Hemocompatible, antioxidative and antibacterial polypropylene prepared by attaching silver nanoparticles capped with TPGS.
Identifieur interne : 000721 ( Main/Corpus ); précédent : 000720; suivant : 000722Hemocompatible, antioxidative and antibacterial polypropylene prepared by attaching silver nanoparticles capped with TPGS.
Auteurs : Chunming Li ; Bing Cai ; Jing Jin ; Jingchuan Liu ; Xiaodong Xu ; Jinghua Yin ; Ligang YinSource :
- Journal of materials chemistry. B [ 2050-7518 ] ; 2015.
Abstract
Infections associated with medical devices cause significant costs, morbidity, and mortality. Medical devices with hemocompatibility, antioxidative stress, and antibacterial properties are difficult to fabricate. In this study, silver nanoparticles (Ag NPs) were synthesized for the first time in the presence of carboxylic d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as antibacterial agents. The Ag NPs were characterized by UV-visible spectroscopy, transmission electron microscopy, and zeta potential measurements. The results showed that Ag NPs had a good dispersion stability and uniform size distribution. The introduction of TPGS dispersed the Ag NPs in solution and provided active protection against Ag NP-induced free radical damage. N-Isopropylacrylamide (NIPAAm) and N-(3-aminopropyl) methacrylamide hydrochloride (APMA) were then co-grafted onto polypropylene (PP) membranes by ultraviolet grafting, which can provide antifouling properties. The modified PP surface can be used as a platform to load the Ag NPs capped with TPGS. The loading efficiency of Ag NPs was mediated by electrostatic interactions between the positively charged APMA and the negatively charged Ag NPs. The loaded TPGS can slow the lipid peroxidation of erythrocytes and fill the lipid bilayer of erythrocytes to prevent antioxidative stress and hemolysis. The bacteria adhesion, bacterial activity, and biofilm formation proved that the modified PP surfaces loaded with Ag NPs had excellent antibacterial and bactericidal properties. Therefore, our approach can serve as a basis for developing medical devices with excellent hemocompatibility, as well as simultaneous antioxidative and antibacterial properties, thereby providing a potential prevention measure of medical-device-associated infections.
DOI: 10.1039/c5tb01554e
PubMed: 32262894
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China. jjin@ciac.ac.cn yinjh@ciac.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Cai, Bing" sort="Cai, Bing" uniqKey="Cai B" first="Bing" last="Cai">Bing Cai</name></author><author><name sortKey="Jin, Jing" sort="Jin, Jing" uniqKey="Jin J" first="Jing" last="Jin">Jing Jin</name></author><author><name sortKey="Liu, Jingchuan" sort="Liu, Jingchuan" uniqKey="Liu J" first="Jingchuan" last="Liu">Jingchuan Liu</name></author><author><name sortKey="Xu, Xiaodong" sort="Xu, Xiaodong" uniqKey="Xu X" first="Xiaodong" last="Xu">Xiaodong Xu</name></author><author><name sortKey="Yin, Jinghua" sort="Yin, Jinghua" uniqKey="Yin J" first="Jinghua" last="Yin">Jinghua Yin</name></author><author><name sortKey="Yin, Ligang" sort="Yin, Ligang" uniqKey="Yin L" first="Ligang" last="Yin">Ligang Yin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:32262894</idno><idno type="pmid">32262894</idno><idno type="doi">10.1039/c5tb01554e</idno><idno type="wicri:Area/Main/Corpus">000721</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000721</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hemocompatible, antioxidative and antibacterial polypropylene prepared by attaching silver nanoparticles capped with TPGS.</title><author><name sortKey="Li, Chunming" sort="Li, Chunming" uniqKey="Li C" first="Chunming" last="Li">Chunming Li</name><affiliation><nlm:affiliation>State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. jjin@ciac.ac.cn yinjh@ciac.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Cai, Bing" sort="Cai, Bing" uniqKey="Cai B" first="Bing" last="Cai">Bing Cai</name></author><author><name sortKey="Jin, Jing" sort="Jin, Jing" uniqKey="Jin J" first="Jing" last="Jin">Jing Jin</name></author><author><name sortKey="Liu, Jingchuan" sort="Liu, Jingchuan" uniqKey="Liu J" first="Jingchuan" last="Liu">Jingchuan Liu</name></author><author><name sortKey="Xu, Xiaodong" sort="Xu, Xiaodong" uniqKey="Xu X" first="Xiaodong" last="Xu">Xiaodong Xu</name></author><author><name sortKey="Yin, Jinghua" sort="Yin, Jinghua" uniqKey="Yin J" first="Jinghua" last="Yin">Jinghua Yin</name></author><author><name sortKey="Yin, Ligang" sort="Yin, Ligang" uniqKey="Yin L" first="Ligang" last="Yin">Ligang Yin</name></author></analytic><series><title level="j">Journal of materials chemistry. B</title><idno type="eISSN">2050-7518</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infections associated with medical devices cause significant costs, morbidity, and mortality. Medical devices with hemocompatibility, antioxidative stress, and antibacterial properties are difficult to fabricate. In this study, silver nanoparticles (Ag NPs) were synthesized for the first time in the presence of carboxylic d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as antibacterial agents. The Ag NPs were characterized by UV-visible spectroscopy, transmission electron microscopy, and zeta potential measurements. The results showed that Ag NPs had a good dispersion stability and uniform size distribution. The introduction of TPGS dispersed the Ag NPs in solution and provided active protection against Ag NP-induced free radical damage. N-Isopropylacrylamide (NIPAAm) and N-(3-aminopropyl) methacrylamide hydrochloride (APMA) were then co-grafted onto polypropylene (PP) membranes by ultraviolet grafting, which can provide antifouling properties. The modified PP surface can be used as a platform to load the Ag NPs capped with TPGS. The loading efficiency of Ag NPs was mediated by electrostatic interactions between the positively charged APMA and the negatively charged Ag NPs. The loaded TPGS can slow the lipid peroxidation of erythrocytes and fill the lipid bilayer of erythrocytes to prevent antioxidative stress and hemolysis. The bacteria adhesion, bacterial activity, and biofilm formation proved that the modified PP surfaces loaded with Ag NPs had excellent antibacterial and bactericidal properties. Therefore, our approach can serve as a basis for developing medical devices with excellent hemocompatibility, as well as simultaneous antioxidative and antibacterial properties, thereby providing a potential prevention measure of medical-device-associated infections.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32262894</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2050-7518</ISSN><JournalIssue CitedMedium="Internet"><Volume>3</Volume><Issue>42</Issue><PubDate><Year>2015</Year><Month>Nov</Month><Day>14</Day></PubDate></JournalIssue><Title>Journal of materials chemistry. B</Title><ISOAbbreviation>J Mater Chem B</ISOAbbreviation></Journal><ArticleTitle>Hemocompatible, antioxidative and antibacterial polypropylene prepared by attaching silver nanoparticles capped with TPGS.</ArticleTitle><Pagination><MedlinePgn>8410-8420</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c5tb01554e</ELocationID><Abstract><AbstractText>Infections associated with medical devices cause significant costs, morbidity, and mortality. Medical devices with hemocompatibility, antioxidative stress, and antibacterial properties are difficult to fabricate. In this study, silver nanoparticles (Ag NPs) were synthesized for the first time in the presence of carboxylic d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as antibacterial agents. The Ag NPs were characterized by UV-visible spectroscopy, transmission electron microscopy, and zeta potential measurements. The results showed that Ag NPs had a good dispersion stability and uniform size distribution. The introduction of TPGS dispersed the Ag NPs in solution and provided active protection against Ag NP-induced free radical damage. N-Isopropylacrylamide (NIPAAm) and N-(3-aminopropyl) methacrylamide hydrochloride (APMA) were then co-grafted onto polypropylene (PP) membranes by ultraviolet grafting, which can provide antifouling properties. The modified PP surface can be used as a platform to load the Ag NPs capped with TPGS. The loading efficiency of Ag NPs was mediated by electrostatic interactions between the positively charged APMA and the negatively charged Ag NPs. The loaded TPGS can slow the lipid peroxidation of erythrocytes and fill the lipid bilayer of erythrocytes to prevent antioxidative stress and hemolysis. The bacteria adhesion, bacterial activity, and biofilm formation proved that the modified PP surfaces loaded with Ag NPs had excellent antibacterial and bactericidal properties. Therefore, our approach can serve as a basis for developing medical devices with excellent hemocompatibility, as well as simultaneous antioxidative and antibacterial properties, thereby providing a potential prevention measure of medical-device-associated infections.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chunming</ForeName><Initials>C</Initials><Suffix></Suffix><AffiliationInfo><Affiliation>State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. jjin@ciac.ac.cn yinjh@ciac.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Bing</ForeName><Initials>B</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Jin</LastName><ForeName>Jing</ForeName><Initials>J</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jingchuan</ForeName><Initials>J</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Xiaodong</ForeName><Initials>X</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Jinghua</ForeName><Initials>J</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Yin</LastName><ForeName>Ligang</ForeName><Initials>L</Initials><Suffix></Suffix></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Mater Chem B</MedlineTA><NlmUniqueID>101598493</NlmUniqueID><ISSNLinking>2050-750X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>11</Month><Day>14</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>11</Month><Day>14</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32262894</ArticleId><ArticleId IdType="doi">10.1039/c5tb01554e</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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