Electron transfer driven highly valent silver for chronic wound treatment.
Identifieur interne : 000626 ( Main/Corpus ); précédent : 000625; suivant : 000627Electron transfer driven highly valent silver for chronic wound treatment.
Auteurs : K. Yang ; J. Liu ; H G Shi ; W. Zhang ; W. Qu ; G X Wang ; P L Wang ; J H JiSource :
- Journal of materials chemistry. B [ 2050-7518 ] ; 2016.
Abstract
Although silver is widely added to various chronic wounds to kill higher concentrations (107-108 CFU mL-1) of bacteria, overdose of silver remains a major cause of diverse side effects, such as cytotoxicity and tissue and organ damage. Here we showed that reducing the dose level of silver, additionally conferring electron transfer potential, could simultaneously achieve good biocompatibility and strong bactericidal ability without introducing extra chemical residuals for chronic wound treatment. A systematic investigation demonstrated that 1 ppm trivalent silver ions performed rapid (5 min) and effective antibacterial activities against pathogens while not significantly affecting cell viability which were equivalent to 20 ppm monovalent silver ions with cytotoxicity, and accelerated the healing process and improved the tissue quality of burn wounds. The killing effect is independent of material and is mainly controlled by the electron transfer potentials of trivalent silver ions, which disrupts the electron transport of bacteria membrane respiration and leads to the death of bacteria. Together, such trivalent silver opens up new possibilities for dispelling the concern of silver usage in biosafety and provides an avenue for designing antibiotics or other biomedical applications.
DOI: 10.1039/c6tb01339b
PubMed: 32263864
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Electron transfer driven highly valent silver for chronic wound treatment.</title><author><name sortKey="Yang, K" sort="Yang, K" uniqKey="Yang K" first="K" last="Yang">K. Yang</name><affiliation><nlm:affiliation>Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. weizhang@mail.ipc.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, J" sort="Liu, J" uniqKey="Liu J" first="J" last="Liu">J. Liu</name></author><author><name sortKey="Shi, H G" sort="Shi, H G" uniqKey="Shi H" first="H G" last="Shi">H G Shi</name></author><author><name sortKey="Zhang, W" sort="Zhang, W" uniqKey="Zhang W" first="W" last="Zhang">W. Zhang</name></author><author><name sortKey="Qu, W" sort="Qu, W" uniqKey="Qu W" first="W" last="Qu">W. Qu</name></author><author><name sortKey="Wang, G X" sort="Wang, G X" uniqKey="Wang G" first="G X" last="Wang">G X Wang</name></author><author><name sortKey="Wang, P L" sort="Wang, P L" uniqKey="Wang P" first="P L" last="Wang">P L Wang</name></author><author><name sortKey="Ji, J H" sort="Ji, J H" uniqKey="Ji J" first="J H" last="Ji">J H Ji</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:32263864</idno><idno type="pmid">32263864</idno><idno type="doi">10.1039/c6tb01339b</idno><idno type="wicri:Area/Main/Corpus">000626</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000626</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Electron transfer driven highly valent silver for chronic wound treatment.</title><author><name sortKey="Yang, K" sort="Yang, K" uniqKey="Yang K" first="K" last="Yang">K. Yang</name><affiliation><nlm:affiliation>Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. weizhang@mail.ipc.ac.cn.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, J" sort="Liu, J" uniqKey="Liu J" first="J" last="Liu">J. Liu</name></author><author><name sortKey="Shi, H G" sort="Shi, H G" uniqKey="Shi H" first="H G" last="Shi">H G Shi</name></author><author><name sortKey="Zhang, W" sort="Zhang, W" uniqKey="Zhang W" first="W" last="Zhang">W. Zhang</name></author><author><name sortKey="Qu, W" sort="Qu, W" uniqKey="Qu W" first="W" last="Qu">W. Qu</name></author><author><name sortKey="Wang, G X" sort="Wang, G X" uniqKey="Wang G" first="G X" last="Wang">G X Wang</name></author><author><name sortKey="Wang, P L" sort="Wang, P L" uniqKey="Wang P" first="P L" last="Wang">P L Wang</name></author><author><name sortKey="Ji, J H" sort="Ji, J H" uniqKey="Ji J" first="J H" last="Ji">J H Ji</name></author></analytic><series><title level="j">Journal of materials chemistry. B</title><idno type="eISSN">2050-7518</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although silver is widely added to various chronic wounds to kill higher concentrations (10<sup>7</sup>-10<sup>8</sup> CFU mL<sup>-1</sup>) of bacteria, overdose of silver remains a major cause of diverse side effects, such as cytotoxicity and tissue and organ damage. Here we showed that reducing the dose level of silver, additionally conferring electron transfer potential, could simultaneously achieve good biocompatibility and strong bactericidal ability without introducing extra chemical residuals for chronic wound treatment. A systematic investigation demonstrated that 1 ppm trivalent silver ions performed rapid (5 min) and effective antibacterial activities against pathogens while not significantly affecting cell viability which were equivalent to 20 ppm monovalent silver ions with cytotoxicity, and accelerated the healing process and improved the tissue quality of burn wounds. The killing effect is independent of material and is mainly controlled by the electron transfer potentials of trivalent silver ions, which disrupts the electron transport of bacteria membrane respiration and leads to the death of bacteria. Together, such trivalent silver opens up new possibilities for dispelling the concern of silver usage in biosafety and provides an avenue for designing antibiotics or other biomedical applications.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32263864</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2050-7518</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>34</Issue><PubDate><Year>2016</Year><Month>Sep</Month><Day>14</Day></PubDate></JournalIssue><Title>Journal of materials chemistry. B</Title><ISOAbbreviation>J Mater Chem B</ISOAbbreviation></Journal><ArticleTitle>Electron transfer driven highly valent silver for chronic wound treatment.</ArticleTitle><Pagination><MedlinePgn>5729-5736</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c6tb01339b</ELocationID><Abstract><AbstractText>Although silver is widely added to various chronic wounds to kill higher concentrations (10<sup>7</sup>-10<sup>8</sup> CFU mL<sup>-1</sup>) of bacteria, overdose of silver remains a major cause of diverse side effects, such as cytotoxicity and tissue and organ damage. Here we showed that reducing the dose level of silver, additionally conferring electron transfer potential, could simultaneously achieve good biocompatibility and strong bactericidal ability without introducing extra chemical residuals for chronic wound treatment. A systematic investigation demonstrated that 1 ppm trivalent silver ions performed rapid (5 min) and effective antibacterial activities against pathogens while not significantly affecting cell viability which were equivalent to 20 ppm monovalent silver ions with cytotoxicity, and accelerated the healing process and improved the tissue quality of burn wounds. The killing effect is independent of material and is mainly controlled by the electron transfer potentials of trivalent silver ions, which disrupts the electron transport of bacteria membrane respiration and leads to the death of bacteria. Together, such trivalent silver opens up new possibilities for dispelling the concern of silver usage in biosafety and provides an avenue for designing antibiotics or other biomedical applications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>K</ForeName><Initials>K</Initials><Suffix></Suffix><AffiliationInfo><Affiliation>Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China. weizhang@mail.ipc.ac.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>J</ForeName><Initials>J</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>H G</ForeName><Initials>HG</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>W</ForeName><Initials>W</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Qu</LastName><ForeName>W</ForeName><Initials>W</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>G X</ForeName><Initials>GX</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>P L</ForeName><Initials>PL</Initials><Suffix></Suffix></Author><Author ValidYN="Y"><LastName>Ji</LastName><ForeName>J H</ForeName><Initials>JH</Initials><Suffix></Suffix></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>08</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Mater Chem B</MedlineTA><NlmUniqueID>101598493</NlmUniqueID><ISSNLinking>2050-750X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>9</Month><Day>14</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>14</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32263864</ArticleId><ArticleId IdType="doi">10.1039/c6tb01339b</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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