[Antibacterial activity of silver nanoparticles against multiple drug resistant strains].
Identifieur interne : 000420 ( Main/Corpus ); précédent : 000419; suivant : 000421[Antibacterial activity of silver nanoparticles against multiple drug resistant strains].
Auteurs : Xueqing Chen ; Jiaxuan Jiang ; Zhihong Ren ; Juan Li ; Hongying Zhang ; Jianguo Xu ; Huamao DuSource :
- Wei sheng wu xue bao = Acta microbiologica Sinica [ 0001-6209 ] ; 2017.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (chemistry), Anti-Bacterial Agents (pharmacology), Drug Resistance, Multiple, Bacterial (MeSH), Escherichia coli (drug effects), Escherichia coli (growth & development), Metal Nanoparticles (chemistry), Microbial Sensitivity Tests (MeSH), Silver (chemistry), Silver (pharmacology), Staphylococcus aureus (drug effects), Staphylococcus aureus (growth & development).
- MESH :
- chemical , chemistry : Anti-Bacterial Agents, Silver.
- chemical , pharmacology : Anti-Bacterial Agents, Silver.
- chemistry : Metal Nanoparticles.
- drug effects : Escherichia coli, Staphylococcus aureus.
- growth & development : Escherichia coli, Staphylococcus aureus.
- Drug Resistance, Multiple, Bacterial, Microbial Sensitivity Tests.
Abstract
Objective
The objective of the study was to assess the antimicrobial activity of silver nanoparticles (AgNPs) against multiple drug resistant strains.
Methods
Minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgNPs against three model microbes, namely Escherichia coli, Staphylococcus aureus, Candida albicans were measured by microdilution broth method. Time-kill curve within 24 h was made according to colony count method after three model microbes were treated with a series concentration of AgNPs. Post-antibiotic effect was tested by colony count method. Finally, we determined the antimicrobial efficacy against multiple drug resistant strains in biological safety laboratory grade 2 (BSL-2).
Results
AgNPs with a diameter of 5 nm to 30 nm were synthesized by the biological method. The zeta potential was -19.5 mV. The time-kill curve of the three model microbes showed time-dependent antibacterial activity. The effect of AgNPs on E. coli and C. albicans after "antibiotic effect" increased with time, there was no obvious "post-antibiotic effect" on S. aureus. Both MIC values and MBC values of AgNPs for the three model microbes were between 1 μg/mL and 4 μg/mL. However, the MIC value of AgNPs for the three human multidrug-resistant strains was 6 μg/mL to 26 μg/mL and MBC value of AgNPs was 10 μg/mL to 32 μg/mL. The MIC values of AgNPs for 14 animal multi-drug resistant strains were between 4 μg/mL and 10 μg/mL, and the MBC values were between 8 μg/mL and 16 μg/mL. The MBC/MIC values of all the tested strains were less than 2.
Conclusion
AgNPs is a time-dependent antimicrobial agent with different "post-antibiotic effect", which can inhibit both human and animal-derived multi-drug resistant bacteria.
PubMed: 29756737
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pubmed:29756737Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Antibacterial activity of silver nanoparticles against multiple drug resistant strains].</title><author><name sortKey="Chen, Xueqing" sort="Chen, Xueqing" uniqKey="Chen X" first="Xueqing" last="Chen">Xueqing Chen</name></author><author><name sortKey="Jiang, Jiaxuan" sort="Jiang, Jiaxuan" uniqKey="Jiang J" first="Jiaxuan" last="Jiang">Jiaxuan Jiang</name></author><author><name sortKey="Ren, Zhihong" sort="Ren, Zhihong" uniqKey="Ren Z" first="Zhihong" last="Ren">Zhihong Ren</name></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name></author><author><name sortKey="Zhang, Hongying" sort="Zhang, Hongying" uniqKey="Zhang H" first="Hongying" last="Zhang">Hongying Zhang</name></author><author><name sortKey="Xu, Jianguo" sort="Xu, Jianguo" uniqKey="Xu J" first="Jianguo" last="Xu">Jianguo Xu</name></author><author><name sortKey="Du, Huamao" sort="Du, Huamao" uniqKey="Du H" first="Huamao" last="Du">Huamao Du</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29756737</idno><idno type="pmid">29756737</idno><idno type="wicri:Area/Main/Corpus">000420</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000420</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Antibacterial activity of silver nanoparticles against multiple drug resistant strains].</title><author><name sortKey="Chen, Xueqing" sort="Chen, Xueqing" uniqKey="Chen X" first="Xueqing" last="Chen">Xueqing Chen</name></author><author><name sortKey="Jiang, Jiaxuan" sort="Jiang, Jiaxuan" uniqKey="Jiang J" first="Jiaxuan" last="Jiang">Jiaxuan Jiang</name></author><author><name sortKey="Ren, Zhihong" sort="Ren, Zhihong" uniqKey="Ren Z" first="Zhihong" last="Ren">Zhihong Ren</name></author><author><name sortKey="Li, Juan" sort="Li, Juan" uniqKey="Li J" first="Juan" last="Li">Juan Li</name></author><author><name sortKey="Zhang, Hongying" sort="Zhang, Hongying" uniqKey="Zhang H" first="Hongying" last="Zhang">Hongying Zhang</name></author><author><name sortKey="Xu, Jianguo" sort="Xu, Jianguo" uniqKey="Xu J" first="Jianguo" last="Xu">Jianguo Xu</name></author><author><name sortKey="Du, Huamao" sort="Du, Huamao" uniqKey="Du H" first="Huamao" last="Du">Huamao Du</name></author></analytic><series><title level="j">Wei sheng wu xue bao = Acta microbiologica Sinica</title><idno type="ISSN">0001-6209</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anti-Bacterial Agents (chemistry)</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Drug Resistance, Multiple, Bacterial (MeSH)</term><term>Escherichia coli (drug effects)</term><term>Escherichia coli (growth & development)</term><term>Metal Nanoparticles (chemistry)</term><term>Microbial Sensitivity Tests (MeSH)</term><term>Silver (chemistry)</term><term>Silver (pharmacology)</term><term>Staphylococcus aureus (drug effects)</term><term>Staphylococcus aureus (growth & development)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Silver</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Silver</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Escherichia coli</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Escherichia coli</term><term>Staphylococcus aureus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Resistance, Multiple, Bacterial</term><term>Microbial Sensitivity Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Objective</b></p><p>The objective of the study was to assess the antimicrobial activity of silver nanoparticles (AgNPs) against multiple drug resistant strains.</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>Minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgNPs against three model microbes, namely Escherichia coli, Staphylococcus aureus, Candida albicans were measured by microdilution broth method. Time-kill curve within 24 h was made according to colony count method after three model microbes were treated with a series concentration of AgNPs. Post-antibiotic effect was tested by colony count method. Finally, we determined the antimicrobial efficacy against multiple drug resistant strains in biological safety laboratory grade 2 (BSL-2).</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>AgNPs with a diameter of 5 nm to 30 nm were synthesized by the biological method. The zeta potential was -19.5 mV. The time-kill curve of the three model microbes showed time-dependent antibacterial activity. The effect of AgNPs on E. coli and C. albicans after "antibiotic effect" increased with time, there was no obvious "post-antibiotic effect" on S. aureus. Both MIC values and MBC values of AgNPs for the three model microbes were between 1 μg/mL and 4 μg/mL. However, the MIC value of AgNPs for the three human multidrug-resistant strains was 6 μg/mL to 26 μg/mL and MBC value of AgNPs was 10 μg/mL to 32 μg/mL. The MIC values of AgNPs for 14 animal multi-drug resistant strains were between 4 μg/mL and 10 μg/mL, and the MBC values were between 8 μg/mL and 16 μg/mL. The MBC/MIC values of all the tested strains were less than 2.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>AgNPs is a time-dependent antimicrobial agent with different "post-antibiotic effect", which can inhibit both human and animal-derived multi-drug resistant bacteria.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29756737</PMID><DateCompleted><Year>2018</Year><Month>07</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>07</Month><Day>05</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-6209</ISSN><JournalIssue CitedMedium="Print"><Volume>57</Volume><Issue>4</Issue><PubDate><Year>2017</Year><Month>Apr</Month><Day>04</Day></PubDate></JournalIssue><Title>Wei sheng wu xue bao = Acta microbiologica Sinica</Title><ISOAbbreviation>Wei Sheng Wu Xue Bao</ISOAbbreviation></Journal><ArticleTitle>[Antibacterial activity of silver nanoparticles against multiple drug resistant strains].</ArticleTitle><Pagination><MedlinePgn>539-49</MedlinePgn></Pagination><Abstract><AbstractText Label="Objective">The objective of the study was to assess the antimicrobial activity of silver nanoparticles (AgNPs) against multiple drug resistant strains.</AbstractText><AbstractText Label="Methods">Minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of AgNPs against three model microbes, namely Escherichia coli, Staphylococcus aureus, Candida albicans were measured by microdilution broth method. Time-kill curve within 24 h was made according to colony count method after three model microbes were treated with a series concentration of AgNPs. Post-antibiotic effect was tested by colony count method. Finally, we determined the antimicrobial efficacy against multiple drug resistant strains in biological safety laboratory grade 2 (BSL-2).</AbstractText><AbstractText Label="Results">AgNPs with a diameter of 5 nm to 30 nm were synthesized by the biological method. The zeta potential was -19.5 mV. The time-kill curve of the three model microbes showed time-dependent antibacterial activity. The effect of AgNPs on E. coli and C. albicans after "antibiotic effect" increased with time, there was no obvious "post-antibiotic effect" on S. aureus. Both MIC values and MBC values of AgNPs for the three model microbes were between 1 μg/mL and 4 μg/mL. However, the MIC value of AgNPs for the three human multidrug-resistant strains was 6 μg/mL to 26 μg/mL and MBC value of AgNPs was 10 μg/mL to 32 μg/mL. The MIC values of AgNPs for 14 animal multi-drug resistant strains were between 4 μg/mL and 10 μg/mL, and the MBC values were between 8 μg/mL and 16 μg/mL. The MBC/MIC values of all the tested strains were less than 2.</AbstractText><AbstractText Label="Conclusion">AgNPs is a time-dependent antimicrobial agent with different "post-antibiotic effect", which can inhibit both human and animal-derived multi-drug resistant bacteria.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xueqing</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Jiaxuan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Zhihong</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Juan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Hongying</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Jianguo</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Huamao</ForeName><Initials>H</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Wei Sheng Wu Xue Bao</MedlineTA><NlmUniqueID>21610860R</NlmUniqueID><ISSNLinking>0001-6209</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>3M4G523W1G</RegistryNumber><NameOfSubstance UI="D012834">Silver</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024901" MajorTopicYN="Y">Drug Resistance, Multiple, Bacterial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004926" MajorTopicYN="N">Escherichia coli</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053768" MajorTopicYN="N">Metal Nanoparticles</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008826" MajorTopicYN="N">Microbial Sensitivity Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012834" MajorTopicYN="N">Silver</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013211" MajorTopicYN="N">Staphylococcus aureus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000254" MajorTopicYN="N">growth & development</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>5</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>5</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29756737</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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