SilverBacteriV1, Main, Corpus, bibRecord, 000327

Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.

Identifieur interne : 000327 ( Main/Corpus ); précédent : 000326; suivant : 000328

Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.

Auteurs : Meng-Meng Lu ; Yuran Ge ; Jing Qiu ; Dan Shao ; Yue Zhang ; Jing Bai ; Xiao Zheng ; Zhi-Min Chang ; Zheng Wang ; Wen-Fei Dong ; Chun-Bo Tang

Source :

International journal of nanomedicine [ 1178-2013 ] ; 2018.

RBID : pubmed:30538453

English descriptors

KwdEn :
- Animals (MeSH), Anti-Bacterial Agents (pharmacology), Biocompatible Materials (chemistry), Biofilms (drug effects), Cell Death (drug effects), Chlorhexidine (pharmacology), Delayed-Action Preparations (pharmacology), Drug Liberation (MeSH), Epithelial Cells (drug effects), Epithelial Cells (pathology), Humans (MeSH), Hydrogen-Ion Concentration (MeSH), Ions (MeSH), Metal Nanoparticles (chemistry), Metal Nanoparticles (ultrastructure), Mice (MeSH), Microbial Sensitivity Tests (MeSH), Mouth (microbiology), Nanoparticles (chemistry), Organ Specificity (MeSH), Oxidation-Reduction (MeSH), Silicon Dioxide (chemistry), Silver (pharmacology), Streptococcus mutans (drug effects), Streptococcus mutans (ultrastructure).
MESH :
- chemical , chemistry : Biocompatible Materials, Silicon Dioxide.
- chemical , pharmacology : Anti-Bacterial Agents, Chlorhexidine, Delayed-Action Preparations, Silver.
- chemistry : Metal Nanoparticles, Nanoparticles.
- drug effects : Biofilms, Cell Death, Epithelial Cells, Streptococcus mutans.
- microbiology : Mouth.
- pathology : Epithelial Cells.
- ultrastructure : Metal Nanoparticles, Streptococcus mutans.
- Animals, Drug Liberation, Humans, Hydrogen-Ion Concentration, Ions, Mice, Microbial Sensitivity Tests, Organ Specificity, Oxidation-Reduction.

Abstract

Background

Oral plaque biofilms pose a threat to periodontal health and are challenging to eradicate. There is a growing belief that a combination of silver nanoparticles and chlorhexidine (CHX) is a promising strategy against oral biofilms.

Purpose

To overcome the side effects of this strategy and to exert maximum efficiency, we fabricated biodegradable disulfide-bridged mesoporous silica nanoparticles (MSNs) to co-deliver silver nanoparticles and CHX for biofilm inhibition.

Materials and methods

CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) were fabricated after CHX loading, and the pH- and glutathione-responsive release profiles of CHX and silver ions along with their mechanism of degradation were systematically investigated. Then, the efficacy of Ag-MSNs@CHX against

Results

The obtained Ag-MSNs@CHX possessed redox/pH-responsive release properties of CHX and silver ions, which may be attributed to the redox-triggered matrix degradation mechanism of exposure to biofilm-mimetic microenvironments. Ag-MSNs@CHX displayed dose-dependent antibacterial activity against planktonic and clone formation of

Conclusion

Our findings constitute a highly effective and safe strategy against biofilms that has a good potential as an oral biofilm therapy.

DOI: 10.2147/IJN.S181168
PubMed: 30538453
PubMed Central: PMC6251470

Links to Exploration step

pubmed:30538453

Le document en format XML

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<author><name sortKey="Lu, Meng Meng" sort="Lu, Meng Meng" uniqKey="Lu M" first="Meng-Meng" last="Lu">Meng-Meng Lu</name>
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<author><name sortKey="Shao, Dan" sort="Shao, Dan" uniqKey="Shao D" first="Dan" last="Shao">Dan Shao</name>
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<author><name sortKey="Zheng, Xiao" sort="Zheng, Xiao" uniqKey="Zheng X" first="Xiao" last="Zheng">Xiao Zheng</name>
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<author><name sortKey="Chang, Zhi Min" sort="Chang, Zhi Min" uniqKey="Chang Z" first="Zhi-Min" last="Chang">Zhi-Min Chang</name>
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<author><name sortKey="Wang, Zheng" sort="Wang, Zheng" uniqKey="Wang Z" first="Zheng" last="Wang">Zheng Wang</name>
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<affiliation><nlm:affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.</title>
<author><name sortKey="Lu, Meng Meng" sort="Lu, Meng Meng" uniqKey="Lu M" first="Meng-Meng" last="Lu">Meng-Meng Lu</name>
<affiliation><nlm:affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ge, Yuran" sort="Ge, Yuran" uniqKey="Ge Y" first="Yuran" last="Ge">Yuran Ge</name>
<affiliation><nlm:affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Qiu, Jing" sort="Qiu, Jing" uniqKey="Qiu J" first="Jing" last="Qiu">Jing Qiu</name>
<affiliation><nlm:affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shao, Dan" sort="Shao, Dan" uniqKey="Shao D" first="Dan" last="Shao">Dan Shao</name>
<affiliation><nlm:affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Yue" sort="Zhang, Yue" uniqKey="Zhang Y" first="Yue" last="Zhang">Yue Zhang</name>
<affiliation><nlm:affiliation>School of Materials Science and Engineering, Southeast University, Nanjing, 211189, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bai, Jing" sort="Bai, Jing" uniqKey="Bai J" first="Jing" last="Bai">Jing Bai</name>
<affiliation><nlm:affiliation>School of Materials Science and Engineering, Southeast University, Nanjing, 211189, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zheng, Xiao" sort="Zheng, Xiao" uniqKey="Zheng X" first="Xiao" last="Zheng">Xiao Zheng</name>
<affiliation><nlm:affiliation>Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chang, Zhi Min" sort="Chang, Zhi Min" uniqKey="Chang Z" first="Zhi-Min" last="Chang">Zhi-Min Chang</name>
<affiliation><nlm:affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Zheng" sort="Wang, Zheng" uniqKey="Wang Z" first="Zheng" last="Wang">Zheng Wang</name>
<affiliation><nlm:affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dong, Wen Fei" sort="Dong, Wen Fei" uniqKey="Dong W" first="Wen-Fei" last="Dong">Wen-Fei Dong</name>
<affiliation><nlm:affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tang, Chun Bo" sort="Tang, Chun Bo" uniqKey="Tang C" first="Chun-Bo" last="Tang">Chun-Bo Tang</name>
<affiliation><nlm:affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
<affiliation><nlm:affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of nanomedicine</title>
<idno type="eISSN">1178-2013</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Anti-Bacterial Agents (pharmacology)</term>
<term>Biocompatible Materials (chemistry)</term>
<term>Biofilms (drug effects)</term>
<term>Cell Death (drug effects)</term>
<term>Chlorhexidine (pharmacology)</term>
<term>Delayed-Action Preparations (pharmacology)</term>
<term>Drug Liberation (MeSH)</term>
<term>Epithelial Cells (drug effects)</term>
<term>Epithelial Cells (pathology)</term>
<term>Humans (MeSH)</term>
<term>Hydrogen-Ion Concentration (MeSH)</term>
<term>Ions (MeSH)</term>
<term>Metal Nanoparticles (chemistry)</term>
<term>Metal Nanoparticles (ultrastructure)</term>
<term>Mice (MeSH)</term>
<term>Microbial Sensitivity Tests (MeSH)</term>
<term>Mouth (microbiology)</term>
<term>Nanoparticles (chemistry)</term>
<term>Organ Specificity (MeSH)</term>
<term>Oxidation-Reduction (MeSH)</term>
<term>Silicon Dioxide (chemistry)</term>
<term>Silver (pharmacology)</term>
<term>Streptococcus mutans (drug effects)</term>
<term>Streptococcus mutans (ultrastructure)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Biocompatible Materials</term>
<term>Silicon Dioxide</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Chlorhexidine</term>
<term>Delayed-Action Preparations</term>
<term>Silver</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term>
<term>Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Biofilms</term>
<term>Cell Death</term>
<term>Epithelial Cells</term>
<term>Streptococcus mutans</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Mouth</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelial Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Metal Nanoparticles</term>
<term>Streptococcus mutans</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Drug Liberation</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Ions</term>
<term>Mice</term>
<term>Microbial Sensitivity Tests</term>
<term>Organ Specificity</term>
<term>Oxidation-Reduction</term>
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<front><div type="abstract" xml:lang="en"><p><b>Background</b>
</p>
<p>Oral plaque biofilms pose a threat to periodontal health and are challenging to eradicate. There is a growing belief that a combination of silver nanoparticles and chlorhexidine (CHX) is a promising strategy against oral biofilms.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Purpose</b>
</p>
<p>To overcome the side effects of this strategy and to exert maximum efficiency, we fabricated biodegradable disulfide-bridged mesoporous silica nanoparticles (MSNs) to co-deliver silver nanoparticles and CHX for biofilm inhibition.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Materials and methods</b>
</p>
<p>CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) were fabricated after CHX loading, and the pH- and glutathione-responsive release profiles of CHX and silver ions along with their mechanism of degradation were systematically investigated. Then, the efficacy of Ag-MSNs@CHX against </p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>The obtained Ag-MSNs@CHX possessed redox/pH-responsive release properties of CHX and silver ions, which may be attributed to the redox-triggered matrix degradation mechanism of exposure to biofilm-mimetic microenvironments. Ag-MSNs@CHX displayed dose-dependent antibacterial activity against planktonic and clone formation of </p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusion</b>
</p>
<p>Our findings constitute a highly effective and safe strategy against biofilms that has a good potential as an oral biofilm therapy.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30538453</PMID>
<DateCompleted><Year>2019</Year>
<Month>01</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>14</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1178-2013</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<PubDate><Year>2018</Year>
</PubDate>
</JournalIssue>
<Title>International journal of nanomedicine</Title>
<ISOAbbreviation>Int J Nanomedicine</ISOAbbreviation>
</Journal>
<ArticleTitle>Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.</ArticleTitle>
<Pagination><MedlinePgn>7697-7709</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.2147/IJN.S181168</ELocationID>
<Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Oral plaque biofilms pose a threat to periodontal health and are challenging to eradicate. There is a growing belief that a combination of silver nanoparticles and chlorhexidine (CHX) is a promising strategy against oral biofilms.</AbstractText>
<AbstractText Label="Purpose" NlmCategory="UNASSIGNED">To overcome the side effects of this strategy and to exert maximum efficiency, we fabricated biodegradable disulfide-bridged mesoporous silica nanoparticles (MSNs) to co-deliver silver nanoparticles and CHX for biofilm inhibition.</AbstractText>
<AbstractText Label="Materials and methods" NlmCategory="UNASSIGNED">CHX-loaded, silver-decorated mesoporous silica nanoparticles (Ag-MSNs@CHX) were fabricated after CHX loading, and the pH- and glutathione-responsive release profiles of CHX and silver ions along with their mechanism of degradation were systematically investigated. Then, the efficacy of Ag-MSNs@CHX against <i>Streptococcus mutans</i>
 and its biofilm was comprehensively assessed by determining the minimum inhibitory concentration, minimum bactericidal concentration, minimal biofilm inhibitory concentration, and the inhibitory effect on <i>S. mutans</i>
 biofilm formation. In addition, the biosafety of nanocarriers was evaluated by oral epithelial cells and a mouse model.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">The obtained Ag-MSNs@CHX possessed redox/pH-responsive release properties of CHX and silver ions, which may be attributed to the redox-triggered matrix degradation mechanism of exposure to biofilm-mimetic microenvironments. Ag-MSNs@CHX displayed dose-dependent antibacterial activity against planktonic and clone formation of <i>S. mutans</i>
. Importantly, Ag-MSNs@CHX had an increased and long-term ability to restrict the growth of <i>S. mutans</i>
 biofilms compared to free CHX. Moreover, Ag-MSNs@CHX showed less cytotoxicity to oral epithelial cells, whereas orally administered Ag-MSNs exhibited no obvious toxic effects in mice.</AbstractText>
<AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Our findings constitute a highly effective and safe strategy against biofilms that has a good potential as an oral biofilm therapy.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Meng-Meng</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ge</LastName>
<ForeName>Yuran</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qiu</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shao</LastName>
<ForeName>Dan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Yue</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>School of Materials Science and Engineering, Southeast University, Nanjing, 211189, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bai</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>School of Materials Science and Engineering, Southeast University, Nanjing, 211189, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Xiao</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun, 130021, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Zhi-Min</ForeName>
<Initials>ZM</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Zheng</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dong</LastName>
<ForeName>Wen-Fei</ForeName>
<Initials>WF</Initials>
<AffiliationInfo><Affiliation>CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China, stanauagate@outlook.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Chun-Bo</ForeName>
<Initials>CB</Initials>
<AffiliationInfo><Affiliation>Department of Oral Implantology, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China, cbtang@njmu.edu.cn.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
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<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>11</Month>
<Day>19</Day>
</ArticleDate>
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Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.

Redox/pH dual-controlled release of chlorhexidine and silver ions from biodegradable mesoporous silica nanoparticles against oral biofilms.

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