Middle Ear Prosthesis with Bactericidal Efficacy-In Vitro Investigation.
Identifieur interne : 000496 ( Main/Corpus ); précédent : 000495; suivant : 000497Middle Ear Prosthesis with Bactericidal Efficacy-In Vitro Investigation.
Auteurs : Magdalena Zi Bka ; Michał Dziadek ; El Bieta Menaszek ; Rafał Banasiuk ; Aleksandra Kr LickaSource :
- Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2017.
English descriptors
- KwdEn :
- Acrylic Resins (chemistry), Anti-Bacterial Agents (pharmacology), Butadienes (chemistry), Cell Line (MeSH), Cell Proliferation (drug effects), Cell Survival (drug effects), Fibroblasts (cytology), Fibroblasts (drug effects), Humans (MeSH), Metal Nanoparticles (chemistry), Microbial Sensitivity Tests (methods), Ossicular Prosthesis (MeSH), Polystyrenes (chemistry), Prosthesis-Related Infections (prevention & control), Pseudomonadaceae (drug effects), Silver (chemistry), Staphylococcus aureus (drug effects), Surface Properties (MeSH).
- MESH :
- chemical , chemistry : Acrylic Resins, Butadienes, Polystyrenes, Silver.
- chemical , pharmacology : Anti-Bacterial Agents.
- chemistry : Metal Nanoparticles.
- cytology : Fibroblasts.
- drug effects : Cell Proliferation, Cell Survival, Fibroblasts, Pseudomonadaceae, Staphylococcus aureus.
- methods : Microbial Sensitivity Tests.
- prevention & control : Prosthesis-Related Infections.
- Cell Line, Humans, Ossicular Prosthesis, Surface Properties.
Abstract
Materials used in ossicular replacement prostheses must possess appropriate biological properties, such as biocompatibility, stability, no cytotoxicity. Due to the risk of infection (otitis media and chronic otitis media), it is desirable to use an antibacterial agent for illness prevention during the ossicular reconstruction. The goal of this work was to observe biological properties of a new composite prosthesis made of ABS containing silver nanoparticles (AgNPs 45T). Samples for biological tests and then a prototype of middle ear prosthesis were prepared using injection moulding and extrusion techniques. In vitro experiments were carried out to assess bactericidal efficacy against Staphylococcus aureus and Pseudomona aeruginosa standard strains, cell proliferation, viability and cytotoxicity, using Hs680.Tr. fibroblast cells. Surface parameters of the samples were evaluated, including roughness and wettability. The silver ions were continually released from the polymer in aqueous solution. The silver ions release was measured as increasing with time and concentration of the silver nanoparticles in the polymer matrix. No cytotoxicity effect was observed, while bactericidal efficacy was noticed for silver nanoparticles. The roughness studies showed an increase in roughness for the samples with silver nanoparticles. All polymer and composite materials containing silver nanoparticles showed hydrophilic properties. The composites were found to release silver ions at a concentration level capable of rendering the antimicrobial efficacy even with the lowest concentration of silver nanoparticles in the material. Our results demonstrate that middle ear prosthesis made of polymer and silver nanoparticles may eliminate bacteria during inflammation in the middle ear.
DOI: 10.3390/molecules22101681
PubMed: 28994723
PubMed Central: PMC6151403
Links to Exploration step
pubmed:28994723Le document en format XML
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E" first="El Bieta" last="Menaszek">El Bieta Menaszek</name><affiliation><nlm:affiliation>UJ-Jagiellonian University, Medical College, Faculty of Pharmacy, Department of Cytobiology, Krakow 30-001, Poland. elzbieta.menaszek@uj.edu.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Banasiuk, Rafal" sort="Banasiuk, Rafal" uniqKey="Banasiuk R" first="Rafał" last="Banasiuk">Rafał Banasiuk</name><affiliation><nlm:affiliation>University of Gdansk, Intercollegiate Faculty of Biotechnology UG-GUMed, Department of Biotechnology, Laboratory of Biologically Active Compounds, Gdansk 80-307, Poland. rafal.banasiuk@biotech.ug.edu.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Kr Licka, Aleksandra" sort="Kr Licka, Aleksandra" uniqKey="Kr Licka A" first="Aleksandra" last="Kr Licka">Aleksandra Kr Licka</name><affiliation><nlm:affiliation>University of Gdansk, Intercollegiate Faculty of Biotechnology UG-GUMed, Department of Biotechnology, Laboratory of Biologically 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ziabka@agh.edu.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Dziadek, Michal" sort="Dziadek, Michal" uniqKey="Dziadek M" first="Michał" last="Dziadek">Michał Dziadek</name><affiliation><nlm:affiliation>AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Glass Technology and Amorphous Coatings, Krakow 30-059, Poland. dziadek@agh.edu.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Menaszek, El Bieta" sort="Menaszek, El Bieta" uniqKey="Menaszek E" first="El Bieta" last="Menaszek">El Bieta Menaszek</name><affiliation><nlm:affiliation>UJ-Jagiellonian University, Medical College, Faculty of Pharmacy, Department of Cytobiology, Krakow 30-001, Poland. elzbieta.menaszek@uj.edu.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Banasiuk, Rafal" sort="Banasiuk, Rafal" uniqKey="Banasiuk R" first="Rafał" last="Banasiuk">Rafał Banasiuk</name><affiliation><nlm:affiliation>University of Gdansk, Intercollegiate Faculty of Biotechnology UG-GUMed, Department of Biotechnology, Laboratory of Biologically Active Compounds, Gdansk 80-307, Poland. rafal.banasiuk@biotech.ug.edu.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Kr Licka, Aleksandra" sort="Kr Licka, Aleksandra" uniqKey="Kr Licka A" first="Aleksandra" last="Kr Licka">Aleksandra Kr Licka</name><affiliation><nlm:affiliation>University of Gdansk, Intercollegiate Faculty of Biotechnology UG-GUMed, Department of Biotechnology, Laboratory of Biologically Active Compounds, Gdansk 80-307, Poland. aleksandra.krolicka@biotech.ug.edu.pl.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecules (Basel, Switzerland)</title><idno type="eISSN">1420-3049</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acrylic Resins (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Butadienes (chemistry)</term><term>Cell Line (MeSH)</term><term>Cell Proliferation (drug effects)</term><term>Cell Survival (drug effects)</term><term>Fibroblasts (cytology)</term><term>Fibroblasts (drug effects)</term><term>Humans (MeSH)</term><term>Metal Nanoparticles (chemistry)</term><term>Microbial Sensitivity Tests (methods)</term><term>Ossicular Prosthesis (MeSH)</term><term>Polystyrenes (chemistry)</term><term>Prosthesis-Related Infections (prevention & control)</term><term>Pseudomonadaceae (drug effects)</term><term>Silver (chemistry)</term><term>Staphylococcus aureus (drug effects)</term><term>Surface Properties (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Acrylic Resins</term><term>Butadienes</term><term>Polystyrenes</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Fibroblasts</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Cell Survival</term><term>Fibroblasts</term><term>Pseudomonadaceae</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Microbial Sensitivity Tests</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Prosthesis-Related Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Humans</term><term>Ossicular Prosthesis</term><term>Surface Properties</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Materials used in ossicular replacement prostheses must possess appropriate biological properties, such as biocompatibility, stability, no cytotoxicity. Due to the risk of infection (otitis media and chronic otitis media), it is desirable to use an antibacterial agent for illness prevention during the ossicular reconstruction. The goal of this work was to observe biological properties of a new composite prosthesis made of ABS containing silver nanoparticles (AgNPs 45T). Samples for biological tests and then a prototype of middle ear prosthesis were prepared using injection moulding and extrusion techniques. In vitro experiments were carried out to assess bactericidal efficacy against <i>Staphylococcus aureus</i> and <i>Pseudomona aeruginosa</i> standard strains, cell proliferation, viability and cytotoxicity, using Hs680.Tr. fibroblast cells. Surface parameters of the samples were evaluated, including roughness and wettability. The silver ions were continually released from the polymer in aqueous solution. The silver ions release was measured as increasing with time and concentration of the silver nanoparticles in the polymer matrix. No cytotoxicity effect was observed, while bactericidal efficacy was noticed for silver nanoparticles. The roughness studies showed an increase in roughness for the samples with silver nanoparticles. All polymer and composite materials containing silver nanoparticles showed hydrophilic properties. The composites were found to release silver ions at a concentration level capable of rendering the antimicrobial efficacy even with the lowest concentration of silver nanoparticles in the material. Our results demonstrate that middle ear prosthesis made of polymer and silver nanoparticles may eliminate bacteria during inflammation in the middle ear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28994723</PMID><DateCompleted><Year>2019</Year><Month>03</Month><Day>07</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>07</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1420-3049</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>10</Issue><PubDate><Year>2017</Year><Month>Oct</Month><Day>10</Day></PubDate></JournalIssue><Title>Molecules (Basel, Switzerland)</Title><ISOAbbreviation>Molecules</ISOAbbreviation></Journal><ArticleTitle>Middle Ear Prosthesis with Bactericidal Efficacy-In Vitro Investigation.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E1681</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/molecules22101681</ELocationID><Abstract><AbstractText>Materials used in ossicular replacement prostheses must possess appropriate biological properties, such as biocompatibility, stability, no cytotoxicity. Due to the risk of infection (otitis media and chronic otitis media), it is desirable to use an antibacterial agent for illness prevention during the ossicular reconstruction. The goal of this work was to observe biological properties of a new composite prosthesis made of ABS containing silver nanoparticles (AgNPs 45T). Samples for biological tests and then a prototype of middle ear prosthesis were prepared using injection moulding and extrusion techniques. In vitro experiments were carried out to assess bactericidal efficacy against <i>Staphylococcus aureus</i> and <i>Pseudomona aeruginosa</i> standard strains, cell proliferation, viability and cytotoxicity, using Hs680.Tr. fibroblast cells. Surface parameters of the samples were evaluated, including roughness and wettability. The silver ions were continually released from the polymer in aqueous solution. The silver ions release was measured as increasing with time and concentration of the silver nanoparticles in the polymer matrix. No cytotoxicity effect was observed, while bactericidal efficacy was noticed for silver nanoparticles. The roughness studies showed an increase in roughness for the samples with silver nanoparticles. All polymer and composite materials containing silver nanoparticles showed hydrophilic properties. The composites were found to release silver ions at a concentration level capable of rendering the antimicrobial efficacy even with the lowest concentration of silver nanoparticles in the material. Our results demonstrate that middle ear prosthesis made of polymer and silver nanoparticles may eliminate bacteria during inflammation in the middle ear.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ziąbka</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Ceramics and Refractories, Krakow 30-059, Poland. ziabka@agh.edu.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dziadek</LastName><ForeName>Michał</ForeName><Initials>M</Initials><Identifier Source="ORCID">0000-0001-5661-5467</Identifier><AffiliationInfo><Affiliation>AGH University of Science and Technology, Faculty of Materials Science and Ceramics, Department of Glass Technology and Amorphous Coatings, Krakow 30-059, Poland. dziadek@agh.edu.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Menaszek</LastName><ForeName>Elżbieta</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0002-0602-3583</Identifier><AffiliationInfo><Affiliation>UJ-Jagiellonian University, Medical College, Faculty of Pharmacy, Department of Cytobiology, Krakow 30-001, Poland. elzbieta.menaszek@uj.edu.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Banasiuk</LastName><ForeName>Rafał</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>University of Gdansk, Intercollegiate Faculty of Biotechnology UG-GUMed, Department of Biotechnology, Laboratory of Biologically Active Compounds, Gdansk 80-307, Poland. rafal.banasiuk@biotech.ug.edu.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Królicka</LastName><ForeName>Aleksandra</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0001-5231-283X</Identifier><AffiliationInfo><Affiliation>University of Gdansk, Intercollegiate Faculty of Biotechnology UG-GUMed, Department of Biotechnology, Laboratory of Biologically Active Compounds, Gdansk 80-307, Poland. aleksandra.krolicka@biotech.ug.edu.pl.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Molecules</MedlineTA><NlmUniqueID>100964009</NlmUniqueID><ISSNLinking>1420-3049</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000180">Acrylic Resins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002070">Butadienes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011137">Polystyrenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>9003-56-9</RegistryNumber><NameOfSubstance UI="C024636">ABS resin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000180" MajorTopicYN="N">Acrylic Resins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002070" MajorTopicYN="N">Butadienes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="N">Cell Proliferation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="N">Metal Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009998" MajorTopicYN="Y">Ossicular Prosthesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011137" MajorTopicYN="N">Polystyrenes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016459" MajorTopicYN="N">Prosthesis-Related Infections</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011548" MajorTopicYN="N">Pseudomonadaceae</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013499" MajorTopicYN="N">Surface Properties</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">bactericidal efficacy</Keyword><Keyword MajorTopicYN="N">cytotoxicity</Keyword><Keyword MajorTopicYN="N">middle ear prosthesis</Keyword><Keyword MajorTopicYN="N">ossicular reconstruction</Keyword></KeywordList><CoiStatement>The authors declare no conflict of interest.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>10</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>3</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28994723</ArticleId><ArticleId IdType="pii">molecules22101681</ArticleId><ArticleId IdType="doi">10.3390/molecules22101681</ArticleId><ArticleId IdType="pmc">PMC6151403</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Biomed Mater Res. 2000 Feb;49(2):155-66</Citation><ArticleIdList><ArticleId IdType="pubmed">10571901</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Cell Mater. 2002 Sep 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