Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane.
Identifieur interne : 000A72 ( Main/Corpus ); précédent : 000A71; suivant : 000A73Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane.
Auteurs : Hung-Li Liu ; Shenghong A. Dai ; Keng-Yen Fu ; Shan-Hui HsuSource :
- International journal of nanomedicine [ 1178-2013 ] ; 2010.
English descriptors
- KwdEn :
- Analysis of Variance (MeSH), Animals (MeSH), Anti-Bacterial Agents (administration & dosage), Anti-Bacterial Agents (chemistry), Cattle (MeSH), Cell Adhesion (drug effects), Cell Line (MeSH), Cell Proliferation (drug effects), Cell Survival (drug effects), Drug Stability (MeSH), Humans (MeSH), Metal Nanoparticles (administration & dosage), Metal Nanoparticles (chemistry), Mice (MeSH), Microbial Sensitivity Tests (MeSH), Nanocomposites (administration & dosage), Nanocomposites (chemistry), Particle Size (MeSH), Polyurethanes (administration & dosage), Polyurethanes (chemistry), Silver (administration & dosage), Silver (chemistry).
- MESH :
- chemical , administration & dosage : Anti-Bacterial Agents, Polyurethanes, Silver.
- chemical , chemistry : Anti-Bacterial Agents, Polyurethanes, Silver.
- administration & dosage : Metal Nanoparticles, Nanocomposites.
- chemistry : Metal Nanoparticles, Nanocomposites.
- drug effects : Cell Adhesion, Cell Proliferation, Cell Survival.
- Analysis of Variance, Animals, Cattle, Cell Line, Drug Stability, Humans, Mice, Microbial Sensitivity Tests, Particle Size.
Abstract
Silver nanoparticles (AgNPs) are strong bactericidal agents but they are also cytotoxic. Embedding them in a polymer matrix may reduce their cytotoxic effect. In the present study, AgNPs in three average sizes were tested for their antibacterial activities and cytotoxicity. Nanocomposites from a new waterborne polyetherurethane (PEU) ionomer and AgNPs were prepared without the use of any crosslinker. It was observed that the antibacterial activity of AgNPs against Escherichia coli started at the effective concentration of 0.1-1 ppm, while that against Staphylococcus aureus started at higher concentrations of 1-10 ppm. Cytotoxicity of AgNPs was observed at the concentration of 10 ppm. AgNPs with smaller average size showed greater antibacterial activity as well as cytotoxicity. The PEU synthesized in this study showed high tensile strength, and the addition of AgNPs at all sizes further increased its thermal stability. The delicate surface features of nanophases, however, were only observed in nanocomposites with either small-or medium-sized AgNPs. PEU-Ag nanocomposites had a strong bacteriostatic effect on the growth of E. coli and S. aureus. The proliferation of endothelial cells on PEU-Ag nanocomposites was enhanced, whereas the platelet adhesion was reduced. The expression of endothelial nitric oxide synthase gene was upregulated on PEU-Ag containing small-sized AgNPs (30 ppm) or medium-sized AgNPs (60 ppm). This effect was not as remarkable in nanocomposites from large-sized AgNPs. Overall, nanocomposites from the PEU and 60 ppm of the medium-sized (5 nm) AgNPs showed the best biocompatibility and antibacterial activity. Addition of smaller or larger AgNPs did not produce as substantial an effect in PEU, especially for the larger AgNPs.
DOI: 10.2147/IJN.S14572
PubMed: 21187943
PubMed Central: PMC3010153
Links to Exploration step
pubmed:21187943Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane.</title><author><name sortKey="Liu, Hung Li" sort="Liu, Hung Li" uniqKey="Liu H" first="Hung-Li" last="Liu">Hung-Li Liu</name><affiliation><nlm:affiliation>Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Dai, Shenghong A" sort="Dai, Shenghong A" uniqKey="Dai S" first="Shenghong A" last="Dai">Shenghong A. Dai</name></author><author><name sortKey="Fu, Keng Yen" sort="Fu, Keng Yen" uniqKey="Fu K" first="Keng-Yen" last="Fu">Keng-Yen Fu</name></author><author><name sortKey="Hsu, Shan Hui" sort="Hsu, Shan Hui" uniqKey="Hsu S" first="Shan-Hui" last="Hsu">Shan-Hui Hsu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:21187943</idno><idno type="pmid">21187943</idno><idno type="doi">10.2147/IJN.S14572</idno><idno type="pmc">PMC3010153</idno><idno type="wicri:Area/Main/Corpus">000A72</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane.</title><author><name sortKey="Liu, Hung Li" sort="Liu, Hung Li" uniqKey="Liu H" first="Hung-Li" last="Liu">Hung-Li Liu</name><affiliation><nlm:affiliation>Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Dai, Shenghong A" sort="Dai, Shenghong A" uniqKey="Dai S" first="Shenghong A" last="Dai">Shenghong A. Dai</name></author><author><name sortKey="Fu, Keng Yen" sort="Fu, Keng Yen" uniqKey="Fu K" first="Keng-Yen" last="Fu">Keng-Yen Fu</name></author><author><name sortKey="Hsu, Shan Hui" sort="Hsu, Shan Hui" uniqKey="Hsu S" first="Shan-Hui" last="Hsu">Shan-Hui Hsu</name></author></analytic><series><title level="j">International journal of nanomedicine</title><idno type="eISSN">1178-2013</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance (MeSH)</term><term>Animals (MeSH)</term><term>Anti-Bacterial Agents (administration & dosage)</term><term>Anti-Bacterial Agents (chemistry)</term><term>Cattle (MeSH)</term><term>Cell Adhesion (drug effects)</term><term>Cell Line (MeSH)</term><term>Cell Proliferation (drug effects)</term><term>Cell Survival (drug effects)</term><term>Drug Stability (MeSH)</term><term>Humans (MeSH)</term><term>Metal Nanoparticles (administration & dosage)</term><term>Metal Nanoparticles (chemistry)</term><term>Mice (MeSH)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Nanocomposites (administration & dosage)</term><term>Nanocomposites (chemistry)</term><term>Particle Size (MeSH)</term><term>Polyurethanes (administration & dosage)</term><term>Polyurethanes (chemistry)</term><term>Silver (administration & dosage)</term><term>Silver (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Polyurethanes</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Polyurethanes</term><term>Silver</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Metal Nanoparticles</term><term>Nanocomposites</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term><term>Nanocomposites</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Adhesion</term><term>Cell Proliferation</term><term>Cell Survival</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Cattle</term><term>Cell Line</term><term>Drug Stability</term><term>Humans</term><term>Mice</term><term>Microbial Sensitivity Tests</term><term>Particle Size</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Silver nanoparticles (AgNPs) are strong bactericidal agents but they are also cytotoxic. Embedding them in a polymer matrix may reduce their cytotoxic effect. In the present study, AgNPs in three average sizes were tested for their antibacterial activities and cytotoxicity. Nanocomposites from a new waterborne polyetherurethane (PEU) ionomer and AgNPs were prepared without the use of any crosslinker. It was observed that the antibacterial activity of AgNPs against Escherichia coli started at the effective concentration of 0.1-1 ppm, while that against Staphylococcus aureus started at higher concentrations of 1-10 ppm. Cytotoxicity of AgNPs was observed at the concentration of 10 ppm. AgNPs with smaller average size showed greater antibacterial activity as well as cytotoxicity. The PEU synthesized in this study showed high tensile strength, and the addition of AgNPs at all sizes further increased its thermal stability. The delicate surface features of nanophases, however, were only observed in nanocomposites with either small-or medium-sized AgNPs. PEU-Ag nanocomposites had a strong bacteriostatic effect on the growth of E. coli and S. aureus. The proliferation of endothelial cells on PEU-Ag nanocomposites was enhanced, whereas the platelet adhesion was reduced. The expression of endothelial nitric oxide synthase gene was upregulated on PEU-Ag containing small-sized AgNPs (30 ppm) or medium-sized AgNPs (60 ppm). This effect was not as remarkable in nanocomposites from large-sized AgNPs. Overall, nanocomposites from the PEU and 60 ppm of the medium-sized (5 nm) AgNPs showed the best biocompatibility and antibacterial activity. Addition of smaller or larger AgNPs did not produce as substantial an effect in PEU, especially for the larger AgNPs.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21187943</PMID><DateCompleted><Year>2011</Year><Month>04</Month><Day>18</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1178-2013</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><PubDate><Year>2010</Year><Month>Nov</Month><Day>19</Day></PubDate></JournalIssue><Title>International journal of nanomedicine</Title><ISOAbbreviation>Int J Nanomedicine</ISOAbbreviation></Journal><ArticleTitle>Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane.</ArticleTitle><Pagination><MedlinePgn>1017-28</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2147/IJN.S14572</ELocationID><Abstract><AbstractText>Silver nanoparticles (AgNPs) are strong bactericidal agents but they are also cytotoxic. Embedding them in a polymer matrix may reduce their cytotoxic effect. In the present study, AgNPs in three average sizes were tested for their antibacterial activities and cytotoxicity. Nanocomposites from a new waterborne polyetherurethane (PEU) ionomer and AgNPs were prepared without the use of any crosslinker. It was observed that the antibacterial activity of AgNPs against Escherichia coli started at the effective concentration of 0.1-1 ppm, while that against Staphylococcus aureus started at higher concentrations of 1-10 ppm. Cytotoxicity of AgNPs was observed at the concentration of 10 ppm. AgNPs with smaller average size showed greater antibacterial activity as well as cytotoxicity. The PEU synthesized in this study showed high tensile strength, and the addition of AgNPs at all sizes further increased its thermal stability. The delicate surface features of nanophases, however, were only observed in nanocomposites with either small-or medium-sized AgNPs. PEU-Ag nanocomposites had a strong bacteriostatic effect on the growth of E. coli and S. aureus. The proliferation of endothelial cells on PEU-Ag nanocomposites was enhanced, whereas the platelet adhesion was reduced. The expression of endothelial nitric oxide synthase gene was upregulated on PEU-Ag containing small-sized AgNPs (30 ppm) or medium-sized AgNPs (60 ppm). This effect was not as remarkable in nanocomposites from large-sized AgNPs. Overall, nanocomposites from the PEU and 60 ppm of the medium-sized (5 nm) AgNPs showed the best biocompatibility and antibacterial activity. Addition of smaller or larger AgNPs did not produce as substantial an effect in PEU, especially for the larger AgNPs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hung-Li</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Shenghong A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Keng-Yen</ForeName><Initials>KY</Initials></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Shan-Hui</ForeName><Initials>SH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate 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