An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.
Identifieur interne : 000444 ( Main/Corpus ); précédent : 000443; suivant : 000445An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.
Auteurs : Menglong Liu ; Danfeng He ; Tao Yang ; Wei Liu ; Li Mao ; Yang Zhu ; Jun Wu ; Gaoxing Luo ; Jun DengSource :
- Journal of nanobiotechnology [ 1477-3155 ] ; 2018.
English descriptors
- KwdEn :
- Abscess (drug therapy), Abscess (microbiology), Abscess (pathology), Animals (MeSH), Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Carbocyanines (chemistry), Chitosan (chemistry), Escherichia coli (drug effects), Escherichia coli (growth & development), Escherichia coli (pathogenicity), Fluorescent Dyes (chemistry), Gold (chemistry), Hemolysis (drug effects), Humans (MeSH), Hydrogen-Ion Concentration (MeSH), Hyperthermia, Induced (methods), Indoles (chemistry), Male (MeSH), Metal Nanoparticles (chemistry), Metal Nanoparticles (ultrastructure), Methicillin-Resistant Staphylococcus aureus (drug effects), Methicillin-Resistant Staphylococcus aureus (growth & development), Methicillin-Resistant Staphylococcus aureus (pathogenicity), Mice (MeSH), Mice, Inbred BALB C (MeSH), Nanotubes (chemistry), Nanotubes (ultrastructure), Phototherapy (methods), Polymers (chemistry), Silver (chemistry), Silver (pharmacology), Skin (drug effects), Skin (microbiology), Skin (pathology), Staphylococcal Infections (drug therapy), Staphylococcal Infections (microbiology), Staphylococcal Infections (pathology), Static Electricity (MeSH).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Carbocyanines, Chitosan, Fluorescent Dyes, Gold, Indoles, Polymers, Silver.
- chemistry : Metal Nanoparticles, Nanotubes.
- drug effects : Escherichia coli, Hemolysis, Methicillin-Resistant Staphylococcus aureus, Skin.
- drug therapy : Abscess, Staphylococcal Infections.
- growth & development : Escherichia coli, Methicillin-Resistant Staphylococcus aureus.
- methods : Hyperthermia, Induced, Phototherapy.
- microbiology : Abscess, Skin, Staphylococcal Infections.
- pathogenicity : Escherichia coli, Methicillin-Resistant Staphylococcus aureus.
- pathology : Abscess, Skin, Staphylococcal Infections.
- chemical , pharmacology : Anti-Bacterial Agents, Silver.
- ultrastructure : Metal Nanoparticles, Nanotubes.
- Animals, Humans, Hydrogen-Ion Concentration, Male, Mice, Mice, Inbred BALB C, Static Electricity.
Abstract
BACKGROUND
Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents.
RESULTS
In this study, a chemo-photothermal therapeutic platform based on polydopamine (PDA)-coated gold nanorods (GNRs) was developed. The PDA coating acquired high Ag
CONCLUSIONS
Our studies demonstrate that Ag
DOI: 10.1186/s12951-018-0348-z
PubMed: 29548342
PubMed Central: PMC5857115
Links to Exploration step
pubmed:29548342Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.</title><author><name sortKey="Liu, Menglong" sort="Liu, Menglong" uniqKey="Liu M" first="Menglong" last="Liu">Menglong Liu</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Danfeng" sort="He, Danfeng" uniqKey="He D" first="Danfeng" last="He">Danfeng He</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Tao" sort="Yang, Tao" uniqKey="Yang T" first="Tao" last="Yang">Tao Yang</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mao, Li" sort="Mao, Li" uniqKey="Mao L" first="Li" last="Mao">Li Mao</name><affiliation><nlm:affiliation>Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, (Army Medical University), Chongqing, 400038, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Yang" sort="Zhu, Yang" uniqKey="Zhu Y" first="Yang" last="Zhu">Yang Zhu</name><affiliation><nlm:affiliation>Departments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, 94720, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Jun" sort="Wu, Jun" uniqKey="Wu J" first="Jun" last="Wu">Jun Wu</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. editorinchief@burninchina.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Burns, The First Affiliated Hospital, SunYat-Sen University, Guangzhou, 510080, China. editorinchief@burninchina.com.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Gaoxing" sort="Luo, Gaoxing" uniqKey="Luo G" first="Gaoxing" last="Luo">Gaoxing Luo</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. logxw@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Jun" sort="Deng, Jun" uniqKey="Deng J" first="Jun" last="Deng">Jun Deng</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. djun.123@163.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29548342</idno><idno type="pmid">29548342</idno><idno type="doi">10.1186/s12951-018-0348-z</idno><idno type="pmc">PMC5857115</idno><idno type="wicri:Area/Main/Corpus">000444</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000444</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.</title><author><name sortKey="Liu, Menglong" sort="Liu, Menglong" uniqKey="Liu M" first="Menglong" last="Liu">Menglong Liu</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Danfeng" sort="He, Danfeng" uniqKey="He D" first="Danfeng" last="He">Danfeng He</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Tao" sort="Yang, Tao" uniqKey="Yang T" first="Tao" last="Yang">Tao Yang</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</nlm:affiliation></affiliation></author><author><name sortKey="Mao, Li" sort="Mao, Li" uniqKey="Mao L" first="Li" last="Mao">Li Mao</name><affiliation><nlm:affiliation>Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, (Army Medical University), Chongqing, 400038, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Yang" sort="Zhu, Yang" uniqKey="Zhu Y" first="Yang" last="Zhu">Yang Zhu</name><affiliation><nlm:affiliation>Departments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, 94720, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Jun" sort="Wu, Jun" uniqKey="Wu J" first="Jun" last="Wu">Jun Wu</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. editorinchief@burninchina.com.</nlm:affiliation></affiliation><affiliation><nlm:affiliation>Department of Burns, The First Affiliated Hospital, SunYat-Sen University, Guangzhou, 510080, China. editorinchief@burninchina.com.</nlm:affiliation></affiliation></author><author><name sortKey="Luo, Gaoxing" sort="Luo, Gaoxing" uniqKey="Luo G" first="Gaoxing" last="Luo">Gaoxing Luo</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. logxw@yahoo.com.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Jun" sort="Deng, Jun" uniqKey="Deng J" first="Jun" last="Deng">Jun Deng</name><affiliation><nlm:affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. djun.123@163.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of nanobiotechnology</title><idno type="eISSN">1477-3155</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abscess (drug therapy)</term><term>Abscess (microbiology)</term><term>Abscess (pathology)</term><term>Animals (MeSH)</term><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Carbocyanines (chemistry)</term><term>Chitosan (chemistry)</term><term>Escherichia coli (drug effects)</term><term>Escherichia coli (growth & development)</term><term>Escherichia coli (pathogenicity)</term><term>Fluorescent Dyes (chemistry)</term><term>Gold (chemistry)</term><term>Hemolysis (drug effects)</term><term>Humans (MeSH)</term><term>Hydrogen-Ion Concentration (MeSH)</term><term>Hyperthermia, Induced (methods)</term><term>Indoles (chemistry)</term><term>Male (MeSH)</term><term>Metal Nanoparticles (chemistry)</term><term>Metal Nanoparticles (ultrastructure)</term><term>Methicillin-Resistant Staphylococcus aureus (drug effects)</term><term>Methicillin-Resistant Staphylococcus aureus (growth & development)</term><term>Methicillin-Resistant Staphylococcus aureus (pathogenicity)</term><term>Mice (MeSH)</term><term>Mice, Inbred BALB C (MeSH)</term><term>Nanotubes (chemistry)</term><term>Nanotubes (ultrastructure)</term><term>Phototherapy (methods)</term><term>Polymers (chemistry)</term><term>Silver (chemistry)</term><term>Silver (pharmacology)</term><term>Skin (drug effects)</term><term>Skin (microbiology)</term><term>Skin (pathology)</term><term>Staphylococcal Infections (drug therapy)</term><term>Staphylococcal Infections (microbiology)</term><term>Staphylococcal Infections (pathology)</term><term>Static Electricity (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Carbocyanines</term><term>Chitosan</term><term>Fluorescent Dyes</term><term>Gold</term><term>Indoles</term><term>Polymers</term><term>Silver</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term><term>Nanotubes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Escherichia coli</term><term>Hemolysis</term><term>Methicillin-Resistant Staphylococcus aureus</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Abscess</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Escherichia coli</term><term>Methicillin-Resistant Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Hyperthermia, Induced</term><term>Phototherapy</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Abscess</term><term>Skin</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Escherichia coli</term><term>Methicillin-Resistant Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Abscess</term><term>Skin</term><term>Staphylococcal Infections</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Silver</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Metal Nanoparticles</term><term>Nanotubes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Hydrogen-Ion Concentration</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Static Electricity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In this study, a chemo-photothermal therapeutic platform based on polydopamine (PDA)-coated gold nanorods (GNRs) was developed. The PDA coating acquired high Ag</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Our studies demonstrate that Ag</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29548342</PMID><DateCompleted><Year>2018</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1477-3155</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>Mar</Month><Day>16</Day></PubDate></JournalIssue><Title>Journal of nanobiotechnology</Title><ISOAbbreviation>J Nanobiotechnology</ISOAbbreviation></Journal><ArticleTitle>An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.</ArticleTitle><Pagination><MedlinePgn>23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12951-018-0348-z</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In this study, a chemo-photothermal therapeutic platform based on polydopamine (PDA)-coated gold nanorods (GNRs) was developed. The PDA coating acquired high Ag<sup>+</sup> ions loading efficiency and Cy5-SE fluorescent agent labeled glycol chitosan (GCS) conjugation (Ag<sup>+</sup>-GCS-PDA@GNRs). This platform became positively charged in the low pH environment of the abscess, allowing their accumulation in local infection site as revealed by thermal/florescence imaging. The loaded Ag<sup>+</sup> ions was released in a pH-sensitive manner, resulting in selective Ag<sup>+</sup> ions delivery to the abscess environment (pH ~ 6.3). More importantly, the ultralow dose of Ag<sup>+</sup> ions could effectively damage the bacterial membrane, causing the permeability increase and the heat resistance reduction of the cell membrane, leading to the large improvement on bactericidal efficiency of PTT. On the other hand, the hyperthermia could trigger more Ag<sup>+</sup> ions release, resulting in further improvement on bactericidal efficiency of chemotherapy. Combinational chemo-hyperthermia therapy of Ag<sup>+</sup>-GCS-PDA@GNRs could thoroughly ablate abscess and accelerate wound healing via a synergistic antibacterial effect.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our studies demonstrate that Ag<sup>+</sup>-GCS-PDA@GNRs is a robust and practical platform for use in chemo-thermal focal infection therapy with outstanding synergistic bacteria ablating.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Menglong</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Danfeng</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Laboratory Medicine, Southwest Hospital, Third Military Medical University, (Army Medical University), Chongqing, 400038, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Departments of Bioengineering and Materials Science and Engineering, University of California, Berkeley, CA, 94720, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. editorinchief@burninchina.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Burns, The First Affiliated Hospital, SunYat-Sen University, Guangzhou, 510080, China. editorinchief@burninchina.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Gaoxing</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. logxw@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China. djun.123@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>No. SWH2016ZDCX2014</GrantID><Agency>Science and Technology Innovation Plan of Southwest Hospital</Agency><Country></Country></Grant><Grant><GrantID>SWH2016JCYB-04</GrantID><Agency>Science and Technology Innovation Plan of Southwest Hospital</Agency><Country></Country></Grant><Grant><GrantID>Grant No. 2016XPY12</GrantID><Agency>Third Military Medical University Foundation</Agency><Country></Country></Grant><Grant><GrantID>51703243</GrantID><Agency>Natural Science Foundation of China</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>03</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Nanobiotechnology</MedlineTA><NlmUniqueID>101152208</NlmUniqueID><ISSNLinking>1477-3155</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002232">Carbocyanines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005456">Fluorescent Dyes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007211">Indoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011108">Polymers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C085321">cyanine dye 5</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C568283">polydopamine</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-57-5</RegistryNumber><NameOfSubstance UI="D006046">Gold</NameOfSubstance></Chemical><Chemical><RegistryNumber>9012-76-4</RegistryNumber><NameOfSubstance UI="D048271">Chitosan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000038" MajorTopicYN="N">Abscess</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002232" MajorTopicYN="N">Carbocyanines</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048271" MajorTopicYN="N">Chitosan</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005456" MajorTopicYN="N">Fluorescent Dyes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006046" MajorTopicYN="N">Gold</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006461" MajorTopicYN="N">Hemolysis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006863" MajorTopicYN="N">Hydrogen-Ion Concentration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006979" MajorTopicYN="N">Hyperthermia, Induced</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007211" MajorTopicYN="N">Indoles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" 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