Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria.
Identifieur interne : 000463 ( Main/Corpus ); précédent : 000462; suivant : 000464Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria.
Auteurs : Fei Xu ; Ying Li ; Justen Ahmad ; Yonggang Wang ; Dorothy E. Scott ; Jaroslav G. VostalSource :
- FEMS microbiology letters [ 1574-6968 ] ; 2018.
English descriptors
- KwdEn :
- Bacterial Infections (blood), Bacterial Infections (drug therapy), Bacterial Infections (metabolism), Bacterial Infections (therapy), Escherichia coli (metabolism), Escherichia coli (radiation effects), Humans (MeSH), Photochemotherapy (MeSH), Photosensitizing Agents (pharmacology), Pseudomonas aeruginosa (metabolism), Pseudomonas aeruginosa (radiation effects), Reactive Oxygen Species (metabolism), Staphylococcus aureus (metabolism), Staphylococcus aureus (radiation effects), Staphylococcus epidermidis (metabolism), Staphylococcus epidermidis (radiation effects), Ultraviolet Rays (MeSH), Vitamin K 3 (analogs & derivatives), Vitamin K 3 (pharmacology).
- MESH :
- chemical , analogs & derivatives : Vitamin K 3.
- chemical , metabolism : Reactive Oxygen Species.
- chemical , pharmacology : Photosensitizing Agents, Vitamin K 3.
- blood : Bacterial Infections.
- drug therapy : Bacterial Infections.
- metabolism : Bacterial Infections, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis.
- radiation effects : Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis.
- therapy : Bacterial Infections.
- Humans, Photochemotherapy, Ultraviolet Rays.
Abstract
Photodynamic treatment combining light and a photosensitizer molecule can be an effective method to inactivate pathogenic bacteria. This study identified vitamin K5 as an efficient photosensitizer for ultraviolet light A (UVA)-induced bacterial inactivation. Six bacterial species, Bacillus cereus (vegetative form), Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and two species of antibiotic-resistant bacteria, Pseudomonas aeruginosa* and Staphylococcus aureus*, were suspended in aqueous solutions with or without vitamin K5 and exposed to UVA irradiation. UVA irradiation (5.8 J cm-2) with vitamin K5 (1600 μmol l-1) reduced the colony forming units (CFU) of these bacteria by three to seven logs. Antibiotic resistant bacteria were also susceptible to the bactericidal effects of UVA and vitamin K5 combination treatment. Inactivation of bacteria in human plasma required higher doses of UVA light and vitamin K5. UVA irradiation (30 J cm-2) with vitamin K5 (2000 μmol l-1) reduced E. coli and S. aureus spiked into human plasma by seven logs CFU/ml. Reactive oxygen species, such as superoxide anion radicals and hydroxyl radicals, were found to be generated in vitamin K5 aqueous solution after UVA irradiation, suggesting these oxygen species may mediate the inactivation of the bacteria.
DOI: 10.1093/femsle/fny005
PubMed: 29346538
Links to Exploration step
pubmed:29346538Le document en format XML
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Scott</name><affiliation><nlm:affiliation>Division of Plasma Protein Therapeutics, OTAT, CBER, FDA, Silver Spring, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vostal, Jaroslav G" sort="Vostal, Jaroslav G" uniqKey="Vostal J" first="Jaroslav G" last="Vostal">Jaroslav G. Vostal</name><affiliation><nlm:affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29346538</idno><idno type="pmid">29346538</idno><idno type="doi">10.1093/femsle/fny005</idno><idno type="wicri:Area/Main/Corpus">000463</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000463</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria.</title><author><name sortKey="Xu, Fei" sort="Xu, Fei" uniqKey="Xu F" first="Fei" last="Xu">Fei Xu</name><affiliation><nlm:affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Ying" sort="Li, Ying" uniqKey="Li Y" first="Ying" last="Li">Ying Li</name><affiliation><nlm:affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ahmad, Justen" sort="Ahmad, Justen" uniqKey="Ahmad J" first="Justen" last="Ahmad">Justen Ahmad</name><affiliation><nlm:affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yonggang" sort="Wang, Yonggang" uniqKey="Wang Y" first="Yonggang" last="Wang">Yonggang Wang</name><affiliation><nlm:affiliation>Division of Plasma Protein Therapeutics, OTAT, CBER, FDA, Silver Spring, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Dorothy E" sort="Scott, Dorothy E" uniqKey="Scott D" first="Dorothy E" last="Scott">Dorothy E. Scott</name><affiliation><nlm:affiliation>Division of Plasma Protein Therapeutics, OTAT, CBER, FDA, Silver Spring, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vostal, Jaroslav G" sort="Vostal, Jaroslav G" uniqKey="Vostal J" first="Jaroslav G" last="Vostal">Jaroslav G. Vostal</name><affiliation><nlm:affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">FEMS microbiology letters</title><idno type="eISSN">1574-6968</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bacterial Infections (blood)</term><term>Bacterial Infections (drug therapy)</term><term>Bacterial Infections (metabolism)</term><term>Bacterial Infections (therapy)</term><term>Escherichia coli (metabolism)</term><term>Escherichia coli (radiation effects)</term><term>Humans (MeSH)</term><term>Photochemotherapy (MeSH)</term><term>Photosensitizing Agents (pharmacology)</term><term>Pseudomonas aeruginosa (metabolism)</term><term>Pseudomonas aeruginosa (radiation effects)</term><term>Reactive Oxygen Species (metabolism)</term><term>Staphylococcus aureus (metabolism)</term><term>Staphylococcus aureus (radiation effects)</term><term>Staphylococcus epidermidis (metabolism)</term><term>Staphylococcus epidermidis (radiation effects)</term><term>Ultraviolet Rays (MeSH)</term><term>Vitamin K 3 (analogs & derivatives)</term><term>Vitamin K 3 (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vitamin K 3</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Photosensitizing Agents</term><term>Vitamin K 3</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bacterial Infections</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Bacterial Infections</term><term>Escherichia coli</term><term>Pseudomonas aeruginosa</term><term>Staphylococcus aureus</term><term>Staphylococcus epidermidis</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Escherichia coli</term><term>Pseudomonas aeruginosa</term><term>Staphylococcus aureus</term><term>Staphylococcus epidermidis</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Bacterial Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Photochemotherapy</term><term>Ultraviolet Rays</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Photodynamic treatment combining light and a photosensitizer molecule can be an effective method to inactivate pathogenic bacteria. This study identified vitamin K5 as an efficient photosensitizer for ultraviolet light A (UVA)-induced bacterial inactivation. Six bacterial species, Bacillus cereus (vegetative form), Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and two species of antibiotic-resistant bacteria, Pseudomonas aeruginosa* and Staphylococcus aureus*, were suspended in aqueous solutions with or without vitamin K5 and exposed to UVA irradiation. UVA irradiation (5.8 J cm-2) with vitamin K5 (1600 μmol l-1) reduced the colony forming units (CFU) of these bacteria by three to seven logs. Antibiotic resistant bacteria were also susceptible to the bactericidal effects of UVA and vitamin K5 combination treatment. Inactivation of bacteria in human plasma required higher doses of UVA light and vitamin K5. UVA irradiation (30 J cm-2) with vitamin K5 (2000 μmol l-1) reduced E. coli and S. aureus spiked into human plasma by seven logs CFU/ml. Reactive oxygen species, such as superoxide anion radicals and hydroxyl radicals, were found to be generated in vitamin K5 aqueous solution after UVA irradiation, suggesting these oxygen species may mediate the inactivation of the bacteria.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29346538</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1574-6968</ISSN><JournalIssue CitedMedium="Internet"><Volume>365</Volume><Issue>4</Issue><PubDate><Year>2018</Year><Month>02</Month><Day>01</Day></PubDate></JournalIssue><Title>FEMS microbiology letters</Title><ISOAbbreviation>FEMS Microbiol Lett</ISOAbbreviation></Journal><ArticleTitle>Vitamin K5 is an efficient photosensitizer for ultraviolet A light inactivation of bacteria.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1093/femsle/fny005</ELocationID><Abstract><AbstractText>Photodynamic treatment combining light and a photosensitizer molecule can be an effective method to inactivate pathogenic bacteria. This study identified vitamin K5 as an efficient photosensitizer for ultraviolet light A (UVA)-induced bacterial inactivation. Six bacterial species, Bacillus cereus (vegetative form), Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Klebsiella pneumoniae, and two species of antibiotic-resistant bacteria, Pseudomonas aeruginosa* and Staphylococcus aureus*, were suspended in aqueous solutions with or without vitamin K5 and exposed to UVA irradiation. UVA irradiation (5.8 J cm-2) with vitamin K5 (1600 μmol l-1) reduced the colony forming units (CFU) of these bacteria by three to seven logs. Antibiotic resistant bacteria were also susceptible to the bactericidal effects of UVA and vitamin K5 combination treatment. Inactivation of bacteria in human plasma required higher doses of UVA light and vitamin K5. UVA irradiation (30 J cm-2) with vitamin K5 (2000 μmol l-1) reduced E. coli and S. aureus spiked into human plasma by seven logs CFU/ml. Reactive oxygen species, such as superoxide anion radicals and hydroxyl radicals, were found to be generated in vitamin K5 aqueous solution after UVA irradiation, suggesting these oxygen species may mediate the inactivation of the bacteria.</AbstractText><CopyrightInformation>Published by Oxford University Press on behalf of FEMS 2018.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Fei</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmad</LastName><ForeName>Justen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yonggang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Plasma Protein Therapeutics, OTAT, CBER, FDA, Silver Spring, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Dorothy E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Division of Plasma Protein Therapeutics, OTAT, CBER, FDA, Silver Spring, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vostal</LastName><ForeName>Jaroslav G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Division of Blood Components and Devices, OBRR, CBER, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>FEMS Microbiol Lett</MedlineTA><NlmUniqueID>7705721</NlmUniqueID><ISSNLinking>0378-1097</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017319">Photosensitizing Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical><Chemical><RegistryNumber>723JX6CXY5</RegistryNumber><NameOfSubstance UI="D024483">Vitamin K 3</NameOfSubstance></Chemical><Chemical><RegistryNumber>KKP97T7O0X</RegistryNumber><NameOfSubstance UI="C024534">vitamin k5</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001424" MajorTopicYN="N">Bacterial Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010778" MajorTopicYN="N">Photochemotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017319" MajorTopicYN="N">Photosensitizing Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011550" MajorTopicYN="N">Pseudomonas aeruginosa</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013212" MajorTopicYN="N">Staphylococcus epidermidis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000528" MajorTopicYN="Y">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014466" MajorTopicYN="N">Ultraviolet Rays</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D024483" MajorTopicYN="N">Vitamin K 3</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">photodynamic inactivation</Keyword><Keyword MajorTopicYN="Y">reactive oxygen species</Keyword><Keyword MajorTopicYN="Y">ultraviolet light</Keyword><Keyword MajorTopicYN="Y">vitamin K5</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>08</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>01</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29346538</ArticleId><ArticleId IdType="pii">4810545</ArticleId><ArticleId IdType="doi">10.1093/femsle/fny005</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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