" MajorTopicYN="N">Colloids</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011550" MajorTopicYN="N">Pseudomonas aeruginosa</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018030" MajorTopicYN="N">Silver Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>4</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>11</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>4</Month><Day>30</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15114827</ArticleId><ArticleId IdType="doi">10.12968/jowc.2004.13.4.26606</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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