An innovative approach to treating dental decay in children. A new anti-caries agent.
Identifieur interne : 000844 ( Main/Corpus ); précédent : 000843; suivant : 000845An innovative approach to treating dental decay in children. A new anti-caries agent.
Auteurs : Andréa Gadelha Ribeiro Targino ; Miguel Angel Pelagio Flores ; Valdeci Elias Dos Santos Junior ; Fabiana De Godoy Bené Bezerra ; Hilzeth De Luna Freire ; André Galembeck ; Aronita RosenblattSource :
- Journal of materials science. Materials in medicine [ 1573-4838 ] ; 2014.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (pharmacology), Anti-Bacterial Agents (therapeutic use), Child (MeSH), Dental Caries (drug therapy), Humans (MeSH), Metal Nanoparticles (MeSH), Microbial Sensitivity Tests (MeSH), Microscopy, Electron, Transmission (MeSH), Spectrophotometry, Ultraviolet (MeSH), Streptococcus mutans (drug effects).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents.
- chemical , therapeutic use : Anti-Bacterial Agents.
- drug effects : Streptococcus mutans.
- drug therapy : Dental Caries.
- Child, Humans, Metal Nanoparticles, Microbial Sensitivity Tests, Microscopy, Electron, Transmission, Spectrophotometry, Ultraviolet.
Abstract
The aim of this work is to evaluate the antimicrobial and cytotoxic activity of a formulation containing silver nanoparticles and chitosan, provisionally called nano silver fluoride (NSF), against Streptococcus mutans in comparison to chlorhexidine and silver diamine fluoride (SDF). The product was characterised by transmission electron microscopy and UV-Vis absorption spectroscopy. The minimum inhibition concentration (MIC) was evaluated by the spectrophotometric microdilution method and turbidity. The minimum bactericide concentration (MBC) was evaluated in brain heart infusion plates, and cytotoxicity was evaluated by haemolytic activity. The MIC and MBC for NSF were, respectively, 33.54 ± 14.52 and 50.32 µg/mL; for SDF were 33.33 ± 14.43 and 50.0 µg/mL, respectively; and for CHX were 3.3 ± 0.5 and 6 µg/mL, respectively. An ANOVA for MIC gave P = 0.032, and for MBC P = 0.035. The cytotoxic effect of NSF compared to SDF demonstrated a statistically significant difference in the MIC value (t test P < 0.05). The NSF formulation may be effective against S. mutans with much lower doses, may have lower toxicity than SDF, and may not stain teeth.
DOI: 10.1007/s10856-014-5221-5
PubMed: 24818873
Links to Exploration step
pubmed:24818873Le document en format XML
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<front><div type="abstract" xml:lang="en">The aim of this work is to evaluate the antimicrobial and cytotoxic activity of a formulation containing silver nanoparticles and chitosan, provisionally called nano silver fluoride (NSF), against Streptococcus mutans in comparison to chlorhexidine and silver diamine fluoride (SDF). The product was characterised by transmission electron microscopy and UV-Vis absorption spectroscopy. The minimum inhibition concentration (MIC) was evaluated by the spectrophotometric microdilution method and turbidity. The minimum bactericide concentration (MBC) was evaluated in brain heart infusion plates, and cytotoxicity was evaluated by haemolytic activity. The MIC and MBC for NSF were, respectively, 33.54 ± 14.52 and 50.32 µg/mL; for SDF were 33.33 ± 14.43 and 50.0 µg/mL, respectively; and for CHX were 3.3 ± 0.5 and 6 µg/mL, respectively. An ANOVA for MIC gave P = 0.032, and for MBC P = 0.035. The cytotoxic effect of NSF compared to SDF demonstrated a statistically significant difference in the MIC value (t test P < 0.05). The NSF formulation may be effective against S. mutans with much lower doses, may have lower toxicity than SDF, and may not stain teeth. </div>
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<Abstract><AbstractText>The aim of this work is to evaluate the antimicrobial and cytotoxic activity of a formulation containing silver nanoparticles and chitosan, provisionally called nano silver fluoride (NSF), against Streptococcus mutans in comparison to chlorhexidine and silver diamine fluoride (SDF). The product was characterised by transmission electron microscopy and UV-Vis absorption spectroscopy. The minimum inhibition concentration (MIC) was evaluated by the spectrophotometric microdilution method and turbidity. The minimum bactericide concentration (MBC) was evaluated in brain heart infusion plates, and cytotoxicity was evaluated by haemolytic activity. The MIC and MBC for NSF were, respectively, 33.54 ± 14.52 and 50.32 µg/mL; for SDF were 33.33 ± 14.43 and 50.0 µg/mL, respectively; and for CHX were 3.3 ± 0.5 and 6 µg/mL, respectively. An ANOVA for MIC gave P = 0.032, and for MBC P = 0.035. The cytotoxic effect of NSF compared to SDF demonstrated a statistically significant difference in the MIC value (t test P < 0.05). The NSF formulation may be effective against S. mutans with much lower doses, may have lower toxicity than SDF, and may not stain teeth. </AbstractText>
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