In vitro efficacy of bismuth thiols against biofilms formed by bacteria isolated from human chronic wounds.
Identifieur interne : 000A42 ( Main/Corpus ); précédent : 000A41; suivant : 000A43In vitro efficacy of bismuth thiols against biofilms formed by bacteria isolated from human chronic wounds.
Auteurs : J P Folsom ; B. Baker ; P S StewartSource :
- Journal of applied microbiology [ 1365-2672 ] ; 2011.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (pharmacology), Biofilms (drug effects), Bismuth (pharmacology), Dimercaprol (analogs & derivatives), Dimercaprol (pharmacology), Humans (MeSH), Methicillin-Resistant Staphylococcus aureus (drug effects), Microbial Viability (MeSH), Organometallic Compounds (pharmacology), Pseudomonas aeruginosa (drug effects), Sulfhydryl Compounds (pharmacology).
- MESH :
- chemical , analogs & derivatives : Dimercaprol.
- chemical , pharmacology : Anti-Bacterial Agents, Bismuth, Dimercaprol, Organometallic Compounds, Sulfhydryl Compounds.
- drug effects : Biofilms, Methicillin-Resistant Staphylococcus aureus, Pseudomonas aeruginosa.
- Humans, Microbial Viability.
Abstract
AIMS
The purpose of this study was to evaluate the antimicrobial efficacy of thirteen bismuth thiol preparations for bactericidal activity against established biofilms formed by two bacteria isolated from human chronic wounds.
METHODS
Single species biofilms of a Pseudomonas aeruginosa or a methicillin-resistant Staphylococcus aureus were grown in either colony biofilm or drip-flow reactors systems. Biofilms were challenged with bismuth thiols, antibiotics or silver sulfadiazine, and log reductions were determined by plating for colony formation.
CONCLUSIONS
Antibiotics were ineffective or inconsistent against biofilms of both bacterial species tested. None of the antibiotics tested were able to achieve >2 log reductions in both biofilm models. The 13 different bismuth thiols tested in this investigation achieved widely varying degrees of killing, even against the same micro-organism in the same biofilm model. For each micro-organism, the best bismuth thiol easily outperformed the best conventional antibiotic. Against P. aeruginosa biofilms, bismuth-2,3-dimercaptopropanol (BisBAL) at 40-80 μg ml⁻¹ achieved > 7·7 mean log reduction for the two biofilm models. Against MRSA biofilms, bismuth-1,3-propanedithiol/bismuth-2-mercaptopyridine N-oxide (BisBDT/PYR) achieved a 4·9 log reduction.
SIGNIFICANCE AND IMPACT OF THE STUDY
Bismuth thiols are effective antimicrobial agents against biofilms formed by wound bacteria and merit further development as topical antiseptics for the suppression of biofilms in chronic wounds.
DOI: 10.1111/j.1365-2672.2011.05110.x
PubMed: 21794034
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pubmed:21794034Le document en format XML
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Baker</name></author><author><name sortKey="Stewart, P S" sort="Stewart, P S" uniqKey="Stewart P" first="P S" last="Stewart">P S Stewart</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21794034</idno><idno type="pmid">21794034</idno><idno type="doi">10.1111/j.1365-2672.2011.05110.x</idno><idno type="wicri:Area/Main/Corpus">000A42</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000A42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">In vitro efficacy of bismuth thiols against biofilms formed by bacteria isolated from human chronic wounds.</title><author><name sortKey="Folsom, J P" sort="Folsom, J P" uniqKey="Folsom J" first="J P" last="Folsom">J P Folsom</name><affiliation><nlm:affiliation>Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA Microbion Corporation, Bozeman, MT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Baker, B" sort="Baker, B" uniqKey="Baker B" first="B" last="Baker">B. Baker</name></author><author><name sortKey="Stewart, P S" sort="Stewart, P S" uniqKey="Stewart P" first="P S" last="Stewart">P S Stewart</name></author></analytic><series><title level="j">Journal of applied microbiology</title><idno type="eISSN">1365-2672</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (pharmacology)</term><term>Biofilms (drug effects)</term><term>Bismuth (pharmacology)</term><term>Dimercaprol (analogs & derivatives)</term><term>Dimercaprol (pharmacology)</term><term>Humans (MeSH)</term><term>Methicillin-Resistant Staphylococcus aureus (drug effects)</term><term>Microbial Viability (MeSH)</term><term>Organometallic Compounds (pharmacology)</term><term>Pseudomonas aeruginosa (drug effects)</term><term>Sulfhydryl Compounds (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Dimercaprol</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Bismuth</term><term>Dimercaprol</term><term>Organometallic Compounds</term><term>Sulfhydryl Compounds</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biofilms</term><term>Methicillin-Resistant Staphylococcus aureus</term><term>Pseudomonas aeruginosa</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Microbial Viability</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIMS</b></p><p>The purpose of this study was to evaluate the antimicrobial efficacy of thirteen bismuth thiol preparations for bactericidal activity against established biofilms formed by two bacteria isolated from human chronic wounds.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Single species biofilms of a Pseudomonas aeruginosa or a methicillin-resistant Staphylococcus aureus were grown in either colony biofilm or drip-flow reactors systems. Biofilms were challenged with bismuth thiols, antibiotics or silver sulfadiazine, and log reductions were determined by plating for colony formation.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Antibiotics were ineffective or inconsistent against biofilms of both bacterial species tested. None of the antibiotics tested were able to achieve >2 log reductions in both biofilm models. The 13 different bismuth thiols tested in this investigation achieved widely varying degrees of killing, even against the same micro-organism in the same biofilm model. For each micro-organism, the best bismuth thiol easily outperformed the best conventional antibiotic. Against P. aeruginosa biofilms, bismuth-2,3-dimercaptopropanol (BisBAL) at 40-80 μg ml⁻¹ achieved > 7·7 mean log reduction for the two biofilm models. Against MRSA biofilms, bismuth-1,3-propanedithiol/bismuth-2-mercaptopyridine N-oxide (BisBDT/PYR) achieved a 4·9 log reduction.</p></div><div type="abstract" xml:lang="en"><p><b>SIGNIFICANCE AND IMPACT OF THE STUDY</b></p><p>Bismuth thiols are effective antimicrobial agents against biofilms formed by wound bacteria and merit further development as topical antiseptics for the suppression of biofilms in chronic wounds.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">21794034</PMID><DateCompleted><Year>2012</Year><Month>01</Month><Day>23</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1365-2672</ISSN><JournalIssue CitedMedium="Internet"><Volume>111</Volume><Issue>4</Issue><PubDate><Year>2011</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of applied microbiology</Title><ISOAbbreviation>J Appl Microbiol</ISOAbbreviation></Journal><ArticleTitle>In vitro efficacy of bismuth thiols against biofilms formed by bacteria isolated from human chronic wounds.</ArticleTitle><Pagination><MedlinePgn>989-96</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-2672.2011.05110.x</ELocationID><Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">The purpose of this study was to evaluate the antimicrobial efficacy of thirteen bismuth thiol preparations for bactericidal activity against established biofilms formed by two bacteria isolated from human chronic wounds.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Single species biofilms of a Pseudomonas aeruginosa or a methicillin-resistant Staphylococcus aureus were grown in either colony biofilm or drip-flow reactors systems. Biofilms were challenged with bismuth thiols, antibiotics or silver sulfadiazine, and log reductions were determined by plating for colony formation.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Antibiotics were ineffective or inconsistent against biofilms of both bacterial species tested. None of the antibiotics tested were able to achieve >2 log reductions in both biofilm models. The 13 different bismuth thiols tested in this investigation achieved widely varying degrees of killing, even against the same micro-organism in the same biofilm model. For each micro-organism, the best bismuth thiol easily outperformed the best conventional antibiotic. Against P. aeruginosa biofilms, bismuth-2,3-dimercaptopropanol (BisBAL) at 40-80 μg ml⁻¹ achieved > 7·7 mean log reduction for the two biofilm models. Against MRSA biofilms, bismuth-1,3-propanedithiol/bismuth-2-mercaptopyridine N-oxide (BisBDT/PYR) achieved a 4·9 log reduction.</AbstractText><AbstractText Label="SIGNIFICANCE AND IMPACT OF THE STUDY" NlmCategory="CONCLUSIONS">Bismuth thiols are effective antimicrobial agents against biofilms formed by wound bacteria and merit further development as topical antiseptics for the suppression of biofilms in chronic wounds.</AbstractText><CopyrightInformation>© 2011 The Authors. Journal of Applied Microbiology © 2011 The Society for Applied Microbiology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Folsom</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Center for Biofilm Engineering, Montana State University, Bozeman, MT, USA Microbion Corporation, Bozeman, MT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Stewart</LastName><ForeName>P S</ForeName><Initials>PS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>08</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Appl Microbiol</MedlineTA><NlmUniqueID>9706280</NlmUniqueID><ISSNLinking>1364-5072</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009942">Organometallic Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013438">Sulfhydryl Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C103324">bismuth dimercaptopropanol</NameOfSubstance></Chemical><Chemical><RegistryNumber>0CPP32S55X</RegistryNumber><NameOfSubstance UI="D004112">Dimercaprol</NameOfSubstance></Chemical><Chemical><RegistryNumber>U015TT5I8H</RegistryNumber><NameOfSubstance UI="D001729">Bismuth</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001729" MajorTopicYN="N">Bismuth</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004112" MajorTopicYN="N">Dimercaprol</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055624" MajorTopicYN="N">Methicillin-Resistant Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050296" MajorTopicYN="N">Microbial Viability</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009942" MajorTopicYN="N">Organometallic Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011550" MajorTopicYN="N">Pseudomonas aeruginosa</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013438" MajorTopicYN="N">Sulfhydryl Compounds</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21794034</ArticleId><ArticleId IdType="doi">10.1111/j.1365-2672.2011.05110.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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