Simultaneous Delivery of Multiple Antibacterial Agents from Additively Manufactured Porous Biomaterials to Fully Eradicate Planktonic and Adherent Staphylococcus aureus.
Identifieur interne : 000531 ( Main/Corpus ); précédent : 000530; suivant : 000532Simultaneous Delivery of Multiple Antibacterial Agents from Additively Manufactured Porous Biomaterials to Fully Eradicate Planktonic and Adherent Staphylococcus aureus.
Auteurs : S. Bakhshandeh ; Z. Gorgin Karaji ; K. Lietaert ; A C Fluit ; C H E. Boel ; H C Vogely ; T. Vermonden ; W E Hennink ; H. Weinans ; A A Zadpoor ; S. Amin YavariSource :
- ACS applied materials & interfaces [ 1944-8252 ] ; 2017.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Anti-Bacterial Agents.
- chemical : Biocompatible Materials, Coated Materials, Biocompatible, Silver, Titanium.
- Plankton, Staphylococcal Infections, Staphylococcus aureus.
Abstract
Implant-associated infections are notoriously difficult to treat and may even result in amputation and death. The first few days after surgery are the most critical time to prevent those infections, preferably through full eradication of the micro-organisms entering the body perioperatively. That is particularly important for patients with a compromised immune system such as orthopedic oncology patients, as they are at higher risk for infection and complications. Full eradication of bacteria is, especially in a biofilm, extremely challenging due to the toxicity barrier that prevents delivery of high doses of antibacterial agents. This study aimed to use the potential synergistic effects of multiple antibacterial agents to prevent the use of toxic levels of these agents and achieve full eradication of planktonic and adherent bacteria. Silver ions and vancomycin were therefore simultaneously delivered from additively manufactured highly porous titanium implants with an extremely high surface area incorporating a bactericidal coating made from chitosan and gelatin applied by electrophoretic deposition (EPD). The presence of the chitosan/gelatin (Ch+Gel) coating, Ag, and vancomycin (Vanco) was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). The release of vancomycin and silver ions continued for at least 21 days as measured by inductively coupled plasma (ICP) and UV-spectroscopy. Antibacterial behavior against Staphylococcus aureus, both planktonic and in biofilm, was evaluated for up to 21 days. The Ch+Gel coating showed some bactericidal behavior on its own, while the loaded hydrogels (Ch+Gel+Ag and Ch+Gel+Vanco) achieved full eradication of both planktonic and adherent bacteria without causing significant levels of toxicity. Combining silver and vancomycin improved the release profiles of both agents and revealed a synergistic behavior that further increased the bactericidal effects.
DOI: 10.1021/acsami.7b04950
PubMed: 28696671
PubMed Central: PMC5553095
Links to Exploration step
pubmed:28696671Le document en format XML
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Lietaert</name><affiliation><nlm:affiliation>3D Systems - LayerWise NV , 3001 Leuven, Belgium.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Metallurgy and Materials Engineering, KU Leuven , 3000 Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Fluit, A C" sort="Fluit, A C" uniqKey="Fluit A" first="A C" last="Fluit">A C Fluit</name></author><author><name sortKey="Boel, C H E" sort="Boel, C H E" uniqKey="Boel C" first="C H E" last="Boel">C H E. Boel</name></author><author><name sortKey="Vogely, H C" sort="Vogely, H C" uniqKey="Vogely H" first="H C" last="Vogely">H C Vogely</name></author><author><name sortKey="Vermonden, T" sort="Vermonden, T" uniqKey="Vermonden T" first="T" last="Vermonden">T. Vermonden</name><affiliation><nlm:affiliation>Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University , 3512 JE Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hennink, W E" sort="Hennink, W E" uniqKey="Hennink W" first="W E" last="Hennink">W E Hennink</name><affiliation><nlm:affiliation>Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University , 3512 JE Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Weinans, H" sort="Weinans, H" uniqKey="Weinans H" first="H" last="Weinans">H. Weinans</name><affiliation><nlm:affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zadpoor, A A" sort="Zadpoor, A A" uniqKey="Zadpoor A" first="A A" last="Zadpoor">A A Zadpoor</name><affiliation><nlm:affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Amin Yavari, S" sort="Amin Yavari, S" uniqKey="Amin Yavari S" first="S" last="Amin Yavari">S. Amin Yavari</name><affiliation><nlm:affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28696671</idno><idno type="pmid">28696671</idno><idno type="doi">10.1021/acsami.7b04950</idno><idno type="pmc">PMC5553095</idno><idno type="wicri:Area/Main/Corpus">000531</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000531</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Simultaneous Delivery of Multiple Antibacterial Agents from Additively Manufactured Porous Biomaterials to Fully Eradicate Planktonic and Adherent Staphylococcus aureus.</title><author><name sortKey="Bakhshandeh, S" sort="Bakhshandeh, S" uniqKey="Bakhshandeh S" first="S" last="Bakhshandeh">S. Bakhshandeh</name><affiliation><nlm:affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gorgin Karaji, Z" sort="Gorgin Karaji, Z" uniqKey="Gorgin Karaji Z" first="Z" last="Gorgin Karaji">Z. Gorgin Karaji</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, Kermanshah University of Technology , Kermanshah, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Lietaert, K" sort="Lietaert, K" uniqKey="Lietaert K" first="K" last="Lietaert">K. Lietaert</name><affiliation><nlm:affiliation>3D Systems - LayerWise NV , 3001 Leuven, Belgium.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Metallurgy and Materials Engineering, KU Leuven , 3000 Leuven, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Fluit, A C" sort="Fluit, A C" uniqKey="Fluit A" first="A C" last="Fluit">A C Fluit</name></author><author><name sortKey="Boel, C H E" sort="Boel, C H E" uniqKey="Boel C" first="C H E" last="Boel">C H E. Boel</name></author><author><name sortKey="Vogely, H C" sort="Vogely, H C" uniqKey="Vogely H" first="H C" last="Vogely">H C Vogely</name></author><author><name sortKey="Vermonden, T" sort="Vermonden, T" uniqKey="Vermonden T" first="T" last="Vermonden">T. Vermonden</name><affiliation><nlm:affiliation>Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University , 3512 JE Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hennink, W E" sort="Hennink, W E" uniqKey="Hennink W" first="W E" last="Hennink">W E Hennink</name><affiliation><nlm:affiliation>Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University , 3512 JE Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Weinans, H" sort="Weinans, H" uniqKey="Weinans H" first="H" last="Weinans">H. Weinans</name><affiliation><nlm:affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zadpoor, A A" sort="Zadpoor, A A" uniqKey="Zadpoor A" first="A A" last="Zadpoor">A A Zadpoor</name><affiliation><nlm:affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Amin Yavari, S" sort="Amin Yavari, S" uniqKey="Amin Yavari S" first="S" last="Amin Yavari">S. Amin Yavari</name><affiliation><nlm:affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</nlm:affiliation></affiliation></author></analytic><series><title level="j">ACS applied materials & interfaces</title><idno type="eISSN">1944-8252</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Biocompatible Materials (MeSH)</term><term>Coated Materials, Biocompatible (MeSH)</term><term>Plankton (MeSH)</term><term>Silver (MeSH)</term><term>Staphylococcal Infections (MeSH)</term><term>Staphylococcus aureus (MeSH)</term><term>Titanium (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biocompatible Materials</term><term>Coated Materials, Biocompatible</term><term>Silver</term><term>Titanium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Plankton</term><term>Staphylococcal Infections</term><term>Staphylococcus aureus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Implant-associated infections are notoriously difficult to treat and may even result in amputation and death. The first few days after surgery are the most critical time to prevent those infections, preferably through full eradication of the micro-organisms entering the body perioperatively. That is particularly important for patients with a compromised immune system such as orthopedic oncology patients, as they are at higher risk for infection and complications. Full eradication of bacteria is, especially in a biofilm, extremely challenging due to the toxicity barrier that prevents delivery of high doses of antibacterial agents. This study aimed to use the potential synergistic effects of multiple antibacterial agents to prevent the use of toxic levels of these agents and achieve full eradication of planktonic and adherent bacteria. Silver ions and vancomycin were therefore simultaneously delivered from additively manufactured highly porous titanium implants with an extremely high surface area incorporating a bactericidal coating made from chitosan and gelatin applied by electrophoretic deposition (EPD). The presence of the chitosan/gelatin (Ch+Gel) coating, Ag, and vancomycin (Vanco) was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). The release of vancomycin and silver ions continued for at least 21 days as measured by inductively coupled plasma (ICP) and UV-spectroscopy. Antibacterial behavior against Staphylococcus aureus, both planktonic and in biofilm, was evaluated for up to 21 days. The Ch+Gel coating showed some bactericidal behavior on its own, while the loaded hydrogels (Ch+Gel+Ag and Ch+Gel+Vanco) achieved full eradication of both planktonic and adherent bacteria without causing significant levels of toxicity. Combining silver and vancomycin improved the release profiles of both agents and revealed a synergistic behavior that further increased the bactericidal effects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">28696671</PMID><DateCompleted><Year>2018</Year><Month>12</Month><Day>11</Day></DateCompleted><DateRevised><Year>2019</Year><Month>01</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1944-8252</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>31</Issue><PubDate><Year>2017</Year><Month>Aug</Month><Day>09</Day></PubDate></JournalIssue><Title>ACS applied materials & interfaces</Title><ISOAbbreviation>ACS Appl Mater Interfaces</ISOAbbreviation></Journal><ArticleTitle>Simultaneous Delivery of Multiple Antibacterial Agents from Additively Manufactured Porous Biomaterials to Fully Eradicate Planktonic and Adherent Staphylococcus aureus.</ArticleTitle><Pagination><MedlinePgn>25691-25699</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/acsami.7b04950</ELocationID><Abstract><AbstractText>Implant-associated infections are notoriously difficult to treat and may even result in amputation and death. The first few days after surgery are the most critical time to prevent those infections, preferably through full eradication of the micro-organisms entering the body perioperatively. That is particularly important for patients with a compromised immune system such as orthopedic oncology patients, as they are at higher risk for infection and complications. Full eradication of bacteria is, especially in a biofilm, extremely challenging due to the toxicity barrier that prevents delivery of high doses of antibacterial agents. This study aimed to use the potential synergistic effects of multiple antibacterial agents to prevent the use of toxic levels of these agents and achieve full eradication of planktonic and adherent bacteria. Silver ions and vancomycin were therefore simultaneously delivered from additively manufactured highly porous titanium implants with an extremely high surface area incorporating a bactericidal coating made from chitosan and gelatin applied by electrophoretic deposition (EPD). The presence of the chitosan/gelatin (Ch+Gel) coating, Ag, and vancomycin (Vanco) was confirmed by X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). The release of vancomycin and silver ions continued for at least 21 days as measured by inductively coupled plasma (ICP) and UV-spectroscopy. Antibacterial behavior against Staphylococcus aureus, both planktonic and in biofilm, was evaluated for up to 21 days. The Ch+Gel coating showed some bactericidal behavior on its own, while the loaded hydrogels (Ch+Gel+Ag and Ch+Gel+Vanco) achieved full eradication of both planktonic and adherent bacteria without causing significant levels of toxicity. Combining silver and vancomycin improved the release profiles of both agents and revealed a synergistic behavior that further increased the bactericidal effects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bakhshandeh</LastName><ForeName>S</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6956-7900</Identifier><AffiliationInfo><Affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorgin Karaji</LastName><ForeName>Z</ForeName><Initials>Z</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2719-7192</Identifier><AffiliationInfo><Affiliation>Department of Mechanical Engineering, Kermanshah University of Technology , Kermanshah, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lietaert</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>3D Systems - LayerWise NV , 3001 Leuven, Belgium.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Metallurgy and Materials Engineering, KU Leuven , 3000 Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fluit</LastName><ForeName>A C</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Boel</LastName><ForeName>C H E</ForeName><Initials>CHE</Initials></Author><Author ValidYN="Y"><LastName>Vogely</LastName><ForeName>H C</ForeName><Initials>HC</Initials></Author><Author ValidYN="Y"><LastName>Vermonden</LastName><ForeName>T</ForeName><Initials>T</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6047-5900</Identifier><AffiliationInfo><Affiliation>Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University , 3512 JE Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hennink</LastName><ForeName>W E</ForeName><Initials>WE</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University , 3512 JE Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinans</LastName><ForeName>H</ForeName><Initials>H</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2275-6170</Identifier><AffiliationInfo><Affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zadpoor</LastName><ForeName>A A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin Yavari</LastName><ForeName>S</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1677-5751</Identifier><AffiliationInfo><Affiliation>Department of Biomechanical Engineering, Delft University of Technology , 2628 CD Delft, The Netherlands.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Appl Mater Interfaces</MedlineTA><NlmUniqueID>101504991</NlmUniqueID><ISSNLinking>1944-8244</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001672">Biocompatible Materials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020099">Coated Materials, Biocompatible</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>D1JT611TNE</RegistryNumber><NameOfSubstance UI="D014025">Titanium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001672" MajorTopicYN="N">Biocompatible Materials</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020099" MajorTopicYN="N">Coated Materials, Biocompatible</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010933" MajorTopicYN="N">Plankton</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013203" MajorTopicYN="N">Staphylococcal Infections</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014025" MajorTopicYN="N">Titanium</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">additive manufacturing</Keyword><Keyword MajorTopicYN="N">antibacterial surfaces/coatings</Keyword><Keyword MajorTopicYN="N">electrophoretic deposition</Keyword><Keyword MajorTopicYN="N">hydrogels</Keyword><Keyword MajorTopicYN="N">multifunctional biomaterials</Keyword><Keyword MajorTopicYN="N">porous implants</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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