Approaches for Controlled Ag+ Ion Release: Influence of Surface Topography, Roughness, and Bactericide Content.
Identifieur interne : 000592 ( Main/Corpus ); précédent : 000591; suivant : 000593Approaches for Controlled Ag+ Ion Release: Influence of Surface Topography, Roughness, and Bactericide Content.
Auteurs : I V Sukhorukova ; A N Sheveyko ; N V Shvindina ; E A Denisenko ; S G Ignatov ; D V ShtanskySource :
- ACS applied materials & interfaces [ 1944-8252 ] ; 2017.
Abstract
Silver is the most famous bactericidal element known from ancient times. Its antibacterial and antifungal effects are typically associated with the Ag ionization and concentration of Ag+ ions in a bacterial culture. Herein we thoroughly studied the influence of surface topography and roughness on the rate of Ag+ ion release. We considered two types of biocompatible and bioactive TiCaPCON-Ag films with 1 and 2 at. % of Ag and nine types of Ti surfaces with an average roughness varying in the range from 5.4 × 10-2 to 12.6 μm and different topographic features obtained through polishing, sandblasting, laser treatment, and pulsed electrospark deposition. It is demonstrated that the Ag+ ion release rates do not depend on the Ag content in the films as the main parameter, and it is other factors, such as the state of Ag agglomeration, surface topography and roughness, as well as kinetics of surface oxidation, that play a critical role. The obtained results clearly show a synergistic effect of the Ag content in the film and surface topography and roughness on Ag+ ion release. By changing the surface topographical features at a constant content of bactericidal element, we showed that the Ag+ ion release can be either accelerated by 2.5 times or almost completely suppressed. Despite low Ag+ ion concentration in physiological solution (<40 ppb), samples with specially fabricated surface reliefs (flakes or holes) showed a pronounced antibacterial effect already after 3 h of immersion in E. coli bacterial culture. Thus, our results open up new possibilities for the production of cost-effective, scalable, and biologically safe implants with pronounced antibacterial characteristics for future applications in the orthopedic field.
DOI: 10.1021/acsami.6b15096
PubMed: 28051310
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and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Denisenko, E A" sort="Denisenko, E A" uniqKey="Denisenko E" first="E A" last="Denisenko">E A Denisenko</name><affiliation><nlm:affiliation>State Research Center for Applied Microbiology and Biotechnology , Obolensk, Moscow Region 142279, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Ignatov, S G" sort="Ignatov, S G" uniqKey="Ignatov S" first="S G" last="Ignatov">S G Ignatov</name><affiliation><nlm:affiliation>State Research Center for Applied Microbiology and Biotechnology , Obolensk, Moscow Region 142279, Russia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Moscow State University , Department of Geocryology, Moscow 119992, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Shtansky, D V" sort="Shtansky, D V" uniqKey="Shtansky D" first="D V" last="Shtansky">D V Shtansky</name><affiliation><nlm:affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28051310</idno><idno type="pmid">28051310</idno><idno type="doi">10.1021/acsami.6b15096</idno><idno type="wicri:Area/Main/Corpus">000592</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000592</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Approaches for Controlled Ag<sup>+</sup> Ion Release: Influence of Surface Topography, Roughness, and Bactericide Content.</title><author><name sortKey="Sukhorukova, I V" sort="Sukhorukova, I V" uniqKey="Sukhorukova I" first="I V" last="Sukhorukova">I V Sukhorukova</name><affiliation><nlm:affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Sheveyko, A N" sort="Sheveyko, A N" uniqKey="Sheveyko A" first="A N" last="Sheveyko">A N Sheveyko</name><affiliation><nlm:affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Shvindina, N V" sort="Shvindina, N V" uniqKey="Shvindina N" first="N V" last="Shvindina">N V Shvindina</name><affiliation><nlm:affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Denisenko, E A" sort="Denisenko, E A" uniqKey="Denisenko E" first="E A" last="Denisenko">E A Denisenko</name><affiliation><nlm:affiliation>State Research Center for Applied Microbiology and Biotechnology , Obolensk, Moscow Region 142279, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Ignatov, S G" sort="Ignatov, S G" uniqKey="Ignatov S" first="S G" last="Ignatov">S G Ignatov</name><affiliation><nlm:affiliation>State Research Center for Applied Microbiology and Biotechnology , Obolensk, Moscow Region 142279, Russia.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Moscow State University , Department of Geocryology, Moscow 119992, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Shtansky, D V" sort="Shtansky, D V" uniqKey="Shtansky D" first="D V" last="Shtansky">D V Shtansky</name><affiliation><nlm:affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">ACS applied materials & interfaces</title><idno type="eISSN">1944-8252</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Silver is the most famous bactericidal element known from ancient times. Its antibacterial and antifungal effects are typically associated with the Ag ionization and concentration of Ag<sup>+</sup> ions in a bacterial culture. Herein we thoroughly studied the influence of surface topography and roughness on the rate of Ag<sup>+</sup> ion release. We considered two types of biocompatible and bioactive TiCaPCON-Ag films with 1 and 2 at. % of Ag and nine types of Ti surfaces with an average roughness varying in the range from 5.4 × 10<sup>-2</sup> to 12.6 μm and different topographic features obtained through polishing, sandblasting, laser treatment, and pulsed electrospark deposition. It is demonstrated that the Ag<sup>+</sup> ion release rates do not depend on the Ag content in the films as the main parameter, and it is other factors, such as the state of Ag agglomeration, surface topography and roughness, as well as kinetics of surface oxidation, that play a critical role. The obtained results clearly show a synergistic effect of the Ag content in the film and surface topography and roughness on Ag<sup>+</sup> ion release. By changing the surface topographical features at a constant content of bactericidal element, we showed that the Ag<sup>+</sup> ion release can be either accelerated by 2.5 times or almost completely suppressed. Despite low Ag<sup>+</sup> ion concentration in physiological solution (<40 ppb), samples with specially fabricated surface reliefs (flakes or holes) showed a pronounced antibacterial effect already after 3 h of immersion in E. coli bacterial culture. Thus, our results open up new possibilities for the production of cost-effective, scalable, and biologically safe implants with pronounced antibacterial characteristics for future applications in the orthopedic field.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28051310</PMID><DateCompleted><Year>2018</Year><Month>07</Month><Day>27</Day></DateCompleted><DateRevised><Year>2018</Year><Month>07</Month><Day>27</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1944-8252</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Feb</Month><Day>01</Day></PubDate></JournalIssue><Title>ACS applied materials & interfaces</Title><ISOAbbreviation>ACS Appl Mater Interfaces</ISOAbbreviation></Journal><ArticleTitle>Approaches for Controlled Ag<sup>+</sup> Ion Release: Influence of Surface Topography, Roughness, and Bactericide Content.</ArticleTitle><Pagination><MedlinePgn>4259-4271</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/acsami.6b15096</ELocationID><Abstract><AbstractText>Silver is the most famous bactericidal element known from ancient times. Its antibacterial and antifungal effects are typically associated with the Ag ionization and concentration of Ag<sup>+</sup> ions in a bacterial culture. Herein we thoroughly studied the influence of surface topography and roughness on the rate of Ag<sup>+</sup> ion release. We considered two types of biocompatible and bioactive TiCaPCON-Ag films with 1 and 2 at. % of Ag and nine types of Ti surfaces with an average roughness varying in the range from 5.4 × 10<sup>-2</sup> to 12.6 μm and different topographic features obtained through polishing, sandblasting, laser treatment, and pulsed electrospark deposition. It is demonstrated that the Ag<sup>+</sup> ion release rates do not depend on the Ag content in the films as the main parameter, and it is other factors, such as the state of Ag agglomeration, surface topography and roughness, as well as kinetics of surface oxidation, that play a critical role. The obtained results clearly show a synergistic effect of the Ag content in the film and surface topography and roughness on Ag<sup>+</sup> ion release. By changing the surface topographical features at a constant content of bactericidal element, we showed that the Ag<sup>+</sup> ion release can be either accelerated by 2.5 times or almost completely suppressed. Despite low Ag<sup>+</sup> ion concentration in physiological solution (<40 ppb), samples with specially fabricated surface reliefs (flakes or holes) showed a pronounced antibacterial effect already after 3 h of immersion in E. coli bacterial culture. Thus, our results open up new possibilities for the production of cost-effective, scalable, and biologically safe implants with pronounced antibacterial characteristics for future applications in the orthopedic field.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sukhorukova</LastName><ForeName>I V</ForeName><Initials>IV</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2458-164X</Identifier><AffiliationInfo><Affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sheveyko</LastName><ForeName>A N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shvindina</LastName><ForeName>N V</ForeName><Initials>NV</Initials><AffiliationInfo><Affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denisenko</LastName><ForeName>E A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>State Research Center for Applied Microbiology and Biotechnology , Obolensk, Moscow Region 142279, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ignatov</LastName><ForeName>S G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>State Research Center for Applied Microbiology and Biotechnology , Obolensk, Moscow Region 142279, Russia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Moscow State University , Department of Geocryology, Moscow 119992, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shtansky</LastName><ForeName>D V</ForeName><Initials>DV</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7304-2461</Identifier><AffiliationInfo><Affiliation>National University of Science and Technology "MISIS" , Leninsky prospect 4, Moscow 119049, Russia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Appl Mater Interfaces</MedlineTA><NlmUniqueID>101504991</NlmUniqueID><ISSNLinking>1944-8244</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">antibacterial activity</Keyword><Keyword MajorTopicYN="N">electrochemical behavior</Keyword><Keyword MajorTopicYN="N">multicomponent films</Keyword><Keyword MajorTopicYN="N">roughness</Keyword><Keyword MajorTopicYN="N">silver ion release</Keyword><Keyword MajorTopicYN="N">surface topography</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>1</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28051310</ArticleId><ArticleId IdType="doi">10.1021/acsami.6b15096</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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