Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity.
Identifieur interne : 000618 ( Main/Corpus ); précédent : 000617; suivant : 000619Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity.
Auteurs : Xin Ding ; Peiyan Yuan ; Nengyue Gao ; Hai Zhu ; Yi Yan Yang ; Qing-Hua XuSource :
- Nanomedicine : nanotechnology, biology, and medicine [ 1549-9642 ] ; 2017.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (pharmacology), Biofilms (drug effects), Cells, Cultured (MeSH), Fibroblasts (drug effects), Gold (chemistry), Humans (MeSH), Luminescence (MeSH), Luminescent Measurements (MeSH), Metal Nanoparticles (chemistry), Microbial Sensitivity Tests (MeSH), Silver (chemistry), Staphylococcus aureus (drug effects).
- MESH :
- chemical , chemistry : Gold, Silver.
- chemical , pharmacology : Anti-Bacterial Agents.
- chemistry : Metal Nanoparticles.
- drug effects : Biofilms, Fibroblasts, Staphylococcus aureus.
- Cells, Cultured, Humans, Luminescence, Luminescent Measurements, Microbial Sensitivity Tests.
Abstract
Au@Ag nanoparticles (NPs) were recently found to display giant two-photon photoluminescence (2PPL) enhancement, with an enhancement factor up to 815 fold upon aggregate formation. Based on this finding, two-photon imaging of bacteria by Au@Ag NPs under near-infrared (NIR) femtosecond laser pulses was demonstrated in this study, as positively charged Au@Ag NPs can form aggregates on the negatively charged bacterial surface, yielding strong 2PPL emission. The aggregation-enhanced 2PPL of Au@Ag NPs stemmed from higher two-photon excitation efficiency, implying strong two-photon photothermal effects. Au@Ag NPs showed strong antibacterial activity (minimum inhibition concentration as low as 7.5pM against Staphylococcus aureus) and negligible toxicity to human dermal fibroblasts. Their bactericidal activity was further enhanced under NIR irradiation due to strong two-photon photothermal effects. Au@Ag NPs effectively removed 85% of the notorious bacterial biofilm within 4 min under NIR irradiation. These Au@Ag NPs can potentially be used as imaging and antibacterial agents.
DOI: 10.1016/j.nano.2016.09.003
PubMed: 27697618
Links to Exploration step
pubmed:27697618Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity.</title><author><name sortKey="Ding, Xin" sort="Ding, Xin" uniqKey="Ding X" first="Xin" last="Ding">Xin Ding</name><affiliation><nlm:affiliation>Institute of Bioengineering and Nanotechnology, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Peiyan" sort="Yuan, Peiyan" uniqKey="Yuan P" first="Peiyan" last="Yuan">Peiyan Yuan</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Nengyue" sort="Gao, Nengyue" uniqKey="Gao N" first="Nengyue" last="Gao">Nengyue Gao</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Hai" sort="Zhu, Hai" uniqKey="Zhu H" first="Hai" last="Zhu">Hai Zhu</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Yi Yan" sort="Yang, Yi Yan" uniqKey="Yang Y" first="Yi Yan" last="Yang">Yi Yan Yang</name><affiliation><nlm:affiliation>Institute of Bioengineering and Nanotechnology, Singapore. Electronic address: yyyang@ibn.a-star.edu.sg.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Qing Hua" sort="Xu, Qing Hua" uniqKey="Xu Q" first="Qing-Hua" last="Xu">Qing-Hua Xu</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore. Electronic address: chmxqh@nus.edu.sg.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27697618</idno><idno type="pmid">27697618</idno><idno type="doi">10.1016/j.nano.2016.09.003</idno><idno type="wicri:Area/Main/Corpus">000618</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000618</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity.</title><author><name sortKey="Ding, Xin" sort="Ding, Xin" uniqKey="Ding X" first="Xin" last="Ding">Xin Ding</name><affiliation><nlm:affiliation>Institute of Bioengineering and Nanotechnology, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Peiyan" sort="Yuan, Peiyan" uniqKey="Yuan P" first="Peiyan" last="Yuan">Peiyan Yuan</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Nengyue" sort="Gao, Nengyue" uniqKey="Gao N" first="Nengyue" last="Gao">Nengyue Gao</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Hai" sort="Zhu, Hai" uniqKey="Zhu H" first="Hai" last="Zhu">Hai Zhu</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Yi Yan" sort="Yang, Yi Yan" uniqKey="Yang Y" first="Yi Yan" last="Yang">Yi Yan Yang</name><affiliation><nlm:affiliation>Institute of Bioengineering and Nanotechnology, Singapore. Electronic address: yyyang@ibn.a-star.edu.sg.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Qing Hua" sort="Xu, Qing Hua" uniqKey="Xu Q" first="Qing-Hua" last="Xu">Qing-Hua Xu</name><affiliation><nlm:affiliation>Department of Chemistry, National University of Singapore, Singapore. Electronic address: chmxqh@nus.edu.sg.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nanomedicine : nanotechnology, biology, and medicine</title><idno type="eISSN">1549-9642</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (pharmacology)</term><term>Biofilms (drug effects)</term><term>Cells, Cultured (MeSH)</term><term>Fibroblasts (drug effects)</term><term>Gold (chemistry)</term><term>Humans (MeSH)</term><term>Luminescence (MeSH)</term><term>Luminescent Measurements (MeSH)</term><term>Metal Nanoparticles (chemistry)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Silver (chemistry)</term><term>Staphylococcus aureus (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Gold</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biofilms</term><term>Fibroblasts</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cells, Cultured</term><term>Humans</term><term>Luminescence</term><term>Luminescent Measurements</term><term>Microbial Sensitivity Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Au@Ag nanoparticles (NPs) were recently found to display giant two-photon photoluminescence (2PPL) enhancement, with an enhancement factor up to 815 fold upon aggregate formation. Based on this finding, two-photon imaging of bacteria by Au@Ag NPs under near-infrared (NIR) femtosecond laser pulses was demonstrated in this study, as positively charged Au@Ag NPs can form aggregates on the negatively charged bacterial surface, yielding strong 2PPL emission. The aggregation-enhanced 2PPL of Au@Ag NPs stemmed from higher two-photon excitation efficiency, implying strong two-photon photothermal effects. Au@Ag NPs showed strong antibacterial activity (minimum inhibition concentration as low as 7.5pM against Staphylococcus aureus) and negligible toxicity to human dermal fibroblasts. Their bactericidal activity was further enhanced under NIR irradiation due to strong two-photon photothermal effects. Au@Ag NPs effectively removed 85% of the notorious bacterial biofilm within 4 min under NIR irradiation. These Au@Ag NPs can potentially be used as imaging and antibacterial agents.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">27697618</PMID><DateCompleted><Year>2017</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>12</Month><Day>02</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1549-9642</ISSN><JournalIssue CitedMedium="Internet"><Volume>13</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>01</Month></PubDate></JournalIssue><Title>Nanomedicine : nanotechnology, biology, and medicine</Title><ISOAbbreviation>Nanomedicine</ISOAbbreviation></Journal><ArticleTitle>Au-Ag core-shell nanoparticles for simultaneous bacterial imaging and synergistic antibacterial activity.</ArticleTitle><Pagination><MedlinePgn>297-305</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1549-9634(16)30153-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nano.2016.09.003</ELocationID><Abstract><AbstractText>Au@Ag nanoparticles (NPs) were recently found to display giant two-photon photoluminescence (2PPL) enhancement, with an enhancement factor up to 815 fold upon aggregate formation. Based on this finding, two-photon imaging of bacteria by Au@Ag NPs under near-infrared (NIR) femtosecond laser pulses was demonstrated in this study, as positively charged Au@Ag NPs can form aggregates on the negatively charged bacterial surface, yielding strong 2PPL emission. The aggregation-enhanced 2PPL of Au@Ag NPs stemmed from higher two-photon excitation efficiency, implying strong two-photon photothermal effects. Au@Ag NPs showed strong antibacterial activity (minimum inhibition concentration as low as 7.5pM against Staphylococcus aureus) and negligible toxicity to human dermal fibroblasts. Their bactericidal activity was further enhanced under NIR irradiation due to strong two-photon photothermal effects. Au@Ag NPs effectively removed 85% of the notorious bacterial biofilm within 4 min under NIR irradiation. These Au@Ag NPs can potentially be used as imaging and antibacterial agents.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute of Bioengineering and Nanotechnology, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Peiyan</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Chemistry, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Nengyue</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Chemistry, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Hai</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Chemistry, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Yi Yan</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Institute of Bioengineering and Nanotechnology, Singapore. Electronic address: yyyang@ibn.a-star.edu.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Qing-Hua</ForeName><Initials>QH</Initials><AffiliationInfo><Affiliation>Department of Chemistry, National University of Singapore, Singapore. Electronic address: chmxqh@nus.edu.sg.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Nanomedicine</MedlineTA><NlmUniqueID>101233142</NlmUniqueID><ISSNLinking>1549-9634</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-57-5</RegistryNumber><NameOfSubstance UI="D006046">Gold</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018441" MajorTopicYN="N">Biofilms</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006046" MajorTopicYN="N">Gold</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049449" MajorTopicYN="N">Luminescence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008163" MajorTopicYN="N">Luminescent Measurements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="N">Metal Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Anti-biofilm</Keyword><Keyword MajorTopicYN="Y">Antibacterial</Keyword><Keyword MajorTopicYN="Y">Bio-imaging</Keyword><Keyword MajorTopicYN="Y">Nanoparticles</Keyword><Keyword MajorTopicYN="Y">Two-photon excitation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>08</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27697618</ArticleId><ArticleId IdType="pii">S1549-9634(16)30153-8</ArticleId><ArticleId IdType="doi">10.1016/j.nano.2016.09.003</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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