SilverBacteriV1, Main, Corpus, bibRecord, 000308

Silver nanoparticles inhibit beige fat function and promote adiposity.

Identifieur interne : 000308 ( Main/Corpus ); précédent : 000307; suivant : 000309

Silver nanoparticles inhibit beige fat function and promote adiposity.

Auteurs : Lishu Yue ; Wenjun Zhao ; Dongmei Wang ; Meiyao Meng ; Ying Zheng ; Yu Li ; Jin Qiu ; Jian Yu ; Yang Yan ; Peng Lu ; Youmin Sun ; Jie Fu ; Jiqiu Wang ; Qiang Zhang ; Lingyan Xu ; Xinran Ma

Source :

Molecular metabolism [ 2212-8778 ] ; 2019.

RBID : pubmed:30737105

English descriptors

KwdEn :
- Adipocytes, Beige (drug effects), Adipocytes, Beige (metabolism), Adiposity (drug effects), Animals (MeSH), Cell Survival (drug effects), Cells, Cultured (MeSH), Metal Nanoparticles (administration & dosage), Metal Nanoparticles (adverse effects), Metal Nanoparticles (chemistry), Mice (MeSH), Obesity (drug therapy), Obesity (metabolism), Reactive Oxygen Species (analysis), Reactive Oxygen Species (metabolism), Silver (administration & dosage), Silver (adverse effects), Silver (chemistry), Silver (pharmacology).
MESH :
- chemical , administration & dosage : Silver.
- chemical , adverse effects : Silver.
- chemical , analysis : Reactive Oxygen Species.
- administration & dosage : Metal Nanoparticles.
- adverse effects : Metal Nanoparticles.
- chemistry : Metal Nanoparticles, Silver.
- drug effects : Adipocytes, Beige, Adiposity, Cell Survival.
- drug therapy : Obesity.
- metabolism : Adipocytes, Beige, Obesity, Reactive Oxygen Species.
- chemical , pharmacology : Silver.
- Animals, Cells, Cultured, Mice.

Abstract

OBJECTIVE

Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution of environmental pollutants frequent in modern society. Silver nanoparticles (AgNPs) are widely used for bactericidal purpose in various applications in daily life. However, their potential toxicity and contribution to the obesity epidemic are not clear.

METHODS

Beige adipocytes are newly discovered adipocytes characterized by high thermogenic and energy dissipating capacity upon activation and the "browning" process. In the present study, we assess the impact of AgNPs exposure on beige adipocytes differentiation and functionality both in vitro and in vivo. We also systematically investigate the influence of AgNPs on adiposity and metabolic performance in mice, as well as the possible underlying molecular mechanism.

RESULTS

The results showed that, independent of particle size, AgNPs inhibit the adipogenic, mitochondrial, and thermogenic gene programs of beige adipocytes, thus suppressing their differentiation ability, mitochondrial activity, and thermogenic response. Importantly, exposure to AgNPs in mice suppresses browning gene programs in subcutaneous fat, leading to decreased energy expenditure and increased adiposity in mice. Mechanistically, we found that AgNPs increase reactive oxidative species (ROS) levels and specifically activate MAPK-ERK signaling in beige adipocytes. The negative impacts of AgNPs on beige adipocytes can be ameliorated by antioxidant or ERK inhibitor FR180204 treatment.

CONCLUSIONS

Taken together, these results revealed an unexpected role of AgNPs in promoting adiposity through the inhibition of beige adipocyte differentiation and functionality, possibly by disrupting ROS homeostasis and ERK phosphorylation. Future assessments on the health risk of AgNPs applications and their safe dosages are warranted.

DOI: 10.1016/j.molmet.2019.01.005
PubMed: 30737105
PubMed Central: PMC6437600

Links to Exploration step

pubmed:30737105

Le document en format XML

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<author><name sortKey="Zhao, Wenjun" sort="Zhao, Wenjun" uniqKey="Zhao W" first="Wenjun" last="Zhao">Wenjun Zhao</name>
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<author><name sortKey="Lu, Peng" sort="Lu, Peng" uniqKey="Lu P" first="Peng" last="Lu">Peng Lu</name>
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<author><name sortKey="Sun, Youmin" sort="Sun, Youmin" uniqKey="Sun Y" first="Youmin" last="Sun">Youmin Sun</name>
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<author><name sortKey="Fu, Jie" sort="Fu, Jie" uniqKey="Fu J" first="Jie" last="Fu">Jie Fu</name>
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<author><name sortKey="Wang, Jiqiu" sort="Wang, Jiqiu" uniqKey="Wang J" first="Jiqiu" last="Wang">Jiqiu Wang</name>
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</affiliation>
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<author><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name>
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</affiliation>
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<author><name sortKey="Xu, Lingyan" sort="Xu, Lingyan" uniqKey="Xu L" first="Lingyan" last="Xu">Lingyan Xu</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Silver nanoparticles inhibit beige fat function and promote adiposity.</title>
<author><name sortKey="Yue, Lishu" sort="Yue, Lishu" uniqKey="Yue L" first="Lishu" last="Yue">Lishu Yue</name>
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<author><name sortKey="Zhao, Wenjun" sort="Zhao, Wenjun" uniqKey="Zhao W" first="Wenjun" last="Zhao">Wenjun Zhao</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Dongmei" sort="Wang, Dongmei" uniqKey="Wang D" first="Dongmei" last="Wang">Dongmei Wang</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Meng, Meiyao" sort="Meng, Meiyao" uniqKey="Meng M" first="Meiyao" last="Meng">Meiyao Meng</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zheng, Ying" sort="Zheng, Ying" uniqKey="Zheng Y" first="Ying" last="Zheng">Ying Zheng</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Li, Yu" sort="Li, Yu" uniqKey="Li Y" first="Yu" last="Li">Yu Li</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Qiu, Jin" sort="Qiu, Jin" uniqKey="Qiu J" first="Jin" last="Qiu">Jin Qiu</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yu, Jian" sort="Yu, Jian" uniqKey="Yu J" first="Jian" last="Yu">Jian Yu</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yan, Yang" sort="Yan, Yang" uniqKey="Yan Y" first="Yang" last="Yan">Yang Yan</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lu, Peng" sort="Lu, Peng" uniqKey="Lu P" first="Peng" last="Lu">Peng Lu</name>
<affiliation><nlm:affiliation>Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sun, Youmin" sort="Sun, Youmin" uniqKey="Sun Y" first="Youmin" last="Sun">Youmin Sun</name>
<affiliation><nlm:affiliation>Department of Environmental Science & Engineering, Fudan University, Shanghai, 200433, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fu, Jie" sort="Fu, Jie" uniqKey="Fu J" first="Jie" last="Fu">Jie Fu</name>
<affiliation><nlm:affiliation>Department of Environmental Science & Engineering, Fudan University, Shanghai, 200433, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Jiqiu" sort="Wang, Jiqiu" uniqKey="Wang J" first="Jiqiu" last="Wang">Jiqiu Wang</name>
<affiliation><nlm:affiliation>Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Qiang" sort="Zhang, Qiang" uniqKey="Zhang Q" first="Qiang" last="Zhang">Qiang Zhang</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Xu, Lingyan" sort="Xu, Lingyan" uniqKey="Xu L" first="Lingyan" last="Xu">Lingyan Xu</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. Electronic address: lyxu@bio.ecnu.edu.cn.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ma, Xinran" sort="Ma, Xinran" uniqKey="Ma X" first="Xinran" last="Ma">Xinran Ma</name>
<affiliation><nlm:affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. Electronic address: xrma@bio.ecnu.edu.cn.</nlm:affiliation>
</affiliation>
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<series><title level="j">Molecular metabolism</title>
<idno type="eISSN">2212-8778</idno>
<imprint><date when="2019" type="published">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipocytes, Beige (drug effects)</term>
<term>Adipocytes, Beige (metabolism)</term>
<term>Adiposity (drug effects)</term>
<term>Animals (MeSH)</term>
<term>Cell Survival (drug effects)</term>
<term>Cells, Cultured (MeSH)</term>
<term>Metal Nanoparticles (administration & dosage)</term>
<term>Metal Nanoparticles (adverse effects)</term>
<term>Metal Nanoparticles (chemistry)</term>
<term>Mice (MeSH)</term>
<term>Obesity (drug therapy)</term>
<term>Obesity (metabolism)</term>
<term>Reactive Oxygen Species (analysis)</term>
<term>Reactive Oxygen Species (metabolism)</term>
<term>Silver (administration & dosage)</term>
<term>Silver (adverse effects)</term>
<term>Silver (chemistry)</term>
<term>Silver (pharmacology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Silver</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Silver</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Reactive Oxygen Species</term>
</keywords>
<keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Metal Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Metal Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Metal Nanoparticles</term>
<term>Silver</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Adipocytes, Beige</term>
<term>Adiposity</term>
<term>Cell Survival</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipocytes, Beige</term>
<term>Obesity</term>
<term>Reactive Oxygen Species</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Silver</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Mice</term>
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<front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b>
</p>
<p>Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution of environmental pollutants frequent in modern society. Silver nanoparticles (AgNPs) are widely used for bactericidal purpose in various applications in daily life. However, their potential toxicity and contribution to the obesity epidemic are not clear.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Beige adipocytes are newly discovered adipocytes characterized by high thermogenic and energy dissipating capacity upon activation and the "browning" process. In the present study, we assess the impact of AgNPs exposure on beige adipocytes differentiation and functionality both in vitro and in vivo. We also systematically investigate the influence of AgNPs on adiposity and metabolic performance in mice, as well as the possible underlying molecular mechanism.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The results showed that, independent of particle size, AgNPs inhibit the adipogenic, mitochondrial, and thermogenic gene programs of beige adipocytes, thus suppressing their differentiation ability, mitochondrial activity, and thermogenic response. Importantly, exposure to AgNPs in mice suppresses browning gene programs in subcutaneous fat, leading to decreased energy expenditure and increased adiposity in mice. Mechanistically, we found that AgNPs increase reactive oxidative species (ROS) levels and specifically activate MAPK-ERK signaling in beige adipocytes. The negative impacts of AgNPs on beige adipocytes can be ameliorated by antioxidant or ERK inhibitor FR180204 treatment.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Taken together, these results revealed an unexpected role of AgNPs in promoting adiposity through the inhibition of beige adipocyte differentiation and functionality, possibly by disrupting ROS homeostasis and ERK phosphorylation. Future assessments on the health risk of AgNPs applications and their safe dosages are warranted.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30737105</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2212-8778</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>22</Volume>
<PubDate><Year>2019</Year>
<Month>04</Month>
</PubDate>
</JournalIssue>
<Title>Molecular metabolism</Title>
<ISOAbbreviation>Mol Metab</ISOAbbreviation>
</Journal>
<ArticleTitle>Silver nanoparticles inhibit beige fat function and promote adiposity.</ArticleTitle>
<Pagination><MedlinePgn>1-11</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S2212-8778(18)31008-1</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.molmet.2019.01.005</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE">Obesity is a complex chronic disease of high prevalence worldwide. Multiple factors play integral roles in obesity development, with rising interest focusing on the contribution of environmental pollutants frequent in modern society. Silver nanoparticles (AgNPs) are widely used for bactericidal purpose in various applications in daily life. However, their potential toxicity and contribution to the obesity epidemic are not clear.</AbstractText>
<AbstractText Label="METHODS">Beige adipocytes are newly discovered adipocytes characterized by high thermogenic and energy dissipating capacity upon activation and the "browning" process. In the present study, we assess the impact of AgNPs exposure on beige adipocytes differentiation and functionality both in vitro and in vivo. We also systematically investigate the influence of AgNPs on adiposity and metabolic performance in mice, as well as the possible underlying molecular mechanism.</AbstractText>
<AbstractText Label="RESULTS">The results showed that, independent of particle size, AgNPs inhibit the adipogenic, mitochondrial, and thermogenic gene programs of beige adipocytes, thus suppressing their differentiation ability, mitochondrial activity, and thermogenic response. Importantly, exposure to AgNPs in mice suppresses browning gene programs in subcutaneous fat, leading to decreased energy expenditure and increased adiposity in mice. Mechanistically, we found that AgNPs increase reactive oxidative species (ROS) levels and specifically activate MAPK-ERK signaling in beige adipocytes. The negative impacts of AgNPs on beige adipocytes can be ameliorated by antioxidant or ERK inhibitor FR180204 treatment.</AbstractText>
<AbstractText Label="CONCLUSIONS">Taken together, these results revealed an unexpected role of AgNPs in promoting adiposity through the inhibition of beige adipocyte differentiation and functionality, possibly by disrupting ROS homeostasis and ERK phosphorylation. Future assessments on the health risk of AgNPs applications and their safe dosages are warranted.</AbstractText>
<CopyrightInformation>Copyright © 2019 The Authors. Published by Elsevier GmbH.. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yue</LastName>
<ForeName>Lishu</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Wenjun</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Dongmei</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meng</LastName>
<ForeName>Meiyao</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Ying</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Qiu</LastName>
<ForeName>Jin</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yu</LastName>
<ForeName>Jian</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yan</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Peng</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Youmin</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Environmental Science & Engineering, Fudan University, Shanghai, 200433, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fu</LastName>
<ForeName>Jie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Environmental Science & Engineering, Fudan University, Shanghai, 200433, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jiqiu</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Qiang</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Lingyan</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. Electronic address: lyxu@bio.ecnu.edu.cn.</Affiliation>
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<ForeName>Xinran</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. Electronic address: xrma@bio.ecnu.edu.cn.</Affiliation>
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<Month>01</Month>
<Day>24</Day>
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<Keyword MajorTopicYN="Y">Beige fat</Keyword>
<Keyword MajorTopicYN="Y">Browning</Keyword>
<Keyword MajorTopicYN="Y">Energy expenditure</Keyword>
<Keyword MajorTopicYN="Y">Reactive oxidative species</Keyword>
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<Month>01</Month>
<Day>09</Day>
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<ArticleIdList><ArticleId IdType="pubmed">30737105</ArticleId>
<ArticleId IdType="pii">S2212-8778(18)31008-1</ArticleId>
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<ReferenceList><Reference><Citation>Nature. 2016 Apr 7;532(7597):112-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27027295</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Health Perspect. 2015 Jun;123(6):636-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25738596</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2008 May 15;22(10):1269-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18483216</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Enzymol. 2013;528:27-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23849857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neurotoxicology. 2016 Jan;52:210-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26702581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2015 Oct 7;7(308):308re8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26446958</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14289-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25225406</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Nanomedicine. 2014 May 20;9:2469-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24899804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Agric Environ Med. 2013;20(1):48-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23540211</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nanotechnology. 2016 Oct 14;27(41):412003</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27609489</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2012 Jan 11;481(7382):463-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22237023</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Soc Rev. 2015 Dec 7;44(23):8410-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26435358</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Metab. 2014 May 6;19(5):810-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24709624</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nanotechnology. 2015 Oct 30;26(43):435101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26437254</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Biol. 2018 May 11;16(5):e2004225</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29750781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2014 Oct 15;9(10):e85556</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25329153</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Endocr Rev. 2014 Aug;35(4):557-601</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24483949</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Circulation. 2009 Feb 3;119(4):538-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19153269</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PeerJ. 2015 Mar 24;3:e856</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25825681</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2015 Oct 9;350(6257):1242477</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26450215</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Manag Care. 2014 Jul;20(10 Spec No):E8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25549559</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Endocrinol (Lausanne). 2012 Feb 06;3:14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22654854</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Metab. 2014 Sep 2;20(3):396-407</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25127354</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2014 Jan 29;6(221):221ra15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24477002</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Toxicol In Vitro. 2013 Feb;27(1):330-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22940466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Aging Cell. 2018 Apr;17(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29383825</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biomed Nanotechnol. 2014 Apr;10(4):669-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24734519</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Part Fibre Toxicol. 2010 Aug 06;7:20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20691052</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Cell Physiol. 2013 Apr 15;304(8):C729-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23302779</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Endocrinol Metab. 2012 Feb;97(2):E223-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22090277</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Endocr Regul. 2012 Jan;46(1):37-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22329821</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2017 Aug 15;318(7):603</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28810033</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Metab. 2015 Oct 6;22(4):695-708</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26344102</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomaterials. 2014 Aug;35(24):6498-507</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24797880</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Sci Technol. 2017 Aug 1;51(15):8735-8745</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28699343</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharm Res. 2014 Nov;31(11):2952-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24805277</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Int. 2017 Nov;108:11-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28779625</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Diabetes. 2018 Jun;10(6):442-448</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28097815</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2014 Jan 16;156(1-2):20-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24439368</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Health Perspect. 2016 Dec;124(12):1891-1897</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27285825</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>

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Silver nanoparticles inhibit beige fat function and promote adiposity.

Silver nanoparticles inhibit beige fat function and promote adiposity.

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