An innovative approach to treating dental decay in children. A new anti-caries agent.
Identifieur interne : 000844 ( Main/Corpus ); précédent : 000843; suivant : 000845An innovative approach to treating dental decay in children. A new anti-caries agent.
Auteurs : Andréa Gadelha Ribeiro Targino ; Miguel Angel Pelagio Flores ; Valdeci Elias Dos Santos Junior ; Fabiana De Godoy Bené Bezerra ; Hilzeth De Luna Freire ; André Galembeck ; Aronita RosenblattSource :
- Journal of materials science. Materials in medicine [ 1573-4838 ] ; 2014.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (pharmacology), Anti-Bacterial Agents (therapeutic use), Child (MeSH), Dental Caries (drug therapy), Humans (MeSH), Metal Nanoparticles (MeSH), Microbial Sensitivity Tests (MeSH), Microscopy, Electron, Transmission (MeSH), Spectrophotometry, Ultraviolet (MeSH), Streptococcus mutans (drug effects).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents.
- chemical , therapeutic use : Anti-Bacterial Agents.
- drug effects : Streptococcus mutans.
- drug therapy : Dental Caries.
- Child, Humans, Metal Nanoparticles, Microbial Sensitivity Tests, Microscopy, Electron, Transmission, Spectrophotometry, Ultraviolet.
Abstract
The aim of this work is to evaluate the antimicrobial and cytotoxic activity of a formulation containing silver nanoparticles and chitosan, provisionally called nano silver fluoride (NSF), against Streptococcus mutans in comparison to chlorhexidine and silver diamine fluoride (SDF). The product was characterised by transmission electron microscopy and UV-Vis absorption spectroscopy. The minimum inhibition concentration (MIC) was evaluated by the spectrophotometric microdilution method and turbidity. The minimum bactericide concentration (MBC) was evaluated in brain heart infusion plates, and cytotoxicity was evaluated by haemolytic activity. The MIC and MBC for NSF were, respectively, 33.54 ± 14.52 and 50.32 µg/mL; for SDF were 33.33 ± 14.43 and 50.0 µg/mL, respectively; and for CHX were 3.3 ± 0.5 and 6 µg/mL, respectively. An ANOVA for MIC gave P = 0.032, and for MBC P = 0.035. The cytotoxic effect of NSF compared to SDF demonstrated a statistically significant difference in the MIC value (t test P < 0.05). The NSF formulation may be effective against S. mutans with much lower doses, may have lower toxicity than SDF, and may not stain teeth.
DOI: 10.1007/s10856-014-5221-5
PubMed: 24818873
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pubmed:24818873Le document en format XML
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Newton Cavalcanti nº 1650, Camaragibe, PE, CEP 54 753-020, Brazil, andreadoutorado@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Flores, Miguel Angel Pelagio" sort="Flores, Miguel Angel Pelagio" uniqKey="Flores M" first="Miguel Angel Pelagio" last="Flores">Miguel Angel Pelagio Flores</name></author><author><name sortKey="Dos Santos Junior, Valdeci Elias" sort="Dos Santos Junior, Valdeci Elias" uniqKey="Dos Santos Junior V" first="Valdeci Elias" last="Dos Santos Junior">Valdeci Elias Dos Santos Junior</name></author><author><name sortKey="De Godoy Bene Bezerra, Fabiana" sort="De Godoy Bene Bezerra, Fabiana" uniqKey="De Godoy Bene Bezerra F" first="Fabiana" last="De Godoy Bené Bezerra">Fabiana De Godoy Bené Bezerra</name></author><author><name sortKey="De Luna Freire, Hilzeth" sort="De Luna Freire, Hilzeth" uniqKey="De Luna Freire H" first="Hilzeth" last="De Luna Freire">Hilzeth De Luna Freire</name></author><author><name sortKey="Galembeck, Andre" sort="Galembeck, Andre" uniqKey="Galembeck A" first="André" last="Galembeck">André Galembeck</name></author><author><name sortKey="Rosenblatt, Aronita" sort="Rosenblatt, Aronita" uniqKey="Rosenblatt A" first="Aronita" last="Rosenblatt">Aronita Rosenblatt</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24818873</idno><idno type="pmid">24818873</idno><idno type="doi">10.1007/s10856-014-5221-5</idno><idno type="wicri:Area/Main/Corpus">000844</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000844</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An innovative approach to treating dental decay in children. A new anti-caries agent.</title><author><name sortKey="Targino, Andrea Gadelha Ribeiro" sort="Targino, Andrea Gadelha Ribeiro" uniqKey="Targino A" first="Andréa Gadelha Ribeiro" last="Targino">Andréa Gadelha Ribeiro Targino</name><affiliation><nlm:affiliation>Department of Paediatric Dentistry, Faculty of Dentistry, University of Pernambuco, Av: Gal. Newton Cavalcanti nº 1650, Camaragibe, PE, CEP 54 753-020, Brazil, andreadoutorado@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Flores, Miguel Angel Pelagio" sort="Flores, Miguel Angel Pelagio" uniqKey="Flores M" first="Miguel Angel Pelagio" last="Flores">Miguel Angel Pelagio Flores</name></author><author><name sortKey="Dos Santos Junior, Valdeci Elias" sort="Dos Santos Junior, Valdeci Elias" uniqKey="Dos Santos Junior V" first="Valdeci Elias" last="Dos Santos Junior">Valdeci Elias Dos Santos Junior</name></author><author><name sortKey="De Godoy Bene Bezerra, Fabiana" sort="De Godoy Bene Bezerra, Fabiana" uniqKey="De Godoy Bene Bezerra F" first="Fabiana" last="De Godoy Bené Bezerra">Fabiana De Godoy Bené Bezerra</name></author><author><name sortKey="De Luna Freire, Hilzeth" sort="De Luna Freire, Hilzeth" uniqKey="De Luna Freire H" first="Hilzeth" last="De Luna Freire">Hilzeth De Luna Freire</name></author><author><name sortKey="Galembeck, Andre" sort="Galembeck, Andre" uniqKey="Galembeck A" first="André" last="Galembeck">André Galembeck</name></author><author><name sortKey="Rosenblatt, Aronita" sort="Rosenblatt, Aronita" uniqKey="Rosenblatt A" first="Aronita" last="Rosenblatt">Aronita Rosenblatt</name></author></analytic><series><title level="j">Journal of materials science. Materials in medicine</title><idno type="eISSN">1573-4838</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (pharmacology)</term><term>Anti-Bacterial Agents (therapeutic use)</term><term>Child (MeSH)</term><term>Dental Caries (drug therapy)</term><term>Humans (MeSH)</term><term>Metal Nanoparticles (MeSH)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Microscopy, Electron, Transmission (MeSH)</term><term>Spectrophotometry, Ultraviolet (MeSH)</term><term>Streptococcus mutans (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Streptococcus mutans</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dental Caries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Humans</term><term>Metal Nanoparticles</term><term>Microbial Sensitivity Tests</term><term>Microscopy, Electron, Transmission</term><term>Spectrophotometry, Ultraviolet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work is to evaluate the antimicrobial and cytotoxic activity of a formulation containing silver nanoparticles and chitosan, provisionally called nano silver fluoride (NSF), against Streptococcus mutans in comparison to chlorhexidine and silver diamine fluoride (SDF). The product was characterised by transmission electron microscopy and UV-Vis absorption spectroscopy. The minimum inhibition concentration (MIC) was evaluated by the spectrophotometric microdilution method and turbidity. The minimum bactericide concentration (MBC) was evaluated in brain heart infusion plates, and cytotoxicity was evaluated by haemolytic activity. The MIC and MBC for NSF were, respectively, 33.54 ± 14.52 and 50.32 µg/mL; for SDF were 33.33 ± 14.43 and 50.0 µg/mL, respectively; and for CHX were 3.3 ± 0.5 and 6 µg/mL, respectively. An ANOVA for MIC gave P = 0.032, and for MBC P = 0.035. The cytotoxic effect of NSF compared to SDF demonstrated a statistically significant difference in the MIC value (t test P < 0.05). The NSF formulation may be effective against S. mutans with much lower doses, may have lower toxicity than SDF, and may not stain teeth. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24818873</PMID><DateCompleted><Year>2015</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-4838</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>8</Issue><PubDate><Year>2014</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of materials science. Materials in medicine</Title><ISOAbbreviation>J Mater Sci Mater Med</ISOAbbreviation></Journal><ArticleTitle>An innovative approach to treating dental decay in children. A new anti-caries agent.</ArticleTitle><Pagination><MedlinePgn>2041-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s10856-014-5221-5</ELocationID><Abstract><AbstractText>The aim of this work is to evaluate the antimicrobial and cytotoxic activity of a formulation containing silver nanoparticles and chitosan, provisionally called nano silver fluoride (NSF), against Streptococcus mutans in comparison to chlorhexidine and silver diamine fluoride (SDF). The product was characterised by transmission electron microscopy and UV-Vis absorption spectroscopy. The minimum inhibition concentration (MIC) was evaluated by the spectrophotometric microdilution method and turbidity. The minimum bactericide concentration (MBC) was evaluated in brain heart infusion plates, and cytotoxicity was evaluated by haemolytic activity. The MIC and MBC for NSF were, respectively, 33.54 ± 14.52 and 50.32 µg/mL; for SDF were 33.33 ± 14.43 and 50.0 µg/mL, respectively; and for CHX were 3.3 ± 0.5 and 6 µg/mL, respectively. An ANOVA for MIC gave P = 0.032, and for MBC P = 0.035. The cytotoxic effect of NSF compared to SDF demonstrated a statistically significant difference in the MIC value (t test P < 0.05). The NSF formulation may be effective against S. mutans with much lower doses, may have lower toxicity than SDF, and may not stain teeth. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Targino</LastName><ForeName>Andréa Gadelha Ribeiro</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Paediatric Dentistry, Faculty of Dentistry, University of Pernambuco, Av: Gal. Newton Cavalcanti nº 1650, Camaragibe, PE, CEP 54 753-020, Brazil, andreadoutorado@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Flores</LastName><ForeName>Miguel Angel Pelagio</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>dos Santos Junior</LastName><ForeName>Valdeci Elias</ForeName><Initials>VE</Initials></Author><Author ValidYN="Y"><LastName>de Godoy Bené Bezerra</LastName><ForeName>Fabiana</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>de Luna Freire</LastName><ForeName>Hilzeth</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Galembeck</LastName><ForeName>André</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rosenblatt</LastName><ForeName>Aronita</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, 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