Highly potent bactericidal activity of porous metal-organic frameworks.
Identifieur interne : 000973 ( Main/Corpus ); précédent : 000972; suivant : 000974Highly potent bactericidal activity of porous metal-organic frameworks.
Auteurs : Wenjuan Zhuang ; Daqiang Yuan ; Jian-Rong Li ; Zhiping Luo ; Hong-Cai Zhou ; Sajid Bashir ; Jingbo LiuSource :
- Advanced healthcare materials [ 2192-2640 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Cobalt, Organic Chemicals.
- chemical , pharmacology : Anti-Bacterial Agents, Cobalt, Organic Chemicals.
- drug effects : Cell Survival, Escherichia coli.
- physiology : Escherichia coli.
- Porosity.
Abstract
Recent outbreaks of bacterial infection leading to human fatalities have been a motivational force for us to develop antibacterial agents with high potency and long-term stability. A novel cobalt (Co) based metal-organic framework (MOF) was tested and shown to be highly effective at inactivating model microorganisms. Gram-negative bacteria, Escherichia coli (strains DH5alpha and XL1-Blue) were selected to determine the antibacterial activities of the Co MOF. In this MOF, the Co serves as a central element and an octa-topic carboxylate ligand, tetrakis [(3,5-dicarboxyphenyl)-oxamethyl] methane (TDM(8-) ) serves as a bridging linker. X-ray crystallographic studies indicate that Co-TDM crystallizes in tetragonal space group P$\overline 4$2(1) m with a porous 3D framework. The potency of the Co-TDM disinfectant was evaluated using a minimal bactericidal concentration (MBC) benchmark and was determined to be 10-15 ppm within a short incubation time period (<60 min). Compared with previous work using silver nanoparticles and silver-modified TiO(2) nano- composites over the same time period, the MBC and effectiveness of Co-TDM are superior. Electron microscopy images indicate that the Co-TDM displayed distinctive grain boundaries and well-developed reticulates. The Co active sites rapidly catalyzed the lipid peroxidation, causing rupture of the bacterial membrane followed by inactivation, with 100% recycling and high persistence (>4 weeks). This MOF-based approach may lead to a new paradigm for MOF applications in diverse biological fields due to their inherent porous structure, tunable surface functional groups, and adjustable metal coordination environments.
DOI: 10.1002/adhm.201100043
PubMed: 23184726
Links to Exploration step
pubmed:23184726Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Highly potent bactericidal activity of porous metal-organic frameworks.</title><author><name sortKey="Zhuang, Wenjuan" sort="Zhuang, Wenjuan" uniqKey="Zhuang W" first="Wenjuan" last="Zhuang">Wenjuan Zhuang</name><affiliation><nlm:affiliation>Chemistry Department, Texas A&M University, College Station, TX 77843, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Daqiang" sort="Yuan, Daqiang" uniqKey="Yuan D" first="Daqiang" last="Yuan">Daqiang Yuan</name></author><author><name sortKey="Li, Jian Rong" sort="Li, Jian Rong" uniqKey="Li J" first="Jian-Rong" last="Li">Jian-Rong Li</name></author><author><name sortKey="Luo, Zhiping" sort="Luo, Zhiping" uniqKey="Luo Z" first="Zhiping" last="Luo">Zhiping Luo</name></author><author><name sortKey="Zhou, Hong Cai" sort="Zhou, Hong Cai" uniqKey="Zhou H" first="Hong-Cai" last="Zhou">Hong-Cai Zhou</name></author><author><name sortKey="Bashir, Sajid" sort="Bashir, Sajid" uniqKey="Bashir S" first="Sajid" last="Bashir">Sajid Bashir</name></author><author><name sortKey="Liu, Jingbo" sort="Liu, Jingbo" uniqKey="Liu J" first="Jingbo" last="Liu">Jingbo Liu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:23184726</idno><idno type="pmid">23184726</idno><idno type="doi">10.1002/adhm.201100043</idno><idno type="wicri:Area/Main/Corpus">000973</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000973</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Highly potent bactericidal activity of porous metal-organic frameworks.</title><author><name sortKey="Zhuang, Wenjuan" sort="Zhuang, Wenjuan" uniqKey="Zhuang W" first="Wenjuan" last="Zhuang">Wenjuan Zhuang</name><affiliation><nlm:affiliation>Chemistry Department, Texas A&M University, College Station, TX 77843, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Daqiang" sort="Yuan, Daqiang" uniqKey="Yuan D" first="Daqiang" last="Yuan">Daqiang Yuan</name></author><author><name sortKey="Li, Jian Rong" sort="Li, Jian Rong" uniqKey="Li J" first="Jian-Rong" last="Li">Jian-Rong Li</name></author><author><name sortKey="Luo, Zhiping" sort="Luo, Zhiping" uniqKey="Luo Z" first="Zhiping" last="Luo">Zhiping Luo</name></author><author><name sortKey="Zhou, Hong Cai" sort="Zhou, Hong Cai" uniqKey="Zhou H" first="Hong-Cai" last="Zhou">Hong-Cai Zhou</name></author><author><name sortKey="Bashir, Sajid" sort="Bashir, Sajid" uniqKey="Bashir S" first="Sajid" last="Bashir">Sajid Bashir</name></author><author><name sortKey="Liu, Jingbo" sort="Liu, Jingbo" uniqKey="Liu J" first="Jingbo" last="Liu">Jingbo Liu</name></author></analytic><series><title level="j">Advanced healthcare materials</title><idno type="ISSN">2192-2640</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Cell Survival (drug effects)</term><term>Cobalt (chemistry)</term><term>Cobalt (pharmacology)</term><term>Escherichia coli (drug effects)</term><term>Escherichia coli (physiology)</term><term>Organic Chemicals (chemistry)</term><term>Organic Chemicals (pharmacology)</term><term>Porosity (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Cobalt</term><term>Organic Chemicals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Cobalt</term><term>Organic Chemicals</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Escherichia coli</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Escherichia coli</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Porosity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent outbreaks of bacterial infection leading to human fatalities have been a motivational force for us to develop antibacterial agents with high potency and long-term stability. A novel cobalt (Co) based metal-organic framework (MOF) was tested and shown to be highly effective at inactivating model microorganisms. Gram-negative bacteria, Escherichia coli (strains DH5alpha and XL1-Blue) were selected to determine the antibacterial activities of the Co MOF. In this MOF, the Co serves as a central element and an octa-topic carboxylate ligand, tetrakis [(3,5-dicarboxyphenyl)-oxamethyl] methane (TDM(8-) ) serves as a bridging linker. X-ray crystallographic studies indicate that Co-TDM crystallizes in tetragonal space group P$\overline 4$2(1) m with a porous 3D framework. The potency of the Co-TDM disinfectant was evaluated using a minimal bactericidal concentration (MBC) benchmark and was determined to be 10-15 ppm within a short incubation time period (<60 min). Compared with previous work using silver nanoparticles and silver-modified TiO(2) nano- composites over the same time period, the MBC and effectiveness of Co-TDM are superior. Electron microscopy images indicate that the Co-TDM displayed distinctive grain boundaries and well-developed reticulates. The Co active sites rapidly catalyzed the lipid peroxidation, causing rupture of the bacterial membrane followed by inactivation, with 100% recycling and high persistence (>4 weeks). This MOF-based approach may lead to a new paradigm for MOF applications in diverse biological fields due to their inherent porous structure, tunable surface functional groups, and adjustable metal coordination environments.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23184726</PMID><DateCompleted><Year>2013</Year><Month>01</Month><Day>03</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">2192-2640</ISSN><JournalIssue CitedMedium="Print"><Volume>1</Volume><Issue>2</Issue><PubDate><Year>2012</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Advanced healthcare materials</Title><ISOAbbreviation>Adv Healthc Mater</ISOAbbreviation></Journal><ArticleTitle>Highly potent bactericidal activity of porous metal-organic frameworks.</ArticleTitle><Pagination><MedlinePgn>225-38</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/adhm.201100043</ELocationID><Abstract><AbstractText>Recent outbreaks of bacterial infection leading to human fatalities have been a motivational force for us to develop antibacterial agents with high potency and long-term stability. A novel cobalt (Co) based metal-organic framework (MOF) was tested and shown to be highly effective at inactivating model microorganisms. Gram-negative bacteria, Escherichia coli (strains DH5alpha and XL1-Blue) were selected to determine the antibacterial activities of the Co MOF. In this MOF, the Co serves as a central element and an octa-topic carboxylate ligand, tetrakis [(3,5-dicarboxyphenyl)-oxamethyl] methane (TDM(8-) ) serves as a bridging linker. X-ray crystallographic studies indicate that Co-TDM crystallizes in tetragonal space group P$\overline 4$2(1) m with a porous 3D framework. The potency of the Co-TDM disinfectant was evaluated using a minimal bactericidal concentration (MBC) benchmark and was determined to be 10-15 ppm within a short incubation time period (<60 min). Compared with previous work using silver nanoparticles and silver-modified TiO(2) nano- composites over the same time period, the MBC and effectiveness of Co-TDM are superior. Electron microscopy images indicate that the Co-TDM displayed distinctive grain boundaries and well-developed reticulates. The Co active sites rapidly catalyzed the lipid peroxidation, causing rupture of the bacterial membrane followed by inactivation, with 100% recycling and high persistence (>4 weeks). This MOF-based approach may lead to a new paradigm for MOF applications in diverse biological fields due to their inherent porous structure, tunable surface functional groups, and adjustable metal coordination environments.</AbstractText><CopyrightInformation>Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhuang</LastName><ForeName>Wenjuan</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Chemistry Department, Texas A&M University, College Station, TX 77843, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Daqiang</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jian-Rong</ForeName><Initials>JR</Initials></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Zhiping</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Hong-Cai</ForeName><Initials>HC</Initials></Author><Author ValidYN="Y"><LastName>Bashir</LastName><ForeName>Sajid</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jingbo</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Adv Healthc Mater</MedlineTA><NlmUniqueID>101581613</NlmUniqueID><ISSNLinking>2192-2640</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009930">Organic Chemicals</NameOfSubstance></Chemical><Chemical><RegistryNumber>3G0H8C9362</RegistryNumber><NameOfSubstance UI="D003035">Cobalt</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003035" MajorTopicYN="N">Cobalt</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009930" MajorTopicYN="N">Organic Chemicals</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016062" MajorTopicYN="N">Porosity</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>12</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2012</Year><Month>01</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>11</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>1</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23184726</ArticleId><ArticleId IdType="doi">10.1002/adhm.201100043</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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