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Electrospun titanium dioxide nanofibers containing hydroxyapatite and silver nanoparticles as future implant materials.

Identifieur interne : 000A99 ( Main/Corpus ); précédent : 000A98; suivant : 000B00

Electrospun titanium dioxide nanofibers containing hydroxyapatite and silver nanoparticles as future implant materials.

Auteurs : Faheem A. Sheikh ; Nasser A M. Barakat ; Muzafar A. Kanjwal ; R. Nirmala ; John Hwa Lee ; Hern Kim ; Hak Yong Kim

Source :

RBID : pubmed:20652376

English descriptors

Abstract

In this study, a good combination consisting of electrospun titanium dioxide (TiO(2)) nanofibers incorporated with high purity hydroxyapatite (HAp) nanoparticles (NPs) and antimicrobial silver NPs is introduced for hard tissue engineering applications. The synthesized nanofibers were characterized by various state of art techniques like; SEM, XRD, TEM, TEM EDS and XPS analyses. SEM results confirmed well oriented nanofibers and good dispersion of HAp and silver NPs, respectively. XRD results demonstrated well crystalline feature of three components used for electrospinning. Silver NPs were having a diameter in range of 5-8 nm indicated by TEM analysis. Moreover, TEM EDS analysis demonstrated the presence of each component with good dispersion over TiO(2) nanofiber. The surface analyses of nanofibers were investigated by XPS which indicated the presence of silver NPs on the surfaces of nanofibers. The obtained nanofibers were checked for antimicrobial activity by using two model organisms E. coli and S. aureus. Subsequently, antimicrobial tests have indicated that the prepared nanofibers do possess high bactericidal effect. Accordingly, these results strongly recommend the use of obtained nanofiber mats as future implant materials.

DOI: 10.1007/s10856-010-4102-9
PubMed: 20652376

Links to Exploration step

pubmed:20652376

Le document en format XML

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<name sortKey="Sheikh, Faheem A" sort="Sheikh, Faheem A" uniqKey="Sheikh F" first="Faheem A" last="Sheikh">Faheem A. Sheikh</name>
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<name sortKey="Barakat, Nasser A M" sort="Barakat, Nasser A M" uniqKey="Barakat N" first="Nasser A M" last="Barakat">Nasser A M. Barakat</name>
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<name sortKey="Kanjwal, Muzafar A" sort="Kanjwal, Muzafar A" uniqKey="Kanjwal M" first="Muzafar A" last="Kanjwal">Muzafar A. Kanjwal</name>
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<name sortKey="Nirmala, R" sort="Nirmala, R" uniqKey="Nirmala R" first="R" last="Nirmala">R. Nirmala</name>
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<name sortKey="Lee, John Hwa" sort="Lee, John Hwa" uniqKey="Lee J" first="John Hwa" last="Lee">John Hwa Lee</name>
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<name sortKey="Kim, Hern" sort="Kim, Hern" uniqKey="Kim H" first="Hern" last="Kim">Hern Kim</name>
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<div type="abstract" xml:lang="en">In this study, a good combination consisting of electrospun titanium dioxide (TiO(2)) nanofibers incorporated with high purity hydroxyapatite (HAp) nanoparticles (NPs) and antimicrobial silver NPs is introduced for hard tissue engineering applications. The synthesized nanofibers were characterized by various state of art techniques like; SEM, XRD, TEM, TEM EDS and XPS analyses. SEM results confirmed well oriented nanofibers and good dispersion of HAp and silver NPs, respectively. XRD results demonstrated well crystalline feature of three components used for electrospinning. Silver NPs were having a diameter in range of 5-8 nm indicated by TEM analysis. Moreover, TEM EDS analysis demonstrated the presence of each component with good dispersion over TiO(2) nanofiber. The surface analyses of nanofibers were investigated by XPS which indicated the presence of silver NPs on the surfaces of nanofibers. The obtained nanofibers were checked for antimicrobial activity by using two model organisms E. coli and S. aureus. Subsequently, antimicrobial tests have indicated that the prepared nanofibers do possess high bactericidal effect. Accordingly, these results strongly recommend the use of obtained nanofiber mats as future implant materials.</div>
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