Fabrication of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays for enhancing bactericidal effect and osteoinductivity.
Identifieur interne : 000672 ( Main/Corpus ); précédent : 000671; suivant : 000673Fabrication of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays for enhancing bactericidal effect and osteoinductivity.
Auteurs : Bo Tian ; Wei Chen ; Degang Yu ; Yong Lei ; Qinfei Ke ; Yaping Guo ; Zhenan ZhuSource :
- Journal of the mechanical behavior of biomedical materials [ 1878-0180 ] ; 2016.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Cells, Cultured (MeSH), Coated Materials, Biocompatible (MeSH), Durapatite (chemistry), Humans (MeSH), Metal Nanoparticles (chemistry), Microscopy, Electron, Scanning (MeSH), Silver (chemistry), Staphylococcus aureus (MeSH), Stromal Cells (cytology), Titanium (MeSH), X-Ray Diffraction (MeSH).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Durapatite, Silver.
- chemistry : Metal Nanoparticles.
- cytology : Stromal Cells.
- Cells, Cultured, Coated Materials, Biocompatible, Humans, Microscopy, Electron, Scanning, Staphylococcus aureus, Titanium, X-Ray Diffraction.
Abstract
Implant-associated infection is a common postoperative complication and remains a serious problem in orthopedic surgery. This work describes the synthesis of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays (AgNP-BHAC). The resulting nanostructure was investigated using scanning electron microscopy, energy-dispersive spectrometry, transmission electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy. AgNP-BHAC exhibited excellent antimicrobial activity toward gram-negative Escherichia coli and gram-positive Staphylococcus aureus owing to the antibacterial effects of the silver nanoparticles. Human bone marrow stromal cells (hBMSC) culture revealed that the AgNP-BHAC exhibited better biocompatibility, and permitted improved cell proliferation, attachment, and osteoinductivity than uncoated Ti-6Al-4V titanium alloy, the favored material for biomedical applications. In summary, this study presents a convenient and effective method for the incorporation of silver into HA coatings with block morphology. This method can be utilized to modify a variety of metallic implant surfaces to improve their antimicrobial effects and reduce potential long-term cytotoxicity.
DOI: 10.1016/j.jmbbm.2016.04.002
PubMed: 27107263
Links to Exploration step
pubmed:27107263Le document en format XML
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<term>Durapatite (chemistry)</term>
<term>Humans (MeSH)</term>
<term>Metal Nanoparticles (chemistry)</term>
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<front><div type="abstract" xml:lang="en">Implant-associated infection is a common postoperative complication and remains a serious problem in orthopedic surgery. This work describes the synthesis of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays (AgNP-BHAC). The resulting nanostructure was investigated using scanning electron microscopy, energy-dispersive spectrometry, transmission electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy. AgNP-BHAC exhibited excellent antimicrobial activity toward gram-negative Escherichia coli and gram-positive Staphylococcus aureus owing to the antibacterial effects of the silver nanoparticles. Human bone marrow stromal cells (hBMSC) culture revealed that the AgNP-BHAC exhibited better biocompatibility, and permitted improved cell proliferation, attachment, and osteoinductivity than uncoated Ti-6Al-4V titanium alloy, the favored material for biomedical applications. In summary, this study presents a convenient and effective method for the incorporation of silver into HA coatings with block morphology. This method can be utilized to modify a variety of metallic implant surfaces to improve their antimicrobial effects and reduce potential long-term cytotoxicity.</div>
</front>
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<Abstract><AbstractText>Implant-associated infection is a common postoperative complication and remains a serious problem in orthopedic surgery. This work describes the synthesis of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays (AgNP-BHAC). The resulting nanostructure was investigated using scanning electron microscopy, energy-dispersive spectrometry, transmission electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy. AgNP-BHAC exhibited excellent antimicrobial activity toward gram-negative Escherichia coli and gram-positive Staphylococcus aureus owing to the antibacterial effects of the silver nanoparticles. Human bone marrow stromal cells (hBMSC) culture revealed that the AgNP-BHAC exhibited better biocompatibility, and permitted improved cell proliferation, attachment, and osteoinductivity than uncoated Ti-6Al-4V titanium alloy, the favored material for biomedical applications. In summary, this study presents a convenient and effective method for the incorporation of silver into HA coatings with block morphology. This method can be utilized to modify a variety of metallic implant surfaces to improve their antimicrobial effects and reduce potential long-term cytotoxicity.</AbstractText>
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